Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O95365

- ZBT7A_HUMAN

UniProt

O95365 - ZBT7A_HUMAN

Protein

Zinc finger and BTB domain-containing protein 7A

Gene

ZBTB7A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals By similarity. Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri382 – 40423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri410 – 43223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 46023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri466 – 49025C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. histone acetyltransferase binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. negative regulation of transcription, DNA-templated Source: UniProtKB
    4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiO95365.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 7A
    Alternative name(s):
    Factor binding IST protein 1
    Short name:
    FBI-1
    Factor that binds to inducer of short transcripts protein 1
    HIV-1 1st-binding protein 1
    Leukemia/lymphoma-related factor
    POZ and Krueppel erythroid myeloid ontogenic factor
    Short name:
    POK erythroid myeloid ontogenic factor
    Short name:
    Pokemon
    TTF-I-interacting peptide 21
    Short name:
    TIP21
    Zinc finger protein 857A
    Gene namesi
    Name:ZBTB7A
    Synonyms:FBI1, LRF, ZBTB7, ZNF857A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:18078. ZBTB7A.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134885165.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 584584Zinc finger and BTB domain-containing protein 7APRO_0000047715Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei337 – 3371Phosphoserine2 Publications
    Modified residuei341 – 3411Phosphoserine1 Publication
    Modified residuei511 – 5111Phosphoserine1 Publication
    Modified residuei525 – 5251Phosphoserine1 Publication
    Modified residuei526 – 5261Phosphoserine1 Publication
    Modified residuei549 – 5491Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95365.
    PaxDbiO95365.
    PRIDEiO95365.

    PTM databases

    PhosphoSiteiO95365.

    Expressioni

    Tissue specificityi

    Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level).2 Publications

    Gene expression databases

    BgeeiO95365.
    CleanExiHS_ZBTB7A.
    GenevestigatoriO95365.

    Organism-specific databases

    HPAiCAB037214.

    Interactioni

    Subunit structurei

    Interacts with BCL6.By similarity

    Protein-protein interaction databases

    BioGridi119488. 28 interactions.
    IntActiO95365. 1 interaction.
    STRINGi9606.ENSP00000323670.

    Structurei

    Secondary structure

    1
    584
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi9 – 124
    Helixi16 – 2914
    Beta strandi36 – 405
    Beta strandi43 – 475
    Helixi49 – 557
    Helixi57 – 648
    Beta strandi73 – 764
    Helixi82 – 9413
    Beta strandi95 – 995
    Helixi101 – 1033
    Helixi104 – 11310
    Helixi117 – 12711

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IF5X-ray2.00A9-128[»]
    2NN2X-ray2.10A/B1-131[»]
    ProteinModelPortaliO95365.
    SMRiO95365. Positions 9-128, 363-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95365.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 10168BTBPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi175 – 21137Ala-richAdd
    BLAST
    Compositional biasi175 – 1817Poly-Ala
    Compositional biasi560 – 5656Poly-Gly

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri382 – 40423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri410 – 43223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 46023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri466 – 49025C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000082521.
    HOVERGENiHBG106747.
    InParanoidiO95365.
    KOiK10494.
    OMAiTRDRQAP.
    OrthoDBiEOG70W3D4.
    PhylomeDBiO95365.
    TreeFamiTF331824.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95365-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS    50
    VLAACSQYFK KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS 100
    TANVGDILSA ARLLEIPAVS HVCADLLDRQ ILAADAGADA GQLDLVDQID 150
    QRNLLRAKEY LEFFQSNPMN SLPPAAAAAA ASFPWSAFGA SDDDLDATKE 200
    AVAAAVAAVA AGDCNGLDFY GPGPPAERPP TGDGDEGDSN PGLWPERDED 250
    APTGGLFPPP VAPPAATQNG HYGRGGEEEA ASLSEAAPEP GDSPGFLSGA 300
    AEGEDGDGPD VDGLAASTLL QQMMSSVGRA GAAAGDSDEE SRADDKGVMD 350
    YYLKYFSGAH DGDVYPAWSQ KVEKKIRAKA FQKCPICEKV IQGAGKLPRH 400
    IRTHTGEKPY ECNICKVRFT RQDKLKVHMR KHTGEKPYLC QQCGAAFAHN 450
    YDLKNHMRVH TGLRPYQCDS CCKTFVRSDH LHRHLKKDGC NGVPSRRGRK 500
    PRVRGGAPDP SPGATATPGA PAQPSSPDAR RNGQEKHFKD EDEDEDVASP 550
    DGLGRLNVAG AGGGGDSGGG PGAATDGNFT AGLA 584
    Length:584
    Mass (Da):61,439
    Last modified:May 1, 1999 - v1
    Checksum:i50073663F3D393A0
    GO

    Sequence cautioni

    The sequence AAB58414.1 differs from that shown. Reason: Frameshift at positions 8 and 324.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti554 – 5541G → C in AAH84568. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097916 mRNA. Translation: AAC72973.1.
    AF000561 mRNA. Translation: AAB58414.1. Frameshift.
    CH471139 Genomic DNA. Translation: EAW69267.1.
    CH471139 Genomic DNA. Translation: EAW69268.1.
    CH471139 Genomic DNA. Translation: EAW69270.1.
    CH471139 Genomic DNA. Translation: EAW69271.1.
    CH471139 Genomic DNA. Translation: EAW69272.1.
    BC084568 mRNA. Translation: AAH84568.1.
    BC113511 mRNA. Translation: AAI13512.1.
    CCDSiCCDS12119.1.
    RefSeqiNP_056982.1. NM_015898.2.
    XP_005259627.2. XM_005259570.2.
    XP_005259628.1. XM_005259571.2.
    XP_005259629.1. XM_005259572.1.
    UniGeneiHs.591384.

    Genome annotation databases

    EnsembliENST00000322357; ENSP00000323670; ENSG00000178951.
    ENST00000601588; ENSP00000471865; ENSG00000178951.
    GeneIDi51341.
    KEGGihsa:51341.
    UCSCiuc002lzh.3. human.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097916 mRNA. Translation: AAC72973.1 .
    AF000561 mRNA. Translation: AAB58414.1 . Frameshift.
    CH471139 Genomic DNA. Translation: EAW69267.1 .
    CH471139 Genomic DNA. Translation: EAW69268.1 .
    CH471139 Genomic DNA. Translation: EAW69270.1 .
    CH471139 Genomic DNA. Translation: EAW69271.1 .
    CH471139 Genomic DNA. Translation: EAW69272.1 .
    BC084568 mRNA. Translation: AAH84568.1 .
    BC113511 mRNA. Translation: AAI13512.1 .
    CCDSi CCDS12119.1.
    RefSeqi NP_056982.1. NM_015898.2.
    XP_005259627.2. XM_005259570.2.
    XP_005259628.1. XM_005259571.2.
    XP_005259629.1. XM_005259572.1.
    UniGenei Hs.591384.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IF5 X-ray 2.00 A 9-128 [» ]
    2NN2 X-ray 2.10 A/B 1-131 [» ]
    ProteinModelPortali O95365.
    SMRi O95365. Positions 9-128, 363-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119488. 28 interactions.
    IntActi O95365. 1 interaction.
    STRINGi 9606.ENSP00000323670.

    PTM databases

    PhosphoSitei O95365.

    Proteomic databases

    MaxQBi O95365.
    PaxDbi O95365.
    PRIDEi O95365.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322357 ; ENSP00000323670 ; ENSG00000178951 .
    ENST00000601588 ; ENSP00000471865 ; ENSG00000178951 .
    GeneIDi 51341.
    KEGGi hsa:51341.
    UCSCi uc002lzh.3. human.

    Organism-specific databases

    CTDi 51341.
    GeneCardsi GC19M004045.
    HGNCi HGNC:18078. ZBTB7A.
    HPAi CAB037214.
    MIMi 605878. gene.
    neXtProti NX_O95365.
    PharmGKBi PA134885165.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000082521.
    HOVERGENi HBG106747.
    InParanoidi O95365.
    KOi K10494.
    OMAi TRDRQAP.
    OrthoDBi EOG70W3D4.
    PhylomeDBi O95365.
    TreeFami TF331824.

    Enzyme and pathway databases

    SignaLinki O95365.

    Miscellaneous databases

    ChiTaRSi ZBTB7A. human.
    EvolutionaryTracei O95365.
    GeneWikii ZBTB7A.
    GenomeRNAii 51341.
    NextBioi 54786.
    PROi O95365.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95365.
    CleanExi HS_ZBTB7A.
    Genevestigatori O95365.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein."
      Morrison D.J., Pendergrast P.S., Stavropoulos P., Colmenares S.U., Kobayashi R., Hernandez N.
      Nucleic Acids Res. 27:1251-1262(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Carcinoma.
    2. "cDNA encoding TTF-I interacting peptide 21 (TIP21)."
      Jansa P., Grummt I.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Pancreas.
    5. "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene."
      Davies J.M., Hawe N., Kabarowski J., Huang Q.-H., Zhu J., Brand N.J., Leprince D., Dhordain P., Cook M., Moriss-Kay G., Zelent A.
      Oncogene 18:365-375(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Role of the proto-oncogene Pokemon in cellular transformation and ARF repression."
      Maeda T., Hobbs R.M., Merghoub T., Guernah I., Zelent A., Cordon-Cardo C., Teruya-Feldstein J., Pandolfi P.P.
      Nature 433:278-285(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337 AND SER-549, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511 AND SER-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337; SER-341 AND SER-549, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Structure of the POZ domain of human LRF, a master regulator of oncogenesis."
      Schubot F.D., Tropea J.E., Waugh D.S.
      Biochem. Biophys. Res. Commun. 351:1-6(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 9-128.
    14. "Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator."
      Stogios P.J., Chen L., Prive G.G.
      Protein Sci. 16:336-342(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-131.

    Entry informationi

    Entry nameiZBT7A_HUMAN
    AccessioniPrimary (citable) accession number: O95365
    Secondary accession number(s): D6W619
    , O00456, Q14D41, Q5XG86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3