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O95279

- KCNK5_HUMAN

UniProt

O95279 - KCNK5_HUMAN

Protein

Potassium channel subfamily K member 5

Gene

KCNK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K+ concentrations.

    GO - Molecular functioni

    1. potassium channel activity Source: ProtInc
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. excretion Source: ProtInc
    2. potassium ion transport Source: ProtInc

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Protein family/group databases

    TCDBi1.A.1.8.2. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily K member 5
    Alternative name(s):
    Acid-sensitive potassium channel protein TASK-2
    TWIK-related acid-sensitive K(+) channel 2
    Gene namesi
    Name:KCNK5
    Synonyms:TASK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6280. KCNK5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30062.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 499499Potassium channel subfamily K member 5PRO_0000101749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 – 51Interchain
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Modified residuei371 – 3711Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO95279.
    PRIDEiO95279.

    PTM databases

    PhosphoSiteiO95279.

    Expressioni

    Tissue specificityi

    Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.

    Gene expression databases

    BgeeiO95279.
    CleanExiHS_KCNK5.
    GenevestigatoriO95279.

    Organism-specific databases

    HPAiHPA059148.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.

    Protein-protein interaction databases

    BioGridi114197. 3 interactions.
    IntActiO95279. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO95279.
    SMRiO95279. Positions 19-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini134 – 15724CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 32575CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei85 – 11228Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
    BLAST
    Intramembranei190 – 21526Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2619HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 18023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG323264.
    HOGENOMiHOG000113211.
    HOVERGENiHBG052236.
    InParanoidiO95279.
    KOiK04916.
    OMAiPYEQLMN.
    OrthoDBiEOG7TTQ85.
    PhylomeDBiO95279.
    TreeFamiTF313947.

    Family and domain databases

    InterProiIPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    [Graphical view]
    PfamiPF07885. Ion_trans_2. 2 hits.
    [Graphical view]
    PRINTSiPR01333. 2POREKCHANEL.
    PR01095. TASKCHANNEL.

    Sequencei

    Sequence statusi: Complete.

    O95279-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDRGPLLTS AIIFYLAIGA AIFEVLEEPH WKEAKKNYYT QKLHLLKEFP    50
    CLGQEGLDKI LEVVSDAAGQ GVAITGNQTF NNWNWPNAMI FAATVITTIG 100
    YGNVAPKTPA GRLFCVFYGL FGVPLCLTWI SALGKFFGGR AKRLGQFLTK 150
    RGVSLRKAQI TCTVIFIVWG VLVHLVIPPF VFMVTEGWNY IEGLYYSFIT 200
    ISTIGFGDFV AGVNPSANYH ALYRYFVELW IYLGLAWLSL FVNWKVSMFV 250
    EVHKAIKKRR RRRKESFESS PHSRKALQVK GSTASKDVNI FSFLSKKEET 300
    YNDLIKQIGK KAMKTSGGGE TGPGPGLGPQ GGGLPALPPS LVPLVVYSKN 350
    RVPTLEEVSQ TLRSKGHVSR SPDEEAVARA PEDSSPAPEV FMNQLDRISE 400
    ECEPWDAQDY HPLIFQDASI TFVNTEAGLS DEETSKSSLE DNLAGEESPQ 450
    QGAEAKAPLN MGEFPSSSES TFTSTESELS VPYEQLMNEY NKANSPKGT 499
    Length:499
    Mass (Da):55,130
    Last modified:May 1, 1999 - v1
    Checksum:iE871A7A4823DDA00
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti423 – 4231V → A in BAG36953. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti465 – 4651P → T.
    Corresponds to variant rs9462487 [ dbSNP | Ensembl ].
    VAR_052425

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084830 mRNA. Translation: AAC79458.1.
    EU978936 mRNA. Translation: ACH86095.1.
    AK314298 mRNA. Translation: BAG36953.1.
    AL451185 Genomic DNA. Translation: CAH70466.1.
    CH471081 Genomic DNA. Translation: EAX03979.1.
    BC060793 mRNA. Translation: AAH60793.1.
    BC069573 mRNA. Translation: AAH69573.1.
    CCDSiCCDS4841.1.
    RefSeqiNP_003731.1. NM_003740.3.
    UniGeneiHs.444448.

    Genome annotation databases

    EnsembliENST00000359534; ENSP00000352527; ENSG00000164626.
    GeneIDi8645.
    KEGGihsa:8645.
    UCSCiuc003oon.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF084830 mRNA. Translation: AAC79458.1 .
    EU978936 mRNA. Translation: ACH86095.1 .
    AK314298 mRNA. Translation: BAG36953.1 .
    AL451185 Genomic DNA. Translation: CAH70466.1 .
    CH471081 Genomic DNA. Translation: EAX03979.1 .
    BC060793 mRNA. Translation: AAH60793.1 .
    BC069573 mRNA. Translation: AAH69573.1 .
    CCDSi CCDS4841.1.
    RefSeqi NP_003731.1. NM_003740.3.
    UniGenei Hs.444448.

    3D structure databases

    ProteinModelPortali O95279.
    SMRi O95279. Positions 19-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114197. 3 interactions.
    IntActi O95279. 1 interaction.

    Protein family/group databases

    TCDBi 1.A.1.8.2. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei O95279.

    Proteomic databases

    PaxDbi O95279.
    PRIDEi O95279.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359534 ; ENSP00000352527 ; ENSG00000164626 .
    GeneIDi 8645.
    KEGGi hsa:8645.
    UCSCi uc003oon.3. human.

    Organism-specific databases

    CTDi 8645.
    GeneCardsi GC06M039242.
    HGNCi HGNC:6280. KCNK5.
    HPAi HPA059148.
    MIMi 603493. gene.
    neXtProti NX_O95279.
    PharmGKBi PA30062.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323264.
    HOGENOMi HOG000113211.
    HOVERGENi HBG052236.
    InParanoidi O95279.
    KOi K04916.
    OMAi PYEQLMN.
    OrthoDBi EOG7TTQ85.
    PhylomeDBi O95279.
    TreeFami TF313947.

    Miscellaneous databases

    ChiTaRSi KCNK5. human.
    GeneWikii KCNK5.
    GenomeRNAii 8645.
    NextBioi 32411.
    PROi O95279.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95279.
    CleanExi HS_KCNK5.
    Genevestigatori O95279.

    Family and domain databases

    InterProi IPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    [Graphical view ]
    Pfami PF07885. Ion_trans_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01333. 2POREKCHANEL.
    PR01095. TASKCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney."
      Reyes R., Duprat F., Lesage F., Fink M., Salinas M., Farman N., Lazdunski M.
      J. Biol. Chem. 273:30863-30869(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein."
      Gierten J., Ficker E., Bloehs R., Schlomer K., Kathofer S., Scholz E., Zitron E., Kiesecker C., Bauer A., Becker R., Katus H.A., Karle C.A., Thomas D.
      Br. J. Pharmacol. 154:1680-1690(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    7. "Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity."
      Niemeyer M.I., Cid L.P., Valenzuela X., Paeile V., Sepulveda F.V.
      Mol. Membr. Biol. 20:185-191(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERCHAIN DISULFIDE BOND.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-371, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiKCNK5_HUMAN
    AccessioniPrimary (citable) accession number: O95279
    Secondary accession number(s): B2RAQ6, B5TJL2, Q5VV76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Inhibited by quinine, quinidine and external acidification.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3