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Protein

Olfactory receptor 2C1

Gene

OR2C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2C1
Alternative name(s):
OLFmf3
Olfactory receptor 2C2
Olfactory receptor OR16-1
Olfactory receptor OR16-2
Gene namesi
Name:OR2C1
Synonyms:OR2C2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:8242. OR2C1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19638ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21923Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32147.

Polymorphism and mutation databases

BioMutaiOR2C1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2C1PRO_0000150465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95371.
PRIDEiO95371.

Expressioni

Gene expression databases

BgeeiENSG00000168158.
CleanExiHS_OR2C1.
GenevisibleiO95371. HS.

Organism-specific databases

HPAiCAB010455.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307726.

Structurei

3D structure databases

ProteinModelPortaliO95371.
SMRiO95371. Positions 27-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKIM. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO95371.
KOiK04257.
OMAiIIVISYC.
OrthoDBiEOG091G0CU6.
PhylomeDBiO95371.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGVNDSSLQ GFVLMGISDH PQLEMIFFIA ILFSYLLTLL GNSTIILLSR
60 70 80 90 100
LEARLHTPMY FFLSNLSSLD LAFATSSVPQ MLINLWGPGK TISYGGCITQ
110 120 130 140 150
LYVFLWLGAT ECILLVVMAF DRYVAVCRPL RYTAIMNPQL CWLLAVIACL
160 170 180 190 200
GGLGNSVIQS TFTLQLPLCG HRRVEGFLCE VPAMIKLACG DTSLNQAVLN
210 220 230 240 250
GVCTFFTAVP LSIIVISYCL IAQAVLKIRS AEGRRKAFNT CLSHLLVVFL
260 270 280 290 300
FYGSASYGYL LPAKNSKQDQ GKFISLFYSL VTPMVNPLIY TLRNMEVKGA
310
LRRLLGKGRE VG
Length:312
Mass (Da):34,412
Last modified:November 2, 2010 - v3
Checksum:i33A2697D06ED8E9E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161G → S.2 Publications
Corresponds to variant rs1218762 [ dbSNP | Ensembl ].
VAR_047490
Natural varianti149 – 1491C → W.4 Publications
Corresponds to variant rs1218763 [ dbSNP | Ensembl ].
VAR_047491
Natural varianti229 – 2291R → H.2 Publications
Corresponds to variant rs11648783 [ dbSNP | Ensembl ].
VAR_047492

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098664 Genomic DNA. Translation: AAC83557.1.
AC025283 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85373.1.
BC069456 mRNA. Translation: AAH69456.1.
BC126269 mRNA. Translation: AAI26270.1.
BC130328 mRNA. Translation: AAI30329.1.
BK004407 Genomic DNA. Translation: DAA04805.1.
BK004428 Genomic DNA. Translation: DAA04826.1.
CCDSiCCDS10502.1.
RefSeqiNP_036500.2. NM_012368.2.
UniGeneiHs.258574.

Genome annotation databases

EnsembliENST00000304936; ENSP00000307726; ENSG00000168158.
GeneIDi4993.
KEGGihsa:4993.
UCSCiuc002cuw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098664 Genomic DNA. Translation: AAC83557.1.
AC025283 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85373.1.
BC069456 mRNA. Translation: AAH69456.1.
BC126269 mRNA. Translation: AAI26270.1.
BC130328 mRNA. Translation: AAI30329.1.
BK004407 Genomic DNA. Translation: DAA04805.1.
BK004428 Genomic DNA. Translation: DAA04826.1.
CCDSiCCDS10502.1.
RefSeqiNP_036500.2. NM_012368.2.
UniGeneiHs.258574.

3D structure databases

ProteinModelPortaliO95371.
SMRiO95371. Positions 27-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000307726.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2C1.

Proteomic databases

PaxDbiO95371.
PRIDEiO95371.

Protocols and materials databases

DNASUi4993.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304936; ENSP00000307726; ENSG00000168158.
GeneIDi4993.
KEGGihsa:4993.
UCSCiuc002cuw.2. human.

Organism-specific databases

CTDi4993.
GeneCardsiOR2C1.
H-InvDBHIX0202332.
HGNCiHGNC:8242. OR2C1.
HPAiCAB010455.
neXtProtiNX_O95371.
PharmGKBiPA32147.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKIM. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO95371.
KOiK04257.
OMAiIIVISYC.
OrthoDBiEOG091G0CU6.
PhylomeDBiO95371.
TreeFamiTF336512.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2C1.
GenomeRNAii4993.
PROiO95371.

Gene expression databases

BgeeiENSG00000168158.
CleanExiHS_OR2C1.
GenevisibleiO95371. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2C1_HUMAN
AccessioniPrimary (citable) accession number: O95371
Secondary accession number(s): A0AVA4, Q6IF34, Q6IF55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: September 7, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.