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O95365

- ZBT7A_HUMAN

UniProt

O95365 - ZBT7A_HUMAN

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Protein

Zinc finger and BTB domain-containing protein 7A

Gene

ZBTB7A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri382 – 40423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 49025C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. histone acetyltransferase binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. negative regulation of transcription, DNA-templated Source: UniProtKB
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiO95365.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 7A
Alternative name(s):
Factor binding IST protein 1
Short name:
FBI-1
Factor that binds to inducer of short transcripts protein 1
HIV-1 1st-binding protein 1
Leukemia/lymphoma-related factor
POZ and Krueppel erythroid myeloid ontogenic factor
Short name:
POK erythroid myeloid ontogenic factor
Short name:
Pokemon
TTF-I-interacting peptide 21
Short name:
TIP21
Zinc finger protein 857A
Gene namesi
Name:ZBTB7A
Synonyms:FBI1, LRF, ZBTB7, ZNF857A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:18078. ZBTB7A.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Zinc finger and BTB domain-containing protein 7APRO_0000047715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei337 – 3371Phosphoserine2 Publications
Modified residuei341 – 3411Phosphoserine1 Publication
Modified residuei511 – 5111Phosphoserine1 Publication
Modified residuei525 – 5251Phosphoserine1 Publication
Modified residuei526 – 5261Phosphoserine1 Publication
Modified residuei549 – 5491Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95365.
PaxDbiO95365.
PRIDEiO95365.

PTM databases

PhosphoSiteiO95365.

Expressioni

Tissue specificityi

Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level).2 Publications

Gene expression databases

BgeeiO95365.
CleanExiHS_ZBTB7A.
GenevestigatoriO95365.

Organism-specific databases

HPAiCAB037214.

Interactioni

Subunit structurei

Interacts with BCL6.By similarity

Protein-protein interaction databases

BioGridi119488. 30 interactions.
IntActiO95365. 1 interaction.
STRINGi9606.ENSP00000323670.

Structurei

Secondary structure

1
584
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 124
Helixi16 – 2914
Beta strandi36 – 405
Beta strandi43 – 475
Helixi49 – 557
Helixi57 – 648
Beta strandi73 – 764
Helixi82 – 9413
Beta strandi95 – 995
Helixi101 – 1033
Helixi104 – 11310
Helixi117 – 12711

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IF5X-ray2.00A9-128[»]
2NN2X-ray2.10A/B1-131[»]
ProteinModelPortaliO95365.
SMRiO95365. Positions 9-128, 383-484.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95365.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10168BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi175 – 21137Ala-richAdd
BLAST
Compositional biasi175 – 1817Poly-Ala
Compositional biasi560 – 5656Poly-Gly

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri382 – 40423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 49025C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118922.
HOGENOMiHOG000082521.
HOVERGENiHBG106747.
InParanoidiO95365.
KOiK10494.
OMAiTRDRQAP.
OrthoDBiEOG70W3D4.
PhylomeDBiO95365.
TreeFamiTF331824.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95365-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS
60 70 80 90 100
VLAACSQYFK KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS
110 120 130 140 150
TANVGDILSA ARLLEIPAVS HVCADLLDRQ ILAADAGADA GQLDLVDQID
160 170 180 190 200
QRNLLRAKEY LEFFQSNPMN SLPPAAAAAA ASFPWSAFGA SDDDLDATKE
210 220 230 240 250
AVAAAVAAVA AGDCNGLDFY GPGPPAERPP TGDGDEGDSN PGLWPERDED
260 270 280 290 300
APTGGLFPPP VAPPAATQNG HYGRGGEEEA ASLSEAAPEP GDSPGFLSGA
310 320 330 340 350
AEGEDGDGPD VDGLAASTLL QQMMSSVGRA GAAAGDSDEE SRADDKGVMD
360 370 380 390 400
YYLKYFSGAH DGDVYPAWSQ KVEKKIRAKA FQKCPICEKV IQGAGKLPRH
410 420 430 440 450
IRTHTGEKPY ECNICKVRFT RQDKLKVHMR KHTGEKPYLC QQCGAAFAHN
460 470 480 490 500
YDLKNHMRVH TGLRPYQCDS CCKTFVRSDH LHRHLKKDGC NGVPSRRGRK
510 520 530 540 550
PRVRGGAPDP SPGATATPGA PAQPSSPDAR RNGQEKHFKD EDEDEDVASP
560 570 580
DGLGRLNVAG AGGGGDSGGG PGAATDGNFT AGLA
Length:584
Mass (Da):61,439
Last modified:May 1, 1999 - v1
Checksum:i50073663F3D393A0
GO

Sequence cautioni

The sequence AAB58414.1 differs from that shown. Reason: Frameshift at positions 8 and 324.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti554 – 5541G → C in AAH84568. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097916 mRNA. Translation: AAC72973.1.
AF000561 mRNA. Translation: AAB58414.1. Frameshift.
CH471139 Genomic DNA. Translation: EAW69267.1.
CH471139 Genomic DNA. Translation: EAW69268.1.
CH471139 Genomic DNA. Translation: EAW69270.1.
CH471139 Genomic DNA. Translation: EAW69271.1.
CH471139 Genomic DNA. Translation: EAW69272.1.
BC084568 mRNA. Translation: AAH84568.1.
BC113511 mRNA. Translation: AAI13512.1.
CCDSiCCDS12119.1.
RefSeqiNP_056982.1. NM_015898.2.
XP_005259627.2. XM_005259570.2.
XP_005259628.1. XM_005259571.2.
XP_005259629.1. XM_005259572.1.
UniGeneiHs.591384.

Genome annotation databases

EnsembliENST00000322357; ENSP00000323670; ENSG00000178951.
ENST00000601588; ENSP00000471865; ENSG00000178951.
GeneIDi51341.
KEGGihsa:51341.
UCSCiuc002lzh.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097916 mRNA. Translation: AAC72973.1 .
AF000561 mRNA. Translation: AAB58414.1 . Frameshift.
CH471139 Genomic DNA. Translation: EAW69267.1 .
CH471139 Genomic DNA. Translation: EAW69268.1 .
CH471139 Genomic DNA. Translation: EAW69270.1 .
CH471139 Genomic DNA. Translation: EAW69271.1 .
CH471139 Genomic DNA. Translation: EAW69272.1 .
BC084568 mRNA. Translation: AAH84568.1 .
BC113511 mRNA. Translation: AAI13512.1 .
CCDSi CCDS12119.1.
RefSeqi NP_056982.1. NM_015898.2.
XP_005259627.2. XM_005259570.2.
XP_005259628.1. XM_005259571.2.
XP_005259629.1. XM_005259572.1.
UniGenei Hs.591384.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2IF5 X-ray 2.00 A 9-128 [» ]
2NN2 X-ray 2.10 A/B 1-131 [» ]
ProteinModelPortali O95365.
SMRi O95365. Positions 9-128, 383-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119488. 30 interactions.
IntActi O95365. 1 interaction.
STRINGi 9606.ENSP00000323670.

PTM databases

PhosphoSitei O95365.

Proteomic databases

MaxQBi O95365.
PaxDbi O95365.
PRIDEi O95365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322357 ; ENSP00000323670 ; ENSG00000178951 .
ENST00000601588 ; ENSP00000471865 ; ENSG00000178951 .
GeneIDi 51341.
KEGGi hsa:51341.
UCSCi uc002lzh.3. human.

Organism-specific databases

CTDi 51341.
GeneCardsi GC19M004045.
HGNCi HGNC:18078. ZBTB7A.
HPAi CAB037214.
MIMi 605878. gene.
neXtProti NX_O95365.
PharmGKBi PA134885165.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118922.
HOGENOMi HOG000082521.
HOVERGENi HBG106747.
InParanoidi O95365.
KOi K10494.
OMAi TRDRQAP.
OrthoDBi EOG70W3D4.
PhylomeDBi O95365.
TreeFami TF331824.

Enzyme and pathway databases

SignaLinki O95365.

Miscellaneous databases

ChiTaRSi ZBTB7A. human.
EvolutionaryTracei O95365.
GeneWikii ZBTB7A.
GenomeRNAii 51341.
NextBioi 54786.
PROi O95365.
SOURCEi Search...

Gene expression databases

Bgeei O95365.
CleanExi HS_ZBTB7A.
Genevestigatori O95365.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein."
    Morrison D.J., Pendergrast P.S., Stavropoulos P., Colmenares S.U., Kobayashi R., Hernandez N.
    Nucleic Acids Res. 27:1251-1262(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Carcinoma.
  2. "cDNA encoding TTF-I interacting peptide 21 (TIP21)."
    Jansa P., Grummt I.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Pancreas.
  5. "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene."
    Davies J.M., Hawe N., Kabarowski J., Huang Q.-H., Zhu J., Brand N.J., Leprince D., Dhordain P., Cook M., Moriss-Kay G., Zelent A.
    Oncogene 18:365-375(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Role of the proto-oncogene Pokemon in cellular transformation and ARF repression."
    Maeda T., Hobbs R.M., Merghoub T., Guernah I., Zelent A., Cordon-Cardo C., Teruya-Feldstein J., Pandolfi P.P.
    Nature 433:278-285(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337 AND SER-549, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511 AND SER-525, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337; SER-341 AND SER-549, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Structure of the POZ domain of human LRF, a master regulator of oncogenesis."
    Schubot F.D., Tropea J.E., Waugh D.S.
    Biochem. Biophys. Res. Commun. 351:1-6(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 9-128.
  14. "Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator."
    Stogios P.J., Chen L., Prive G.G.
    Protein Sci. 16:336-342(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-131.

Entry informationi

Entry nameiZBT7A_HUMAN
AccessioniPrimary (citable) accession number: O95365
Secondary accession number(s): D6W619
, O00456, Q14D41, Q5XG86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3