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O95302 (FKBP9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP9

Short name=PPIase FKBP9
EC=5.2.1.8
Alternative name(s):
63 kDa FK506-binding protein
Short name=63 kDa FKBP
Short name=FKBP-63
FK506-binding protein 9
Short name=FKBP-9
Rotamase
Gene names
Name:FKBP9
Synonyms:FKBP60, FKBP63
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by FK506 By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Post-translational modification

Phosphorylated By similarity.

Sequence similarities

Contains 2 EF-hand domains.

Contains 4 PPIase FKBP-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 570546Peptidyl-prolyl cis-trans isomerase FKBP9
PRO_0000045760

Regions

Domain54 – 14289PPIase FKBP-type 1
Domain166 – 25489PPIase FKBP-type 2
Domain278 – 36588PPIase FKBP-type 3
Domain389 – 47789PPIase FKBP-type 4
Domain488 – 52336EF-hand 1
Domain533 – 56836EF-hand 2
Calcium binding501 – 513131 Potential
Calcium binding546 – 557122 Potential
Motif567 – 5704Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1741N-linked (GlcNAc...) Ref.4
Glycosylation2861N-linked (GlcNAc...) Ref.4
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3971N-linked (GlcNAc...) Ref.4

Sequences

Sequence LengthMass (Da)Tools
O95302 [UniParc].

Last modified January 10, 2006. Version 2.
Checksum: E1F44A2FA6E112F8

FASTA57063,084
        10         20         30         40         50         60 
MAFRGWRPPP PPLLLLLLWV TGQAAPVAGL GSDAELQIER RFVPDECPRT VRSGDFVRYH 

        70         80         90        100        110        120 
YVGTFPDGQK FDSSYDRDST FNVFVGKGQL ITGMDQALVG MCVNERRFVK IPPKLAYGNE 

       130        140        150        160        170        180 
GVSGVIPPNS VLHFDVLLMD IWNSEDQVQI HTYFKPPSCP RTIQVSDFVR YHYNGTFLDG 

       190        200        210        220        230        240 
TLFDSSHNRM KTYDTYVGIG WLIPGMDKGL LGMCVGEKRI ITIPPFLAYG EDGDGKDIPG 

       250        260        270        280        290        300 
QASLVFDVAL LDLHNPKDSI SIENKVVPEN CERISQSGDF LRYHYNGTLL DGTLFDSSYS 

       310        320        330        340        350        360 
RNRTFDTYIG QGYVIPGMDE GLLGVCIGEK RRIVVPPHLG YGEEGRGNIP GSAVLVFDIH 

       370        380        390        400        410        420 
VIDFHNPSDS ISITSHYKPP DCSVLSKKGD YLKYHYNASL LDGTLLDSTW NLGKTYNIVL 

       430        440        450        460        470        480 
GSGQVVLGMD MGLREMCVGE KRTVIIPPHL GYGEAGVDGE VPGSAVLVFD IELLELVAGL 

       490        500        510        520        530        540 
PEGYMFIWNG EVSPNLFEEI DKDGNGEVLL EEFSEYIHAQ VASGKGKLAP GFDAELIVKN 

       550        560        570 
MFTNQDRNGD GKVTAEEFKL KDQEAKHDEL 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trachea.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney, Liver, Lung and PNS.
[3]"Biochemical analysis of mouse FKBP60, a novel member of the FKBP family."
Shadidy M., Caubit X., Olsen R., Seternes O.M., Moens U., Krauss S.
Biochim. Biophys. Acta 1446:295-307(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-570.
[4]"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H., Li X.-J., Martin D.B., Aebersold R.
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-174; ASN-286 AND ASN-397.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK128597 mRNA. Translation: BAG54697.1.
BC007443 mRNA. Translation: AAH07443.2.
BC064418 mRNA. Translation: AAH64418.1.
BC072422 mRNA. Translation: AAH72422.1.
BC101723 mRNA. Translation: AAI01724.1.
BC112053 mRNA. Translation: AAI12054.1.
AF089745 mRNA. Translation: AAC78853.1.
RefSeqNP_009201.2. NM_007270.4.
UniGeneHs.103934.

3D structure databases

ProteinModelPortalO95302.
SMRO95302. Positions 22-477, 495-559.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116456. 22 interactions.
IntActO95302. 1 interaction.
STRING9606.ENSP00000242209.

PTM databases

PhosphoSiteO95302.

Proteomic databases

PRIDEO95302.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000242209; ENSP00000242209; ENSG00000122642.
GeneID11328.
KEGGhsa:11328.
UCSCuc003tdh.3. human.

Organism-specific databases

CTD11328.
GeneCardsGC07P032997.
H-InvDBHIX0006586.
HIX0167892.
HGNCHGNC:3725. FKBP9.
HPAHPA012595.
neXtProtNX_O95302.
PharmGKBPA28166.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG051620.
InParanoidO95302.
KOK09575.
OrthoDBEOG7T1R9S.
PhylomeDBO95302.
TreeFamTF105296.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressO95302.
BgeeO95302.
CleanExHS_FKBP9.
GenevestigatorO95302.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFKBP9.
GenomeRNAi11328.
NextBio43031.
PROO95302.

Entry information

Entry nameFKBP9_HUMAN
AccessionPrimary (citable) accession number: O95302
Secondary accession number(s): B3KY35 expand/collapse secondary AC list , Q2M2A1, Q3MIR7, Q6IN76, Q6P2N1, Q96EX5, Q96IJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 10, 2006
Last modified: April 16, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM