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O95352

- ATG7_HUMAN

UniProt

O95352 - ATG7_HUMAN

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Protein
Ubiquitin-like modifier-activating enzyme ATG7
Gene
ATG7, APG7L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei572 – 5721Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. Atg12 activating enzyme activity Source: UniProtKB
  2. Atg8 activating enzyme Source: RefGenome
  3. protein binding Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. transcription factor binding Source: UniProtKB
  6. ubiquitin activating enzyme activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. C-terminal protein lipidation Source: RefGenome
  2. adult walking behavior Source: Ensembl
  3. cardiac muscle cell development Source: Ensembl
  4. cellular amino acid metabolic process Source: Ensembl
  5. cellular protein modification process Source: ProtInc
  6. cellular response to hyperoxia Source: UniProtKB
  7. cellular response to nitrogen starvation Source: RefGenome
  8. cellular response to starvation Source: UniProtKB
  9. central nervous system neuron axonogenesis Source: Ensembl
  10. cerebellar Purkinje cell layer development Source: Ensembl
  11. cerebral cortex development Source: Ensembl
  12. late nucleophagy Source: RefGenome
  13. liver development Source: Ensembl
  14. membrane fusion Source: ProtInc
  15. mitochondrion degradation Source: RefGenome
  16. negative regulation of apoptotic process Source: Ensembl
  17. neurological system process Source: Ensembl
  18. organelle organization Source: Ensembl
  19. piecemeal microautophagy of nucleus Source: RefGenome
  20. positive regulation of apoptotic process Source: UniProtKB
  21. positive regulation of autophagy Source: UniProtKB
  22. positive regulation of macroautophagy Source: BHF-UCL
  23. positive regulation of protein catabolic process Source: UniProtKB
  24. positive regulation of protein modification process Source: MGI
  25. post-embryonic development Source: Ensembl
  26. protein catabolic process Source: RefGenome
  27. protein lipidation Source: MGI
  28. protein modification by small protein conjugation Source: RefGenome
  29. protein transport Source: UniProtKB-KW
  30. protein ubiquitination Source: GOC
  31. pyramidal neuron development Source: Ensembl
  32. regulation of protein ubiquitination Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like modifier-activating enzyme ATG7
Alternative name(s):
ATG12-activating enzyme E1 ATG7
Autophagy-related protein 7
Short name:
APG7-like
Short name:
hAGP7
Ubiquitin-activating enzyme E1-like protein
Gene namesi
Name:ATG7
Synonyms:APG7L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:16935. ATG7.

Subcellular locationi

Cytoplasm By similarity. Preautophagosomal structure By similarity
Note: Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme By similarity.

GO - Cellular componenti

  1. axoneme Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: RefGenome
  4. pre-autophagosomal structure Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi15 – 151F → D: Impairs conjugation activity; when associated with D-16 and D-17. 1 Publication
Mutagenesisi16 – 161A → D: Impairs conjugation activity; when associated with D-15 and D-17. 1 Publication
Mutagenesisi17 – 171P → D: Impairs conjugation activity; when associated with D-15 and D-16. 1 Publication

Organism-specific databases

PharmGKBiPA134983397.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 703702Ubiquitin-like modifier-activating enzyme ATG7
PRO_0000212806Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications

Post-translational modificationi

Acetylated by EP300.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO95352.
PaxDbiO95352.
PRIDEiO95352.

PTM databases

PhosphoSiteiO95352.

Expressioni

Tissue specificityi

Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.1 Publication

Inductioni

Expression is up-regulated by the transcription factor HSF1.1 Publication

Gene expression databases

ArrayExpressiO95352.
BgeeiO95352.
CleanExiHS_ATG7.
GenevestigatoriO95352.

Organism-specific databases

HPAiCAB018771.
HPA007639.

Interactioni

Subunit structurei

Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Forms intermediate conjugates with ATG8-like proteins such as GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A. Interacts with EP300 acetyltransferase. Interacts with FOXO1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1DP296922EBI-987834,EBI-358607
GABARAPO951668EBI-987834,EBI-712001
GABARAPL1Q9H0R86EBI-987834,EBI-746969
GABARAPL2P605207EBI-987834,EBI-720116
IRF2P143162EBI-987834,EBI-2866589
MAP1LC3BQ9GZQ87EBI-987834,EBI-373144

Protein-protein interaction databases

BioGridi115787. 43 interactions.
DIPiDIP-29759N.
IntActiO95352. 14 interactions.
STRINGi9606.ENSP00000346437.

Structurei

3D structure databases

ProteinModelPortaliO95352.
SMRiO95352. Positions 13-690.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi15 – 173FAP motif

Domaini

The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 By similarity.
The N-terminal FAP motif (residues 15 to 17) is essential for the formation of the ATG89-PE and ATG5-ATG12 conjugates (1 Publication).

Sequence similaritiesi

Belongs to the ATG7 family.

Phylogenomic databases

eggNOGiCOG0476.
HOGENOMiHOG000162379.
HOVERGENiHBG080877.
InParanoidiO95352.
KOiK08337.
OMAiLGCQVAR.
OrthoDBiEOG7X0VGG.
PhylomeDBiO95352.
TreeFamiTF105689.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006285. Atg7.
IPR009036. Molybdenum_cofac_synth_MoeB.
IPR016040. NAD(P)-bd_dom.
IPR000594. ThiF_NAD_FAD-bd.
[Graphical view]
PANTHERiPTHR10953:SF3. PTHR10953:SF3. 1 hit.
PfamiPF00899. ThiF. 1 hit.
[Graphical view]
SUPFAMiSSF69572. SSF69572. 2 hits.
TIGRFAMsiTIGR01381. E1_like_apg7. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95352-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAATGDPGL SKLQFAPFSS ALDVGFWHEL TQKKLNEYRL DEAPKDIKGY    50
YYNGDSAGLP ARLTLEFSAF DMSAPTPARC CPAIGTLYNT NTLESFKTAD 100
KKLLLEQAAN EIWESIKSGT ALENPVLLNK FLLLTFADLK KYHFYYWFCY 150
PALCLPESLP LIQGPVGLDQ RFSLKQIEAL ECAYDNLCQT EGVTALPYFL 200
IKYDENMVLV SLLKHYSDFF QGQRTKITIG VYDPCNLAQY PGWPLRNFLV 250
LAAHRWSSSF QSVEVVCFRD RTMQGARDVA HSIIFEVKLP EMAFSPDCPK 300
AVGWEKNQKG GMGPRMVNLS ECMDPKRLAE SSVDLNLKLM CWRLVPTLDL 350
DKVVSVKCLL LGAGTLGCNV ARTLMGWGVR HITFVDNAKI SYSNPVRQPL 400
YEFEDCLGGG KPKALAAADR LQKIFPGVNA RGFNMSIPMP GHPVNFSSVT 450
LEQARRDVEQ LEQLIESHDV VFLLMDTRES RWLPAVIAAS KRKLVINAAL 500
GFDTFVVMRH GLKKPKQQGA GDLCPNHPVA SADLLGSSLF ANIPGYKLGC 550
YFCNDVVAPG DSTRDRTLDQ QCTVSRPGLA VIAGALAVEL MVSVLQHPEG 600
GYAIASSSDD RMNEPPTSLG LVPHQIRGFL SRFDNVLPVS LAFDKCTACS 650
SKVLDQYERE GFNFLAKVFN SSHSFLEDLT GLTLLHQETQ AAEIWDMSDD 700
ETI 703
Length:703
Mass (Da):77,960
Last modified:May 1, 1999 - v1
Checksum:iABBD1A29A6C58356
GO
Isoform 2 (identifier: O95352-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-652: Missing.

Show »
Length:676
Mass (Da):75,002
Checksum:i184E1A7A3B989524
GO
Isoform 3 (identifier: O95352-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-176: Missing.
     653-693: Missing.

Show »
Length:623
Mass (Da):68,618
Checksum:i2186C29D24B11D6E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti471 – 4711V → A.
Corresponds to variant rs36117895 [ dbSNP | Ensembl ].
VAR_053014

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei138 – 17639Missing in isoform 3.
VSP_045206Add
BLAST
Alternative sequencei626 – 65227Missing in isoform 2.
VSP_013205Add
BLAST
Alternative sequencei653 – 69341Missing in isoform 3.
VSP_045207Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti210 – 2101V → A in BAG64682. 1 Publication
Sequence conflicti346 – 3461P → L in BAG64682. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF094516 mRNA. Translation: AAC69630.1.
AK303694 mRNA. Translation: BAG64682.1.
AC020750 Genomic DNA. No translation available.
AC022001 Genomic DNA. No translation available.
AC026185 Genomic DNA. No translation available.
AC083855 Genomic DNA. No translation available.
BC000091 mRNA. Translation: AAH00091.1.
AL122075 mRNA. Translation: CAB59250.1.
CCDSiCCDS2605.1. [O95352-1]
CCDS46752.1. [O95352-2]
CCDS46753.1. [O95352-3]
PIRiT34556.
RefSeqiNP_001129503.2. NM_001136031.2. [O95352-2]
NP_001138384.1. NM_001144912.1. [O95352-3]
NP_006386.1. NM_006395.2. [O95352-1]
UniGeneiHs.38032.

Genome annotation databases

EnsembliENST00000354449; ENSP00000346437; ENSG00000197548. [O95352-1]
ENST00000354956; ENSP00000347042; ENSG00000197548. [O95352-2]
ENST00000446450; ENSP00000412580; ENSG00000197548. [O95352-3]
GeneIDi10533.
KEGGihsa:10533.
UCSCiuc003bwc.3. human. [O95352-1]
uc003bwd.3. human. [O95352-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF094516 mRNA. Translation: AAC69630.1 .
AK303694 mRNA. Translation: BAG64682.1 .
AC020750 Genomic DNA. No translation available.
AC022001 Genomic DNA. No translation available.
AC026185 Genomic DNA. No translation available.
AC083855 Genomic DNA. No translation available.
BC000091 mRNA. Translation: AAH00091.1 .
AL122075 mRNA. Translation: CAB59250.1 .
CCDSi CCDS2605.1. [O95352-1 ]
CCDS46752.1. [O95352-2 ]
CCDS46753.1. [O95352-3 ]
PIRi T34556.
RefSeqi NP_001129503.2. NM_001136031.2. [O95352-2 ]
NP_001138384.1. NM_001144912.1. [O95352-3 ]
NP_006386.1. NM_006395.2. [O95352-1 ]
UniGenei Hs.38032.

3D structure databases

ProteinModelPortali O95352.
SMRi O95352. Positions 13-690.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115787. 43 interactions.
DIPi DIP-29759N.
IntActi O95352. 14 interactions.
STRINGi 9606.ENSP00000346437.

Chemistry

ChEMBLi CHEMBL2321621.

PTM databases

PhosphoSitei O95352.

Proteomic databases

MaxQBi O95352.
PaxDbi O95352.
PRIDEi O95352.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354449 ; ENSP00000346437 ; ENSG00000197548 . [O95352-1 ]
ENST00000354956 ; ENSP00000347042 ; ENSG00000197548 . [O95352-2 ]
ENST00000446450 ; ENSP00000412580 ; ENSG00000197548 . [O95352-3 ]
GeneIDi 10533.
KEGGi hsa:10533.
UCSCi uc003bwc.3. human. [O95352-1 ]
uc003bwd.3. human. [O95352-2 ]

Organism-specific databases

CTDi 10533.
GeneCardsi GC03P011313.
HGNCi HGNC:16935. ATG7.
HPAi CAB018771.
HPA007639.
MIMi 608760. gene.
neXtProti NX_O95352.
PharmGKBi PA134983397.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0476.
HOGENOMi HOG000162379.
HOVERGENi HBG080877.
InParanoidi O95352.
KOi K08337.
OMAi LGCQVAR.
OrthoDBi EOG7X0VGG.
PhylomeDBi O95352.
TreeFami TF105689.

Enzyme and pathway databases

Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GeneWikii ATG7.
GenomeRNAii 10533.
NextBioi 39961.
PROi O95352.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95352.
Bgeei O95352.
CleanExi HS_ATG7.
Genevestigatori O95352.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006285. Atg7.
IPR009036. Molybdenum_cofac_synth_MoeB.
IPR016040. NAD(P)-bd_dom.
IPR000594. ThiF_NAD_FAD-bd.
[Graphical view ]
PANTHERi PTHR10953:SF3. PTHR10953:SF3. 1 hit.
Pfami PF00899. ThiF. 1 hit.
[Graphical view ]
SUPFAMi SSF69572. SSF69572. 2 hits.
TIGRFAMsi TIGR01381. E1_like_apg7. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein."
    Yuan W., Stromhaug P.E., Dunn W.A. Jr.
    Mol. Biol. Cell 10:1353-1366(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Kidney.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 179-703 (ISOFORM 1).
    Tissue: Testis.
  6. "The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."
    Tanida I., Tanida-Miyake E., Ueno T., Kominami E.
    J. Biol. Chem. 276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH ATG12; GABARAP; GABARAPL2 AND MAP1LC3A.
  7. "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs."
    Tanida I., Tanida-Miyake E., Nishitani T., Komatsu M., Yamazaki H., Ueno T., Kominami E.
    Biochem. Biophys. Res. Commun. 292:256-262(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
    Tanida I., Tanida-Miyake E., Komatsu M., Ueno T., Kominami E.
    J. Biol. Chem. 277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATG3 AND ATG12.
    Tissue: Brain.
  9. "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16."
    Sou Y.S., Tanida I., Komatsu M., Ueno T., Kominami E.
    J. Biol. Chem. 281:3017-3024(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GABARAP; GABARAPL2 AND MAP1LC3A.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  11. "Regulation of autophagy by the p300 acetyltransferase."
    Lee I.H., Finkel T.
    J. Biol. Chem. 284:6322-6328(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION, INTERACTION WITH EP300.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity."
    Zhao Y., Yang J., Liao W., Liu X., Zhang H., Wang S., Wang D., Feng J., Yu L., Zhu W.G.
    Nat. Cell Biol. 12:665-675(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FOXO1.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation."
    Tanida I., Yamasaki M., Komatsu M., Ueno T.
    Autophagy 8:88-97(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF PHE-15; ALA-16 AND PRO-17.
  17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7)."
    Desai S., Liu Z., Yao J., Patel N., Chen J., Wu Y., Ahn E.E., Fodstad O., Tan M.
    J. Biol. Chem. 288:9165-9176(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiATG7_HUMAN
AccessioniPrimary (citable) accession number: O95352
Secondary accession number(s): B4E170
, E9PB95, Q7L8L0, Q9BWP2, Q9UFH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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