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O95292

- VAPB_HUMAN

UniProt

O95292 - VAPB_HUMAN

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Protein

Vesicle-associated membrane protein-associated protein B/C

Gene
VAPB, UNQ484/PRO983
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.3 Publications

GO - Molecular functioni

  1. beta-tubulin binding Source: UniProtKB
  2. enzyme binding Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. protein heterodimerization activity Source: UniProtKB
  5. protein homodimerization activity Source: UniProtKB
  6. structural molecule activity Source: InterPro

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: UniProtKB
  2. cell death Source: UniProtKB-KW
  3. cellular calcium ion homeostasis Source: UniProtKB
  4. endoplasmic reticulum unfolded protein response Source: UniProtKB
  5. modulation by virus of host morphology or physiology Source: UniProtKB
  6. positive regulation of viral genome replication Source: UniProtKB
  7. small molecule metabolic process Source: Reactome
  8. sphingolipid biosynthetic process Source: Reactome
  9. sphingolipid metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Unfolded protein response

Enzyme and pathway databases

ReactomeiREACT_115810. Sphingolipid de novo biosynthesis.

Protein family/group databases

TCDBi9.B.17.1.1. the vamp-associated protein (vap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein-associated protein B/C
Short name:
VAMP-B/VAMP-C
Short name:
VAMP-associated protein B/C
Short name:
VAP-B/VAP-C
Gene namesi
Name:VAPB
ORF Names:UNQ484/PRO983
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:12649. VAPB.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type IV membrane protein By similarity
Note: Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 222221Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei223 – 24321Helical; Anchor for type IV membrane protein; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB
  3. Golgi apparatus Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Amyotrophic lateral sclerosis 8 (ALS8) [MIM:608627]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Note: The disease is caused by mutations affecting the gene represented in this entry.4 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461T → I in ALS8; it forms insoluble cytosolic aggregates; cannot activate the UPR pathway through ERN1/IRE1 induction; results in ubiquitinated aggregates accumulation and cell death. 1 Publication
Corresponds to variant rs281875284 [ dbSNP | Ensembl ].
VAR_067964
Natural varianti56 – 561P → S in ALS8 and SMAPAD; it forms insoluble cytosolic aggregates; cannot activate the UPR pathway; affects interaction with RMDN3; affects cellular calcium homeostasis. 4 Publications
Corresponds to variant rs74315431 [ dbSNP | Ensembl ].
VAR_026743
Spinal muscular atrophy, proximal, adult, autosomal dominant (SMAPAD) [MIM:182980]: A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAPAD is characterized by proximal muscle weakness that begins in the lower limbs and then progresses to upper limbs, onset in late adulthood (after third decade) and a benign course. Most of the patients remain ambulatory 10 to 40 years after clinical onset.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561P → S in ALS8 and SMAPAD; it forms insoluble cytosolic aggregates; cannot activate the UPR pathway; affects interaction with RMDN3; affects cellular calcium homeostasis. 4 Publications
Corresponds to variant rs74315431 [ dbSNP | Ensembl ].
VAR_026743

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

MIMi182980. phenotype.
608627. phenotype.
Orphaneti209335. Adult-onset proximal spinal muscular atrophy, autosomal dominant.
803. Amyotrophic lateral sclerosis.
PharmGKBiPA37273.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 243242Vesicle-associated membrane protein-associated protein B/CPRO_0000213473Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei150 – 1501Phosphothreonine2 Publications
Modified residuei156 – 1561Phosphoserine2 Publications
Modified residuei160 – 1601Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95292.
PaxDbiO95292.
PRIDEiO95292.

PTM databases

PhosphoSiteiO95292.

Expressioni

Tissue specificityi

Ubiquitous. Isoform 1 predominates.

Gene expression databases

ArrayExpressiO95292.
BgeeiO95292.
CleanExiHS_VAPB.
GenevestigatoriO95292.

Organism-specific databases

HPAiCAB013722.
HPA013144.

Interactioni

Subunit structurei

Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2. Interacts with HCV NS5A and NS5B. Interacts (via MSP domain) with ZFYVE27. Interacts with RMDN3.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q034633EBI-9350855,EBI-8803474From a different organism.
Epha4Q031372EBI-1188298,EBI-1539152From a different organism.
VAPAQ9P0L02EBI-9350848,EBI-1059156
YIF1AO950709EBI-1188298,EBI-2799703
ZFYVE27Q5T4F42EBI-1188298,EBI-3892947

Protein-protein interaction databases

BioGridi114650. 36 interactions.
IntActiO95292. 23 interactions.
STRINGi9606.ENSP00000417175.

Structurei

Secondary structure

1
243
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni4 – 74
Beta strandi8 – 2013
Beta strandi26 – 338
Beta strandi36 – 383
Beta strandi40 – 478
Turni49 – 513
Beta strandi52 – 6110
Beta strandi66 – 738
Turni82 – 843
Beta strandi88 – 947
Turni104 – 1085
Beta strandi111 – 1133
Beta strandi115 – 12410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MDKNMR-A1-125[»]
3IKKX-ray2.50A/B1-125[»]
ProteinModelPortaliO95292.
SMRiO95292. Positions 1-125.

Miscellaneous databases

EvolutionaryTraceiO95292.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 124118MSPAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili159 – 19638 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 MSP domain.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5066.
HOGENOMiHOG000293182.
HOVERGENiHBG028551.
InParanoidiO95292.
KOiK10707.
OMAiPHDIEIN.
OrthoDBiEOG7CK389.
PhylomeDBiO95292.
TreeFamiTF317024.

Family and domain databases

Gene3Di2.60.40.360. 1 hit.
InterProiIPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view]
PfamiPF00635. Motile_Sperm. 1 hit.
[Graphical view]
PIRSFiPIRSF019693. VAMP-associated. 1 hit.
SUPFAMiSSF49354. SSF49354. 1 hit.
PROSITEiPS50202. MSP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95292-1) [UniParc]FASTAAdd to Basket

Also known as: VAP-B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR    50
RYCVRPNSGI IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS 100
DMEAVWKEAK PEDLMDSKLR CVFELPAEND KPHDVEINKI ISTTASKTET 150
PIVSKSLSSS LDDTEVKKVM EECKRLQGEV QRLREENKQF KEEDGLRMRK 200
TVQSNSPISA LAPTGKEEGL STRLLALVVL FFIVGVIIGK IAL 243
Length:243
Mass (Da):27,228
Last modified:January 23, 2007 - v3
Checksum:i22AEEF9EC7FC0B3F
GO
Isoform 2 (identifier: O95292-2) [UniParc]FASTAAdd to Basket

Also known as: VAP-C

The sequence of this isoform differs from the canonical sequence as follows:
     71-99: VMLQPFDYDPNEKSKHKFMVQSMFAPTDT → GRRWTADEEDSAEQQPHFSISPNWEGRRP
     100-243: Missing.

Show »
Length:99
Mass (Da):11,152
Checksum:i042285C56B89CCDC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461T → I in ALS8; it forms insoluble cytosolic aggregates; cannot activate the UPR pathway through ERN1/IRE1 induction; results in ubiquitinated aggregates accumulation and cell death. 1 Publication
Corresponds to variant rs281875284 [ dbSNP | Ensembl ].
VAR_067964
Natural varianti56 – 561P → S in ALS8 and SMAPAD; it forms insoluble cytosolic aggregates; cannot activate the UPR pathway; affects interaction with RMDN3; affects cellular calcium homeostasis. 4 Publications
Corresponds to variant rs74315431 [ dbSNP | Ensembl ].
VAR_026743

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei71 – 9929VMLQP…APTDT → GRRWTADEEDSAEQQPHFSI SPNWEGRRP in isoform 2. VSP_003277Add
BLAST
Alternative sequencei100 – 243144Missing in isoform 2. VSP_003278Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601I → V in AAF67013. 1 Publication
Sequence conflicti67 – 671I → L in AAF67013. 1 Publication
Sequence conflicti97 – 971T → P in AAF67013. 1 Publication
Sequence conflicti103 – 1064EAVW → DGTR in AAF67013. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF086628 mRNA. Translation: AAD13577.1.
AF086629 mRNA. Translation: AAD13578.1.
AF160212 mRNA. Translation: AAF67013.1.
AY358464 mRNA. Translation: AAQ88829.1.
AL035455 Genomic DNA. Translation: CAC15021.1.
AL035455 Genomic DNA. Translation: CAM27023.1.
BC001712 mRNA. Translation: AAH01712.1.
CCDSiCCDS33498.1. [O95292-1]
CCDS56198.1. [O95292-2]
PIRiJG0186.
RefSeqiNP_001182606.1. NM_001195677.1. [O95292-2]
NP_004729.1. NM_004738.4. [O95292-1]
UniGeneiHs.182625.

Genome annotation databases

EnsembliENST00000395802; ENSP00000379147; ENSG00000124164. [O95292-2]
ENST00000475243; ENSP00000417175; ENSG00000124164. [O95292-1]
GeneIDi9217.
KEGGihsa:9217.
UCSCiuc002xza.3. human. [O95292-1]
uc002xzd.2. human. [O95292-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Alsod

ALS genetic mutations db

Mendelian genes VAMP (vesicle-associated membrane protein)-associated protein B and C (VAPB)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF086628 mRNA. Translation: AAD13577.1 .
AF086629 mRNA. Translation: AAD13578.1 .
AF160212 mRNA. Translation: AAF67013.1 .
AY358464 mRNA. Translation: AAQ88829.1 .
AL035455 Genomic DNA. Translation: CAC15021.1 .
AL035455 Genomic DNA. Translation: CAM27023.1 .
BC001712 mRNA. Translation: AAH01712.1 .
CCDSi CCDS33498.1. [O95292-1 ]
CCDS56198.1. [O95292-2 ]
PIRi JG0186.
RefSeqi NP_001182606.1. NM_001195677.1. [O95292-2 ]
NP_004729.1. NM_004738.4. [O95292-1 ]
UniGenei Hs.182625.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2MDK NMR - A 1-125 [» ]
3IKK X-ray 2.50 A/B 1-125 [» ]
ProteinModelPortali O95292.
SMRi O95292. Positions 1-125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114650. 36 interactions.
IntActi O95292. 23 interactions.
STRINGi 9606.ENSP00000417175.

Protein family/group databases

TCDBi 9.B.17.1.1. the vamp-associated protein (vap) family.

PTM databases

PhosphoSitei O95292.

Proteomic databases

MaxQBi O95292.
PaxDbi O95292.
PRIDEi O95292.

Protocols and materials databases

DNASUi 9217.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395802 ; ENSP00000379147 ; ENSG00000124164 . [O95292-2 ]
ENST00000475243 ; ENSP00000417175 ; ENSG00000124164 . [O95292-1 ]
GeneIDi 9217.
KEGGi hsa:9217.
UCSCi uc002xza.3. human. [O95292-1 ]
uc002xzd.2. human. [O95292-2 ]

Organism-specific databases

CTDi 9217.
GeneCardsi GC20P056964.
GeneReviewsi VAPB.
HGNCi HGNC:12649. VAPB.
HPAi CAB013722.
HPA013144.
MIMi 182980. phenotype.
605704. gene.
608627. phenotype.
neXtProti NX_O95292.
Orphaneti 209335. Adult-onset proximal spinal muscular atrophy, autosomal dominant.
803. Amyotrophic lateral sclerosis.
PharmGKBi PA37273.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5066.
HOGENOMi HOG000293182.
HOVERGENi HBG028551.
InParanoidi O95292.
KOi K10707.
OMAi PHDIEIN.
OrthoDBi EOG7CK389.
PhylomeDBi O95292.
TreeFami TF317024.

Enzyme and pathway databases

Reactomei REACT_115810. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSi VAPB. human.
EvolutionaryTracei O95292.
GeneWikii VAPB.
GenomeRNAii 9217.
NextBioi 34553.
PROi O95292.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95292.
Bgeei O95292.
CleanExi HS_VAPB.
Genevestigatori O95292.

Family and domain databases

Gene3Di 2.60.40.360. 1 hit.
InterProi IPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view ]
Pfami PF00635. Motile_Sperm. 1 hit.
[Graphical view ]
PIRSFi PIRSF019693. VAMP-associated. 1 hit.
SUPFAMi SSF49354. SSF49354. 1 hit.
PROSITEi PS50202. MSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins."
    Nishimura Y., Hayashi M., Inada H., Tanaka T.
    Biochem. Biophys. Res. Commun. 254:21-26(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Heart.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adrenal gland.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph.
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-19.
    Tissue: Platelet.
  7. "Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B."
    Hamamoto I., Nishimura Y., Okamoto T., Aizaki H., Liu M., Mori Y., Abe T., Suzuki T., Lai M.M., Miyamura T., Moriishi K., Matsuura Y.
    J. Virol. 79:13473-13482(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HCV NS5A AND NS5B.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)."
    Kanekura K., Nishimoto I., Aiso S., Matsuoka M.
    J. Biol. Chem. 281:30223-30233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE, CHARACTERIZATION OF VARIANT ALS8 SER-56.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-150; SER-156 AND SER-160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  13. "Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein."
    Saita S., Shirane M., Natume T., Iemura S., Nakayama K.I.
    J. Biol. Chem. 284:13766-13777(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZFYVE27.
  14. "Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis."
    Chen H.J., Anagnostou G., Chai A., Withers J., Morris A., Adhikaree J., Pennetta G., de Belleroche J.S.
    J. Biol. Chem. 285:40266-40281(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE, VARIANT ALS8 ILE-46, CHARACTERIZATION OF VARIANTS ALS8 ILE-46 AND SER-56.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-150; SER-156 AND SER-160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis."
    De Vos K.J., Morotz G.M., Stoica R., Tudor E.L., Lau K.F., Ackerley S., Warley A., Shaw C.E., Miller C.C.
    Hum. Mol. Genet. 21:1299-1311(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CELLULAR CALCIUM HOMEOSTASIS REGULATION, SUBCELLULAR LOCATION, INTERACTION WITH RMDN3, CHARACTERIZATION OF VARIANT ALS8 SER-56.
  19. "A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis."
    Nishimura A.L., Mitne-Neto M., Silva H.C., Richieri-Costa A., Middleton S., Cascio D., Kok F., Oliveira J.R., Gillingwater T., Webb J., Skehel P., Zatz M.
    Am. J. Hum. Genet. 75:822-831(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ALS8 SER-56, VARIANT SMAPAD SER-56.

Entry informationi

Entry nameiVAPB_HUMAN
AccessioniPrimary (citable) accession number: O95292
Secondary accession number(s): A2A2F2, O95293, Q9P0H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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