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Protein

6-phosphogluconolactonase

Gene

PGLS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

GO - Molecular functioni

  • 6-phosphogluconolactonase activity Source: UniProtKB
  • monosaccharide binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS05370-MONOMER.
BRENDAi3.1.1.31. 2681.
ReactomeiREACT_1859. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:PGLS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8903. PGLS.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33240.

Polymorphism and mutation databases

BioMutaiPGLS.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 2582576-phosphogluconolactonasePRO_0000090078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei49 – 491Phosphoserine1 Publication
Modified residuei180 – 1801N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95336.
PaxDbiO95336.
PeptideAtlasiO95336.
PRIDEiO95336.

2D gel databases

OGPiO95336.
REPRODUCTION-2DPAGEIPI00029997.

PTM databases

PhosphoSiteiO95336.

Expressioni

Gene expression databases

BgeeiO95336.
CleanExiHS_PGLS.
ExpressionAtlasiO95336. baseline and differential.
GenevisibleiO95336. HS.

Organism-specific databases

HPAiHPA040744.
HPA042032.

Interactioni

Protein-protein interaction databases

BioGridi117328. 16 interactions.
MINTiMINT-5000838.
STRINGi9606.ENSP00000252603.

Structurei

3D structure databases

ProteinModelPortaliO95336.
SMRiO95336. Positions 38-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
HOVERGENiHBG000030.
InParanoidiO95336.
KOiK01057.
OMAiSNYRMAR.
OrthoDBiEOG7RZ5QV.
PhylomeDBiO95336.
TreeFamiTF318609.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL
60 70 80 90 100
VSMLARELPA AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL
110 120 130 140 150
SRLPIPESQV ITINPELPVE EAAEDYAKKL RQAFQGDSIP VFDLLILGVG
160 170 180 190 200
PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAARTVI
210 220 230 240 250
FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL DEAAARLLTV

PFEKHSTL
Length:258
Mass (Da):27,547
Last modified:May 30, 2000 - v2
Checksum:iA753FB7E662116DD
GO

Sequence cautioni

The sequence AAC72960.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243972 mRNA. Translation: CAB57866.1.
BC014006 mRNA. Translation: AAH14006.1.
AF091091 mRNA. Translation: AAC72960.1. Different initiation.
CCDSiCCDS12361.1.
RefSeqiNP_036220.1. NM_012088.2.
UniGeneiHs.466165.

Genome annotation databases

EnsembliENST00000252603; ENSP00000252603; ENSG00000130313.
GeneIDi25796.
KEGGihsa:25796.
UCSCiuc002ngw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243972 mRNA. Translation: CAB57866.1.
BC014006 mRNA. Translation: AAH14006.1.
AF091091 mRNA. Translation: AAC72960.1. Different initiation.
CCDSiCCDS12361.1.
RefSeqiNP_036220.1. NM_012088.2.
UniGeneiHs.466165.

3D structure databases

ProteinModelPortaliO95336.
SMRiO95336. Positions 38-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117328. 16 interactions.
MINTiMINT-5000838.
STRINGi9606.ENSP00000252603.

PTM databases

PhosphoSiteiO95336.

Polymorphism and mutation databases

BioMutaiPGLS.

2D gel databases

OGPiO95336.
REPRODUCTION-2DPAGEIPI00029997.

Proteomic databases

MaxQBiO95336.
PaxDbiO95336.
PeptideAtlasiO95336.
PRIDEiO95336.

Protocols and materials databases

DNASUi25796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252603; ENSP00000252603; ENSG00000130313.
GeneIDi25796.
KEGGihsa:25796.
UCSCiuc002ngw.3. human.

Organism-specific databases

CTDi25796.
GeneCardsiGC19P017622.
HGNCiHGNC:8903. PGLS.
HPAiHPA040744.
HPA042032.
MIMi604951. gene.
neXtProtiNX_O95336.
PharmGKBiPA33240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
HOVERGENiHBG000030.
InParanoidiO95336.
KOiK01057.
OMAiSNYRMAR.
OrthoDBiEOG7RZ5QV.
PhylomeDBiO95336.
TreeFamiTF318609.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciMetaCyc:HS05370-MONOMER.
BRENDAi3.1.1.31. 2681.
ReactomeiREACT_1859. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

GenomeRNAii25796.
NextBioi46981.
PROiO95336.
SOURCEiSearch...

Gene expression databases

BgeeiO95336.
CleanExiHS_PGLS.
ExpressionAtlasiO95336. baseline and differential.
GenevisibleiO95336. HS.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway."
    Collard F., Collet J.-F., Gerin I., Veiga-da-Cunha M., van Schaftingen E.
    FEBS Lett. 459:223-226(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 41-72 AND 82-96, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
  4. "Full-insert sequence of mapped XREF EST."
    Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-242.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry namei6PGL_HUMAN
AccessioniPrimary (citable) accession number: O95336
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 22, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.