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Protein

Bile salt export pump

Gene

ABCB11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Kineticsi

  1. KM=30.4 µM for taurocholate1 Publication
  1. Vmax=232 pmol/min/mg enzyme for taurocholate transport1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi455 – 462ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1113 – 1120ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: ProtInc
  • bile acid-exporting ATPase activity Source: Reactome
  • canalicular bile acid transmembrane transporter activity Source: GO_Central
  • sodium-exporting ATPase activity, phosphorylative mechanism Source: ProtInc
  • transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000073734-MONOMER.
ReactomeiR-HSA-159418. Recycling of bile acids and salts.
R-HSA-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.

Protein family/group databases

TCDBi3.A.1.201.2. the atp-binding cassette (abc) superfamily.

Chemistry databases

SwissLipidsiSLP:000001597.

Names & Taxonomyi

Protein namesi
Recommended name:
Bile salt export pump
Alternative name(s):
ATP-binding cassette sub-family B member 11
Gene namesi
Name:ABCB11
Synonyms:BSEP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:42. ABCB11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62CytoplasmicSequence analysisAdd BLAST62
Transmembranei63 – 83HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini84 – 147ExtracellularSequence analysisAdd BLAST64
Transmembranei148 – 168HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini169 – 215CytoplasmicSequence analysisAdd BLAST47
Transmembranei216 – 236HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini237 – 240ExtracellularSequence analysis4
Transmembranei241 – 261HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini262 – 319CytoplasmicSequence analysisAdd BLAST58
Transmembranei320 – 340HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini341 – 353ExtracellularSequence analysisAdd BLAST13
Transmembranei354 – 374HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini375 – 755CytoplasmicSequence analysisAdd BLAST381
Transmembranei756 – 776HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini777 – 794ExtracellularSequence analysisAdd BLAST18
Transmembranei795 – 815HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini816 – 869CytoplasmicSequence analysisAdd BLAST54
Transmembranei870 – 890HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei891 – 911HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini912 – 979CytoplasmicSequence analysisAdd BLAST68
Transmembranei980 – 1000HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1001 – 1011ExtracellularSequence analysisAdd BLAST11
Transmembranei1012 – 1032HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1033 – 1321CytoplasmicSequence analysisAdd BLAST289

GO - Cellular componenti

  • apical part of cell Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intercellular canaliculus Source: Ensembl
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Cholestasis, progressive familial intrahepatic, 2 (PFIC2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood.
See also OMIM:601847
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030388238G → V in PFIC2. 1 PublicationCorresponds to variant rs72551306dbSNPEnsembl.1
Natural variantiVAR_013332284V → L in PFIC2. 1 Publication1
Natural variantiVAR_010271297E → G in PFIC2 and BRIC2; reduced transport capacity for taurocholate. 3 PublicationsCorresponds to variant rs11568372dbSNPEnsembl.1
Natural variantiVAR_030390336C → S in PFIC2. 1 PublicationCorresponds to variant rs72551305dbSNPEnsembl.1
Natural variantiVAR_073967337Y → H in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_013334461K → E in PFIC2. 1 Publication1
Natural variantiVAR_073968472Y → C in PFIC2; compound heterozygous with V-1131. 1 PublicationCorresponds to variant rs369860506dbSNPEnsembl.1
Natural variantiVAR_013335482D → G in PFIC2. 1 PublicationCorresponds to variant rs72549402dbSNPEnsembl.1
Natural variantiVAR_073969696R → W in PFIC2; unknown pathological significance. 1 PublicationCorresponds to variant rs376216286dbSNPEnsembl.1
Natural variantiVAR_073970931Q → P in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_013336982G → R in PFIC2. 1 PublicationCorresponds to variant rs72549399dbSNPEnsembl.1
Natural variantiVAR_0133371004G → D in PFIC2. 1 Publication1
Natural variantiVAR_0739711131D → V in PFIC2; compound heterozygous with C-472. 1 Publication1
Natural variantiVAR_0133381153R → C in PFIC2. 1 PublicationCorresponds to variant rs72549395dbSNPEnsembl.1
Natural variantiVAR_0739721198H → R in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_0133391268R → Q in PFIC2. 1 PublicationCorresponds to variant rs72549394dbSNPEnsembl.1
Cholestasis, benign recurrent intrahepatic, 2 (BRIC2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration. Patients are asymptomatic between episodes, both clinically and biochemically.
See also OMIM:605479
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030386186E → G in BRIC2. 1 PublicationCorresponds to variant rs72551307dbSNPEnsembl.1
Natural variantiVAR_010271297E → G in PFIC2 and BRIC2; reduced transport capacity for taurocholate. 3 PublicationsCorresponds to variant rs11568372dbSNPEnsembl.1
Natural variantiVAR_030391432R → T in BRIC2; reduced transport capacity for taurocholate. 1 PublicationCorresponds to variant rs121908935dbSNPEnsembl.1
Natural variantiVAR_030392570A → T in BRIC2. 1 Publication1
Natural variantiVAR_030394923T → P in BRIC2. 1 PublicationCorresponds to variant rs777469571dbSNPEnsembl.1
Natural variantiVAR_030395926A → P in BRIC2. 1 PublicationCorresponds to variant rs72549400dbSNPEnsembl.1
Natural variantiVAR_0303961050R → C in BRIC2. 1 PublicationCorresponds to variant rs72549398dbSNPEnsembl.1
Natural variantiVAR_0303971128R → H in BRIC2. 1 PublicationCorresponds to variant rs756220860dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Intrahepatic cholestasis

Organism-specific databases

DisGeNETi8647.
MalaCardsiABCB11.
MIMi601847. phenotype.
605479. phenotype.
OpenTargetsiENSG00000073734.
Orphaneti99961. Benign recurrent intrahepatic cholestasis type 2.
69665. Intrahepatic cholestasis of pregnancy.
79304. Progressive familial intrahepatic cholestasis type 2.
PharmGKBiPA374.

Chemistry databases

ChEMBLiCHEMBL6020.
DrugBankiDB00171. Adenosine triphosphate.
DB00559. Bosentan.
DB00477. Chlorpromazine.
DB02659. Cholic Acid.
DB00501. Cimetidine.
DB00845. Clofazimine.
DB00091. Cyclosporine.
DB00694. Daunorubicin.
DB03619. Deoxycholic Acid.
DB01234. Dexamethasone.
DB00390. Digoxin.
DB00997. Doxorubicin.
DB00977. Ethinyl Estradiol.
DB00693. Fluorescein.
DB02703. Fusidic Acid.
DB01016. Glyburide.
DB01026. Ketoconazole.
DB01051. Novobiocin.
DB01229. Paclitaxel.
DB01174. Phenobarbital.
DB08901. Ponatinib.
DB00175. Pravastatin.
DB00396. Progesterone.
DB00908. Quinidine.
DB00206. Reserpine.
DB01045. Rifampicin.
DB01098. Rosuvastatin.
DB00675. Tamoxifen.
DB01586. Ursodeoxycholic acid.
DB00661. Verapamil.
DB00570. Vinblastine.
DB00541. Vincristine.
GuidetoPHARMACOLOGYi778.

Polymorphism and mutation databases

BioMutaiABCB11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000932961 – 1321Bile salt export pumpAdd BLAST1321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...)1 Publication1
Glycosylationi116N-linked (GlcNAc...)1 Publication1
Glycosylationi122N-linked (GlcNAc...)1 Publication1
Glycosylationi125N-linked (GlcNAc...)1 Publication1
Modified residuei586PhosphothreonineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei690PhosphoserineBy similarity1
Modified residuei701PhosphoserineBy similarity1
Modified residuei704PhosphoserineCombined sources1
Modified residuei1214PhosphoserineCombined sources1
Modified residuei1321PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO95342.
MaxQBiO95342.
PaxDbiO95342.
PeptideAtlasiO95342.
PRIDEiO95342.

PTM databases

iPTMnetiO95342.
PhosphoSitePlusiO95342.

Expressioni

Tissue specificityi

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Gene expression databases

BgeeiENSG00000073734.
CleanExiHS_ABCB11.
ExpressionAtlasiO95342. baseline and differential.
GenevisibleiO95342. HS.

Organism-specific databases

HPAiHPA019035.

Interactioni

Subunit structurei

Interacts with HAX1.By similarity

Protein-protein interaction databases

BioGridi114199. 5 interactors.
IntActiO95342. 2 interactors.
MINTiMINT-5003953.
STRINGi9606.ENSP00000263817.

Chemistry databases

BindingDBiO95342.

Structurei

3D structure databases

ProteinModelPortaliO95342.
SMRiO95342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 385ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST324
Domaini420 – 656ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini755 – 1043ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST289
Domaini1078 – 1316ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni651 – 672Interaction with HAX1By similarityAdd BLAST22

Domaini

Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiO95342.
KOiK05664.
OMAiCAFLHGI.
OrthoDBiEOG091G0HVA.
PhylomeDBiO95342.
TreeFamiTF105193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030278. BSEP.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF165. PTHR24221:SF165. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSVILRSI KKFGEENDGF ESDKSYNNDK KSRLQDEKKG DGVRVGFFQL
60 70 80 90 100
FRFSSSTDIW LMFVGSLCAF LHGIAQPGVL LIFGTMTDVF IDYDVELQEL
110 120 130 140 150
QIPGKACVNN TIVWTNSSLN QNMTNGTRCG LLNIESEMIK FASYYAGIAV
160 170 180 190 200
AVLITGYIQI CFWVIAAARQ IQKMRKFYFR RIMRMEIGWF DCNSVGELNT
210 220 230 240 250
RFSDDINKIN DAIADQMALF IQRMTSTICG FLLGFFRGWK LTLVIISVSP
260 270 280 290 300
LIGIGAATIG LSVSKFTDYE LKAYAKAGVV ADEVISSMRT VAAFGGEKRE
310 320 330 340 350
VERYEKNLVF AQRWGIRKGI VMGFFTGFVW CLIFLCYALA FWYGSTLVLD
360 370 380 390 400
EGEYTPGTLV QIFLSVIVGA LNLGNASPCL EAFATGRAAA TSIFETIDRK
410 420 430 440 450
PIIDCMSEDG YKLDRIKGEI EFHNVTFHYP SRPEVKILND LNMVIKPGEM
460 470 480 490 500
TALVGPSGAG KSTALQLIQR FYDPCEGMVT VDGHDIRSLN IQWLRDQIGI
510 520 530 540 550
VEQEPVLFST TIAENIRYGR EDATMEDIVQ AAKEANAYNF IMDLPQQFDT
560 570 580 590 600
LVGEGGGQMS GGQKQRVAIA RALIRNPKIL LLDMATSALD NESEAMVQEV
610 620 630 640 650
LSKIQHGHTI ISVAHRLSTV RAADTIIGFE HGTAVERGTH EELLERKGVY
660 670 680 690 700
FTLVTLQSQG NQALNEEDIK DATEDDMLAR TFSRGSYQDS LRASIRQRSK
710 720 730 740 750
SQLSYLVHEP PLAVVDHKST YEEDRKDKDI PVQEEVEPAP VRRILKFSAP
760 770 780 790 800
EWPYMLVGSV GAAVNGTVTP LYAFLFSQIL GTFSIPDKEE QRSQINGVCL
810 820 830 840 850
LFVAMGCVSL FTQFLQGYAF AKSGELLTKR LRKFGFRAML GQDIAWFDDL
860 870 880 890 900
RNSPGALTTR LATDASQVQG AAGSQIGMIV NSFTNVTVAM IIAFSFSWKL
910 920 930 940 950
SLVILCFFPF LALSGATQTR MLTGFASRDK QALEMVGQIT NEALSNIRTV
960 970 980 990 1000
AGIGKERRFI EALETELEKP FKTAIQKANI YGFCFAFAQC IMFIANSASY
1010 1020 1030 1040 1050
RYGGYLISNE GLHFSYVFRV ISAVVLSATA LGRAFSYTPS YAKAKISAAR
1060 1070 1080 1090 1100
FFQLLDRQPP ISVYNTAGEK WDNFQGKIDF VDCKFTYPSR PDSQVLNGLS
1110 1120 1130 1140 1150
VSISPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGKVMID GHDSKKVNVQ
1160 1170 1180 1190 1200
FLRSNIGIVS QEPVLFACSI MDNIKYGDNT KEIPMERVIA AAKQAQLHDF
1210 1220 1230 1240 1250
VMSLPEKYET NVGSQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD
1260 1270 1280 1290 1300
TESEKTVQVA LDKAREGRTC IVIAHRLSTI QNADIIAVMA QGVVIEKGTH
1310 1320
EELMAQKGAY YKLVTTGSPI S
Length:1,321
Mass (Da):146,407
Last modified:November 3, 2009 - v2
Checksum:i61EE2173E2351D80
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti339L → V in AAC77455 (PubMed:9806540).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05547256S → L.Corresponds to variant rs11568361dbSNPEnsembl.1
Natural variantiVAR_030386186E → G in BRIC2. 1 PublicationCorresponds to variant rs72551307dbSNPEnsembl.1
Natural variantiVAR_030387206I → V.1 PublicationCorresponds to variant rs11568357dbSNPEnsembl.1
Natural variantiVAR_030388238G → V in PFIC2. 1 PublicationCorresponds to variant rs72551306dbSNPEnsembl.1
Natural variantiVAR_035349284V → A.2 PublicationsCorresponds to variant rs200739891dbSNPEnsembl.1
Natural variantiVAR_013332284V → L in PFIC2. 1 Publication1
Natural variantiVAR_010271297E → G in PFIC2 and BRIC2; reduced transport capacity for taurocholate. 3 PublicationsCorresponds to variant rs11568372dbSNPEnsembl.1
Natural variantiVAR_030389299R → K.1 PublicationCorresponds to variant rs2287617dbSNPEnsembl.1
Natural variantiVAR_030390336C → S in PFIC2. 1 PublicationCorresponds to variant rs72551305dbSNPEnsembl.1
Natural variantiVAR_073967337Y → H in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_043074415R → Q.1 PublicationCorresponds to variant rs371656014dbSNPEnsembl.1
Natural variantiVAR_030391432R → T in BRIC2; reduced transport capacity for taurocholate. 1 PublicationCorresponds to variant rs121908935dbSNPEnsembl.1
Natural variantiVAR_013333444V → A Common polymorphism; more frequent in patients with drug-induced cholestasis than healthy controls; associated with lower hepatic expression; does not affect transport capacity for taurocholate. 7 PublicationsCorresponds to variant rs2287622dbSNPEnsembl.1
Natural variantiVAR_059106444V → D.Corresponds to variant rs2287622dbSNPEnsembl.1
Natural variantiVAR_059107444V → G.Corresponds to variant rs2287622dbSNPEnsembl.1
Natural variantiVAR_013334461K → E in PFIC2. 1 Publication1
Natural variantiVAR_073968472Y → C in PFIC2; compound heterozygous with V-1131. 1 PublicationCorresponds to variant rs369860506dbSNPEnsembl.1
Natural variantiVAR_013335482D → G in PFIC2. 1 PublicationCorresponds to variant rs72549402dbSNPEnsembl.1
Natural variantiVAR_030392570A → T in BRIC2. 1 Publication1
Natural variantiVAR_043075591N → S in a patient with intrahepatic cholestasis of pregnancy. 1 PublicationCorresponds to variant rs11568367dbSNPEnsembl.1
Natural variantiVAR_035350616R → G.1 Publication1
Natural variantiVAR_035351619T → A.1 Publication1
Natural variantiVAR_043076676D → Y in fluvastatin-induced cholestasis; does not affect transport capacity for taurocholate. 1 Publication1
Natural variantiVAR_030393677M → V Does not affect transport capacity for taurocholate. 4 PublicationsCorresponds to variant rs11568364dbSNPEnsembl.1
Natural variantiVAR_073969696R → W in PFIC2; unknown pathological significance. 1 PublicationCorresponds to variant rs376216286dbSNPEnsembl.1
Natural variantiVAR_035352698R → H.2 PublicationsCorresponds to variant rs138642043dbSNPEnsembl.1
Natural variantiVAR_043077855G → R in ethinylestradiol/gestodene-induced cholestasis; loss of transport capacity for taurocholate. 1 Publication1
Natural variantiVAR_035353865A → V Polymorphism. 2 PublicationsCorresponds to variant rs118109635dbSNPEnsembl.1
Natural variantiVAR_030394923T → P in BRIC2. 1 PublicationCorresponds to variant rs777469571dbSNPEnsembl.1
Natural variantiVAR_030395926A → P in BRIC2. 1 PublicationCorresponds to variant rs72549400dbSNPEnsembl.1
Natural variantiVAR_073970931Q → P in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_035354958R → Q.1 PublicationCorresponds to variant rs761363245dbSNPEnsembl.1
Natural variantiVAR_013336982G → R in PFIC2. 1 PublicationCorresponds to variant rs72549399dbSNPEnsembl.1
Natural variantiVAR_0133371004G → D in PFIC2. 1 Publication1
Natural variantiVAR_0303961050R → C in BRIC2. 1 PublicationCorresponds to variant rs72549398dbSNPEnsembl.1
Natural variantiVAR_0303971128R → H in BRIC2. 1 PublicationCorresponds to variant rs756220860dbSNPEnsembl.1
Natural variantiVAR_0739711131D → V in PFIC2; compound heterozygous with C-472. 1 Publication1
Natural variantiVAR_0133381153R → C in PFIC2. 1 PublicationCorresponds to variant rs72549395dbSNPEnsembl.1
Natural variantiVAR_0303981186E → K.Corresponds to variant rs1521808dbSNPEnsembl.1
Natural variantiVAR_0739721198H → R in PFIC2; unknown pathological significance. 1 Publication1
Natural variantiVAR_0133391268R → Q in PFIC2. 1 PublicationCorresponds to variant rs72549394dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091582 mRNA. Translation: AAC77455.1.
AF136523 mRNA. Translation: AAD28285.1.
AC008177 Genomic DNA. Translation: AAY24305.1.
AC093723 Genomic DNA. No translation available.
AC069137 Genomic DNA. No translation available.
CCDSiCCDS46444.1.
RefSeqiNP_003733.2. NM_003742.2.
UniGeneiHs.658439.

Genome annotation databases

EnsembliENST00000263817; ENSP00000263817; ENSG00000073734.
GeneIDi8647.
KEGGihsa:8647.
UCSCiuc002ueo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091582 mRNA. Translation: AAC77455.1.
AF136523 mRNA. Translation: AAD28285.1.
AC008177 Genomic DNA. Translation: AAY24305.1.
AC093723 Genomic DNA. No translation available.
AC069137 Genomic DNA. No translation available.
CCDSiCCDS46444.1.
RefSeqiNP_003733.2. NM_003742.2.
UniGeneiHs.658439.

3D structure databases

ProteinModelPortaliO95342.
SMRiO95342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114199. 5 interactors.
IntActiO95342. 2 interactors.
MINTiMINT-5003953.
STRINGi9606.ENSP00000263817.

Chemistry databases

BindingDBiO95342.
ChEMBLiCHEMBL6020.
DrugBankiDB00171. Adenosine triphosphate.
DB00559. Bosentan.
DB00477. Chlorpromazine.
DB02659. Cholic Acid.
DB00501. Cimetidine.
DB00845. Clofazimine.
DB00091. Cyclosporine.
DB00694. Daunorubicin.
DB03619. Deoxycholic Acid.
DB01234. Dexamethasone.
DB00390. Digoxin.
DB00997. Doxorubicin.
DB00977. Ethinyl Estradiol.
DB00693. Fluorescein.
DB02703. Fusidic Acid.
DB01016. Glyburide.
DB01026. Ketoconazole.
DB01051. Novobiocin.
DB01229. Paclitaxel.
DB01174. Phenobarbital.
DB08901. Ponatinib.
DB00175. Pravastatin.
DB00396. Progesterone.
DB00908. Quinidine.
DB00206. Reserpine.
DB01045. Rifampicin.
DB01098. Rosuvastatin.
DB00675. Tamoxifen.
DB01586. Ursodeoxycholic acid.
DB00661. Verapamil.
DB00570. Vinblastine.
DB00541. Vincristine.
GuidetoPHARMACOLOGYi778.
SwissLipidsiSLP:000001597.

Protein family/group databases

TCDBi3.A.1.201.2. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiO95342.
PhosphoSitePlusiO95342.

Polymorphism and mutation databases

BioMutaiABCB11.

Proteomic databases

EPDiO95342.
MaxQBiO95342.
PaxDbiO95342.
PeptideAtlasiO95342.
PRIDEiO95342.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263817; ENSP00000263817; ENSG00000073734.
GeneIDi8647.
KEGGihsa:8647.
UCSCiuc002ueo.2. human.

Organism-specific databases

CTDi8647.
DisGeNETi8647.
GeneCardsiABCB11.
GeneReviewsiABCB11.
H-InvDBHIX0029772.
HGNCiHGNC:42. ABCB11.
HPAiHPA019035.
MalaCardsiABCB11.
MIMi601847. phenotype.
603201. gene.
605479. phenotype.
neXtProtiNX_O95342.
OpenTargetsiENSG00000073734.
Orphaneti99961. Benign recurrent intrahepatic cholestasis type 2.
69665. Intrahepatic cholestasis of pregnancy.
79304. Progressive familial intrahepatic cholestasis type 2.
PharmGKBiPA374.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiO95342.
KOiK05664.
OMAiCAFLHGI.
OrthoDBiEOG091G0HVA.
PhylomeDBiO95342.
TreeFamiTF105193.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000073734-MONOMER.
ReactomeiR-HSA-159418. Recycling of bile acids and salts.
R-HSA-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.

Miscellaneous databases

ChiTaRSiABCB11. human.
GeneWikiiABCB11.
GenomeRNAii8647.
PROiO95342.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000073734.
CleanExiHS_ABCB11.
ExpressionAtlasiO95342. baseline and differential.
GenevisibleiO95342. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030278. BSEP.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF165. PTHR24221:SF165. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCBB_HUMAN
AccessioniPrimary (citable) accession number: O95342
Secondary accession number(s): Q53TL2, Q9UNB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 3, 2009
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.