O95359 (TACC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transforming acidic coiled-coil-containing protein 2

Alternative name(s):
Anti-Zuai-1
Short name=AZU-1

Gene names

Name:

TACC2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2948 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors By similarity. May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Ref.1
Subunit structure	Interacts with CCDC100/CEP120 By similarity. Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF. Ref.3 Ref.9
Subcellular location	Cytoplasm. Nucleus. Cytoplasm › cytoskeleton › centrosome Ref.1 Ref.8 Ref.9.
Tissue specificity	Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea. Ref.3 Ref.6
Developmental stage	Expressed in fetal brain, lung, liver and kidney. Ref.3
Post-translational modification	Phosphorylated by TTK; which is required for localization in centrosome. Ref.8 Ref.10 Ref.11 Ref.12
Sequence similarities	Belongs to the TACC family. Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain.
Sequence caution	The sequence AAF29537.2 differs from that shown. Reason: Intron retention. The sequence AAF63433.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	Golgi apparatus Inferred from direct assay. Source: HPA microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from direct assay. Source: HPA
Molecular function	nuclear hormone receptor binding Inferred from direct assay. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 4 (identifier: O95359-4)

Also known as: Long; TACC2s;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: O95359-1)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1922: Missing.
     1923-1945: APAGDRVEASTPSCPDPAKDLSR → MGGSQSLQPAPASDLNLEASEAM

Isoform 2 (identifier: O95359-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2296: Missing.
     2429-2432: Missing.
     2633-2709: Missing.

Isoform 3 (identifier: O95359-3)

Also known as: ECTACC;

The sequence of this isoform differs from the canonical sequence as follows:
     2633-2709: Missing.

Isoform 5 (identifier: O95359-5)

Also known as: TACC21;

The sequence of this isoform differs from the canonical sequence as follows:
     49-1857: Missing.
     1900-1944: Missing.

Isoform 6 (identifier: O95359-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1922: Missing.
     1923-1945: APAGDRVEASTPSCPDPAKDLSR → MGGSQSLQPAPASDLNLEASEAM
     2680-2709: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2948	2948	Transforming acidic coiled-coil-containing protein 2		PRO_0000179988
Regions
	Domain	2315 – 2403	89	SPAZ
	Coiled coil	2675 – 2703	29	Potential
	Coiled coil	2746 – 2947	202	Potential
	Compositional bias	482 – 549	68	Pro-rich
	Compositional bias	1956 – 2016	61	Pro-rich
	Compositional bias	2420 – 2423	4	Poly-Lys
Amino acid modifications
	Modified residue	197	1	Phosphoserine Ref.11
	Modified residue	201	1	Phosphoserine Ref.11
	Modified residue	493	1	Phosphoserine Ref.11
	Modified residue	571	1	Phosphoserine Ref.11
	Modified residue	575	1	Phosphoserine Ref.11
	Modified residue	758	1	Phosphoserine Ref.11
	Modified residue	962	1	Phosphoserine Ref.11
	Modified residue	1025	1	Phosphoserine Ref.11
	Modified residue	1267	1	Phosphoserine Ref.11
	Modified residue	1313	1	Phosphoserine Ref.11
	Modified residue	1426	1	Phosphothreonine Ref.11
	Modified residue	1562	1	Phosphoserine Ref.11
	Modified residue	1946	1	Phosphoserine By similarity
	Modified residue	1949	1	Phosphoserine By similarity
	Modified residue	2072	1	Phosphoserine Ref.11
	Modified residue	2073	1	Phosphothreonine Ref.11
	Modified residue	2226	1	Phosphoserine Ref.11 Ref.12
	Modified residue	2246	1	Phosphothreonine Ref.11
	Modified residue	2256	1	Phosphoserine Ref.10 Ref.11
	Modified residue	2317	1	Phosphoserine Ref.11
	Modified residue	2321	1	Phosphoserine Ref.11
	Modified residue	2359	1	Phosphoserine Ref.11
	Modified residue	2389	1	Phosphoserine Ref.11
	Modified residue	2390	1	Phosphoserine Ref.11
	Modified residue	2392	1	Phosphoserine Ref.11
	Modified residue	2394	1	Phosphoserine Ref.11
	Modified residue	2403	1	Phosphoserine Ref.11
	Modified residue	2512	1	Phosphoserine Ref.10 Ref.11
	Modified residue	2884	1	N6-acetyllysine Ref.13
Natural variations
	Alternative sequence	1 – 2296	2296	Missing in isoform 2.		VSP_022151
	Alternative sequence	1 – 1922	1922	Missing in isoform 1 and isoform 6.		VSP_022153
	Alternative sequence	49 – 1857	1809	Missing in isoform 5.		VSP_022154
	Alternative sequence	1900 – 1944	45	Missing in isoform 5.		VSP_022155
	Alternative sequence	1923 – 1945	23	APAGD…KDLSR → MGGSQSLQPAPASDLNLEAS EAM in isoform 1 and isoform 6.		VSP_022156
	Alternative sequence	2429 – 2432	4	Missing in isoform 2.		VSP_006368
	Alternative sequence	2633 – 2709	77	Missing in isoform 2 and isoform 3.		VSP_006369
	Alternative sequence	2680 – 2709	30	Missing in isoform 6.		VSP_022158
	Natural variant	170	1	V → I. Corresponds to variant rs11200385 [ dbSNP | Ensembl ].		VAR_053706
	Natural variant	798	1	L → V in a breast cancer sample; somatic mutation. Ref.14		VAR_036381
	Natural variant	830	1	L → F. Ref.3 Corresponds to variant rs10887063 [ dbSNP | Ensembl ].		VAR_053707
	Natural variant	1103	1	W → R. Ref.3 Corresponds to variant rs7073433 [ dbSNP | Ensembl ].		VAR_053708
	Natural variant	1347	1	A → S in a breast cancer sample; somatic mutation. Ref.14		VAR_036382
	Natural variant	1425	1	A → T. Corresponds to variant rs4752642 [ dbSNP | Ensembl ].		VAR_053709
	Natural variant	1492	1	P → L. Corresponds to variant rs7920896 [ dbSNP | Ensembl ].		VAR_053710
	Natural variant	1916	1	E → K. Corresponds to variant rs12765679 [ dbSNP | Ensembl ].		VAR_053711
	Natural variant	2078	1	I → T. Corresponds to variant rs7083331 [ dbSNP | Ensembl ].		VAR_029803
	Natural variant	2102	1	N → S. Corresponds to variant rs3750843 [ dbSNP | Ensembl ].		VAR_020478
	Natural variant	2197	1	V → A. Corresponds to variant rs2295873 [ dbSNP | Ensembl ].		VAR_020479
	Natural variant	2210	1	A → V. Corresponds to variant rs2295874 [ dbSNP | Ensembl ].		VAR_029804
	Natural variant	2216	1	P → L. Corresponds to variant rs2295875 [ dbSNP | Ensembl ].		VAR_053712
	Natural variant	2261	1	L → H. Corresponds to variant rs2295876 [ dbSNP | Ensembl ].		VAR_020480
	Natural variant	2271	1	E → D. Corresponds to variant rs11200483 [ dbSNP | Ensembl ].		VAR_053713
	Natural variant	2718	1	V → I. Corresponds to variant rs2295878 [ dbSNP | Ensembl ].		VAR_020481
	Natural variant	2732	1	A → T. Ref.7 Corresponds to variant rs2295879 [ dbSNP | Ensembl ].		VAR_020482
	Natural variant	2900	1	Q → K. Ref.3 Corresponds to variant rs1063627 [ dbSNP | Ensembl ].		VAR_029805
Experimental info
	Sequence conflict	2896	1	R → Q in AAO62629. Ref.3
	Sequence conflict	2896	1	R → Q in AAO62630. Ref.3
	Sequence conflict	2909	1	S → T in AAH39311. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4 (Long) (TACC2s) [UniParc]. Last modified January 9, 2007. Version 3. Checksum: 9DC4CC5231A5ADBD	FASTA	2,948	309,427
	10 20 30 40 50 60 MGNENSTSDN QRTLSAQTPR SAQPPGNSQN IKRKQQDTPG SPDHRDASSI GSVGLGGFCT 70 80 90 100 110 120 ASESSASLDP CLVSPEVTEP RKDPQGARGP EGSLLPSPPP SQEREHPSSS MPFAECPPEG 130 140 150 160 170 180 CLASPAAAPE DGPQTQSPRR EPAPNAPGDI AAAFPAERDS STPYQEIAAV PSAGRERQPK 190 200 210 220 230 240 EEGQKSSFSF SSGIDQSPGM SPVPLREPMK APLCGEGDQP GGFESQEKEA AGGFPPAESR 250 260 270 280 290 300 QGVASVQVTP EAPAAAQQGT ESSAVLEKSP LKPMAPIPQD PAPRASDRER GQGEAPPQYL 310 320 330 340 350 360 TDDLEFLRAC HLPRSNSGAA PEAEVNAASQ ESCQQPVGAY LPHAELPWGL PSPALVPEAG 370 380 390 400 410 420 GSGKEALDTI DVQGHPQTGM RGTKPNQVVC VAAGGQPEGG LPVSPEPSLL TPTEEAHPAS 430 440 450 460 470 480 SLASFPAAQI PIAVEEPGSS SRESVSKAGM PVSADAAKEV VDAGLVGLER QVSDLGSKGE 490 500 510 520 530 540 HPEGDPGEVP APSPQERGEH LNTEQSHEVQ PGVPPPPLPK EQSHEVQPGA PPPPLPKAPS 550 560 570 580 590 600 ESARGPPGPT DGAKVHEDST SPAVAKEGSR SPGDSPGGKE EAPEPPDGGD PGNLQGEDSQ 610 620 630 640 650 660 AFSSKRDPEV GKDELSKPSS DAESRDHPSS HSAQPPRKGG AGHTDGPHSQ TAEADASGLP 670 680 690 700 710 720 HKLGEEDPVL PPVPDGAGEP TVPEGAIWEG SGLQPKCPDT LQSREGLGRM ESFLTLESEK 730 740 750 760 770 780 SDFPPTPVAE VAPKAQEGES TLEIRKMGSC DGEGLLTSPD QPRGPACDAS RQEFHAGVPH 790 800 810 820 830 840 PPQGENLAAD LGLTALILDQ DQQGIPSCPG EGWIRGAASE WPLLSSEKHL QPSQAQPETS 850 860 870 880 890 900 IFDVLKEQAQ PPENGKETSP SHPGFKDQGA DSSQIHVPVE PQEDNNLPTH GGQEQALGSE 910 920 930 940 950 960 LQSQLPKGTL SDTPTSSPTD MVWESSLTEE SELSAPTRQK LPALGEKRPE GACGDGQSSR 970 980 990 1000 1010 1020 VSPPAADVLK DFSLAGNFSR KETCCTGQGP NKSQQALADA LEEGSQHEEA CQRHPGASEA 1030 1040 1050 1060 1070 1080 ADGCSPLWGL SKREMASGNT GEAPPCQPDS VALLDAVPCL PALAPASPGV TPTQDAPETE 1090 1100 1110 1120 1130 1140 ACDETQEGRQ QPVPAPQQKM ECWATSDAES PKLLASFPSA GEQGGEAGAA ETGGSAGAGD 1150 1160 1170 1180 1190 1200 PGKQQAPEKP GEATLSCGLL QTEHCLTSGE EASTSALRES CQAEHPMASC QDALLPAREL 1210 1220 1230 1240 1250 1260 GGIPRSTMDF STHQAVPDPK ELLLSGPPEV AAPDTPYLHV DSAAQRGAED SGVKAVSSAD 1270 1280 1290 1300 1310 1320 PRAPGESPCP VGEPPLALEN AASLKLFAGS LAPLLQPGAA GGEIPAVQAS SGSPKARTTE 1330 1340 1350 1360 1370 1380 GPVDSMPCLD RMPLLAKGKQ ATGEEKAATA PGAGAKASGE GMAGDAAGET EGSMERMGEP 1390 1400 1410 1420 1430 1440 SQDPKQGTSG GVDTSSEQIA TLTGFPDFRE HIAKIFEKPV LGALATPGEK AGAGRSAVGK 1450 1460 1470 1480 1490 1500 DLTRPLGPEK LLDGPPGVDV TLLPAPPARL QVEKKQQLAG EAEISHLALQ DPASDKLLGP 1510 1520 1530 1540 1550 1560 AGLTWERNLP GAGVGKEMAG VPPTLREDER PEGPGAAWPG LEGQAYSQLE RSRQELASGL 1570 1580 1590 1600 1610 1620 PSPAATQELP VERAAAFQVA PHSHGEEAVA QDRIPSGKQH QETSACDSPH GEDGPGDFAH 1630 1640 1650 1660 1670 1680 TGVPGHVPRS TCAPSPQREV LTVPEANSEP WTLDTLGGER RPGVTAGILE MRNALGNQST 1690 1700 1710 1720 1730 1740 PAPPTGEVAD TPLEPGKVAG AAGEAEGDIT LSTAETQACA SGDLPEAGTT RTFSVVAGDL 1750 1760 1770 1780 1790 1800 VLPGSCQDPA CSDKAPGMEG TAALHGDSPA RPQQAKEQPG PERPIPAGDG KVCVSSPPEP 1810 1820 1830 1840 1850 1860 DETHDPKLQH LAPEELHTDR ESPRPGPSML PSVPKKDAPR VMDKVTSDET RGAEGTESSP 1870 1880 1890 1900 1910 1920 VADDIIQPAA PADLESPTLA ASSYHGDVVG QVSTDLIAQS ISPAAAHAGL PPSAAEHIVS 1930 1940 1950 1960 1970 1980 PSAPAGDRVE ASTPSCPDPA KDLSRSSDSE EAFETPESTT PVKAPPAPPP PPPEVIPEPE 1990 2000 2010 2020 2030 2040 VSTQPPPEEP GCGSETVPVP DGPRSDSVEG SPFRPPSHSF SAVFDEDKPI ASSGTYNLDF 2050 2060 2070 2080 2090 2100 DNIELVDTFQ TLEPRASDAK NQEGKVNTRR KSTDSVPISK STLSRSLSLQ ASDFDGASSS 2110 2120 2130 2140 2150 2160 GNPEAVALAP DAYSTGSSSA SSTLKRTKKP RPPSLKKKQT TKKPTETPPV KETQQEPDEE 2170 2180 2190 2200 2210 2220 SLVPSGENLA SETKTESAKT EGPSPALLEE TPLEPAVGPK AACPLDSESA EGVVPPASGG 2230 2240 2250 2260 2270 2280 GRVQNSPPVG RKTLPLTTAP EAGEVTPSDS GGQEDSPAKG LSVRLEFDYS EDKSSWDNQQ 2290 2300 2310 2320 2330 2340 ENPPPTKKIG KKPVAKMPLR RPKMKKTPEK LDNTPASPPR SPAEPNDIPI AKGTYTFDID 2350 2360 2370 2380 2390 2400 KWDDPNFNPF SSTSKMQESP KLPQQSYNFD PDTCDESVDP FKTSSKTPSS PSKSPASFEI 2410 2420 2430 2440 2450 2460 PASAMEANGV DGDGLNKPAK KKKTPLKTDT FRVKKSPKRS PLSDPPSQDP TPAATPETPP 2470 2480 2490 2500 2510 2520 VISAVVHATD EEKLAVTNQK WTCMTVDLEA DKQDYPQPSD LSTFVNETKF SSPTEELDYR 2530 2540 2550 2560 2570 2580 NSYEIEYMEK IGSSLPQDDD APKKQALYLM FDTSQESPVK SSPVRMSESP TPCSGSSFEE 2590 2600 2610 2620 2630 2640 TEALVNTAAK NQHPVPRGLA PNQESHLQVP EKSSQKELEA MGLGTPSEAI EITAPEGSFA 2650 2660 2670 2680 2690 2700 SADALLSRLA HPVSLCGALD YLEPDLAEKN PPLFAQKLQE ELEFAIMRIE ALKLARQIAL 2710 2720 2730 2740 2750 2760 ASRSHQDAKR EAAHPTDVSI SKTALYSRIG TAEVEKPAGL LFQQPDLDSA LQIARAEIIT 2770 2780 2790 2800 2810 2820 KEREVSEWKD KYEESRREVM EMRKIVAEYE KTIAQMIEDE QREKSVSHQT VQQLVLEKEQ 2830 2840 2850 2860 2870 2880 ALADLNSVEK SLADLFRRYE KMKEVLEGFR KNEEVLKRCA QEYLSRVKKE EQRYQALKVH 2890 2900 2910 2920 2930 2940 AEEKLDRANA EIAQVRGKAQ QEQAAHQASL RKEQLRVDAL ERTLEQKNKE IEELTKICDE LIAKMGKS
	Isoform 1 (Short) [UniParc]. Checksum: E2575FCB446E9CF8	FASTA	1,026	112,111
	10 20 30 40 50 60 MGGSQSLQPA PASDLNLEAS EAMSSDSEEA FETPESTTPV KAPPAPPPPP PEVIPEPEVS 70 80 90 100 110 120 TQPPPEEPGC GSETVPVPDG PRSDSVEGSP FRPPSHSFSA VFDEDKPIAS SGTYNLDFDN 130 140 150 160 170 180 IELVDTFQTL EPRASDAKNQ EGKVNTRRKS TDSVPISKST LSRSLSLQAS DFDGASSSGN 190 200 210 220 230 240 PEAVALAPDA YSTGSSSASS TLKRTKKPRP PSLKKKQTTK KPTETPPVKE TQQEPDEESL 250 260 270 280 290 300 VPSGENLASE TKTESAKTEG PSPALLEETP LEPAVGPKAA CPLDSESAEG VVPPASGGGR 310 320 330 340 350 360 VQNSPPVGRK TLPLTTAPEA GEVTPSDSGG QEDSPAKGLS VRLEFDYSED KSSWDNQQEN 370 380 390 400 410 420 PPPTKKIGKK PVAKMPLRRP KMKKTPEKLD NTPASPPRSP AEPNDIPIAK GTYTFDIDKW 430 440 450 460 470 480 DDPNFNPFSS TSKMQESPKL PQQSYNFDPD TCDESVDPFK TSSKTPSSPS KSPASFEIPA 490 500 510 520 530 540 SAMEANGVDG DGLNKPAKKK KTPLKTDTFR VKKSPKRSPL SDPPSQDPTP AATPETPPVI 550 560 570 580 590 600 SAVVHATDEE KLAVTNQKWT CMTVDLEADK QDYPQPSDLS TFVNETKFSS PTEELDYRNS 610 620 630 640 650 660 YEIEYMEKIG SSLPQDDDAP KKQALYLMFD TSQESPVKSS PVRMSESPTP CSGSSFEETE 670 680 690 700 710 720 ALVNTAAKNQ HPVPRGLAPN QESHLQVPEK SSQKELEAMG LGTPSEAIEI TAPEGSFASA 730 740 750 760 770 780 DALLSRLAHP VSLCGALDYL EPDLAEKNPP LFAQKLQEEL EFAIMRIEAL KLARQIALAS 790 800 810 820 830 840 RSHQDAKREA AHPTDVSISK TALYSRIGTA EVEKPAGLLF QQPDLDSALQ IARAEIITKE 850 860 870 880 890 900 REVSEWKDKY EESRREVMEM RKIVAEYEKT IAQMIEDEQR EKSVSHQTVQ QLVLEKEQAL 910 920 930 940 950 960 ADLNSVEKSL ADLFRRYEKM KEVLEGFRKN EEVLKRCAQE YLSRVKKEEQ RYQALKVHAE 970 980 990 1000 1010 1020 EKLDRANAEI AQVRGKAQQE QAAHQASLRK EQLRVDALER TLEQKNKEIE ELTKICDELI AKMGKS
	Isoform 2 [UniParc]. Checksum: 0C89A2D8C537269B	FASTA	571	64,156
	10 20 30 40 50 60 MPLRRPKMKK TPEKLDNTPA SPPRSPAEPN DIPIAKGTYT FDIDKWDDPN FNPFSSTSKM 70 80 90 100 110 120 QESPKLPQQS YNFDPDTCDE SVDPFKTSSK TPSSPSKSPA SFEIPASAME ANGVDGDGLN 130 140 150 160 170 180 KPAKKKKTPL KTVKKSPKRS PLSDPPSQDP TPAATPETPP VISAVVHATD EEKLAVTNQK 190 200 210 220 230 240 WTCMTVDLEA DKQDYPQPSD LSTFVNETKF SSPTEELDYR NSYEIEYMEK IGSSLPQDDD 250 260 270 280 290 300 APKKQALYLM FDTSQESPVK SSPVRMSESP TPCSGSSFEE TEALVNTAAK NQHPVPRGLA 310 320 330 340 350 360 PNQESHLQVP EKSSQKELEA MGLGTPSEAI EIREAAHPTD VSISKTALYS RIGTAEVEKP 370 380 390 400 410 420 AGLLFQQPDL DSALQIARAE IITKEREVSE WKDKYEESRR EVMEMRKIVA EYEKTIAQMI 430 440 450 460 470 480 EDEQREKSVS HQTVQQLVLE KEQALADLNS VEKSLADLFR RYEKMKEVLE GFRKNEEVLK 490 500 510 520 530 540 RCAQEYLSRV KKEEQRYQAL KVHAEEKLDR ANAEIAQVRG KAQQEQAAHQ ASLRKEQLRV 550 560 570 DALERTLEQK NKEIEELTKI CDELIAKMGK S
	Isoform 3 (ECTACC) [UniParc]. Checksum: FC2C1DE101824B9D	FASTA	2,871	301,058
	10 20 30 40 50 60 MGNENSTSDN QRTLSAQTPR SAQPPGNSQN IKRKQQDTPG SPDHRDASSI GSVGLGGFCT 70 80 90 100 110 120 ASESSASLDP CLVSPEVTEP RKDPQGARGP EGSLLPSPPP SQEREHPSSS MPFAECPPEG 130 140 150 160 170 180 CLASPAAAPE DGPQTQSPRR EPAPNAPGDI AAAFPAERDS STPYQEIAAV PSAGRERQPK 190 200 210 220 230 240 EEGQKSSFSF SSGIDQSPGM SPVPLREPMK APLCGEGDQP GGFESQEKEA AGGFPPAESR 250 260 270 280 290 300 QGVASVQVTP EAPAAAQQGT ESSAVLEKSP LKPMAPIPQD PAPRASDRER GQGEAPPQYL 310 320 330 340 350 360 TDDLEFLRAC HLPRSNSGAA PEAEVNAASQ ESCQQPVGAY LPHAELPWGL PSPALVPEAG 370 380 390 400 410 420 GSGKEALDTI DVQGHPQTGM RGTKPNQVVC VAAGGQPEGG LPVSPEPSLL TPTEEAHPAS 430 440 450 460 470 480 SLASFPAAQI PIAVEEPGSS SRESVSKAGM PVSADAAKEV VDAGLVGLER QVSDLGSKGE 490 500 510 520 530 540 HPEGDPGEVP APSPQERGEH LNTEQSHEVQ PGVPPPPLPK EQSHEVQPGA PPPPLPKAPS 550 560 570 580 590 600 ESARGPPGPT DGAKVHEDST SPAVAKEGSR SPGDSPGGKE EAPEPPDGGD PGNLQGEDSQ 610 620 630 640 650 660 AFSSKRDPEV GKDELSKPSS DAESRDHPSS HSAQPPRKGG AGHTDGPHSQ TAEADASGLP 670 680 690 700 710 720 HKLGEEDPVL PPVPDGAGEP TVPEGAIWEG SGLQPKCPDT LQSREGLGRM ESFLTLESEK 730 740 750 760 770 780 SDFPPTPVAE VAPKAQEGES TLEIRKMGSC DGEGLLTSPD QPRGPACDAS RQEFHAGVPH 790 800 810 820 830 840 PPQGENLAAD LGLTALILDQ DQQGIPSCPG EGWIRGAASE WPLLSSEKHL QPSQAQPETS 850 860 870 880 890 900 IFDVLKEQAQ PPENGKETSP SHPGFKDQGA DSSQIHVPVE PQEDNNLPTH GGQEQALGSE 910 920 930 940 950 960 LQSQLPKGTL SDTPTSSPTD MVWESSLTEE SELSAPTRQK LPALGEKRPE GACGDGQSSR 970 980 990 1000 1010 1020 VSPPAADVLK DFSLAGNFSR KETCCTGQGP NKSQQALADA LEEGSQHEEA CQRHPGASEA 1030 1040 1050 1060 1070 1080 ADGCSPLWGL SKREMASGNT GEAPPCQPDS VALLDAVPCL PALAPASPGV TPTQDAPETE 1090 1100 1110 1120 1130 1140 ACDETQEGRQ QPVPAPQQKM ECWATSDAES PKLLASFPSA GEQGGEAGAA ETGGSAGAGD 1150 1160 1170 1180 1190 1200 PGKQQAPEKP GEATLSCGLL QTEHCLTSGE EASTSALRES CQAEHPMASC QDALLPAREL 1210 1220 1230 1240 1250 1260 GGIPRSTMDF STHQAVPDPK ELLLSGPPEV AAPDTPYLHV DSAAQRGAED SGVKAVSSAD 1270 1280 1290 1300 1310 1320 PRAPGESPCP VGEPPLALEN AASLKLFAGS LAPLLQPGAA GGEIPAVQAS SGSPKARTTE 1330 1340 1350 1360 1370 1380 GPVDSMPCLD RMPLLAKGKQ ATGEEKAATA PGAGAKASGE GMAGDAAGET EGSMERMGEP 1390 1400 1410 1420 1430 1440 SQDPKQGTSG GVDTSSEQIA TLTGFPDFRE HIAKIFEKPV LGALATPGEK AGAGRSAVGK 1450 1460 1470 1480 1490 1500 DLTRPLGPEK LLDGPPGVDV TLLPAPPARL QVEKKQQLAG EAEISHLALQ DPASDKLLGP 1510 1520 1530 1540 1550 1560 AGLTWERNLP GAGVGKEMAG VPPTLREDER PEGPGAAWPG LEGQAYSQLE RSRQELASGL 1570 1580 1590 1600 1610 1620 PSPAATQELP VERAAAFQVA PHSHGEEAVA QDRIPSGKQH QETSACDSPH GEDGPGDFAH 1630 1640 1650 1660 1670 1680 TGVPGHVPRS TCAPSPQREV LTVPEANSEP WTLDTLGGER RPGVTAGILE MRNALGNQST 1690 1700 1710 1720 1730 1740 PAPPTGEVAD TPLEPGKVAG AAGEAEGDIT LSTAETQACA SGDLPEAGTT RTFSVVAGDL 1750 1760 1770 1780 1790 1800 VLPGSCQDPA CSDKAPGMEG TAALHGDSPA RPQQAKEQPG PERPIPAGDG KVCVSSPPEP 1810 1820 1830 1840 1850 1860 DETHDPKLQH LAPEELHTDR ESPRPGPSML PSVPKKDAPR VMDKVTSDET RGAEGTESSP 1870 1880 1890 1900 1910 1920 VADDIIQPAA PADLESPTLA ASSYHGDVVG QVSTDLIAQS ISPAAAHAGL PPSAAEHIVS 1930 1940 1950 1960 1970 1980 PSAPAGDRVE ASTPSCPDPA KDLSRSSDSE EAFETPESTT PVKAPPAPPP PPPEVIPEPE 1990 2000 2010 2020 2030 2040 VSTQPPPEEP GCGSETVPVP DGPRSDSVEG SPFRPPSHSF SAVFDEDKPI ASSGTYNLDF 2050 2060 2070 2080 2090 2100 DNIELVDTFQ TLEPRASDAK NQEGKVNTRR KSTDSVPISK STLSRSLSLQ ASDFDGASSS 2110 2120 2130 2140 2150 2160 GNPEAVALAP DAYSTGSSSA SSTLKRTKKP RPPSLKKKQT TKKPTETPPV KETQQEPDEE 2170 2180 2190 2200 2210 2220 SLVPSGENLA SETKTESAKT EGPSPALLEE TPLEPAVGPK AACPLDSESA EGVVPPASGG 2230 2240 2250 2260 2270 2280 GRVQNSPPVG RKTLPLTTAP EAGEVTPSDS GGQEDSPAKG LSVRLEFDYS EDKSSWDNQQ 2290 2300 2310 2320 2330 2340 ENPPPTKKIG KKPVAKMPLR RPKMKKTPEK LDNTPASPPR SPAEPNDIPI AKGTYTFDID 2350 2360 2370 2380 2390 2400 KWDDPNFNPF SSTSKMQESP KLPQQSYNFD PDTCDESVDP FKTSSKTPSS PSKSPASFEI 2410 2420 2430 2440 2450 2460 PASAMEANGV DGDGLNKPAK KKKTPLKTDT FRVKKSPKRS PLSDPPSQDP TPAATPETPP 2470 2480 2490 2500 2510 2520 VISAVVHATD EEKLAVTNQK WTCMTVDLEA DKQDYPQPSD LSTFVNETKF SSPTEELDYR 2530 2540 2550 2560 2570 2580 NSYEIEYMEK IGSSLPQDDD APKKQALYLM FDTSQESPVK SSPVRMSESP TPCSGSSFEE 2590 2600 2610 2620 2630 2640 TEALVNTAAK NQHPVPRGLA PNQESHLQVP EKSSQKELEA MGLGTPSEAI EIREAAHPTD 2650 2660 2670 2680 2690 2700 VSISKTALYS RIGTAEVEKP AGLLFQQPDL DSALQIARAE IITKEREVSE WKDKYEESRR 2710 2720 2730 2740 2750 2760 EVMEMRKIVA EYEKTIAQMI EDEQREKSVS HQTVQQLVLE KEQALADLNS VEKSLADLFR 2770 2780 2790 2800 2810 2820 RYEKMKEVLE GFRKNEEVLK RCAQEYLSRV KKEEQRYQAL KVHAEEKLDR ANAEIAQVRG 2830 2840 2850 2860 2870 KAQQEQAAHQ ASLRKEQLRV DALERTLEQK NKEIEELTKI CDELIAKMGK S
	Isoform 5 (TACC21) [UniParc]. Checksum: 99E9A4FC30C86B52	FASTA	1,094	119,359
	10 20 30 40 50 60 MGNENSTSDN QRTLSAQTPR SAQPPGNSQN IKRKQQDTPG SPDHRDASSS PVADDIIQPA 70 80 90 100 110 120 APADLESPTL AASSYHGDVV GQVSTDLIAQ RSSDSEEAFE TPESTTPVKA PPAPPPPPPE 130 140 150 160 170 180 VIPEPEVSTQ PPPEEPGCGS ETVPVPDGPR SDSVEGSPFR PPSHSFSAVF DEDKPIASSG 190 200 210 220 230 240 TYNLDFDNIE LVDTFQTLEP RASDAKNQEG KVNTRRKSTD SVPISKSTLS RSLSLQASDF 250 260 270 280 290 300 DGASSSGNPE AVALAPDAYS TGSSSASSTL KRTKKPRPPS LKKKQTTKKP TETPPVKETQ 310 320 330 340 350 360 QEPDEESLVP SGENLASETK TESAKTEGPS PALLEETPLE PAVGPKAACP LDSESAEGVV 370 380 390 400 410 420 PPASGGGRVQ NSPPVGRKTL PLTTAPEAGE VTPSDSGGQE DSPAKGLSVR LEFDYSEDKS 430 440 450 460 470 480 SWDNQQENPP PTKKIGKKPV AKMPLRRPKM KKTPEKLDNT PASPPRSPAE PNDIPIAKGT 490 500 510 520 530 540 YTFDIDKWDD PNFNPFSSTS KMQESPKLPQ QSYNFDPDTC DESVDPFKTS SKTPSSPSKS 550 560 570 580 590 600 PASFEIPASA MEANGVDGDG LNKPAKKKKT PLKTDTFRVK KSPKRSPLSD PPSQDPTPAA 610 620 630 640 650 660 TPETPPVISA VVHATDEEKL AVTNQKWTCM TVDLEADKQD YPQPSDLSTF VNETKFSSPT 670 680 690 700 710 720 EELDYRNSYE IEYMEKIGSS LPQDDDAPKK QALYLMFDTS QESPVKSSPV RMSESPTPCS 730 740 750 760 770 780 GSSFEETEAL VNTAAKNQHP VPRGLAPNQE SHLQVPEKSS QKELEAMGLG TPSEAIEITA 790 800 810 820 830 840 PEGSFASADA LLSRLAHPVS LCGALDYLEP DLAEKNPPLF AQKLQEELEF AIMRIEALKL 850 860 870 880 890 900 ARQIALASRS HQDAKREAAH PTDVSISKTA LYSRIGTAEV EKPAGLLFQQ PDLDSALQIA 910 920 930 940 950 960 RAEIITKERE VSEWKDKYEE SRREVMEMRK IVAEYEKTIA QMIEDEQREK SVSHQTVQQL 970 980 990 1000 1010 1020 VLEKEQALAD LNSVEKSLAD LFRRYEKMKE VLEGFRKNEE VLKRCAQEYL SRVKKEEQRY 1030 1040 1050 1060 1070 1080 QALKVHAEEK LDRANAEIAQ VRGKAQQEQA AHQASLRKEQ LRVDALERTL EQKNKEIEEL 1090 TKICDELIAK MGKS
	Isoform 6 [UniParc]. Checksum: E1DCE1E83FB72A71	FASTA	996	108,690
	10 20 30 40 50 60 MGGSQSLQPA PASDLNLEAS EAMSSDSEEA FETPESTTPV KAPPAPPPPP PEVIPEPEVS 70 80 90 100 110 120 TQPPPEEPGC GSETVPVPDG PRSDSVEGSP FRPPSHSFSA VFDEDKPIAS SGTYNLDFDN 130 140 150 160 170 180 IELVDTFQTL EPRASDAKNQ EGKVNTRRKS TDSVPISKST LSRSLSLQAS DFDGASSSGN 190 200 210 220 230 240 PEAVALAPDA YSTGSSSASS TLKRTKKPRP PSLKKKQTTK KPTETPPVKE TQQEPDEESL 250 260 270 280 290 300 VPSGENLASE TKTESAKTEG PSPALLEETP LEPAVGPKAA CPLDSESAEG VVPPASGGGR 310 320 330 340 350 360 VQNSPPVGRK TLPLTTAPEA GEVTPSDSGG QEDSPAKGLS VRLEFDYSED KSSWDNQQEN 370 380 390 400 410 420 PPPTKKIGKK PVAKMPLRRP KMKKTPEKLD NTPASPPRSP AEPNDIPIAK GTYTFDIDKW 430 440 450 460 470 480 DDPNFNPFSS TSKMQESPKL PQQSYNFDPD TCDESVDPFK TSSKTPSSPS KSPASFEIPA 490 500 510 520 530 540 SAMEANGVDG DGLNKPAKKK KTPLKTDTFR VKKSPKRSPL SDPPSQDPTP AATPETPPVI 550 560 570 580 590 600 SAVVHATDEE KLAVTNQKWT CMTVDLEADK QDYPQPSDLS TFVNETKFSS PTEELDYRNS 610 620 630 640 650 660 YEIEYMEKIG SSLPQDDDAP KKQALYLMFD TSQESPVKSS PVRMSESPTP CSGSSFEETE 670 680 690 700 710 720 ALVNTAAKNQ HPVPRGLAPN QESHLQVPEK SSQKELEAMG LGTPSEAIEI TAPEGSFASA 730 740 750 760 770 780 DALLSRLAHP VSLCGALDYL EPDLAEKNPP LFAQKLQREA AHPTDVSISK TALYSRIGTA 790 800 810 820 830 840 EVEKPAGLLF QQPDLDSALQ IARAEIITKE REVSEWKDKY EESRREVMEM RKIVAEYEKT 850 860 870 880 890 900 IAQMIEDEQR EKSVSHQTVQ QLVLEKEQAL ADLNSVEKSL ADLFRRYEKM KEVLEGFRKN 910 920 930 940 950 960 EEVLKRCAQE YLSRVKKEEQ RYQALKVHAE EKLDRANAEI AQVRGKAQQE QAAHQASLRK 970 980 990 EQLRVDALER TLEQKNKEIE ELTKICDELI AKMGKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression." Chen H.-M., Schmeichel K.L., Mian I.S., Lelievre S., Petersen O.W., Bissell M.J. Mol. Biol. Cell 11:1357-1367(2000) [PubMed: 10749935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, FUNCTION.
[2]	"The TACC domain identifies a family of centrosomal proteins that can interact with microtubules." Gergely F., Karlsson C., Still I.H., Cowell J.K., Kilmartin J., Raff J.W. Proc. Natl. Acad. Sci. U.S.A. 97:14352-14357(2000) [PubMed: 11121038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain, Fetal brain and Skeletal muscle.
[3]	"Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2." Lauffart B., Gangisetty O., Still I.H. Genomics 81:192-201(2003) [PubMed: 12620397] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH YEATS4, VARIANTS PHE-830; ARG-1103 AND LYS-2900.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Placenta and Testis.
[6]	"Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells." Pu J.J., Li C., Rodriguez M., Banerjee D. Cytokine 13:129-137(2001) [PubMed: 11161455] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1990-2948 (ISOFORM 3), TISSUE SPECIFICITY. Tissue: Endothelial cell.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2065-2948 (ISOFORM 3), VARIANT THR-2732. Tissue: Brain.
[8]	"TTK kinase is essential for the centrosomal localization of TACC2." Dou Z., Ding X., Zereshki A., Zhang Y., Zhang J., Wang F., Sun J., Huang H., Yao X. FEBS Lett. 572:51-56(2004) [PubMed: 15304323] [Abstract] Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
[9]	"The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases." Gangisetty O., Lauffart B., Sondarva G.V., Chelsea D.M., Still I.H. Oncogene 23:2559-2563(2004) [PubMed: 14767476] [Abstract] Cited for: INTERACTION WITH GCN5L2 AND PCAF, SUBCELLULAR LOCATION.
[10]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2256 AND SER-2512, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197; SER-201; SER-493; SER-571; SER-575; SER-758; SER-962; SER-1025; SER-1267; SER-1313; THR-1426; SER-1562; SER-2072; THR-2073; SER-2226; THR-2246; SER-2256; SER-2317; SER-2321; SER-2359; SER-2389; SER-2390; SER-2392; SER-2394; SER-2403 AND SER-2512, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2226, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[13]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2884, MASS SPECTROMETRY.
[14]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-798 AND SER-1347.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF176646 mRNA. Translation: AAF63433.1. Different initiation. AF095791 mRNA. Translation: AAC64968.2. AF528098 mRNA. Translation: AAO62629.1. AF528099 mRNA. Translation: AAO62630.1. AL135793, AC063960 Genomic DNA. Translation: CAI95127.1. AL135793 Genomic DNA. Translation: CAI95128.1. AL135793 Genomic DNA. Translation: CAI95131.1. AL135793, AC063960 Genomic DNA. Translation: CAI95134.1. BC000999 mRNA. Translation: AAH00999.1. BC039311 mRNA. Translation: AAH39311.1. AF220152 mRNA. Translation: AAF29537.2. Sequence problems. AL713712 mRNA. Translation: CAD28509.1.
IPI	IPI00030033. IPI00384450. IPI00410127. IPI00642773. IPI00643465. IPI00935164.
RefSeq	NP_008928.1. NM_006997.2. NP_996742.1. NM_206860.1. NP_996743.1. NM_206861.1. NP_996744.2. NM_206862.2.
UniGene	Hs.501252. Hs.713875.
3D structure databases
ProteinModelPortal	O95359.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95359. 2 interactions.
MINT	MINT-1203853.
STRING	O95359.
PTM databases
PhosphoSite	O95359.
Proteomic databases
PRIDE	O95359.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334433; ENSP00000334280; ENSG00000138162. ENST00000369005; ENSP00000358001; ENSG00000138162.
GeneID	10579.
KEGG	hsa:10579.
UCSC	uc001lfv.1. human. uc001lfw.1. human. uc001lfy.1. human. uc001lfz.1. human. uc001lga.1. human. uc001lgb.1. human.
Organism-specific databases
CTD	10579.
GeneCards	GC10P123738.
HGNC	HGNC:11523. TACC2.
HPA	HPA031020.
MIM	605302. gene.
neXtProt	NX_O95359.
PharmGKB	PA36300.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14226.
HOVERGEN	HBG093142.
InParanoid	O95359.
OMA	QVVCVAA.
OrthoDB	EOG44QT02.
PhylomeDB	O95359.
Gene expression databases
ArrayExpress	O95359.
Bgee	O95359.
Genevestigator	O95359.
GermOnline	ENSG00000138162. Homo sapiens.
Family and domain databases
InterPro	IPR007707. TACC. [Graphical view]
KO	K14282.
PANTHER	PTHR13924. TACC. 1 hit.
Pfam	PF05010. TACC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	40155.
SOURCE	Search...

Entry information

Entry name

TACC2_HUMAN

Accession

Primary (citable) accession number: O95359
Secondary accession number(s): Q4VXL0 , Q4VXL3, Q4VXL6, Q4VXL7, Q5U5T7, Q86WG6, Q86WG7, Q8TCK9, Q9BVQ1, Q9NZ41, Q9NZR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.