UniProtKB - O95347 (SMC2_HUMAN)
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Protein
Structural maintenance of chromosomes protein 2
Gene
SMC2
Organism
Homo sapiens (Human)
Status
Functioni
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 32 – 39 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein heterodimerization activity Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- kinetochore organization Source: Ensembl
- meiotic chromosome condensation Source: Ensembl
- meiotic chromosome segregation Source: Ensembl
- mitotic chromosome condensation Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, DNA condensation, Mitosis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-2299718. Condensation of Prophase Chromosomes. R-HSA-2514853. Condensation of Prometaphase Chromosomes. |
Names & Taxonomyi
Protein namesi | Recommended name: Structural maintenance of chromosomes protein 2Short name: SMC protein 2 Short name: SMC-2 Alternative name(s): Chromosome-associated protein E Short name: hCAP-E XCAP-E homolog |
Gene namesi | Name:SMC2 Synonyms:CAPE, SMC2L1 ORF Names:PRO0324 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000136824.18. |
HGNCi | HGNC:14011. SMC2. |
MIMi | 605576. gene. |
neXtProti | NX_O95347. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 10592. |
OpenTargetsi | ENSG00000136824. |
PharmGKBi | PA37833. |
Polymorphism and mutation databases
BioMutai | SMC2. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118995 | 1 – 1197 | Structural maintenance of chromosomes protein 2Add BLAST | 1197 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 114 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 222 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 677 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1158 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1160 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O95347. |
MaxQBi | O95347. |
PaxDbi | O95347. |
PeptideAtlasi | O95347. |
PRIDEi | O95347. |
PTM databases
iPTMneti | O95347. |
PhosphoSitePlusi | O95347. |
Expressioni
Gene expression databases
Bgeei | ENSG00000136824. |
CleanExi | HS_SMC2. |
ExpressionAtlasi | O95347. baseline and differential. |
Genevisiblei | O95347. HS. |
Organism-specific databases
HPAi | HPA071309. |
Interactioni
Subunit structurei
Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Interacts with BRD4 (isoform B), leading to insulate chromatin from DNA damage response pathway.4 Publications
Binary interactionsi
GO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 115841. 81 interactors. |
CORUMi | O95347. |
DIPi | DIP-35422N. |
IntActi | O95347. 48 interactors. |
MINTi | O95347. |
STRINGi | 9606.ENSP00000286398. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 476 – 502 | Combined sources | 27 | |
Helixi | 504 – 506 | Combined sources | 3 | |
Helixi | 519 – 521 | Combined sources | 3 | |
Beta strandi | 522 – 525 | Combined sources | 4 | |
Helixi | 526 – 529 | Combined sources | 4 | |
Beta strandi | 531 – 533 | Combined sources | 3 | |
Helixi | 535 – 537 | Combined sources | 3 | |
Helixi | 538 – 545 | Combined sources | 8 | |
Helixi | 546 – 550 | Combined sources | 5 | |
Beta strandi | 552 – 555 | Combined sources | 4 | |
Helixi | 557 – 566 | Combined sources | 10 | |
Beta strandi | 573 – 577 | Combined sources | 5 | |
Turni | 578 – 580 | Combined sources | 3 | |
Helixi | 588 – 598 | Combined sources | 11 | |
Beta strandi | 602 – 605 | Combined sources | 4 | |
Helixi | 606 – 609 | Combined sources | 4 | |
Helixi | 614 – 616 | Combined sources | 3 | |
Helixi | 617 – 624 | Combined sources | 8 | |
Beta strandi | 628 – 632 | Combined sources | 5 | |
Helixi | 633 – 640 | Combined sources | 8 | |
Turni | 643 – 645 | Combined sources | 3 | |
Beta strandi | 649 – 651 | Combined sources | 3 | |
Beta strandi | 656 – 658 | Combined sources | 3 | |
Turni | 659 – 661 | Combined sources | 3 | |
Beta strandi | 662 – 666 | Combined sources | 5 | |
Helixi | 674 – 704 | Combined sources | 31 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4U4P | X-ray | 1.89 | A | 476-707 | [»] | |
ProteinModelPortali | O95347. | |||||
SMRi | O95347. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 508 – 671 | Flexible hingeAdd BLAST | 164 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 173 – 507 | Sequence analysisAdd BLAST | 335 | |
Coiled coili | 672 – 926 | Sequence analysisAdd BLAST | 255 | |
Coiled coili | 963 – 1031 | Sequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1085 – 1120 | Ala/Asp-rich (DA-box)Add BLAST | 36 |
Domaini
The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.By similarity
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0933. Eukaryota. COG1196. LUCA. |
GeneTreei | ENSGT00550000074857. |
HOGENOMi | HOG000228249. |
HOVERGENi | HBG106605. |
InParanoidi | O95347. |
KOi | K06674. |
OMAi | HNKIAME. |
OrthoDBi | EOG091G03K8. |
PhylomeDBi | O95347. |
TreeFami | TF101157. |
Family and domain databases
CDDi | cd03273. ABC_SMC2_euk. 1 hit. |
InterProi | View protein in InterPro IPR027417. P-loop_NTPase. IPR003395. RecF/RecN/SMC_N. IPR024704. SMC. IPR027120. Smc2_ABC. IPR010935. SMC_hinge. IPR036277. SMC_hinge_sf. |
Pfami | View protein in Pfam PF06470. SMC_hinge. 1 hit. PF02463. SMC_N. 2 hits. |
PIRSFi | PIRSF005719. SMC. 1 hit. |
SMARTi | View protein in SMART SM00968. SMC_hinge. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 2 hits. SSF75553. SSF75553. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95347-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG
60 70 80 90 100
ISNLSQVRAS NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE
110 120 130 140 150
ITVTRQVVIG GRNKYLINGV NANNTRVQDL FCSVGLNVNN PHFLIMQGRI
160 170 180 190 200
TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA AQKTIEKKEA KLKEIKTILE
210 220 230 240 250
EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL LAEDTKVRSA
260 270 280 290 300
EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE
310 320 330 340 350
DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK
360 370 380 390 400
EVKKITDGLH ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG
410 420 430 440 450
QMMACKNDIS KAQTEAKQAQ MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA
460 470 480 490 500
LEAVKRLKEK LEAEMKKLNY EENKEESLLE KRRQLSRDIG RLKETYEALL
510 520 530 540 550
ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA LELVAGERLY
560 570 580 590 600
NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP
610 620 630 640 650
DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV
660 670 680 690 700
TLGGDVFDPH GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE
710 720 730 740 750
ELAGLKNTAE KYRQLKQQWE MKTEEADLLQ TKLQQSSYHK QQEELDALKK
760 770 780 790 800
TIEESEETLK NTKEIQRKAE EKYEVLENKM KNAEAERERE LKDAQKKLDC
810 820 830 840 850
AKTKADASSK KMKEKQQEVE AITLELEELK REHTSYKQQL EAVNEAIKSY
860 870 880 890 900
ESQIEVMAAE VAKNKESVNK AQEEVTKQKE VITAQDTVIK AKYAEVAKHK
910 920 930 940 950
EQNNDSQLKI KELDHNISKH KREAEDGAAK VSKMLKDYDW INAERHLFGQ
960 970 980 990 1000
PNSAYDFKTN NPKEAGQRLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND
1010 1020 1030 1040 1050
LMKKKRIVEN DKSKILTTIE DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP
1060 1070 1080 1090 1100
GANAMLAPPE GQTVLDGLEF KVALGNTWKE NLTELSGGQR SLVALSLILS
1110 1120 1130 1140 1150
MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF IVVSLKEGMF
1160 1170 1180 1190
NNANVLFKTK FVDGVSTVAR FTQCQNGKIS KEAKSKAKPP KGAHVEV
Sequence cautioni
The sequence AAF29579 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 294 | G → V in AAC72360 (PubMed:9789013).Curated | 1 | |
Sequence conflicti | 916 | N → H in AAC72360 (PubMed:9789013).Curated | 1 | |
Sequence conflicti | 998 | Y → C in AAC72360 (PubMed:9789013).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047489 | 1009 | E → K. Corresponds to variant dbSNP:rs4562395Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007243 | 1091 – 1099 | SLVALSLIL → QKQQNHTTG in isoform 2. 1 Publication | 9 | |
Alternative sequenceiVSP_007244 | 1100 – 1197 | Missing in isoform 2. 1 PublicationAdd BLAST | 98 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF092563 mRNA. Translation: AAC72360.1. Frameshift. AL833191 mRNA. Translation: CAI46187.1. AL161791, AL354938 Genomic DNA. Translation: CAI16866.1. AL354938, AL161791 Genomic DNA. Translation: CAI16923.1. CH471105 Genomic DNA. Translation: EAW58973.1. BC130385 mRNA. Translation: AAI30386.1. AF113673 mRNA. Translation: AAF29579.1. Different initiation. BN000163 mRNA. Translation: CAD89875.1. |
CCDSi | CCDS35086.1. [O95347-1] |
RefSeqi | NP_001036015.1. NM_001042550.1. [O95347-1] NP_001036016.1. NM_001042551.1. [O95347-1] NP_001252531.1. NM_001265602.1. [O95347-1] NP_006435.2. NM_006444.2. [O95347-1] XP_006716996.1. XM_006716933.3. [O95347-1] XP_011516450.1. XM_011518148.2. [O95347-1] XP_011516451.1. XM_011518149.2. [O95347-1] XP_011516455.1. XM_011518153.1. [O95347-2] XP_016869695.1. XM_017014206.1. [O95347-1] XP_016869696.1. XM_017014207.1. [O95347-1] XP_016869697.1. XM_017014208.1. [O95347-1] |
UniGenei | Hs.119023. |
Genome annotation databases
Ensembli | ENST00000286398; ENSP00000286398; ENSG00000136824. [O95347-1] ENST00000374787; ENSP00000363919; ENSG00000136824. [O95347-1] ENST00000374793; ENSP00000363925; ENSG00000136824. [O95347-1] |
GeneIDi | 10592. |
KEGGi | hsa:10592. |
UCSCi | uc004bbw.4. human. [O95347-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | SMC2_HUMAN | |
Accessioni | O95347Primary (citable) accession number: O95347 Secondary accession number(s): Q6IEE0, Q9P1P2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | November 25, 2008 | |
Last modified: | March 28, 2018 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |