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Protein

Tripartite motif-containing protein 16

Gene

TRIM16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of keratinocyte differentiation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 122B box-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri126 – 165B box-type 2PROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • interleukin-1 binding Source: UniProtKB
  • NACHT domain binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • histone H3 acetylation Source: UniProtKB
  • histone H4 acetylation Source: UniProtKB
  • positive regulation of interleukin-1 beta secretion Source: UniProtKB
  • positive regulation of keratinocyte differentiation Source: UniProtKB
  • positive regulation of retinoic acid receptor signaling pathway Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • response to growth hormone Source: UniProtKB
  • response to organophosphorus Source: UniProtKB
  • response to retinoic acid Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 16
Alternative name(s):
Estrogen-responsive B box protein
Gene namesi
Name:TRIM16
Synonyms:EBBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:17241. TRIM16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: HPA
  • plasma membrane Source: HPA
  • PML body Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10626.
OpenTargetsiENSG00000221926.
PharmGKBiPA38215.

Polymorphism and mutation databases

BioMutaiTRIM16.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562221 – 564Tripartite motif-containing protein 16Add BLAST564

Proteomic databases

EPDiO95361.
MaxQBiO95361.
PaxDbiO95361.
PeptideAtlasiO95361.
PRIDEiO95361.

PTM databases

iPTMnetiO95361.
PhosphoSitePlusiO95361.

Expressioni

Tissue specificityi

Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.

Gene expression databases

BgeeiENSG00000221926.
CleanExiHS_TRIM16.
ExpressionAtlasiO95361. baseline and differential.
GenevisibleiO95361. HS.

Organism-specific databases

HPAiHPA023623.
HPA066431.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • interleukin-1 binding Source: UniProtKB
  • NACHT domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115870. 18 interactors.
IntActiO95361. 10 interactors.
MINTiMINT-1384373.
STRINGi9606.ENSP00000338989.

Structurei

3D structure databases

ProteinModelPortaliO95361.
SMRiO95361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 553B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili165 – 203Sequence analysisAdd BLAST39
Coiled coili243 – 274Sequence analysisAdd BLAST32
Coiled coili320 – 340Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 122B box-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri126 – 165B box-type 2PROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410II63. Eukaryota.
ENOG4110QZ1. LUCA.
GeneTreeiENSGT00760000118995.
HOGENOMiHOG000060240.
HOVERGENiHBG057134.
InParanoidiO95361.
KOiK12006.
OMAiHRNTEME.
OrthoDBiEOG091G03PP.
PhylomeDBiO95361.
TreeFamiTF351086.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
PfamiView protein in Pfam
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00336. BBOX. 2 hits.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95361-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDLMAPG PLPRATAQPP APLSPDSGSP SPDSGSASPV EEEDVGSSEK
60 70 80 90 100
LGRETEEQDS DSAEQGDPAG EGKEVLCDFC LDDTRRVKAV KSCLTCMVNY
110 120 130 140 150
CEEHLQPHQV NIKLQSHLLT EPVKDHNWRY CPAHHSPLSA FCCPDQQCIC
160 170 180 190 200
QDCCQEHSGH TIVSLDAARR DKEAELQCTQ LDLERKLKLN ENAISRLQAN
210 220 230 240 250
QKSVLVSVSE VKAVAEMQFG ELLAAVRKAQ ANVMLFLEEK EQAALSQANG
260 270 280 290 300
IKAHLEYRSA EMEKSKQELE RMAAISNTVQ FLEEYCKFKN TEDITFPSVY
310 320 330 340 350
VGLKDKLSGI RKVITESTVH LIQLLENYKK KLQEFSKEEE YDIRTQVSAV
360 370 380 390 400
VQRKYWTSKP EPSTREQFLQ YAYDITFDPD TAHKYLRLQE ENRKVTNTTP
410 420 430 440 450
WEHPYPDLPS RFLHWRQVLS QQSLYLHRYY FEVEIFGAGT YVGLTCKGID
460 470 480 490 500
RKGEERNSCI SGNNFSWSLQ WNGKEFTAWY SDMETPLKAG PFRRLGVYID
510 520 530 540 550
FPGGILSFYG VEYDTMTLVH KFACKFSEPV YAAFWLSKKE NAIRIVDLGE
560
EPEKPAPSLV GTAP
Length:564
Mass (Da):63,955
Last modified:April 17, 2007 - v3
Checksum:iA6760717937D82F8
GO
Isoform 2 (identifier: O95361-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.

Show »
Length:348
Mass (Da):40,370
Checksum:i6C2EC2F9E97FEB5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235L → P in AAC79080 (PubMed:9817599).Curated1
Sequence conflicti235L → P (PubMed:11919186).Curated1
Sequence conflicti246S → N in AAC79080 (PubMed:9817599).Curated1
Sequence conflicti246S → N (PubMed:11919186).Curated1
Sequence conflicti465F → L in AAH01564 (PubMed:15489334).Curated1
Sequence conflicti521K → N in AAC79080 (PubMed:9817599).Curated1
Sequence conflicti521K → N (PubMed:11919186).Curated1
Sequence conflicti541N → S in AAC79080 (PubMed:9817599).Curated1
Sequence conflicti541N → S (PubMed:11919186).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017412121E → D. Corresponds to variant dbSNP:rs2074890Ensembl.1
Natural variantiVAR_052133493R → W. Corresponds to variant dbSNP:rs3174720Ensembl.1
Natural variantiVAR_031668561G → V4 PublicationsCorresponds to variant dbSNP:rs1060903Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0090981 – 216Missing in isoform 2. 1 PublicationAdd BLAST216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096870 mRNA. Translation: AAC79080.1.
CR457136 mRNA. Translation: CAG33417.1.
BC001564 mRNA. Translation: AAH01564.1.
BC053514 mRNA. Translation: AAH53514.1.
BC067096 mRNA. Translation: AAH67096.1.
CCDSiCCDS11171.1. [O95361-1]
RefSeqiNP_006461.3. NM_006470.4. [O95361-1]
UniGeneiHs.123534.

Genome annotation databases

EnsembliENST00000336708; ENSP00000338989; ENSG00000221926. [O95361-1]
ENST00000577886; ENSP00000462903; ENSG00000221926. [O95361-2]
ENST00000578237; ENSP00000463188; ENSG00000221926. [O95361-1]
GeneIDi10626.
KEGGihsa:10626.
UCSCiuc002gow.4. human. [O95361-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096870 mRNA. Translation: AAC79080.1.
CR457136 mRNA. Translation: CAG33417.1.
BC001564 mRNA. Translation: AAH01564.1.
BC053514 mRNA. Translation: AAH53514.1.
BC067096 mRNA. Translation: AAH67096.1.
CCDSiCCDS11171.1. [O95361-1]
RefSeqiNP_006461.3. NM_006470.4. [O95361-1]
UniGeneiHs.123534.

3D structure databases

ProteinModelPortaliO95361.
SMRiO95361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115870. 18 interactors.
IntActiO95361. 10 interactors.
MINTiMINT-1384373.
STRINGi9606.ENSP00000338989.

PTM databases

iPTMnetiO95361.
PhosphoSitePlusiO95361.

Polymorphism and mutation databases

BioMutaiTRIM16.

Proteomic databases

EPDiO95361.
MaxQBiO95361.
PaxDbiO95361.
PeptideAtlasiO95361.
PRIDEiO95361.

Protocols and materials databases

DNASUi10626.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336708; ENSP00000338989; ENSG00000221926. [O95361-1]
ENST00000577886; ENSP00000462903; ENSG00000221926. [O95361-2]
ENST00000578237; ENSP00000463188; ENSG00000221926. [O95361-1]
GeneIDi10626.
KEGGihsa:10626.
UCSCiuc002gow.4. human. [O95361-1]

Organism-specific databases

CTDi10626.
DisGeNETi10626.
GeneCardsiTRIM16.
H-InvDBHIX0013608.
HGNCiHGNC:17241. TRIM16.
HPAiHPA023623.
HPA066431.
MIMi609505. gene.
neXtProtiNX_O95361.
OpenTargetsiENSG00000221926.
PharmGKBiPA38215.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II63. Eukaryota.
ENOG4110QZ1. LUCA.
GeneTreeiENSGT00760000118995.
HOGENOMiHOG000060240.
HOVERGENiHBG057134.
InParanoidiO95361.
KOiK12006.
OMAiHRNTEME.
OrthoDBiEOG091G03PP.
PhylomeDBiO95361.
TreeFamiTF351086.

Miscellaneous databases

ChiTaRSiTRIM16. human.
GeneWikiiTRIM16.
GenomeRNAii10626.
PROiO95361.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221926.
CleanExiHS_TRIM16.
ExpressionAtlasiO95361. baseline and differential.
GenevisibleiO95361. HS.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
PfamiView protein in Pfam
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00336. BBOX. 2 hits.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRI16_HUMAN
AccessioniPrimary (citable) accession number: O95361
Secondary accession number(s): Q6IAL8
, Q7Z6I2, Q96BE8, Q96J43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: April 17, 2007
Last modified: March 15, 2017
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.