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O95336

- 6PGL_HUMAN

UniProt

O95336 - 6PGL_HUMAN

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Protein

6-phosphogluconolactonase

Gene
PGLS
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB
  2. monosaccharide binding Source: Ensembl

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. pentose-phosphate shunt Source: UniProtKB
  3. pentose-phosphate shunt, oxidative branch Source: Ensembl
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS05370-MONOMER.
BRENDAi3.1.1.31. 2681.
ReactomeiREACT_1859. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:PGLS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8903. PGLS.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 2582576-phosphogluconolactonasePRO_0000090078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei180 – 1801N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO95336.
PaxDbiO95336.
PeptideAtlasiO95336.
PRIDEiO95336.

2D gel databases

OGPiO95336.
REPRODUCTION-2DPAGEIPI00029997.

PTM databases

PhosphoSiteiO95336.

Expressioni

Gene expression databases

ArrayExpressiO95336.
BgeeiO95336.
CleanExiHS_PGLS.
GenevestigatoriO95336.

Organism-specific databases

HPAiHPA040744.
HPA042032.

Interactioni

Protein-protein interaction databases

BioGridi117328. 8 interactions.
MINTiMINT-5000838.
STRINGi9606.ENSP00000252603.

Structurei

3D structure databases

ProteinModelPortaliO95336.
SMRiO95336. Positions 38-247.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000256285.
HOVERGENiHBG000030.
InParanoidiO95336.
KOiK01057.
OMAiTYGLYKS.
OrthoDBiEOG7RZ5QV.
PhylomeDBiO95336.
TreeFamiTF318609.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95336-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL    50
VSMLARELPA AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL 100
SRLPIPESQV ITINPELPVE EAAEDYAKKL RQAFQGDSIP VFDLLILGVG 150
PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAARTVI 200
FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL DEAAARLLTV 250
PFEKHSTL 258
Length:258
Mass (Da):27,547
Last modified:May 30, 2000 - v2
Checksum:iA753FB7E662116DD
GO

Sequence cautioni

The sequence AAC72960.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243972 mRNA. Translation: CAB57866.1.
BC014006 mRNA. Translation: AAH14006.1.
AF091091 mRNA. Translation: AAC72960.1. Different initiation.
CCDSiCCDS12361.1.
RefSeqiNP_036220.1. NM_012088.2.
UniGeneiHs.466165.

Genome annotation databases

EnsembliENST00000252603; ENSP00000252603; ENSG00000130313.
GeneIDi25796.
KEGGihsa:25796.
UCSCiuc002ngw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ243972 mRNA. Translation: CAB57866.1 .
BC014006 mRNA. Translation: AAH14006.1 .
AF091091 mRNA. Translation: AAC72960.1 . Different initiation.
CCDSi CCDS12361.1.
RefSeqi NP_036220.1. NM_012088.2.
UniGenei Hs.466165.

3D structure databases

ProteinModelPortali O95336.
SMRi O95336. Positions 38-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117328. 8 interactions.
MINTi MINT-5000838.
STRINGi 9606.ENSP00000252603.

PTM databases

PhosphoSitei O95336.

2D gel databases

OGPi O95336.
REPRODUCTION-2DPAGE IPI00029997.

Proteomic databases

MaxQBi O95336.
PaxDbi O95336.
PeptideAtlasi O95336.
PRIDEi O95336.

Protocols and materials databases

DNASUi 25796.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252603 ; ENSP00000252603 ; ENSG00000130313 .
GeneIDi 25796.
KEGGi hsa:25796.
UCSCi uc002ngw.3. human.

Organism-specific databases

CTDi 25796.
GeneCardsi GC19P017622.
HGNCi HGNC:8903. PGLS.
HPAi HPA040744.
HPA042032.
MIMi 604951. gene.
neXtProti NX_O95336.
PharmGKBi PA33240.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0363.
HOGENOMi HOG000256285.
HOVERGENi HBG000030.
InParanoidi O95336.
KOi K01057.
OMAi TYGLYKS.
OrthoDBi EOG7RZ5QV.
PhylomeDBi O95336.
TreeFami TF318609.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00409 .
BioCyci MetaCyc:HS05370-MONOMER.
BRENDAi 3.1.1.31. 2681.
Reactomei REACT_1859. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

GenomeRNAii 25796.
NextBioi 46981.
PROi O95336.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95336.
Bgeei O95336.
CleanExi HS_PGLS.
Genevestigatori O95336.

Family and domain databases

InterProi IPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view ]
Pfami PF01182. Glucosamine_iso. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01198. pgl. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway."
    Collard F., Collet J.-F., Gerin I., Veiga-da-Cunha M., van Schaftingen E.
    FEBS Lett. 459:223-226(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 41-72 AND 82-96, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
  4. "Full-insert sequence of mapped XREF EST."
    Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-242.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei6PGL_HUMAN
AccessioniPrimary (citable) accession number: O95336
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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