O95299 (NDUAA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Alternative name(s):
Complex I-42kD
Short name=CI-42kD
NADH-ubiquinone oxidoreductase 42 kDa subunit

Gene names

Name:

NDUFA10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Cofactor	Binds 1 FAD per subunit.
Subunit structure	Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the complex I NDUFA10 subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Ligand	FAD Flavoprotein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	mitochondrial electron transport, NADH to ubiquinone Non-traceable author statement Ref.1. Source: UniProtKB nucleobase-containing compound metabolic process Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial respiratory chain complex I Inferred from direct assay Ref.3. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activity Non-traceable author statement Ref.1. Source: UniProtKB phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 35	35	Mitochondrion By similarity
	Chain	36 – 355	320	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial		PRO_0000019988
Amino acid modifications
	Modified residue	181	1	N6-acetyllysine By similarity
	Modified residue	242	1	N6-acetyllysine By similarity
	Modified residue	350	1	N6-acetyllysine By similarity
Natural variations
	Natural variant	2	1	A → G. Corresponds to variant rs11541494 [ dbSNP | Ensembl ].		VAR_034149

Sequences

	Sequence		Length	Mass (Da)
	O95299 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: B5C27BC150A3E691	FASTA	355	40,751
	10 20 30 40 50 60 MALRLLKLAA TSASARVVAA GAQRVRGIHS SVQCKLRYGM WHFLLGDKAS KRLTERSRVI 70 80 90 100 110 120 TVDGNICTGK GKLAKEIAEK LGFKHFPEAG IHYPDSTTGD GKPLATDYNG NCSLEKFYDD 130 140 150 160 170 180 PRSNDGNSYR LQSWLYSSRL LQYSDALEHL LTTGQGVVLE RSIFSDFVFL EAMYNQGFIR 190 200 210 220 230 240 KQCVDHYNEV KSVTICDYLP PHLVIYIDVP VPEVQRRIQK KGDPHEMKIT SAYLQDIENA 250 260 270 280 290 300 YKKTFLPEMS EKCEVLQYSA REAQDSKKVV EDIEYLKFDK GPWLKQDNRT LYHLRLLVQD 310 320 330 340 350 KFEVLNYTSI PIFLPEVTIG AHQTDRVLHQ FRELPGRKYS PGYNTEVGDK WIWLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed." Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M. Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed: 9878551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification." Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A. J. Biol. Chem. 278:13619-13622(2003) [PubMed: 12611891] [Abstract] Cited for: MASS SPECTROMETRY, IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF087661 mRNA. Translation: AAD09755.1. BC003417 mRNA. Translation: AAH03417.1.
IPI	IPI00029561.
PIR	JE0385.
RefSeq	NP_004535.1. NM_004544.3.
UniGene	Hs.277677.
3D structure databases
ProteinModelPortal	O95299.
SMR	O95299. Positions 58-87.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95299. 4 interactions.
STRING	O95299.
PTM databases
PhosphoSite	O95299.
Proteomic databases
PeptideAtlas	O95299.
PRIDE	O95299.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252711; ENSP00000252711; ENSG00000130414.
GeneID	4705.
KEGG	hsa:4705.
NMPDR	fig|9606.3.peg.19605.
UCSC	uc002vyn.1. human.
Organism-specific databases
CTD	4705.
GeneCards	GC02M240854.
H-InvDB	HIX0002999.
HGNC	HGNC:7684. NDUFA10.
MIM	603835. gene.
neXtProt	NX_O95299.
Orphanet	255241. Leigh syndrome with leukodystrophy.
PharmGKB	PA31490.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10306.
HOVERGEN	HBG002308.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	O95299.
Bgee	O95299.
CleanEx	HS_NDUFA10.
Genevestigator	O95299.
GermOnline	ENSG00000130414. Homo sapiens.
Family and domain databases
InterPro	IPR002624. Deoxynucleoside_kinase. IPR015828. NADH_UbQ_OxRdtase_42KD_su. [Graphical view]
KO	K03954.
PANTHER	PTHR10513. dNK. 1 hit. PTHR10513:SF2. PTHR10513:SF2. 1 hit.
Pfam	PF01712. dNK. 1 hit. [Graphical view]
PIRSF	PIRSF000543. NADH_UQ_42KD. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00157. NADH.
NextBio	18144.
SOURCE	Search...

Entry information

Entry name

NDUAA_HUMAN

Accession

Primary (citable) accession number: O95299

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.