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Protein

RasGAP-activating-like protein 1

Gene

RASAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003).2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri674 – 71037Btk-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • GTPase activator activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • phospholipid binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5658442. Regulation of RAS by GAPs.

Names & Taxonomyi

Protein namesi
Recommended name:
RasGAP-activating-like protein 1Curated
Alternative name(s):
RAS protein activator like 1Imported
Ras GTPase-activating-like protein1 Publication
Gene namesi
Name:RASAL1Imported
Synonyms:RASAL1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9873. RASAL1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • intrinsic component of the cytoplasmic side of the plasma membrane Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34234.

Polymorphism and mutation databases

BioMutaiRASAL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804RasGAP-activating-like protein 1PRO_0000056645Add
BLAST

Proteomic databases

EPDiO95294.
MaxQBiO95294.
PaxDbiO95294.
PRIDEiO95294.

PTM databases

iPTMnetiO95294.
PhosphoSiteiO95294.

Expressioni

Tissue specificityi

Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea (PubMed:9751798). Expressed in melanocytes (PubMed:23999003).2 Publications

Gene expression databases

BgeeiO95294.
CleanExiHS_RASAL1.
GenevisibleiO95294. HS.

Organism-specific databases

HPAiHPA041650.

Interactioni

Protein-protein interaction databases

BioGridi114017. 4 interactions.
STRINGi9606.ENSP00000450244.

Structurei

3D structure databases

ProteinModelPortaliO95294.
SMRiO95294. Positions 4-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8888C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini120 – 21697C2 2PROSITE-ProRule annotationAdd
BLAST
Domaini301 – 511211Ras-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini565 – 672108PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi499 – 5024Poly-Leu

Sequence similaritiesi

Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri674 – 71037Btk-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2059. Eukaryota.
ENOG410Y128. LUCA.
GeneTreeiENSGT00760000119092.
HOGENOMiHOG000234324.
HOVERGENiHBG106587.
InParanoidiO95294.
KOiK17632.
OMAiFARVFWG.
OrthoDBiEOG7J17Z6.
PhylomeDBiO95294.
TreeFamiTF105302.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
4.10.1130.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR028555. RASAL1.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view]
PANTHERiPTHR10194:SF3. PTHR10194:SF3. 1 hit.
PfamiPF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95294-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKSSSLNVR VVEGRALPAK DVSGSSDPYC LVKVDDEVVA RTATVWRSLG
60 70 80 90 100
PFWGEEYTVH LPLDFHQLAF YVLDEDTVGH DDIIGKISLS REAITADPRG
110 120 130 140 150
IDSWINLSRV DPDAEVQGEI CLSVQMLEDG QGRCLRCHVL QARDLAPRDI
160 170 180 190 200
SGTSDPFARV FWGSQSLETS TIKKTRFPHW DEVLELREMP GAPSPLRVEL
210 220 230 240 250
WDWDMVGKND FLGMVEFSPK TLQQKPPKGW FRLLPFPRAE EDSGGNLGAL
260 270 280 290 300
RVKVRLIEDR VLPSQCYQPL MELLMESVQG PAEEDTASPL ALLEELTLGD
310 320 330 340 350
CRQDLATKLV KLFLGRGLAG RFLDYLTRRE VARTMDPNTL FRSNSLASKS
360 370 380 390 400
MEQFMKLVGM PYLHEVLKPV ISRVFEEKKY MELDPCKMDL GRTRRISFKG
410 420 430 440 450
ALSEEQMRET SLGLLTGYLG PIVDAIVGSV GRCPPAMRLA FKQLHRRVEE
460 470 480 490 500
RFPQAEHQDV KYLAISGFLF LRFFAPAILT PKLFDLRDQH ADPQTSRSLL
510 520 530 540 550
LLAKAVQSIG NLGQQLGQGK ELWMAPLHPF LLQCVSRVRD FLDRLVDVDG
560 570 580 590 600
DEAGVPARAL FPPSAIVREG YLLKRKEEPA GLATRFAFKK RYVWLSGETL
610 620 630 640 650
SFSKSPEWQM CHSIPVSHIR AVERVDEGAF QLPHVMQVVT QDGTGALHTT
660 670 680 690 700
YLQCKNVNEL NQWLSALRKA SAPNPNKLAA CHPGAFRSAR WTCCLQAERS
710 720 730 740 750
AAGCSRTHSA VTLGDWSDPL DPDAEAQTVY RQLLLGRDQL RLKLLEDSNM
760 770 780 790 800
DTTLEADTGA CPEVLARQRA ATARLLEVLA DLDRAHEEFQ QQERGKAALG

PLGP
Length:804
Mass (Da):90,016
Last modified:November 2, 2010 - v3
Checksum:i5D0065A093487FD0
GO
Isoform 2 (identifier: O95294-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-637: Missing.

Note: No experimental confirmation available.
Show »
Length:776
Mass (Da):86,847
Checksum:i3E385FF1F2F41866
GO
Isoform 3 (identifier: O95294-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-458: Q → QQ
     552-552: E → EE

Note: Gene prediction based on EST data.
Show »
Length:806
Mass (Da):90,274
Checksum:i7B82D39FBAD0E59E
GO
Isoform 4 (identifier: O95294-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     552-552: E → EE

Note: No experimental confirmation available.
Show »
Length:805
Mass (Da):90,145
Checksum:i0CBCCAD667337182
GO

Sequence cautioni

The sequence BAD92172.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411Q → H in AAD09006 (PubMed:9751798).Curated
Sequence conflicti346 – 3461L → P in CAB66607 (PubMed:11230166).Curated
Sequence conflicti514 – 5141Q → R in CAB66607 (PubMed:11230166).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111V → L.1 Publication
Corresponds to variant rs7960087 [ dbSNP | Ensembl ].
VAR_031665
Natural varianti58 – 581T → M.1 Publication
Corresponds to variant rs34598602 [ dbSNP | Ensembl ].
VAR_031666
Natural varianti321 – 3211R → H.3 Publications
Corresponds to variant rs1284879 [ dbSNP | Ensembl ].
VAR_031667

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei458 – 4581Q → QQ in isoform 3. 1 PublicationVSP_047005
Alternative sequencei552 – 5521E → EE in isoform 3 and isoform 4. 2 PublicationsVSP_047006
Alternative sequencei610 – 63728Missing in isoform 2. CuratedVSP_001627Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086713 mRNA. Translation: AAD09006.1.
AB208935 mRNA. Translation: BAD92172.1. Different initiation.
AC089999 Genomic DNA. No translation available.
BC014420 mRNA. Translation: AAH14420.1.
BC093724 mRNA. Translation: AAH93724.1.
BC143261 mRNA. Translation: AAI43262.1.
AL136672 Transcribed RNA. Translation: CAB66607.2.
CCDSiCCDS55888.1. [O95294-2]
CCDS55889.1. [O95294-3]
CCDS73529.1. [O95294-4]
CCDS9165.1. [O95294-1]
RefSeqiNP_001180449.1. NM_001193520.1. [O95294-3]
NP_001180450.1. NM_001193521.1. [O95294-2]
NP_001288131.1. NM_001301202.1. [O95294-4]
NP_004649.2. NM_004658.2. [O95294-1]
XP_005254007.1. XM_005253950.3. [O95294-3]
XP_006719704.1. XM_006719641.2. [O95294-3]
XP_011537154.1. XM_011538852.1. [O95294-3]
XP_011537155.1. XM_011538853.1. [O95294-1]
UniGeneiHs.528693.

Genome annotation databases

EnsembliENST00000261729; ENSP00000261729; ENSG00000111344. [O95294-1]
ENST00000446861; ENSP00000395920; ENSG00000111344. [O95294-2]
ENST00000546530; ENSP00000450244; ENSG00000111344. [O95294-3]
ENST00000548055; ENSP00000448510; ENSG00000111344. [O95294-4]
GeneIDi8437.
KEGGihsa:8437.
UCSCiuc001tul.4. human. [O95294-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086713 mRNA. Translation: AAD09006.1.
AB208935 mRNA. Translation: BAD92172.1. Different initiation.
AC089999 Genomic DNA. No translation available.
BC014420 mRNA. Translation: AAH14420.1.
BC093724 mRNA. Translation: AAH93724.1.
BC143261 mRNA. Translation: AAI43262.1.
AL136672 Transcribed RNA. Translation: CAB66607.2.
CCDSiCCDS55888.1. [O95294-2]
CCDS55889.1. [O95294-3]
CCDS73529.1. [O95294-4]
CCDS9165.1. [O95294-1]
RefSeqiNP_001180449.1. NM_001193520.1. [O95294-3]
NP_001180450.1. NM_001193521.1. [O95294-2]
NP_001288131.1. NM_001301202.1. [O95294-4]
NP_004649.2. NM_004658.2. [O95294-1]
XP_005254007.1. XM_005253950.3. [O95294-3]
XP_006719704.1. XM_006719641.2. [O95294-3]
XP_011537154.1. XM_011538852.1. [O95294-3]
XP_011537155.1. XM_011538853.1. [O95294-1]
UniGeneiHs.528693.

3D structure databases

ProteinModelPortaliO95294.
SMRiO95294. Positions 4-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114017. 4 interactions.
STRINGi9606.ENSP00000450244.

PTM databases

iPTMnetiO95294.
PhosphoSiteiO95294.

Polymorphism and mutation databases

BioMutaiRASAL1.

Proteomic databases

EPDiO95294.
MaxQBiO95294.
PaxDbiO95294.
PRIDEiO95294.

Protocols and materials databases

DNASUi8437.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261729; ENSP00000261729; ENSG00000111344. [O95294-1]
ENST00000446861; ENSP00000395920; ENSG00000111344. [O95294-2]
ENST00000546530; ENSP00000450244; ENSG00000111344. [O95294-3]
ENST00000548055; ENSP00000448510; ENSG00000111344. [O95294-4]
GeneIDi8437.
KEGGihsa:8437.
UCSCiuc001tul.4. human. [O95294-1]

Organism-specific databases

CTDi8437.
GeneCardsiRASAL1.
H-InvDBHIX0011016.
HGNCiHGNC:9873. RASAL1.
HPAiHPA041650.
MIMi604118. gene.
neXtProtiNX_O95294.
PharmGKBiPA34234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2059. Eukaryota.
ENOG410Y128. LUCA.
GeneTreeiENSGT00760000119092.
HOGENOMiHOG000234324.
HOVERGENiHBG106587.
InParanoidiO95294.
KOiK17632.
OMAiFARVFWG.
OrthoDBiEOG7J17Z6.
PhylomeDBiO95294.
TreeFamiTF105302.

Enzyme and pathway databases

ReactomeiR-HSA-5658442. Regulation of RAS by GAPs.

Miscellaneous databases

ChiTaRSiRASAL1. human.
GenomeRNAii8437.
NextBioi31566.
PROiO95294.
SOURCEiSearch...

Gene expression databases

BgeeiO95294.
CleanExiHS_RASAL1.
GenevisibleiO95294. HS.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
4.10.1130.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR028555. RASAL1.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view]
PANTHERiPTHR10194:SF3. PTHR10194:SF3. 1 hit.
PfamiPF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog."
    Allen M., Chu S., Brill S., Stotler C., Buckler A.
    Gene 218:17-25(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT HIS-321, PROBABLE FUNCTION, TISSUE SPECIFICITY.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT HIS-321.
    Tissue: Brain.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1/2/4), VARIANTS LEU-11; MET-58 AND HIS-321.
    Tissue: Brain and Lung.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-700 (ISOFORM 4).
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation."
    Yoo J.C., Lim T.Y., Park J.S., Hah Y.S., Park N., Hong S.G., Park J.Y., Yoon T.J.
    J. Dermatol. Sci. 72:246-251(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRASL1_HUMAN
AccessioniPrimary (citable) accession number: O95294
Secondary accession number(s): B7ZKM4
, C9JFK5, F8VQX1, Q52M03, Q59H24, Q96CC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 2, 2010
Last modified: March 16, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.