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O95299 (NDUAA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Alternative name(s):
Complex I-42kD
Short name=CI-42kD
NADH-ubiquinone oxidoreductase 42 kDa subunit
Gene names
Name:NDUFA10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Cofactor

Binds 1 FAD per subunit.

Subunit structure

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Ref.3

Subcellular location

Mitochondrion matrix.

Sequence similarities

Belongs to the complex I NDUFA10 subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3535Mitochondrion By similarity
Chain36 – 355320NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
PRO_0000019988

Amino acid modifications

Modified residue2851N6-succinyllysine By similarity

Natural variations

Natural variant21A → G.
Corresponds to variant rs11541494 [ dbSNP | Ensembl ].
VAR_034149

Sequences

Sequence LengthMass (Da)Tools
O95299 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: B5C27BC150A3E691

FASTA35540,751
        10         20         30         40         50         60 
MALRLLKLAA TSASARVVAA GAQRVRGIHS SVQCKLRYGM WHFLLGDKAS KRLTERSRVI 

        70         80         90        100        110        120 
TVDGNICTGK GKLAKEIAEK LGFKHFPEAG IHYPDSTTGD GKPLATDYNG NCSLEKFYDD 

       130        140        150        160        170        180 
PRSNDGNSYR LQSWLYSSRL LQYSDALEHL LTTGQGVVLE RSIFSDFVFL EAMYNQGFIR 

       190        200        210        220        230        240 
KQCVDHYNEV KSVTICDYLP PHLVIYIDVP VPEVQRRIQK KGDPHEMKIT SAYLQDIENA 

       250        260        270        280        290        300 
YKKTFLPEMS EKCEVLQYSA REAQDSKKVV EDIEYLKFDK GPWLKQDNRT LYHLRLLVQD 

       310        320        330        340        350 
KFEVLNYTSI PIFLPEVTIG AHQTDRVLHQ FRELPGRKYS PGYNTEVGDK WIWLK 

« Hide

References

« Hide 'large scale' references
[1]"cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M.
Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[3]"The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF087661 mRNA. Translation: AAD09755.1.
BC003417 mRNA. Translation: AAH03417.1.
CCDSCCDS2531.1.
PIRJE0385.
RefSeqNP_004535.1. NM_004544.3.
UniGeneHs.277677.

3D structure databases

ProteinModelPortalO95299.
SMRO95299. Positions 60-245.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110785. 11 interactions.
IntActO95299. 5 interactions.
MINTMINT-4991752.
STRING9606.ENSP00000252711.

Chemistry

BindingDBO95299.
ChEMBLCHEMBL2363065.
DrugBankDB00157. NADH.

PTM databases

PhosphoSiteO95299.

Proteomic databases

MaxQBO95299.
PaxDbO95299.
PeptideAtlasO95299.
PRIDEO95299.

Protocols and materials databases

DNASU4705.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252711; ENSP00000252711; ENSG00000130414.
GeneID4705.
KEGGhsa:4705.
UCSCuc002vyn.3. human.

Organism-specific databases

CTD4705.
GeneCardsGC02M240854.
HGNCHGNC:7684. NDUFA10.
MIM603835. gene.
neXtProtNX_O95299.
Orphanet255241. Leigh syndrome with leukodystrophy.
PharmGKBPA31490.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1428.
HOGENOMHOG000267026.
HOVERGENHBG002308.
KOK03954.
PhylomeDBO95299.
TreeFamTF314616.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressO95299.
BgeeO95299.
CleanExHS_NDUFA10.
GenevestigatorO95299.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR002624. Deoxynucleoside_kinase.
IPR015828. NADH_UbQ_OxRdtase_42KD_su.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10513. PTHR10513. 1 hit.
PfamPF01712. dNK. 1 hit.
[Graphical view]
PIRSFPIRSF000543. NADH_UQ_42KD. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

ChiTaRSNDUFA10. human.
GeneWikiNDUFA10.
GenomeRNAi4705.
NextBio18144.
PROO95299.
SOURCESearch...

Entry information

Entry nameNDUAA_HUMAN
AccessionPrimary (citable) accession number: O95299
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM