Reviewed,
UniProtKB/Swiss-Prot O95352 (ATG7_HUMAN)
Last modified
November 25, 2008.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Autophagy-related protein 7 Alternative name(s): APG7-like Ubiquitin-activating enzyme E1-like protein Short name=hAGP7 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 703 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy By similarity. |
| Subunit structure | Homodimer By similarity. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. |
| Subcellular location | CytoplasmProbable. |
| Tissue specificity | Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. |
| Domain | The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 By similarity. |
| Sequence similarities | Belongs to the ATG7 family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Autophagy Protein transport Transport Ubl conjugation pathway |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Alternative splicing |
Gene Ontology (GO) | |
| Biological process | autophagy Inferred from electronic annotation. Source: UniProtKB-KW membrane fusion Ref.1Traceable author statement. Source: ProtInc positive regulation of protein modification processInferred from direct assay. Source: MGI protein amino acid lipidationInferred from direct assay. Source: MGI protein transportInferred from electronic annotation. Source: UniProtKB-KW ubiquitin-dependent protein catabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | protein homodimerization activity Inferred from direct assay. Source: UniProtKB ubiquitin activating enzyme activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: O95352-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: O95352-2) The sequence of this isoform differs from the canonical sequence as follows: 626-652: Missing. |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein." Yuan W., Stromhaug P.E., Dunn W.A. Jr. Mol. Biol. Cell 10:1353-1366(1999) [PubMed: 10233149] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta. |
| [3] | The German cDNA consortium Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 179-703 (ISOFORM 1). Tissue: Testis. |
| [4] | "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs." Tanida I., Tanida-Miyake E., Nishitani T., Komatsu M., Yamazaki H., Ueno T., Kominami E. Biochem. Biophys. Res. Commun. 292:256-262(2002) [PubMed: 11890701] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [5] | "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p." Tanida I., Tanida-Miyake E., Komatsu M., Ueno T., Kominami E. J. Biol. Chem. 277:13739-13744(2002) [PubMed: 11825910] [Abstract] Cited for: INTERACTION WITH ATG3 AND ATG12. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AF094516 mRNA. Translation: AAC69630.1. BC000091 mRNA. Translation: AAH00091.1. AL122075 mRNA. Translation: CAB59250.1. | |
| PIR | T34556. |
| RefSeq | NP_006386.1. |
| UniGene | Hs.38032 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JW9 based on UniProtKB P12282. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O95352. |
PTM databases | |
| PhosphoSite | O95352. |
Genome annotation databases | |
| Ensembl | ENSG00000197548. Homo sapiens. [Contig view] |
| GeneID | 10533. |
| KEGG | hsa:10533. |
Organism-specific databases | |
| H-InvDB | HIX0003055. |
| HGNC | HGNC:16935. ATG7. |
| HPA | CAB018771. HPA007639. |
| MIM | 608760. gene. |
| PharmGKB | PA134983397. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | O95352. |
| HOVERGEN | O95352. |
Gene expression databases | |
| ArrayExpress | O95352. |
| CleanEx | HS_ATG7. |
| GermOnline | ENSG00000197548. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006285. E1_like_Apg7. IPR016040. NAD(P)-bd. IPR000594. ThiF_NAD_FAD_bd. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00899. ThiF. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01381. E1_like_apg7. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 39961. |
| SOURCE | Search... |
Entry information
| Entry name | ATG7_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O95352 Secondary accession number(s): Q7L8L0, Q9BWP2, Q9UFH4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


