O95336 (6PGL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6PGL
EC=3.1.1.31

Gene names

Name:

PGLS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Sequence caution	The sequence AAC72960.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	pentose-phosphate shunt Inferred from direct assay Ref.1. Source: UniProtKB pentose-phosphate shunt, oxidative branch Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	6-phosphogluconolactonase activity Inferred from direct assay Ref.1. Source: UniProtKB monosaccharide binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	6-phosphogluconolactonase		PRO_0000090078
Amino acid modifications
	Modified residue	180	1	N6-acetyllysine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	O95336 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: A753FB7E662116DD	FASTA	258	27,547
	10 20 30 40 50 60 MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL VSMLARELPA 70 80 90 100 110 120 AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL SRLPIPESQV ITINPELPVE 130 140 150 160 170 180 EAAEDYAKKL RQAFQGDSIP VFDLLILGVG PDGHTCSLFP DHPLLQEREK IVAPISDSPK 190 200 210 220 230 240 PPPQRVTLTL PVLNAARTVI FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL 250 DEAAARLLTV PFEKHSTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway." Collard F., Collet J.-F., Gerin I., Veiga-da-Cunha M., van Schaftingen E. FEBS Lett. 459:223-226(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[3]	Lubec G., Vishwanath V., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 41-72 AND 82-96, MASS SPECTROMETRY. Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
[4]	"Full-insert sequence of mapped XREF EST." Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-242.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-180, MASS SPECTROMETRY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ243972 mRNA. Translation: CAB57866.1. BC014006 mRNA. Translation: AAH14006.1. AF091091 mRNA. Translation: AAC72960.1. Different initiation.
IPI	IPI00029997.
RefSeq	NP_036220.1. NM_012088.2.
UniGene	Hs.466165.
3D structure databases
ProteinModelPortal	O95336.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-5000838.
STRING	9606.ENSP00000252603.
PTM databases
PhosphoSite	O95336.
2D gel databases
OGP	O95336.
REPRODUCTION-2DPAGE	IPI00029997.
Proteomic databases
PaxDb	O95336.
PeptideAtlas	O95336.
PRIDE	O95336.
Protocols and materials databases
DNASU	25796.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252603; ENSP00000252603; ENSG00000130313.
GeneID	25796.
KEGG	hsa:25796.
UCSC	uc002ngw.3. human.
Organism-specific databases
CTD	25796.
GeneCards	GC19P017622.
HGNC	HGNC:8903. PGLS.
HPA	HPA040744. HPA042032.
MIM	604951. gene.
neXtProt	NX_O95336.
PharmGKB	PA33240.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0363.
HOGENOM	HOG000256285.
HOVERGEN	HBG000030.
InParanoid	O95336.
KO	K01057.
OMA	IQWQNLH.
OrthoDB	EOG4ZS945.
PhylomeDB	O95336.
Enzyme and pathway databases
BRENDA	3.1.1.31. 2681.
Reactome	REACT_111217. Metabolism.
UniPathway	UPA00115; UER00409.
Gene expression databases
Bgee	O95336.
CleanEx	HS_PGLS.
Genevestigator	O95336.
GermOnline	ENSG00000130313. Homo sapiens.
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase_DevB. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMs	TIGR01198. pgl. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	25796.
NextBio	46981.
SOURCE	Search...

Entry information

Entry name

6PGL_HUMAN

Accession

Primary (citable) accession number: O95336

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	May 1, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.