Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O95347 (SMC2_HUMAN)

UniProt

O95347 - SMC2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Structural maintenance of chromosomes protein 2

Gene

SMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2299718. Condensation of Prophase Chromosomes.
R-HSA-2514853. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 2
Short name:
SMC protein 2
Short name:
SMC-2
Alternative name(s):
Chromosome-associated protein E
Short name:
hCAP-E
XCAP-E homolog
Gene namesi
Name:SMC2
Synonyms:CAPE, SMC2L1
ORF Names:PRO0324
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:14011. SMC2.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication
  • Chromosome 1 Publication

    • Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

GO - Cellular componenti

  • condensed chromosome Source: UniProtKB
  • condensin complex Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nuclear chromosome Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

MalaCardsiSMC2.
PharmGKBiPA37833.

Polymorphism and mutation databases

BioMutaiSMC2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11971197Structural maintenance of chromosomes protein 2PRO_0000118995Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei114 – 1141N6-acetyllysineCombined sources
Modified residuei222 – 2221N6-acetyllysineCombined sources
Modified residuei677 – 6771N6-acetyllysineCombined sources
Modified residuei1158 – 11581N6-acetyllysineCombined sources
Modified residuei1160 – 11601N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO95347.
MaxQBiO95347.
PaxDbiO95347.
PeptideAtlasiO95347.
PRIDEiO95347.

PTM databases

iPTMnetiO95347.
PhosphoSiteiO95347.

Expressioni

Gene expression databases

BgeeiENSG00000136824.
CleanExiHS_SMC2.
ExpressionAtlasiO95347. baseline and differential.
GenevisibleiO95347. HS.

Organism-specific databases

HPAiHPA071309.

Interactioni

Subunit structurei

Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Interacts with BRD4 (isoform B), leading to insulate chromatin from DNA damage response pathway.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCAPHQ150033EBI-355822,EBI-1046410
NCAPH2Q6IBW42EBI-355822,EBI-2548296
SMC4Q9NTJ33EBI-355822,EBI-356173

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi115841. 78 interactions.
DIPiDIP-35422N.
IntActiO95347. 36 interactions.
MINTiMINT-1161754.
STRINGi9606.ENSP00000286398.

Structurei

Secondary structure

1
1197
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi476 – 50227Combined sources
Helixi504 – 5063Combined sources
Helixi519 – 5213Combined sources
Beta strandi522 – 5254Combined sources
Helixi526 – 5294Combined sources
Beta strandi531 – 5333Combined sources
Helixi535 – 5373Combined sources
Helixi538 – 5458Combined sources
Helixi546 – 5505Combined sources
Beta strandi552 – 5554Combined sources
Helixi557 – 56610Combined sources
Beta strandi573 – 5775Combined sources
Turni578 – 5803Combined sources
Helixi588 – 59811Combined sources
Beta strandi602 – 6054Combined sources
Helixi606 – 6094Combined sources
Helixi614 – 6163Combined sources
Helixi617 – 6248Combined sources
Beta strandi628 – 6325Combined sources
Helixi633 – 6408Combined sources
Turni643 – 6453Combined sources
Beta strandi649 – 6513Combined sources
Beta strandi656 – 6583Combined sources
Turni659 – 6613Combined sources
Beta strandi662 – 6665Combined sources
Helixi674 – 70431Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4U4PX-ray1.89A476-707[»]
ProteinModelPortaliO95347.
SMRiO95347. Positions 476-706.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni508 – 671164Flexible hingeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili173 – 507335Sequence analysisAdd
BLAST
Coiled coili672 – 926255Sequence analysisAdd
BLAST
Coiled coili963 – 103169Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1085 – 112036Ala/Asp-rich (DA-box)Add
BLAST

Domaini

The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC2 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0933. Eukaryota.
COG1196. LUCA.
GeneTreeiENSGT00550000074857.
HOGENOMiHOG000228249.
HOVERGENiHBG106605.
InParanoidiO95347.
KOiK06674.
OMAiCQNGKIP.
OrthoDBiEOG091G03K8.
PhylomeDBiO95347.
TreeFamiTF101157.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR027120. Smc2.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF9. PTHR18937:SF9. 1 hit.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 2 hits.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95347-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG 
        60         70         80         90        100
ISNLSQVRAS NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE 
       110        120        130        140        150
ITVTRQVVIG GRNKYLINGV NANNTRVQDL FCSVGLNVNN PHFLIMQGRI 
       160        170        180        190        200
TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA AQKTIEKKEA KLKEIKTILE 
       210        220        230        240        250
EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL LAEDTKVRSA 
       260        270        280        290        300
EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE 
       310        320        330        340        350
DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK 
       360        370        380        390        400
EVKKITDGLH ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG 
       410        420        430        440        450
QMMACKNDIS KAQTEAKQAQ MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA 
       460        470        480        490        500
LEAVKRLKEK LEAEMKKLNY EENKEESLLE KRRQLSRDIG RLKETYEALL 
       510        520        530        540        550
ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA LELVAGERLY 
       560        570        580        590        600
NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP 
       610        620        630        640        650
DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV 
       660        670        680        690        700
TLGGDVFDPH GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE 
       710        720        730        740        750
ELAGLKNTAE KYRQLKQQWE MKTEEADLLQ TKLQQSSYHK QQEELDALKK 
       760        770        780        790        800
TIEESEETLK NTKEIQRKAE EKYEVLENKM KNAEAERERE LKDAQKKLDC 
       810        820        830        840        850
AKTKADASSK KMKEKQQEVE AITLELEELK REHTSYKQQL EAVNEAIKSY 
       860        870        880        890        900
ESQIEVMAAE VAKNKESVNK AQEEVTKQKE VITAQDTVIK AKYAEVAKHK 
       910        920        930        940        950
EQNNDSQLKI KELDHNISKH KREAEDGAAK VSKMLKDYDW INAERHLFGQ 
       960        970        980        990       1000
PNSAYDFKTN NPKEAGQRLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND 
      1010       1020       1030       1040       1050
LMKKKRIVEN DKSKILTTIE DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP 
      1060       1070       1080       1090       1100
GANAMLAPPE GQTVLDGLEF KVALGNTWKE NLTELSGGQR SLVALSLILS 
      1110       1120       1130       1140       1150
MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF IVVSLKEGMF 
      1160       1170       1180       1190 
NNANVLFKTK FVDGVSTVAR FTQCQNGKIS KEAKSKAKPP KGAHVEV
Length:1,197
Mass (Da):135,656
Last modified:November 25, 2008 - v2
Checksum:i15EBB56B31FC1364
GO
Isoform 2 (identifier: O95347-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1091-1099: SLVALSLIL → QKQQNHTTG
     1100-1197: Missing.

Note: No experimental confirmation available.
Show »
Length:1,099
Mass (Da):124,926
Checksum:i68BB895EA6EBA265
GO

Sequence cautioni

The sequence AAC72360 differs from that shown. Reason: Frameshift at positions 890 and 908. Curated
The sequence AAF29579 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti294 – 2941G → V in AAC72360 (PubMed:9789013).Curated
Sequence conflicti916 – 9161N → H in AAC72360 (PubMed:9789013).Curated
Sequence conflicti998 – 9981Y → C in AAC72360 (PubMed:9789013).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1009 – 10091E → K.
Corresponds to variant rs4562395 [ dbSNP | Ensembl ].		VAR_047489

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1091 – 10999SLVALSLIL → QKQQNHTTG in isoform 2. 1 PublicationVSP_007243
Alternative sequencei1100 – 119798Missing in isoform 2. 1 PublicationVSP_007244Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092563 mRNA. Translation: AAC72360.1. Frameshift.
AL833191 mRNA. Translation: CAI46187.1.
AL161791, AL354938 Genomic DNA. Translation: CAI16866.1.
AL354938, AL161791 Genomic DNA. Translation: CAI16923.1.
CH471105 Genomic DNA. Translation: EAW58973.1.
BC130385 mRNA. Translation: AAI30386.1.
AF113673 mRNA. Translation: AAF29579.1. Different initiation.
BN000163 mRNA. Translation: CAD89875.1.
CCDSiCCDS35086.1. [O95347-1]
RefSeqiNP_001036015.1. NM_001042550.1. [O95347-1]
NP_001036016.1. NM_001042551.1. [O95347-1]
NP_001252531.1. NM_001265602.1. [O95347-1]
NP_006435.2. NM_006444.2. [O95347-1]
XP_006716996.1. XM_006716933.3. [O95347-1]
XP_011516450.1. XM_011518148.2. [O95347-1]
XP_011516451.1. XM_011518149.2. [O95347-1]
XP_011516455.1. XM_011518153.1. [O95347-2]
UniGeneiHs.119023.

Genome annotation databases

EnsembliENST00000286398; ENSP00000286398; ENSG00000136824. [O95347-1]
ENST00000374787; ENSP00000363919; ENSG00000136824. [O95347-1]
ENST00000374793; ENSP00000363925; ENSG00000136824. [O95347-1]
GeneIDi10592.
KEGGihsa:10592.
UCSCiuc004bbw.4. human. [O95347-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092563 mRNA. Translation: AAC72360.1. Frameshift.
AL833191 mRNA. Translation: CAI46187.1.
AL161791, AL354938 Genomic DNA. Translation: CAI16866.1.
AL354938, AL161791 Genomic DNA. Translation: CAI16923.1.
CH471105 Genomic DNA. Translation: EAW58973.1.
BC130385 mRNA. Translation: AAI30386.1.
AF113673 mRNA. Translation: AAF29579.1. Different initiation.
BN000163 mRNA. Translation: CAD89875.1.
CCDSiCCDS35086.1. [O95347-1]
RefSeqiNP_001036015.1. NM_001042550.1. [O95347-1]
NP_001036016.1. NM_001042551.1. [O95347-1]
NP_001252531.1. NM_001265602.1. [O95347-1]
NP_006435.2. NM_006444.2. [O95347-1]
XP_006716996.1. XM_006716933.3. [O95347-1]
XP_011516450.1. XM_011518148.2. [O95347-1]
XP_011516451.1. XM_011518149.2. [O95347-1]
XP_011516455.1. XM_011518153.1. [O95347-2]
UniGeneiHs.119023.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4U4PX-ray1.89A476-707[»]
ProteinModelPortaliO95347.
SMRiO95347. Positions 476-706.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115841. 78 interactions.
DIPiDIP-35422N.
IntActiO95347. 36 interactions.
MINTiMINT-1161754.
STRINGi9606.ENSP00000286398.

PTM databases

iPTMnetiO95347.
PhosphoSiteiO95347.

Polymorphism and mutation databases

BioMutaiSMC2.

Proteomic databases

EPDiO95347.
MaxQBiO95347.
PaxDbiO95347.
PeptideAtlasiO95347.
PRIDEiO95347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286398; ENSP00000286398; ENSG00000136824. [O95347-1]
ENST00000374787; ENSP00000363919; ENSG00000136824. [O95347-1]
ENST00000374793; ENSP00000363925; ENSG00000136824. [O95347-1]
GeneIDi10592.
KEGGihsa:10592.
UCSCiuc004bbw.4. human. [O95347-1]

Organism-specific databases

CTDi10592.
GeneCardsiSMC2.
H-InvDBHIX0008250.
HGNCiHGNC:14011. SMC2.
HPAiHPA071309.
MalaCardsiSMC2.
MIMi605576. gene.
neXtProtiNX_O95347.
PharmGKBiPA37833.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0933. Eukaryota.
COG1196. LUCA.
GeneTreeiENSGT00550000074857.
HOGENOMiHOG000228249.
HOVERGENiHBG106605.
InParanoidiO95347.
KOiK06674.
OMAiCQNGKIP.
OrthoDBiEOG091G03K8.
PhylomeDBiO95347.
TreeFamiTF101157.

Enzyme and pathway databases

ReactomeiR-HSA-2299718. Condensation of Prophase Chromosomes.
R-HSA-2514853. Condensation of Prometaphase Chromosomes.

Miscellaneous databases

ChiTaRSiSMC2. human.
GeneWikiiSMC2.
GenomeRNAii10592.
PROiO95347.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136824.
CleanExiHS_SMC2.
ExpressionAtlasiO95347. baseline and differential.
GenevisibleiO95347. HS.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR027120. Smc2.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF9. PTHR18937:SF9. 1 hit.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 2 hits.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMC2_HUMAN
AccessioniPrimary (citable) accession number: O95347
Secondary accession number(s): Q6IEE0, Q9P1P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.