##gff-version 3 O95365 UniProtKB Chain 1 584 . . . ID=PRO_0000047715;Note=Zinc finger and BTB domain-containing protein 7A O95365 UniProtKB Domain 34 101 . . . Note=BTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00037 O95365 UniProtKB Zinc finger 382 404 . . . Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 O95365 UniProtKB Zinc finger 410 432 . . . Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 O95365 UniProtKB Zinc finger 438 460 . . . Note=C2H2-type 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 O95365 UniProtKB Zinc finger 466 490 . . . Note=C2H2-type 4%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 O95365 UniProtKB Region 220 313 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95365 UniProtKB Region 277 584 . . . Note=Mediates interaction with KHDRBS1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24514149;Dbxref=PMID:24514149 O95365 UniProtKB Region 349 584 . . . Note=Mediates interaction with RELA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88939 O95365 UniProtKB Region 377 584 . . . Note=Mediates interaction with SMAD4;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25514493;Dbxref=PMID:25514493 O95365 UniProtKB Region 486 584 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95365 UniProtKB Modified residue 337 337 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:23186163,PMID:24275569 O95365 UniProtKB Modified residue 341 341 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 O95365 UniProtKB Modified residue 511 511 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 O95365 UniProtKB Modified residue 525 525 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 O95365 UniProtKB Modified residue 526 526 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 O95365 UniProtKB Modified residue 549 549 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:23186163,PMID:24275569 O95365 UniProtKB Cross-link 436 436 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 O95365 UniProtKB Cross-link 539 539 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25114211,ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:28112733 O95365 UniProtKB Natural variant 56 56 . . . ID=VAR_086968;Note=In MNDLFH%3B uncertain significance. S->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34515416;Dbxref=PMID:34515416 O95365 UniProtKB Natural variant 278 584 . . . ID=VAR_086969;Note=In MNDLFH. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34515416;Dbxref=PMID:34515416 O95365 UniProtKB Natural variant 370 584 . . . ID=VAR_086970;Note=In MNDLFH. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34515416;Dbxref=PMID:34515416 O95365 UniProtKB Natural variant 384 384 . . . ID=VAR_086971;Note=In MNDLFH. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31645653;Dbxref=PMID:31645653 O95365 UniProtKB Natural variant 405 405 . . . ID=VAR_086972;Note=In MNDLFH. T->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34515416;Dbxref=PMID:34515416 O95365 UniProtKB Natural variant 452 452 . . . ID=VAR_086973;Note=In MNDLFH%3B uncertain significance. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34515416;Dbxref=PMID:34515416 O95365 UniProtKB Mutagenesis 14 14 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 22 22 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 49 49 . . . Note=Increased proteasomal degradation. No effect on nuclear localization. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 60 60 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 61 61 . . . Note=Loss of sumoylation with SUMO1. May decrease interaction with transcriptional corepressors. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595526;Dbxref=PMID:17595526 O95365 UniProtKB Mutagenesis 78 78 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 112 112 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 184 184 . . . Note=Decreased transcription repressor activity. No effect on nuclear localization. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 322 322 . . . Note=Decreased transcription repressor activity. No effect on nuclear localization. Q->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 326 326 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 354 354 . . . Note=No effect on sumoylation with SUMO1. No effect on promoter binding. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595526;Dbxref=PMID:17595526 O95365 UniProtKB Mutagenesis 357 357 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 371 371 . . . Note=No effect on sumoylation with SUMO1. No effect on promoter binding. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595526;Dbxref=PMID:17595526 O95365 UniProtKB Mutagenesis 377 377 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 379 379 . . . Note=No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595526;Dbxref=PMID:17595526 O95365 UniProtKB Mutagenesis 383 383 . . . Note=No effect on sumoylation with SUMO1. No effect on promoter binding. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595526;Dbxref=PMID:17595526 O95365 UniProtKB Mutagenesis 387 387 . . . Note=Decreased transcription repressor activity. No effect on nuclear localization. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 391 391 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. I->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 396 396 . . . Note=No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595526;Dbxref=PMID:17595526 O95365 UniProtKB Mutagenesis 399 399 . . . Note=Decreased transcription repressor activity%2C dominant negative effect. Increased glycolysis and cell proliferation%2C dominant negative effect. No effect on nuclear localization. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 402 402 . . . Note=Decreased transcription repressor activity. Acts as a dominant negative. No effect on nuclear localization. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 403 403 . . . Note=Decreased transcription repressor activity. No effect on nuclear localization. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 404 404 . . . Note=Decreased transcription repressor activity. Acts as a dominant negative. No effect on nuclear localization. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 406 406 . . . Note=Decreased transcription repressor activity. No effect on nuclear localization. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 409 409 . . . Note=Decreased transcription repressor activity. No effect on nuclear localization. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 412 412 . . . Note=Decreased transcription repressor activity. No effect on nuclear localization. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 424 424 . . . Note=Decreased transcription repressor activity. No effect on nuclear localization. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 424 424 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. K->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 430 430 . . . Note=Decreased transcription repressor activity. No effect on nuclear localization. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 461 461 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 463 463 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 466 466 . . . Note=Decreased transcription repressor activity. No effect on nuclear localization. Y->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 486 486 . . . Note=No effect on sumoylation with SUMO1. No effect on promoter binding. No effect on nuclear localization. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595526;Dbxref=PMID:17595526 O95365 UniProtKB Mutagenesis 487 487 . . . Note=No effect on sumoylation with SUMO1. No effect on promoter binding. No effect on nuclear localization. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595526;Dbxref=PMID:17595526 O95365 UniProtKB Mutagenesis 522 522 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 536 536 . . . Note=No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595526;Dbxref=PMID:17595526 O95365 UniProtKB Mutagenesis 539 539 . . . Note=No effect on sumoylation with SUMO1. Decreased transcription repression activity. No effect on promoter binding. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595526;Dbxref=PMID:17595526 O95365 UniProtKB Mutagenesis 541 541 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 562 562 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Mutagenesis 576 576 . . . Note=No effect on transcription repressor activity. No effect on nuclear localization. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26455326;Dbxref=PMID:26455326 O95365 UniProtKB Sequence conflict 554 554 . . . Note=G->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95365 UniProtKB Beta strand 9 12 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2NN2 O95365 UniProtKB Helix 16 29 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IF5 O95365 UniProtKB Beta strand 36 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IF5 O95365 UniProtKB Beta strand 43 47 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IF5 O95365 UniProtKB Helix 49 55 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IF5 O95365 UniProtKB Helix 57 64 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IF5 O95365 UniProtKB Beta strand 73 76 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IF5 O95365 UniProtKB Helix 82 94 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IF5 O95365 UniProtKB Beta strand 95 99 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2NN2 O95365 UniProtKB Helix 101 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IF5 O95365 UniProtKB Helix 104 113 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IF5 O95365 UniProtKB Helix 117 127 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IF5 O95365 UniProtKB Beta strand 381 383 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7N5W O95365 UniProtKB Turn 385 387 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Beta strand 390 393 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Helix 394 396 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7N5S O95365 UniProtKB Helix 397 405 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Turn 413 415 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Beta strand 418 420 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Helix 422 428 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Helix 430 433 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Turn 441 443 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Beta strand 446 449 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Helix 450 456 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Helix 457 459 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8H9H O95365 UniProtKB Turn 461 463 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7N5V O95365 UniProtKB Beta strand 466 468 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7N5V O95365 UniProtKB Turn 469 471 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EYI O95365 UniProtKB Beta strand 474 477 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EYI O95365 UniProtKB Helix 478 486 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EYI O95365 UniProtKB Helix 488 490 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7N5V