##gff-version 3 O95343 UniProtKB Chain 1 332 . . . ID=PRO_0000049299;Note=Homeobox protein SIX3 O95343 UniProtKB DNA binding 206 265 . . . Note=Homeobox;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108 O95343 UniProtKB Region 72 119 . . . Note=Interaction with TLE5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62233 O95343 UniProtKB Region 232 251 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95343 UniProtKB Region 232 234 . . . Note=Bind to RHO promoter;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q62233 O95343 UniProtKB Region 258 332 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95343 UniProtKB Compositional bias 292 332 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O95343 UniProtKB Natural variant 37 37 . . . ID=VAR_071335;Note=In SCHZC and HPE2. G->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18791198,ECO:0000269|PubMed:20157829;Dbxref=dbSNP:rs199823175,PMID:18791198,PMID:20157829 O95343 UniProtKB Natural variant 69 69 . . . ID=VAR_038418;Note=In HPE2. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17001667;Dbxref=dbSNP:rs121917881,PMID:17001667 O95343 UniProtKB Natural variant 79 79 . . . ID=VAR_071336;Note=In HPE2. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20531442;Dbxref=PMID:20531442 O95343 UniProtKB Natural variant 92 92 . . . ID=VAR_023797;Note=In HPE2. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15221788;Dbxref=PMID:15221788 O95343 UniProtKB Natural variant 93 93 . . . ID=VAR_071337;Note=In HPE2. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 105 105 . . . ID=VAR_023798;Note=In HPE2. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15221788;Dbxref=PMID:15221788 O95343 UniProtKB Natural variant 113 113 . . . ID=VAR_071338;Note=In HPE2. W->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=dbSNP:rs137853021,PMID:18791198 O95343 UniProtKB Natural variant 114 114 . . . ID=VAR_071339;Note=In HPE2. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 138 138 . . . ID=VAR_071340;Note=In HPE2. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 155 155 . . . ID=VAR_071341;Note=In HPE2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20531442;Dbxref=PMID:20531442 O95343 UniProtKB Natural variant 157 157 . . . ID=VAR_071342;Note=In HPE2. F->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 167 167 . . . ID=VAR_071343;Note=In SCHZC. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20157829;Dbxref=dbSNP:rs387906868,PMID:20157829 O95343 UniProtKB Natural variant 172 172 . . . ID=VAR_071344;Note=In HPE2. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 173 173 . . . ID=VAR_023799;Note=In HPE2. H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15221788;Dbxref=PMID:15221788 O95343 UniProtKB Natural variant 174 174 . . . ID=VAR_071345;Note=In HPE2. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 202 202 . . . ID=VAR_023800;Note=In HPE2. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15221788;Dbxref=PMID:15221788 O95343 UniProtKB Natural variant 213 213 . . . ID=VAR_071346;Note=In HPE2. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 218 218 . . . ID=VAR_071347;Note=In HPE2. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 218 218 . . . ID=VAR_071348;Note=In HPE2. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 226 226 . . . ID=VAR_003771;Note=In HPE2. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10369266;Dbxref=dbSNP:rs121917878,PMID:10369266 O95343 UniProtKB Natural variant 227 227 . . . ID=VAR_071349;Note=In HPE2. Q->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 231 231 . . . ID=VAR_023801;Note=In HPE2. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15221788;Dbxref=PMID:15221788 O95343 UniProtKB Natural variant 244 244 . . . ID=VAR_071350;Note=In HPE2. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=dbSNP:rs989286015,PMID:18791198 O95343 UniProtKB Natural variant 250 250 . . . ID=VAR_003772;Note=In HPE2%3B Significantly decreased its ability to activate NR4A3. V->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10369266,ECO:0000269|PubMed:15523651;Dbxref=dbSNP:rs121917880,PMID:10369266,PMID:15523651 O95343 UniProtKB Natural variant 254 254 . . . ID=VAR_071351;Note=In HPE2. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 257 257 . . . ID=VAR_071352;Note=In HPE2. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20531442;Dbxref=PMID:20531442 O95343 UniProtKB Natural variant 257 257 . . . ID=VAR_003773;Note=In HPE2%3B Significantly decreased interaction with NR4A3%3B Significantly decreased its ability to activate NR4A3. R->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10369266,ECO:0000269|PubMed:15523651;Dbxref=dbSNP:rs121917879,PMID:10369266,PMID:15523651 O95343 UniProtKB Natural variant 257 257 . . . ID=VAR_023802;Note=In HPE2. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15221788;Dbxref=PMID:15221788 O95343 UniProtKB Natural variant 258 258 . . . ID=VAR_071353;Note=In HPE2. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 262 262 . . . ID=VAR_071354;Note=In HPE2. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 269 269 . . . ID=VAR_071355;Note=In HPE2. R->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20531442;Dbxref=PMID:20531442 O95343 UniProtKB Natural variant 269 269 . . . ID=VAR_071356;Note=In HPE2. R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=PMID:18791198 O95343 UniProtKB Natural variant 269 269 . . . ID=VAR_071357;Note=In HPE2. R->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20531442;Dbxref=PMID:20531442 O95343 UniProtKB Natural variant 297 297 . . . ID=VAR_071358;Note=In HPE2. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18791198;Dbxref=dbSNP:rs780942050,PMID:18791198 O95343 UniProtKB Mutagenesis 87 87 . . . Note=Decreased interaction with TLE5 and loss ineteraction with TLE1. F->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12441302;Dbxref=PMID:12441302 O95343 UniProtKB Mutagenesis 95 95 . . . Note=Loss of interaction with TLE1 and TLE5%3B when associated with P-99. V->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12441302;Dbxref=PMID:12441302 O95343 UniProtKB Mutagenesis 99 99 . . . Note=Loss of interaction with TLE1 and TLE5%3B when associated with P-95. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12441302;Dbxref=PMID:12441302