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O95336

- 6PGL_HUMAN

UniProt

O95336 - 6PGL_HUMAN

Protein

6-phosphogluconolactonase

Gene

PGLS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: UniProtKB
    2. monosaccharide binding Source: Ensembl

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. pentose-phosphate shunt Source: UniProtKB
    3. pentose-phosphate shunt, oxidative branch Source: Ensembl
    4. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciMetaCyc:HS05370-MONOMER.
    BRENDAi3.1.1.31. 2681.
    ReactomeiREACT_1859. Pentose phosphate pathway (hexose monophosphate shunt).
    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconolactonase (EC:3.1.1.31)
    Short name:
    6PGL
    Gene namesi
    Name:PGLS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8903. PGLS.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33240.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 2582576-phosphogluconolactonasePRO_0000090078Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei180 – 1801N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO95336.
    PaxDbiO95336.
    PeptideAtlasiO95336.
    PRIDEiO95336.

    2D gel databases

    OGPiO95336.
    REPRODUCTION-2DPAGEIPI00029997.

    PTM databases

    PhosphoSiteiO95336.

    Expressioni

    Gene expression databases

    ArrayExpressiO95336.
    BgeeiO95336.
    CleanExiHS_PGLS.
    GenevestigatoriO95336.

    Organism-specific databases

    HPAiHPA040744.
    HPA042032.

    Interactioni

    Protein-protein interaction databases

    BioGridi117328. 8 interactions.
    MINTiMINT-5000838.
    STRINGi9606.ENSP00000252603.

    Structurei

    3D structure databases

    ProteinModelPortaliO95336.
    SMRiO95336. Positions 38-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0363.
    HOGENOMiHOG000256285.
    HOVERGENiHBG000030.
    InParanoidiO95336.
    KOiK01057.
    OMAiTYGLYKS.
    OrthoDBiEOG7RZ5QV.
    PhylomeDBiO95336.
    TreeFamiTF318609.

    Family and domain databases

    InterProiIPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view]
    PfamiPF01182. Glucosamine_iso. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01198. pgl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95336-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL    50
    VSMLARELPA AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL 100
    SRLPIPESQV ITINPELPVE EAAEDYAKKL RQAFQGDSIP VFDLLILGVG 150
    PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAARTVI 200
    FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL DEAAARLLTV 250
    PFEKHSTL 258
    Length:258
    Mass (Da):27,547
    Last modified:May 30, 2000 - v2
    Checksum:iA753FB7E662116DD
    GO

    Sequence cautioni

    The sequence AAC72960.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243972 mRNA. Translation: CAB57866.1.
    BC014006 mRNA. Translation: AAH14006.1.
    AF091091 mRNA. Translation: AAC72960.1. Different initiation.
    CCDSiCCDS12361.1.
    RefSeqiNP_036220.1. NM_012088.2.
    UniGeneiHs.466165.

    Genome annotation databases

    EnsembliENST00000252603; ENSP00000252603; ENSG00000130313.
    GeneIDi25796.
    KEGGihsa:25796.
    UCSCiuc002ngw.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243972 mRNA. Translation: CAB57866.1 .
    BC014006 mRNA. Translation: AAH14006.1 .
    AF091091 mRNA. Translation: AAC72960.1 . Different initiation.
    CCDSi CCDS12361.1.
    RefSeqi NP_036220.1. NM_012088.2.
    UniGenei Hs.466165.

    3D structure databases

    ProteinModelPortali O95336.
    SMRi O95336. Positions 38-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117328. 8 interactions.
    MINTi MINT-5000838.
    STRINGi 9606.ENSP00000252603.

    PTM databases

    PhosphoSitei O95336.

    2D gel databases

    OGPi O95336.
    REPRODUCTION-2DPAGE IPI00029997.

    Proteomic databases

    MaxQBi O95336.
    PaxDbi O95336.
    PeptideAtlasi O95336.
    PRIDEi O95336.

    Protocols and materials databases

    DNASUi 25796.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252603 ; ENSP00000252603 ; ENSG00000130313 .
    GeneIDi 25796.
    KEGGi hsa:25796.
    UCSCi uc002ngw.3. human.

    Organism-specific databases

    CTDi 25796.
    GeneCardsi GC19P017622.
    HGNCi HGNC:8903. PGLS.
    HPAi HPA040744.
    HPA042032.
    MIMi 604951. gene.
    neXtProti NX_O95336.
    PharmGKBi PA33240.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0363.
    HOGENOMi HOG000256285.
    HOVERGENi HBG000030.
    InParanoidi O95336.
    KOi K01057.
    OMAi TYGLYKS.
    OrthoDBi EOG7RZ5QV.
    PhylomeDBi O95336.
    TreeFami TF318609.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .
    BioCyci MetaCyc:HS05370-MONOMER.
    BRENDAi 3.1.1.31. 2681.
    Reactomei REACT_1859. Pentose phosphate pathway (hexose monophosphate shunt).

    Miscellaneous databases

    GenomeRNAii 25796.
    NextBioi 46981.
    PROi O95336.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95336.
    Bgeei O95336.
    CleanExi HS_PGLS.
    Genevestigatori O95336.

    Family and domain databases

    InterProi IPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view ]
    Pfami PF01182. Glucosamine_iso. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01198. pgl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway."
      Collard F., Collet J.-F., Gerin I., Veiga-da-Cunha M., van Schaftingen E.
      FEBS Lett. 459:223-226(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    3. Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 41-72 AND 82-96, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
    4. "Full-insert sequence of mapped XREF EST."
      Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-242.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry namei6PGL_HUMAN
    AccessioniPrimary (citable) accession number: O95336
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3