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Protein

CUGBP Elav-like family member 2

Gene

CELF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity).By similarity7 Publications

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • regulation of heart contraction Source: ProtInc
  • RNA processing Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CUGBP Elav-like family member 2
Short name:
CELF-2
Alternative name(s):
Bruno-like protein 3
CUG triplet repeat RNA-binding protein 2
Short name:
CUG-BP2
CUG-BP- and ETR-3-like factor 2
ELAV-type RNA-binding protein 3
Short name:
ETR-3
Neuroblastoma apoptosis-related RNA-binding protein
Short name:
hNAPOR
RNA-binding protein BRUNOL-3
Gene namesi
Name:CELF2
Synonyms:BRUNOL3, CUGBP2, ETR3, NAPOR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:2550. CELF2.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10659.
OpenTargetsiENSG00000048740.
PharmGKBiPA27046.

Polymorphism and mutation databases

BioMutaiCELF2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951891 – 508CUGBP Elav-like family member 2Add BLAST508

Proteomic databases

MaxQBiO95319.
PaxDbiO95319.
PeptideAtlasiO95319.
PRIDEiO95319.

2D gel databases

UCD-2DPAGEO95319.

PTM databases

iPTMnetiO95319.
PhosphoSitePlusiO95319.

Expressioni

Tissue specificityi

Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas.5 Publications

Developmental stagei

Isoform 1 is expressed in fetal brain. Isoform 2 is expressed in fetal heart, brain, thymus, lung, liver, skeletal muscle, kidney and spleen. Isoform 4 is expressed in fetal heart, brain, thymus, lung and skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000048740.
CleanExiHS_CUGBP2.
ExpressionAtlasiO95319. baseline and differential.
GenevisibleiO95319. HS.

Organism-specific databases

HPAiCAB016395.
HPA035813.
HPA065098.

Interactioni

Subunit structurei

Interacts with A1CF.By similarity

Protein-protein interaction databases

BioGridi115902. 10 interactors.
IntActiO95319. 7 interactors.
MINTiMINT-2868664.
STRINGi9606.ENSP00000389951.

Structurei

Secondary structure

1508
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 45Combined sources4
Helixi53 – 60Combined sources8
Helixi61 – 63Combined sources3
Beta strandi66 – 74Combined sources9
Beta strandi76 – 79Combined sources4
Beta strandi81 – 92Combined sources12
Helixi93 – 103Combined sources11
Turni104 – 106Combined sources3
Beta strandi117 – 120Combined sources4
Helixi122 – 124Combined sources3
Helixi129 – 131Combined sources3
Beta strandi133 – 138Combined sources6
Helixi145 – 152Combined sources8
Helixi153 – 155Combined sources3
Beta strandi158 – 165Combined sources8
Beta strandi167 – 169Combined sources3
Beta strandi171 – 182Combined sources12
Helixi183 – 192Combined sources10
Beta strandi206 – 209Combined sources4
Beta strandi424 – 429Combined sources6
Helixi436 – 443Combined sources8
Helixi444 – 446Combined sources3
Beta strandi449 – 456Combined sources8
Turni458 – 460Combined sources3
Beta strandi463 – 473Combined sources11
Helixi474 – 484Combined sources11
Beta strandi495 – 498Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MY7NMR-A416-508[»]
2MY8NMR-A416-508[»]
4LJMX-ray3.00A/B416-508[»]
4LMZX-ray2.78A36-211[»]
4TLQX-ray2.50A/B416-508[»]
ProteinModelPortaliO95319.
SMRiO95319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 123RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini132 – 212RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini423 – 501RRM 3PROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 283Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusionAdd BLAST283
Regioni357 – 508Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusionAdd BLAST152

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi284 – 397Ala-richAdd BLAST114

Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0146. Eukaryota.
ENOG410XNTW. LUCA.
GeneTreeiENSGT00560000076837.
HOVERGENiHBG107646.
InParanoidiO95319.
KOiK13207.
PhylomeDBiO95319.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95319-1) [UniParc]FASTAAdd to basket
Also known as: NAPOR-3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRCPKSAVTM RNEELLLSNG TANKMNGALD HSDQPDPDAI KMFVGQIPRS
60 70 80 90 100
WSEKELKELF EPYGAVYQIN VLRDRSQNPP QSKGCCFVTF YTRKAALEAQ
110 120 130 140 150
NALHNIKTLP GMHHPIQMKP ADSEKSNAVE DRKLFIGMVS KKCNENDIRV
160 170 180 190 200
MFSPFGQIEE CRILRGPDGL SRGCAFVTFS TRAMAQNAIK AMHQSQTMEG
210 220 230 240 250
CSSPIVVKFA DTQKDKEQRR LQQQLAQQMQ QLNTATWGNL TGLGGLTPQY
260 270 280 290 300
LALLQQATSS SNLGAFSGIQ QMAGMNALQL QNLATLAAAA AAAQTSATST
310 320 330 340 350
NANPLSTTSS ALGALTSPVA ASTPNSTAGA AMNSLTSLGT LQGLAGATVG
360 370 380 390 400
LNNINALAGM AALNGGLGAT GLTNGTAGTM DALTQAYSGI QQYAAAALPT
410 420 430 440 450
LYSQSLLQQQ SAAGSQKEGP EGANLFIYHL PQEFGDQDIL QMFMPFGNVI
460 470 480 490 500
SAKVFIDKQT NLSKCFGFVS YDNPVSAQAA IQAMNGFQIG MKRLKVQLKR

SKNDSKPY
Length:508
Mass (Da):54,285
Last modified:May 1, 1999 - v1
Checksum:iC65F337D462717F2
GO
Isoform 2 (identifier: O95319-2) [UniParc]FASTAAdd to basket
Also known as: NAPOR-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     358-358: A → AVAQMLS

Show »
Length:490
Mass (Da):52,268
Checksum:i3A17B1F5F31AC5BD
GO
Isoform 3 (identifier: O95319-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRCPKSAVTMRNEELLLS → MMVEGRLLVPDRI
     358-358: A → AGTINTPRSKRLLLPKDNN

Show »
Length:521
Mass (Da):55,754
Checksum:iDD6E4F77FE6B4073
GO
Isoform 4 (identifier: O95319-4) [UniParc]FASTAAdd to basket
Also known as: NAPOR-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRCPKSAVTMRNEELLLS → MMVEGRLLVPDRI
     358-358: A → AVAQMLS

Show »
Length:509
Mass (Da):54,365
Checksum:i4A0DB5E2372193ED
GO
Isoform 5 (identifier: O95319-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     359-359: G → GTINS

Show »
Length:488
Mass (Da):52,054
Checksum:iCBB835681201C245
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052202438D → H.2 PublicationsCorresponds to variant rs1050942dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0267961 – 24Missing in isoform 2 and isoform 5. 4 PublicationsAdd BLAST24
Alternative sequenceiVSP_0267971 – 18MRCPK…ELLLS → MMVEGRLLVPDRI in isoform 3 and isoform 4. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_026798358A → AVAQMLS in isoform 2 and isoform 4. 3 Publications1
Alternative sequenceiVSP_026799358A → AGTINTPRSKRLLLPKDNN in isoform 3. 1 Publication1
Alternative sequenceiVSP_026800359G → GTINS in isoform 5. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090694 mRNA. Translation: AAD13761.1.
AF090693 mRNA. Translation: AAD13760.1.
AF036956 mRNA. Translation: AAD02074.1.
U69546 mRNA. Translation: AAB09040.1.
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067 Genomic DNA. Translation: AAK72223.1.
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067, AF314199 Genomic DNA. Translation: AAK72224.1.
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067 Genomic DNA. Translation: AAK92699.1.
AF432906 mRNA. Translation: AAL27627.1.
AK316354 mRNA. Translation: BAH14725.1.
AL157704, AC026887, AL136320 Genomic DNA. Translation: CAH70230.1.
AL136320, AC026887, AL157704 Genomic DNA. Translation: CAI20169.1.
CH471072 Genomic DNA. Translation: EAW86346.1.
BC036391 mRNA. Translation: AAH36391.1.
CCDSiCCDS41488.1. [O95319-2]
CCDS44354.1. [O95319-1]
CCDS44356.1. [O95319-5]
RefSeqiNP_001020247.1. NM_001025076.2. [O95319-2]
NP_001020248.1. NM_001025077.2. [O95319-1]
NP_001077060.1. NM_001083591.1. [O95319-5]
NP_001313246.1. NM_001326317.1.
NP_001313247.1. NM_001326318.1. [O95319-2]
NP_001313248.1. NM_001326319.1.
NP_001313249.1. NM_001326320.1. [O95319-2]
NP_001313250.1. NM_001326321.1.
NP_001313253.1. NM_001326324.1. [O95319-2]
NP_001313257.1. NM_001326328.1. [O95319-2]
NP_001313258.1. NM_001326329.1.
NP_001313259.1. NM_001326330.1. [O95319-2]
NP_001313261.1. NM_001326332.1. [O95319-1]
NP_001313262.1. NM_001326333.1.
NP_001313263.1. NM_001326334.1. [O95319-2]
NP_001313265.1. NM_001326336.1.
NP_001313268.1. NM_001326339.1.
NP_001313269.1. NM_001326340.1.
NP_001313271.1. NM_001326342.1.
NP_001313272.1. NM_001326343.1.
NP_001313273.1. NM_001326344.1.
NP_001313274.1. NM_001326345.1. [O95319-2]
NP_001313277.1. NM_001326348.1.
NP_001313278.1. NM_001326349.1. [O95319-2]
NP_006552.3. NM_006561.3.
XP_011517596.1. XM_011519294.2. [O95319-1]
XP_011517599.1. XM_011519297.1.
XP_016871042.1. XM_017015553.1. [O95319-2]
XP_016871043.1. XM_017015554.1.
UniGeneiHs.309288.

Genome annotation databases

EnsembliENST00000399850; ENSP00000382743; ENSG00000048740. [O95319-2]
ENST00000416382; ENSP00000406451; ENSG00000048740. [O95319-1]
ENST00000417956; ENSP00000404834; ENSG00000048740. [O95319-2]
ENST00000608830; ENSP00000476999; ENSG00000048740. [O95319-5]
ENST00000631460; ENSP00000488582; ENSG00000048740. [O95319-1]
ENST00000632728; ENSP00000487802; ENSG00000048740. [O95319-2]
ENST00000638035; ENSP00000490401; ENSG00000048740. [O95319-2]
GeneIDi10659.
KEGGihsa:10659.
UCSCiuc031vxc.2. human. [O95319-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090694 mRNA. Translation: AAD13761.1.
AF090693 mRNA. Translation: AAD13760.1.
AF036956 mRNA. Translation: AAD02074.1.
U69546 mRNA. Translation: AAB09040.1.
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067 Genomic DNA. Translation: AAK72223.1.
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067, AF314199 Genomic DNA. Translation: AAK72224.1.
AF295068
, AF295063, AF295064, AF295065, AF295066, AF295067 Genomic DNA. Translation: AAK92699.1.
AF432906 mRNA. Translation: AAL27627.1.
AK316354 mRNA. Translation: BAH14725.1.
AL157704, AC026887, AL136320 Genomic DNA. Translation: CAH70230.1.
AL136320, AC026887, AL157704 Genomic DNA. Translation: CAI20169.1.
CH471072 Genomic DNA. Translation: EAW86346.1.
BC036391 mRNA. Translation: AAH36391.1.
CCDSiCCDS41488.1. [O95319-2]
CCDS44354.1. [O95319-1]
CCDS44356.1. [O95319-5]
RefSeqiNP_001020247.1. NM_001025076.2. [O95319-2]
NP_001020248.1. NM_001025077.2. [O95319-1]
NP_001077060.1. NM_001083591.1. [O95319-5]
NP_001313246.1. NM_001326317.1.
NP_001313247.1. NM_001326318.1. [O95319-2]
NP_001313248.1. NM_001326319.1.
NP_001313249.1. NM_001326320.1. [O95319-2]
NP_001313250.1. NM_001326321.1.
NP_001313253.1. NM_001326324.1. [O95319-2]
NP_001313257.1. NM_001326328.1. [O95319-2]
NP_001313258.1. NM_001326329.1.
NP_001313259.1. NM_001326330.1. [O95319-2]
NP_001313261.1. NM_001326332.1. [O95319-1]
NP_001313262.1. NM_001326333.1.
NP_001313263.1. NM_001326334.1. [O95319-2]
NP_001313265.1. NM_001326336.1.
NP_001313268.1. NM_001326339.1.
NP_001313269.1. NM_001326340.1.
NP_001313271.1. NM_001326342.1.
NP_001313272.1. NM_001326343.1.
NP_001313273.1. NM_001326344.1.
NP_001313274.1. NM_001326345.1. [O95319-2]
NP_001313277.1. NM_001326348.1.
NP_001313278.1. NM_001326349.1. [O95319-2]
NP_006552.3. NM_006561.3.
XP_011517596.1. XM_011519294.2. [O95319-1]
XP_011517599.1. XM_011519297.1.
XP_016871042.1. XM_017015553.1. [O95319-2]
XP_016871043.1. XM_017015554.1.
UniGeneiHs.309288.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MY7NMR-A416-508[»]
2MY8NMR-A416-508[»]
4LJMX-ray3.00A/B416-508[»]
4LMZX-ray2.78A36-211[»]
4TLQX-ray2.50A/B416-508[»]
ProteinModelPortaliO95319.
SMRiO95319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115902. 10 interactors.
IntActiO95319. 7 interactors.
MINTiMINT-2868664.
STRINGi9606.ENSP00000389951.

PTM databases

iPTMnetiO95319.
PhosphoSitePlusiO95319.

Polymorphism and mutation databases

BioMutaiCELF2.

2D gel databases

UCD-2DPAGEO95319.

Proteomic databases

MaxQBiO95319.
PaxDbiO95319.
PeptideAtlasiO95319.
PRIDEiO95319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399850; ENSP00000382743; ENSG00000048740. [O95319-2]
ENST00000416382; ENSP00000406451; ENSG00000048740. [O95319-1]
ENST00000417956; ENSP00000404834; ENSG00000048740. [O95319-2]
ENST00000608830; ENSP00000476999; ENSG00000048740. [O95319-5]
ENST00000631460; ENSP00000488582; ENSG00000048740. [O95319-1]
ENST00000632728; ENSP00000487802; ENSG00000048740. [O95319-2]
ENST00000638035; ENSP00000490401; ENSG00000048740. [O95319-2]
GeneIDi10659.
KEGGihsa:10659.
UCSCiuc031vxc.2. human. [O95319-1]

Organism-specific databases

CTDi10659.
DisGeNETi10659.
GeneCardsiCELF2.
HGNCiHGNC:2550. CELF2.
HPAiCAB016395.
HPA035813.
HPA065098.
MIMi602538. gene.
neXtProtiNX_O95319.
OpenTargetsiENSG00000048740.
PharmGKBiPA27046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0146. Eukaryota.
ENOG410XNTW. LUCA.
GeneTreeiENSGT00560000076837.
HOVERGENiHBG107646.
InParanoidiO95319.
KOiK13207.
PhylomeDBiO95319.

Miscellaneous databases

ChiTaRSiCELF2. human.
GeneWikiiCUGBP2.
GenomeRNAii10659.
PROiO95319.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000048740.
CleanExiHS_CUGBP2.
ExpressionAtlasiO95319. baseline and differential.
GenevisibleiO95319. HS.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCELF2_HUMAN
AccessioniPrimary (citable) accession number: O95319
Secondary accession number(s): B7ZAN9
, Q7KYU4, Q8N499, Q92950, Q96NW9, Q96RQ5, Q96RQ6, Q9UL67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.