O95298 (NDUC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C2

Alternative name(s):
Complex I-B14.5b
Short name=CI-B14.5b
Human lung cancer oncogene 1 protein
Short name=HLC-1
NADH-ubiquinone oxidoreductase subunit B14.5b

Gene names

Name:	NDUFC2
ORF Names:	HLC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subunit structure	Complex I is composed of 45 different subunits.
Subcellular location	Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Sequence similarities	Belongs to the complex I NDUFC2 subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	mitochondrial electron transport, NADH to ubiquinone Non-traceable author statement Ref.1. Source: UniProtKB transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain complex I Inferred from direct assay Ref.7. Source: UniProtKB
Molecular function	NADH dehydrogenase (ubiquinone) activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	NADH dehydrogenase [ubiquinone] 1 subunit C2		PRO_0000118837
Regions
	Transmembrane	56 – 75	20	Helical; Potential
Amino acid modifications
	Modified residue	114	1	N6-acetyllysine Ref.8
Natural variations
	Natural variant	46	1	L → V. Ref.2 Ref.3 Ref.4 Ref.5 Corresponds to variant rs8875 [ dbSNP | Ensembl ].		VAR_014486

Sequences

	Sequence		Length	Mass (Da)
	O95298 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 9A47DEE33DC9244D	FASTA	119	14,188
	10 20 30 40 50 60 MIARRNPEPL RFLPDEARSL PPPKLTDPRL LYIGFLGYCS GLIDNLIRRR PIATAGLHRQ 70 80 90 100 110 LLYITAFFFA GYYLVKREDY LYAVRDREMF GYMKLHPEDF PEEDKKTYGE IFEKFHPIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed." Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M. Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed: 9878551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-46. Tissue: Umbilical cord blood.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-46. Tissue: Kidney.
[4]	"Identification of a new oncogene in human cancer." Kim J.W. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-46.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-46.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[7]	"The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification." Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A. J. Biol. Chem. 278:13619-13622(2003) [PubMed: 12611891] [Abstract] Cited for: MASS SPECTROMETRY, IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-114, MASS SPECTROMETRY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF087659 mRNA. Translation: AAD09754.1. AF070652 mRNA. Translation: AAD20958.1. AL050278 mRNA. Translation: CAB43379.1. AF369951 mRNA. Translation: AAM21294.1. CR533448 mRNA. Translation: CAG38479.1. BC007323 mRNA. Translation: AAH07323.1.
IPI	IPI00029558.
PIR	T08728.
RefSeq	NP_004540.1. NM_004549.5.
UniGene	Hs.407860.
3D structure databases
ProteinModelPortal	O95298.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95298. 1 interaction.
STRING	O95298.
PTM databases
PhosphoSite	O95298.
Proteomic databases
PeptideAtlas	O95298.
PRIDE	O95298.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000281031; ENSP00000281031; ENSG00000151366.
GeneID	4718.
KEGG	hsa:4718.
UCSC	uc009yuw.1. human.
Organism-specific databases
CTD	4718.
GeneCards	GC11M077779.
H-InvDB	HIX0009974.
HGNC	HGNC:7706. NDUFC2.
HPA	HPA038873.
MIM	603845. gene.
neXtProt	NX_O95298.
PharmGKB	PA31517.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20162.
HOGENOM	HBG126738.
HOVERGEN	HBG001727.
InParanoid	O95298.
OMA	MMSGRPG.
OrthoDB	EOG49ZXQV.
PhylomeDB	O95298.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	O95298.
Bgee	O95298.
CleanEx	HS_NDUFC2.
Genevestigator	O95298.
GermOnline	ENSG00000151366. Homo sapiens.
Family and domain databases
InterPro	IPR009423. NADH-UbQ_OxRdtase_b14.5b_su. [Graphical view]
KO	K03968.
PANTHER	PTHR13099. NDUF_C2. 1 hit.
Pfam	PF06374. NDUF_C2. 1 hit. [Graphical view]
PIRSF	PIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB01136. Carvedilol. DB00157. NADH.
NextBio	18198.
SOURCE	Search...

Entry information

Entry name

NDUC2_HUMAN

Accession

Primary (citable) accession number: O95298
Secondary accession number(s): Q6FIH8, Q9UBJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.