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Protein

6-phosphogluconolactonase

Gene

PGLS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase
  2. 6-phosphogluconolactonase (PGLS)
  3. 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating (PGD)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

  • 6-phosphogluconolactonase activity Source: UniProtKB

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • pentose-phosphate shunt Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS05370-MONOMER.
ZFISH:HS05370-MONOMER.
BRENDAi3.1.1.31. 2681.
ReactomeiR-HSA-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:PGLS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8903. PGLS.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi25796.
OpenTargetsiENSG00000130313.
PharmGKBiPA33240.

Polymorphism and mutation databases

BioMutaiPGLS.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000900782 – 2586-phosphogluconolactonaseAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei180N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95336.
MaxQBiO95336.
PaxDbiO95336.
PeptideAtlasiO95336.
PRIDEiO95336.
TopDownProteomicsiO95336.

2D gel databases

OGPiO95336.
REPRODUCTION-2DPAGEIPI00029997.

PTM databases

iPTMnetiO95336.
PhosphoSitePlusiO95336.
SwissPalmiO95336.

Expressioni

Gene expression databases

BgeeiENSG00000130313.
CleanExiHS_PGLS.
ExpressionAtlasiO95336. baseline and differential.
GenevisibleiO95336. HS.

Organism-specific databases

HPAiHPA040744.
HPA042032.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-11307753,EBI-750109

Protein-protein interaction databases

BioGridi117328. 22 interactors.
IntActiO95336. 4 interactors.
MINTiMINT-5000838.
STRINGi9606.ENSP00000252603.

Structurei

3D structure databases

ProteinModelPortaliO95336.
SMRiO95336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147. Eukaryota.
COG0363. LUCA.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
HOVERGENiHBG000030.
InParanoidiO95336.
KOiK01057.
OMAiYWGDERC.
OrthoDBiEOG091G0NKD.
PhylomeDBiO95336.
TreeFamiTF318609.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL
60 70 80 90 100
VSMLARELPA AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL
110 120 130 140 150
SRLPIPESQV ITINPELPVE EAAEDYAKKL RQAFQGDSIP VFDLLILGVG
160 170 180 190 200
PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAARTVI
210 220 230 240 250
FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL DEAAARLLTV

PFEKHSTL
Length:258
Mass (Da):27,547
Last modified:May 30, 2000 - v2
Checksum:iA753FB7E662116DD
GO

Sequence cautioni

The sequence AAC72960 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243972 mRNA. Translation: CAB57866.1.
BC014006 mRNA. Translation: AAH14006.1.
AF091091 mRNA. Translation: AAC72960.1. Different initiation.
CCDSiCCDS12361.1.
RefSeqiNP_036220.1. NM_012088.2.
UniGeneiHs.466165.

Genome annotation databases

EnsembliENST00000252603; ENSP00000252603; ENSG00000130313.
GeneIDi25796.
KEGGihsa:25796.
UCSCiuc002ngw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243972 mRNA. Translation: CAB57866.1.
BC014006 mRNA. Translation: AAH14006.1.
AF091091 mRNA. Translation: AAC72960.1. Different initiation.
CCDSiCCDS12361.1.
RefSeqiNP_036220.1. NM_012088.2.
UniGeneiHs.466165.

3D structure databases

ProteinModelPortaliO95336.
SMRiO95336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117328. 22 interactors.
IntActiO95336. 4 interactors.
MINTiMINT-5000838.
STRINGi9606.ENSP00000252603.

PTM databases

iPTMnetiO95336.
PhosphoSitePlusiO95336.
SwissPalmiO95336.

Polymorphism and mutation databases

BioMutaiPGLS.

2D gel databases

OGPiO95336.
REPRODUCTION-2DPAGEIPI00029997.

Proteomic databases

EPDiO95336.
MaxQBiO95336.
PaxDbiO95336.
PeptideAtlasiO95336.
PRIDEiO95336.
TopDownProteomicsiO95336.

Protocols and materials databases

DNASUi25796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252603; ENSP00000252603; ENSG00000130313.
GeneIDi25796.
KEGGihsa:25796.
UCSCiuc002ngw.4. human.

Organism-specific databases

CTDi25796.
DisGeNETi25796.
GeneCardsiPGLS.
HGNCiHGNC:8903. PGLS.
HPAiHPA040744.
HPA042032.
MIMi604951. gene.
neXtProtiNX_O95336.
OpenTargetsiENSG00000130313.
PharmGKBiPA33240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3147. Eukaryota.
COG0363. LUCA.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
HOVERGENiHBG000030.
InParanoidiO95336.
KOiK01057.
OMAiYWGDERC.
OrthoDBiEOG091G0NKD.
PhylomeDBiO95336.
TreeFamiTF318609.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciMetaCyc:HS05370-MONOMER.
ZFISH:HS05370-MONOMER.
BRENDAi3.1.1.31. 2681.
ReactomeiR-HSA-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

GenomeRNAii25796.
PROiO95336.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130313.
CleanExiHS_PGLS.
ExpressionAtlasiO95336. baseline and differential.
GenevisibleiO95336. HS.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei6PGL_HUMAN
AccessioniPrimary (citable) accession number: O95336
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.