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O95361

- TRI16_HUMAN

UniProt

O95361 - TRI16_HUMAN

Protein

Tripartite motif-containing protein 16

Gene

TRIM16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 3 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of keratinocyte differentiation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri72 – 12251B box-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri126 – 16540B box-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. interleukin-1 binding Source: UniProtKB
    3. NACHT domain binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histone H3 acetylation Source: UniProtKB
    2. histone H4 acetylation Source: UniProtKB
    3. positive regulation of interleukin-1 beta secretion Source: UniProtKB
    4. positive regulation of keratinocyte differentiation Source: UniProtKB
    5. positive regulation of retinoic acid receptor signaling pathway Source: UniProtKB
    6. positive regulation of transcription, DNA-templated Source: UniProtKB
    7. response to growth hormone Source: UniProtKB
    8. response to organophosphorus Source: UniProtKB
    9. response to retinoic acid Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 16
    Alternative name(s):
    Estrogen-responsive B box protein
    Gene namesi
    Name:TRIM16
    Synonyms:EBBP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:17241. TRIM16.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. PML body Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38215.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 564564Tripartite motif-containing protein 16PRO_0000056222Add
    BLAST

    Proteomic databases

    MaxQBiO95361.
    PaxDbiO95361.
    PRIDEiO95361.

    PTM databases

    PhosphoSiteiO95361.

    Expressioni

    Tissue specificityi

    Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.

    Gene expression databases

    BgeeiO95361.
    CleanExiHS_TRIM16.
    GenevestigatoriO95361.

    Organism-specific databases

    HPAiHPA023623.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    E2F1Q010942EBI-727384,EBI-448924
    VIMP086703EBI-727384,EBI-353844

    Protein-protein interaction databases

    BioGridi115870. 12 interactions.
    IntActiO95361. 3 interactions.
    MINTiMINT-1384373.
    STRINGi9606.ENSP00000338989.

    Structurei

    3D structure databases

    ProteinModelPortaliO95361.
    SMRiO95361. Positions 72-334, 364-536.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini355 – 553199B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili165 – 20339Sequence AnalysisAdd
    BLAST
    Coiled coili243 – 27432Sequence AnalysisAdd
    BLAST
    Coiled coili320 – 34021Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri72 – 12251B box-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri126 – 16540B box-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG149040.
    HOGENOMiHOG000060240.
    HOVERGENiHBG057134.
    InParanoidiO95361.
    KOiK12006.
    OMAiVCEECLA.
    PhylomeDBiO95361.
    TreeFamiTF351086.

    Family and domain databases

    Gene3Di4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 2 hits.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95361-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAELDLMAPG PLPRATAQPP APLSPDSGSP SPDSGSASPV EEEDVGSSEK    50
    LGRETEEQDS DSAEQGDPAG EGKEVLCDFC LDDTRRVKAV KSCLTCMVNY 100
    CEEHLQPHQV NIKLQSHLLT EPVKDHNWRY CPAHHSPLSA FCCPDQQCIC 150
    QDCCQEHSGH TIVSLDAARR DKEAELQCTQ LDLERKLKLN ENAISRLQAN 200
    QKSVLVSVSE VKAVAEMQFG ELLAAVRKAQ ANVMLFLEEK EQAALSQANG 250
    IKAHLEYRSA EMEKSKQELE RMAAISNTVQ FLEEYCKFKN TEDITFPSVY 300
    VGLKDKLSGI RKVITESTVH LIQLLENYKK KLQEFSKEEE YDIRTQVSAV 350
    VQRKYWTSKP EPSTREQFLQ YAYDITFDPD TAHKYLRLQE ENRKVTNTTP 400
    WEHPYPDLPS RFLHWRQVLS QQSLYLHRYY FEVEIFGAGT YVGLTCKGID 450
    RKGEERNSCI SGNNFSWSLQ WNGKEFTAWY SDMETPLKAG PFRRLGVYID 500
    FPGGILSFYG VEYDTMTLVH KFACKFSEPV YAAFWLSKKE NAIRIVDLGE 550
    EPEKPAPSLV GTAP 564
    Length:564
    Mass (Da):63,955
    Last modified:April 17, 2007 - v3
    Checksum:iA6760717937D82F8
    GO
    Isoform 2 (identifier: O95361-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-216: Missing.

    Show »
    Length:348
    Mass (Da):40,370
    Checksum:i6C2EC2F9E97FEB5D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti235 – 2351L → P in AAC79080. (PubMed:9817599)Curated
    Sequence conflicti235 – 2351L → P(PubMed:11919186)Curated
    Sequence conflicti246 – 2461S → N in AAC79080. (PubMed:9817599)Curated
    Sequence conflicti246 – 2461S → N(PubMed:11919186)Curated
    Sequence conflicti465 – 4651F → L in AAH01564. (PubMed:15489334)Curated
    Sequence conflicti521 – 5211K → N in AAC79080. (PubMed:9817599)Curated
    Sequence conflicti521 – 5211K → N(PubMed:11919186)Curated
    Sequence conflicti541 – 5411N → S in AAC79080. (PubMed:9817599)Curated
    Sequence conflicti541 – 5411N → S(PubMed:11919186)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti121 – 1211E → D.
    Corresponds to variant rs2074890 [ dbSNP | Ensembl ].
    VAR_017412
    Natural varianti493 – 4931R → W.
    Corresponds to variant rs3174720 [ dbSNP | Ensembl ].
    VAR_052133
    Natural varianti561 – 5611G → V.4 Publications
    Corresponds to variant rs1060903 [ dbSNP | Ensembl ].
    VAR_031668

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 216216Missing in isoform 2. 1 PublicationVSP_009098Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF096870 mRNA. Translation: AAC79080.1.
    CR457136 mRNA. Translation: CAG33417.1.
    BC001564 mRNA. Translation: AAH01564.1.
    BC053514 mRNA. Translation: AAH53514.1.
    BC067096 mRNA. Translation: AAH67096.1.
    CCDSiCCDS11171.1. [O95361-1]
    RefSeqiNP_006461.3. NM_006470.3. [O95361-1]
    UniGeneiHs.123534.

    Genome annotation databases

    EnsembliENST00000336708; ENSP00000338989; ENSG00000221926. [O95361-1]
    ENST00000577886; ENSP00000462903; ENSG00000221926. [O95361-2]
    ENST00000578237; ENSP00000463188; ENSG00000221926. [O95361-1]
    GeneIDi10626.
    KEGGihsa:10626.
    UCSCiuc002gow.3. human. [O95361-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF096870 mRNA. Translation: AAC79080.1 .
    CR457136 mRNA. Translation: CAG33417.1 .
    BC001564 mRNA. Translation: AAH01564.1 .
    BC053514 mRNA. Translation: AAH53514.1 .
    BC067096 mRNA. Translation: AAH67096.1 .
    CCDSi CCDS11171.1. [O95361-1 ]
    RefSeqi NP_006461.3. NM_006470.3. [O95361-1 ]
    UniGenei Hs.123534.

    3D structure databases

    ProteinModelPortali O95361.
    SMRi O95361. Positions 72-334, 364-536.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115870. 12 interactions.
    IntActi O95361. 3 interactions.
    MINTi MINT-1384373.
    STRINGi 9606.ENSP00000338989.

    PTM databases

    PhosphoSitei O95361.

    Proteomic databases

    MaxQBi O95361.
    PaxDbi O95361.
    PRIDEi O95361.

    Protocols and materials databases

    DNASUi 10626.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336708 ; ENSP00000338989 ; ENSG00000221926 . [O95361-1 ]
    ENST00000577886 ; ENSP00000462903 ; ENSG00000221926 . [O95361-2 ]
    ENST00000578237 ; ENSP00000463188 ; ENSG00000221926 . [O95361-1 ]
    GeneIDi 10626.
    KEGGi hsa:10626.
    UCSCi uc002gow.3. human. [O95361-1 ]

    Organism-specific databases

    CTDi 10626.
    GeneCardsi GC17M015531.
    H-InvDB HIX0013608.
    HGNCi HGNC:17241. TRIM16.
    HPAi HPA023623.
    MIMi 609505. gene.
    neXtProti NX_O95361.
    PharmGKBi PA38215.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149040.
    HOGENOMi HOG000060240.
    HOVERGENi HBG057134.
    InParanoidi O95361.
    KOi K12006.
    OMAi VCEECLA.
    PhylomeDBi O95361.
    TreeFami TF351086.

    Miscellaneous databases

    GeneWikii TRIM16.
    GenomeRNAii 10626.
    NextBioi 40372.
    PROi O95361.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95361.
    CleanExi HS_TRIM16.
    Genevestigatori O95361.

    Family and domain databases

    Gene3Di 4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 2 hits.
    SM00589. PRY. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The novel estrogen-responsive B box protein (EBBP) gene is tamoxifen regulated in cells expressing an estrogen receptor DNA-binding domain mutant."
      Liu H.-L.C., Golder-Novoselsky E., Seto M.H., Webster L., McClary J., Zajchowski D.A.
      Mol. Endocrinol. 12:1733-1748(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-561.
      Tissue: Mammary gland.
    2. "The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation."
      Beer H.-D., Munding C., Dubois N., Mamie C., Hohl D., Werner S.
      J. Biol. Chem. 277:20740-20749(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-561.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-561.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-561.
      Tissue: Placenta and Skin.

    Entry informationi

    Entry nameiTRI16_HUMAN
    AccessioniPrimary (citable) accession number: O95361
    Secondary accession number(s): Q6IAL8
    , Q7Z6I2, Q96BE8, Q96J43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3