O95292 (VAPB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vesicle-associated membrane protein-associated protein B/C
Short name=VAMP-B/VAMP-C
Short name=VAMP-associated protein B/C
Short name=VAP-B/VAP-C

Gene names

Name:	VAPB
ORF Names:	UNQ484/PRO983

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. Ref.9 Ref.13 Ref.17
Subunit structure	Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2. Interacts with HCV NS5A and NS5B. Interacts (via MSP domain) with ZFYVE27. Interacts with RMDN3. Ref.7 Ref.12 Ref.17
Subcellular location	Endoplasmic reticulum membrane; Single-pass type IV membrane protein By similarity. Note: Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. Ref.17
Tissue specificity	Ubiquitous. Isoform 1 predominates.
Involvement in disease	Amyotrophic lateral sclerosis 8 (ALS8) [MIM:608627]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.13 Ref.17 Ref.18 Spinal muscular atrophy, proximal, adult, autosomal dominant (SMAPAD) [MIM:182980]: A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAPAD is characterized by proximal muscle weakness that begins in the lower limbs and then progresses to upper limbs, onset in late adulthood (after third decade) and a benign course. Most of the patients remain ambulatory 10 to 40 years after clinical onset. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.18
Sequence similarities	Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. [View classification] Contains 1 MSP domain.

Ontologies

Keywords
Biological process	Host-virus interaction Unfolded protein response
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing
Disease	Amyotrophic lateral sclerosis Disease mutation Neurodegeneration
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	activation of signaling protein activity involved in unfolded protein response Inferred from direct assay Ref.13. Source: UniProtKB cell death Inferred from electronic annotation. Source: UniProtKB-KW cellular calcium ion homeostasis Inferred from mutant phenotype Ref.17. Source: UniProtKB phospholipid metabolic process Traceable author statement. Source: Reactome positive regulation of viral genome replication Inferred from mutant phenotype Ref.7. Source: UniProtKB small molecule metabolic process Traceable author statement. Source: Reactome sphingolipid biosynthetic process Traceable author statement. Source: Reactome virus-host interaction Inferred from direct assay Ref.7. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay Ref.7. Source: UniProtKB endoplasmic reticulum membrane Inferred from direct assay Ref.7. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	beta-tubulin binding Inferred from direct assay PubMed 17540579. Source: UniProtKB structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Epha4	Q03137	2	EBI-1188298,EBI-1539152	From a different organism.
ZFYVE27	Q5T4F4	2	EBI-1188298,EBI-3892947

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95292-1)

Also known as: VAP-B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95292-2)

Also known as: VAP-C;

The sequence of this isoform differs from the canonical sequence as follows:
     71-99: VMLQPFDYDPNEKSKHKFMVQSMFAPTDT → GRRWTADEEDSAEQQPHFSISPNWEGRRP
     100-243: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.6

Chain

2 – 243

242

Vesicle-associated membrane protein-associated protein B/C

PRO_0000213473

Regions

Topological domain

2 – 222

221

Cytoplasmic Potential

Transmembrane

223 – 243

21

Helical; Anchor for type IV membrane protein; Potential

Domain

7 – 124

118

MSP

Coiled coil

159 – 196

38

Potential

Amino acid modifications

Modified residue

150

1

Phosphothreonine Ref.11 Ref.14

Modified residue

156

1

Phosphoserine Ref.11 Ref.14

Modified residue

160

1

Phosphoserine Ref.11 Ref.14

Natural variations

Alternative sequence

71 – 99

29

VMLQP…APTDT → GRRWTADEEDSAEQQPHFSI SPNWEGRRP in isoform 2.

VSP_003277

Alternative sequence

100 – 243

144

Missing in isoform 2.

VSP_003278

Natural variant

46

1

T → I in ALS8; it forms insoluble cytosolic aggregates; cannot activate the UPR pathway through ERN1/IRE1 induction; results in ubiquitinated aggregates accumulation and cell death. Ref.13

VAR_067964

Natural variant

56

1

P → S in ALS8 and SMAPAD; it forms insoluble cytosolic aggregates; cannot activate the UPR pathway; affects interaction with RMDN3; affects cellular calcium homeostasis. Ref.9 Ref.13 Ref.17 Ref.18
Corresponds to variant rs74315431 [ dbSNP | Ensembl ].

VAR_026743

Experimental info

Sequence conflict

60

1

I → V in AAF67013. Ref.2

Sequence conflict

67

1

I → L in AAF67013. Ref.2

Sequence conflict

97

1

T → P in AAF67013. Ref.2

Sequence conflict

103 – 106

4

EAVW → DGTR in AAF67013. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

243

Helix Strand Turn

Details...

Beta strand

8 – 20

13

Beta strand

26 – 33

8

Beta strand

36 – 38

3

Beta strand

40 – 47

8

Turn

49 – 51

3

Beta strand

52 – 61

10

Beta strand

66 – 73

8

Beta strand

88 – 94

7

Turn

104 – 108

5

Beta strand

111 – 113

3

Beta strand

115 – 124

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (VAP-B) [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 22AEEF9EC7FC0B3F	FASTA	243	27,228
	10 20 30 40 50 60 MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI 70 80 90 100 110 120 IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS DMEAVWKEAK PEDLMDSKLR 130 140 150 160 170 180 CVFELPAEND KPHDVEINKI ISTTASKTET PIVSKSLSSS LDDTEVKKVM EECKRLQGEV 190 200 210 220 230 240 QRLREENKQF KEEDGLRMRK TVQSNSPISA LAPTGKEEGL STRLLALVVL FFIVGVIIGK IAL
	Isoform 2 (VAP-C) [UniParc]. Checksum: 042285C56B89CCDC	FASTA	99	11,152
	10 20 30 40 50 60 MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI 70 80 90 IDAGASINVS GRRWTADEED SAEQQPHFSI SPNWEGRRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins." Nishimura Y., Hayashi M., Inada H., Tanaka T. Biochem. Biophys. Res. Commun. 254:21-26(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Heart.
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Adrenal gland.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph.
[6]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-19. Tissue: Platelet.
[7]	"Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B." Hamamoto I., Nishimura Y., Okamoto T., Aizaki H., Liu M., Mori Y., Abe T., Suzuki T., Lai M.M., Miyamura T., Moriishi K., Matsuura Y. J. Virol. 79:13473-13482(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HCV NS5A AND NS5B.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)." Kanekura K., Nishimoto I., Aiso S., Matsuoka M. J. Biol. Chem. 281:30223-30233(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE, CHARACTERIZATION OF VARIANT ALS8 SER-56.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-150; SER-156 AND SER-160, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein." Saita S., Shirane M., Natume T., Iemura S., Nakayama K.I. J. Biol. Chem. 284:13766-13777(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ZFYVE27.
[13]	"Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis." Chen H.J., Anagnostou G., Chai A., Withers J., Morris A., Adhikaree J., Pennetta G., de Belleroche J.S. J. Biol. Chem. 285:40266-40281(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE, VARIANT ALS8 ILE-46, CHARACTERIZATION OF VARIANTS ALS8 ILE-46 AND SER-56.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-150; SER-156 AND SER-160, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]	"VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis." De Vos K.J., Morotz G.M., Stoica R., Tudor E.L., Lau K.F., Ackerley S., Warley A., Shaw C.E., Miller C.C. Hum. Mol. Genet. 21:1299-1311(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN CELLULAR CALCIUM HOMEOSTASIS REGULATION, SUBCELLULAR LOCATION, INTERACTION WITH RMDN3, CHARACTERIZATION OF VARIANT ALS8 SER-56.
[18]	"A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis." Nishimura A.L., Mitne-Neto M., Silva H.C., Richieri-Costa A., Middleton S., Cascio D., Kok F., Oliveira J.R., Gillingwater T., Webb J., Skehel P., Zatz M. Am. J. Hum. Genet. 75:822-831(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ALS8 SER-56, VARIANT SMAPAD SER-56.
+	Additional computationally mapped references.

Web resources

Alsod

ALS genetic mutations db

GeneReviews

Mendelian genes VAMP (vesicle-associated membrane protein)-associated protein B and C (VAPB)

Leiden Open Variation Database (LOVD)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF086628 mRNA. Translation: AAD13577.1.
AF086629 mRNA. Translation: AAD13578.1.
AF160212 mRNA. Translation: AAF67013.1.
AY358464 mRNA. Translation: AAQ88829.1.
AL035455 Genomic DNA. Translation: CAC15021.1.
AL035455 Genomic DNA. Translation: CAM27023.1.
BC001712 mRNA. Translation: AAH01712.1.

IPI

IPI00006211.
IPI00748221.

PIR

JG0186.

RefSeq

NP_001182606.1. NM_001195677.1.
NP_004729.1. NM_004738.4.

UniGene

Hs.182625.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3IKK	X-ray	2.50	A/B	1-125	[»]

ProteinModelPortal

O95292.

ModBase

Search...

Protein-protein interaction databases

IntAct

O95292. 11 interactions.

STRING

9606.ENSP00000417175.

Protein family/group databases

TCDB

9.B.17.1.1. VAMP-associated protein (VAP) family.

PTM databases

PhosphoSite

O95292.

Proteomic databases

PaxDb

O95292.

PRIDE

O95292.

Protocols and materials databases

DNASU

9217.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000395802; ENSP00000379147; ENSG00000124164.
ENST00000475243; ENSP00000417175; ENSG00000124164.

GeneID

9217.

KEGG

hsa:9217.

UCSC

uc002xza.3. human.
uc002xzd.2. human.

Organism-specific databases

CTD

9217.

GeneCards

GC20P056964.

HGNC

HGNC:12649. VAPB.

HPA

CAB013722.
HPA013144.

MIM

182980. phenotype.
605704. gene.
608627. phenotype.

neXtProt

NX_O95292.

Orphanet

209335. Adult-onset proximal spinal muscular atrophy, autosomal dominant.
803. Amyotrophic lateral sclerosis.

PharmGKB

PA37273.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5066.

HOGENOM

HOG000293182.

HOVERGEN

HBG028551.

InParanoid

O95292.

KO

K10707.

OMA

VMSKSIS.

OrthoDB

EOG4DNF5D.

PhylomeDB

O95292.

Enzyme and pathway databases

Reactome

REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

O95292.

Bgee

O95292.

CleanEx

HS_VAPB.

Genevestigator

O95292.

GermOnline

ENSG00000124164. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.360. 1 hit.

InterPro

IPR000535. Major_sperm.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view]

Pfam

PF00635. Motile_Sperm. 1 hit.
[Graphical view]

PIRSF

PIRSF019693. VAMP-associated. 1 hit.

SUPFAM

SSF49354. PapD-like. 1 hit.

PROSITE

PS50202. MSP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

VAPB. human.

EvolutionaryTrace

O95292.

GenomeRNAi

9217.

NextBio

34553.

SOURCE

Search...

Entry information

Entry name

VAPB_HUMAN

Accession

Primary (citable) accession number: O95292
Secondary accession number(s): A2A2F2, O95293, Q9P0H0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 124 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.