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O95361

- TRI16_HUMAN

UniProt

O95361 - TRI16_HUMAN

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Protein

Tripartite motif-containing protein 16

Gene

TRIM16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the regulation of keratinocyte differentiation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri72 – 12251B box-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri126 – 16540B box-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. interleukin-1 binding Source: UniProtKB
  3. NACHT domain binding Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone H3 acetylation Source: UniProtKB
  2. histone H4 acetylation Source: UniProtKB
  3. positive regulation of interleukin-1 beta secretion Source: UniProtKB
  4. positive regulation of keratinocyte differentiation Source: UniProtKB
  5. positive regulation of retinoic acid receptor signaling pathway Source: UniProtKB
  6. positive regulation of transcription, DNA-templated Source: UniProtKB
  7. response to growth hormone Source: UniProtKB
  8. response to organophosphorus Source: UniProtKB
  9. response to retinoic acid Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 16
Alternative name(s):
Estrogen-responsive B box protein
Gene namesi
Name:TRIM16
Synonyms:EBBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:17241. TRIM16.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. PML body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38215.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Tripartite motif-containing protein 16PRO_0000056222Add
BLAST

Proteomic databases

MaxQBiO95361.
PaxDbiO95361.
PRIDEiO95361.

PTM databases

PhosphoSiteiO95361.

Expressioni

Tissue specificityi

Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.

Gene expression databases

BgeeiO95361.
CleanExiHS_TRIM16.
ExpressionAtlasiO95361. baseline.
GenevestigatoriO95361.

Organism-specific databases

HPAiHPA023623.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
E2F1Q010942EBI-727384,EBI-448924
VIMP086703EBI-727384,EBI-353844

Protein-protein interaction databases

BioGridi115870. 13 interactions.
IntActiO95361. 3 interactions.
MINTiMINT-1384373.
STRINGi9606.ENSP00000338989.

Structurei

3D structure databases

ProteinModelPortaliO95361.
SMRiO95361. Positions 72-286, 374-534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini355 – 553199B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili165 – 20339Sequence AnalysisAdd
BLAST
Coiled coili243 – 27432Sequence AnalysisAdd
BLAST
Coiled coili320 – 34021Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri72 – 12251B box-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri126 – 16540B box-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG149040.
GeneTreeiENSGT00760000118995.
HOGENOMiHOG000060240.
HOVERGENiHBG057134.
InParanoidiO95361.
KOiK12006.
OMAiVCEECLA.
PhylomeDBiO95361.
TreeFamiTF351086.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 2 hits.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95361-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDLMAPG PLPRATAQPP APLSPDSGSP SPDSGSASPV EEEDVGSSEK
60 70 80 90 100
LGRETEEQDS DSAEQGDPAG EGKEVLCDFC LDDTRRVKAV KSCLTCMVNY
110 120 130 140 150
CEEHLQPHQV NIKLQSHLLT EPVKDHNWRY CPAHHSPLSA FCCPDQQCIC
160 170 180 190 200
QDCCQEHSGH TIVSLDAARR DKEAELQCTQ LDLERKLKLN ENAISRLQAN
210 220 230 240 250
QKSVLVSVSE VKAVAEMQFG ELLAAVRKAQ ANVMLFLEEK EQAALSQANG
260 270 280 290 300
IKAHLEYRSA EMEKSKQELE RMAAISNTVQ FLEEYCKFKN TEDITFPSVY
310 320 330 340 350
VGLKDKLSGI RKVITESTVH LIQLLENYKK KLQEFSKEEE YDIRTQVSAV
360 370 380 390 400
VQRKYWTSKP EPSTREQFLQ YAYDITFDPD TAHKYLRLQE ENRKVTNTTP
410 420 430 440 450
WEHPYPDLPS RFLHWRQVLS QQSLYLHRYY FEVEIFGAGT YVGLTCKGID
460 470 480 490 500
RKGEERNSCI SGNNFSWSLQ WNGKEFTAWY SDMETPLKAG PFRRLGVYID
510 520 530 540 550
FPGGILSFYG VEYDTMTLVH KFACKFSEPV YAAFWLSKKE NAIRIVDLGE
560
EPEKPAPSLV GTAP
Length:564
Mass (Da):63,955
Last modified:April 17, 2007 - v3
Checksum:iA6760717937D82F8
GO
Isoform 2 (identifier: O95361-2) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.

Show »
Length:348
Mass (Da):40,370
Checksum:i6C2EC2F9E97FEB5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351L → P in AAC79080. (PubMed:9817599)Curated
Sequence conflicti235 – 2351L → P(PubMed:11919186)Curated
Sequence conflicti246 – 2461S → N in AAC79080. (PubMed:9817599)Curated
Sequence conflicti246 – 2461S → N(PubMed:11919186)Curated
Sequence conflicti465 – 4651F → L in AAH01564. (PubMed:15489334)Curated
Sequence conflicti521 – 5211K → N in AAC79080. (PubMed:9817599)Curated
Sequence conflicti521 – 5211K → N(PubMed:11919186)Curated
Sequence conflicti541 – 5411N → S in AAC79080. (PubMed:9817599)Curated
Sequence conflicti541 – 5411N → S(PubMed:11919186)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211E → D.
Corresponds to variant rs2074890 [ dbSNP | Ensembl ].
VAR_017412
Natural varianti493 – 4931R → W.
Corresponds to variant rs3174720 [ dbSNP | Ensembl ].
VAR_052133
Natural varianti561 – 5611G → V.4 Publications
Corresponds to variant rs1060903 [ dbSNP | Ensembl ].
VAR_031668

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 216216Missing in isoform 2. 1 PublicationVSP_009098Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096870 mRNA. Translation: AAC79080.1.
CR457136 mRNA. Translation: CAG33417.1.
BC001564 mRNA. Translation: AAH01564.1.
BC053514 mRNA. Translation: AAH53514.1.
BC067096 mRNA. Translation: AAH67096.1.
CCDSiCCDS11171.1. [O95361-1]
RefSeqiNP_006461.3. NM_006470.3. [O95361-1]
UniGeneiHs.123534.

Genome annotation databases

EnsembliENST00000336708; ENSP00000338989; ENSG00000221926. [O95361-1]
ENST00000577886; ENSP00000462903; ENSG00000221926. [O95361-2]
ENST00000578237; ENSP00000463188; ENSG00000221926. [O95361-1]
GeneIDi10626.
KEGGihsa:10626.
UCSCiuc002gow.3. human. [O95361-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096870 mRNA. Translation: AAC79080.1 .
CR457136 mRNA. Translation: CAG33417.1 .
BC001564 mRNA. Translation: AAH01564.1 .
BC053514 mRNA. Translation: AAH53514.1 .
BC067096 mRNA. Translation: AAH67096.1 .
CCDSi CCDS11171.1. [O95361-1 ]
RefSeqi NP_006461.3. NM_006470.3. [O95361-1 ]
UniGenei Hs.123534.

3D structure databases

ProteinModelPortali O95361.
SMRi O95361. Positions 72-286, 374-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115870. 13 interactions.
IntActi O95361. 3 interactions.
MINTi MINT-1384373.
STRINGi 9606.ENSP00000338989.

PTM databases

PhosphoSitei O95361.

Proteomic databases

MaxQBi O95361.
PaxDbi O95361.
PRIDEi O95361.

Protocols and materials databases

DNASUi 10626.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336708 ; ENSP00000338989 ; ENSG00000221926 . [O95361-1 ]
ENST00000577886 ; ENSP00000462903 ; ENSG00000221926 . [O95361-2 ]
ENST00000578237 ; ENSP00000463188 ; ENSG00000221926 . [O95361-1 ]
GeneIDi 10626.
KEGGi hsa:10626.
UCSCi uc002gow.3. human. [O95361-1 ]

Organism-specific databases

CTDi 10626.
GeneCardsi GC17M015531.
H-InvDB HIX0013608.
HGNCi HGNC:17241. TRIM16.
HPAi HPA023623.
MIMi 609505. gene.
neXtProti NX_O95361.
PharmGKBi PA38215.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149040.
GeneTreei ENSGT00760000118995.
HOGENOMi HOG000060240.
HOVERGENi HBG057134.
InParanoidi O95361.
KOi K12006.
OMAi VCEECLA.
PhylomeDBi O95361.
TreeFami TF351086.

Miscellaneous databases

ChiTaRSi TRIM16. human.
GeneWikii TRIM16.
GenomeRNAii 10626.
NextBioi 40372.
PROi O95361.
SOURCEi Search...

Gene expression databases

Bgeei O95361.
CleanExi HS_TRIM16.
ExpressionAtlasi O95361. baseline.
Genevestigatori O95361.

Family and domain databases

Gene3Di 4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view ]
Pfami PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00336. BBOX. 2 hits.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The novel estrogen-responsive B box protein (EBBP) gene is tamoxifen regulated in cells expressing an estrogen receptor DNA-binding domain mutant."
    Liu H.-L.C., Golder-Novoselsky E., Seto M.H., Webster L., McClary J., Zajchowski D.A.
    Mol. Endocrinol. 12:1733-1748(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-561.
    Tissue: Mammary gland.
  2. "The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation."
    Beer H.-D., Munding C., Dubois N., Mamie C., Hohl D., Werner S.
    J. Biol. Chem. 277:20740-20749(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-561.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-561.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-561.
    Tissue: Placenta and Skin.

Entry informationi

Entry nameiTRI16_HUMAN
AccessioniPrimary (citable) accession number: O95361
Secondary accession number(s): Q6IAL8
, Q7Z6I2, Q96BE8, Q96J43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: April 17, 2007
Last modified: November 26, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3