##gff-version 3 O95278 UniProtKB Chain 1 331 . . . ID=PRO_0000094838;Note=Laforin O95278 UniProtKB Domain 1 124 . . . Note=CBM20;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00594 O95278 UniProtKB Domain 156 323 . . . Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160 O95278 UniProtKB Motif 266 272 . . . Note=Glucan phosphatase signature motif CXAGXGR;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:25544560,ECO:0000305|PubMed:26231210;Dbxref=PMID:25544560,PMID:26231210 O95278 UniProtKB Active site 266 266 . . . Note=Phosphocysteine intermediate;Ontology_term=ECO:0000255,ECO:0000305,ECO:0000305,ECO:0000305,ECO:0000305,ECO:0000305,ECO:0000305;evidence=ECO:0000255|PROSITE-ProRule:PRU00160,ECO:0000305|PubMed:11220751,ECO:0000305|PubMed:11739371,ECO:0000305|PubMed:14532330,ECO:0000305|PubMed:22036712,ECO:0000305|PubMed:25538239,ECO:0000305|PubMed:25544560;Dbxref=PMID:11220751,PMID:11739371,PMID:14532330,PMID:22036712,PMID:25538239,PMID:25544560 O95278 UniProtKB Binding site 32 32 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25544560,ECO:0007744|PDB:4RKK;Dbxref=PMID:25544560 O95278 UniProtKB Binding site 87 87 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25544560,ECO:0007744|PDB:4RKK;Dbxref=PMID:25544560 O95278 UniProtKB Binding site 103 107 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25544560,ECO:0007744|PDB:4RKK;Dbxref=PMID:25544560 O95278 UniProtKB Binding site 197 197 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25544560,ECO:0007744|PDB:4RKK;Dbxref=PMID:25544560 O95278 UniProtKB Binding site 235 235 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25544560,ECO:0007744|PDB:4RKK;Dbxref=PMID:25544560 O95278 UniProtKB Binding site 241 241 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25544560,ECO:0007744|PDB:4RKK;Dbxref=PMID:25544560 O95278 UniProtKB Binding site 267 272 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25544560,ECO:0007744|PDB:4RKK;Dbxref=PMID:25544560 O95278 UniProtKB Binding site 304 304 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:25544560,ECO:0007744|PDB:4RKK;Dbxref=PMID:25544560 O95278 UniProtKB Site 329 329 . . . Note=Required for homodimerization;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23922729;Dbxref=PMID:23922729 O95278 UniProtKB Modified residue 25 25 . . . Note=Phosphoserine%3B by AMPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21728993;Dbxref=PMID:21728993 O95278 UniProtKB Alternative sequence 1 243 . . . ID=VSP_042494;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 O95278 UniProtKB Alternative sequence 1 159 . . . ID=VSP_042495;Note=In isoform 7. MRFRFGVVVPPAVAGARPELLVVGSRPELGRWEPRGAVRLRPAGTAAGDGALALQEPGLWLGEVELAAEEAAQDGAEPGRVDTFWYKFLKREPGGELSWEGNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSR->MIFNK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 O95278 UniProtKB Alternative sequence 1 138 . . . ID=VSP_042493;Note=In isoform 8. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|Ref.4;Dbxref=PMID:14702039 O95278 UniProtKB Alternative sequence 102 199 . . . ID=VSP_011015;Note=In isoform 4. NGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIV->IASRRLPPAQSGSSGPHPQPGPRPRAGPAGPGGARPGLFARVPAHSPGDLG;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 O95278 UniProtKB Alternative sequence 160 293 . . . ID=VSP_042496;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95278 UniProtKB Alternative sequence 200 331 . . . ID=VSP_011016;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 O95278 UniProtKB Alternative sequence 294 331 . . . ID=VSP_042497;Note=In isoform 5. YFLMAKRPAVYIDEEALARAQEDFFQKFGKVRSSVCSL->PSTDAAPGGVPAACAAGEGTHRVRALQRWGGPLHRGCLRLAPVCDGLESEEGAVFPHGQEAGCLH;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95278 UniProtKB Alternative sequence 310 320 . . . ID=VSP_011017;Note=In isoform 2. LARAQEDFFQK->ASQDTFPL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9771710,ECO:0000303|PubMed:9931343;Dbxref=PMID:9771710,PMID:9931343 O95278 UniProtKB Alternative sequence 321 331 . . . ID=VSP_011018;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9771710,ECO:0000303|PubMed:9931343;Dbxref=PMID:9771710,PMID:9931343 O95278 UniProtKB Natural variant 25 25 . . . ID=VAR_019465;Note=In EPM2%3B atypical form%3B does not affect glycogen binding. S->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12019207,ECO:0000269|PubMed:14706656;Dbxref=PMID:12019207,PMID:14706656 O95278 UniProtKB Natural variant 28 28 . . . ID=VAR_019466;Note=In EPM2%3B does not affect glycogen binding. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14706656;Dbxref=dbSNP:rs1776816199,PMID:14706656 O95278 UniProtKB Natural variant 32 32 . . . ID=VAR_019467;Note=In EPM2%3B impairs protein stability%3B affects phosphatase activity%3B abolishes glycogen binding%3B abolishes phosphatase activity with insoluble glucan%3B disrupts the interaction with PPP1R3C. W->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11739371,ECO:0000269|PubMed:12019207,ECO:0000269|PubMed:14532330,ECO:0000269|PubMed:14706656,ECO:0000269|PubMed:25544560,ECO:0000269|PubMed:26231210;Dbxref=dbSNP:rs104893955,PMID:11739371,PMID:12019207,PMID:14532330,PMID:14706656,PMID:25544560,PMID:26231210 O95278 UniProtKB Natural variant 46 46 . . . ID=VAR_019468;Note=Does not affect glycogen binding. A->P;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11735300,ECO:0000269|PubMed:14706656,ECO:0000269|PubMed:16021330;Dbxref=dbSNP:rs374338349,PMID:11735300,PMID:14706656,PMID:16021330 O95278 UniProtKB Natural variant 84 84 . . . ID=VAR_019469;Note=In EPM2%3B affects phosphatase activity and glycogen binding%3B disrupts the interaction with PPP1R3C. F->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11175283,ECO:0000269|PubMed:14532330;Dbxref=dbSNP:rs1362231306,PMID:11175283,PMID:14532330 O95278 UniProtKB Natural variant 88 88 . . . ID=VAR_019470;Note=In EPM2%3B does not affect glycogen binding. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14706656;Dbxref=dbSNP:rs1034706422,dbSNP:rs1463000703,PMID:14706656 O95278 UniProtKB Natural variant 91 91 . . . ID=VAR_019471;Note=In EPM2%3B atypical form%3B learning difficuties with childhood-onset. R->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14722920,ECO:0000269|PubMed:15009235;Dbxref=PMID:14722920,PMID:15009235 O95278 UniProtKB Natural variant 108 108 . . . ID=VAR_019472;Note=In EPM2%3B loss of phosphatase activity%3B reduced self-interaction capacity%3B disrupts the interaction with PPP1R3C. R->C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12019207,ECO:0000269|PubMed:14532330,ECO:0000269|PubMed:9771710;Dbxref=dbSNP:rs137852915,PMID:12019207,PMID:14532330,PMID:9771710 O95278 UniProtKB Natural variant 114 114 . . . ID=VAR_019473;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9771710;Dbxref=PMID:9771710 O95278 UniProtKB Natural variant 140 140 . . . ID=VAR_046383;Note=In EPM2. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18311786;Dbxref=PMID:18311786 O95278 UniProtKB Natural variant 148 148 . . . ID=VAR_046384;Note=In EPM2. N->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18311786;Dbxref=PMID:18311786 O95278 UniProtKB Natural variant 171 171 . . . ID=VAR_019474;Note=In EPM2%3B results in ubiquitin-positive perinuclear aggregates%3B no effect on glycogen binding%3B abolishes phosphatase activity%3B may affect proper folding. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11001928,ECO:0000269|PubMed:12019207,ECO:0000269|PubMed:14722920,ECO:0000269|PubMed:25544560,ECO:0000269|PubMed:9931343;Dbxref=dbSNP:rs137852916,PMID:11001928,PMID:12019207,PMID:14722920,PMID:25544560,PMID:9931343 O95278 UniProtKB Natural variant 187 187 . . . ID=VAR_019475;Note=In EPM2%3B abolishes interaction with NHLRC1. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12560877;Dbxref=PMID:12560877 O95278 UniProtKB Natural variant 194 194 . . . ID=VAR_019476;Note=In EPM2%3B results in ubiquitin-positive perinuclear aggregates%3B loss of phosphatase activity%3B affects glycogen binding%3B reduced self-interaction capacity%3B abolishes interaction with NHLRC1%2C PPP1R3C and PRKAA2%3B no effect on phosphorylation of protein. T->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12019207,ECO:0000269|PubMed:14532330,ECO:0000269|PubMed:9931343;Dbxref=dbSNP:rs375544596,PMID:12019207,PMID:14532330,PMID:9931343 O95278 UniProtKB Natural variant 210 210 . . . ID=VAR_046385;Note=In EPM2. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18311786;Dbxref=PMID:18311786 O95278 UniProtKB Natural variant 240 240 . . . ID=VAR_019477;Note=In EPM2%3B impaired phosphatase activity%3B does not affect glycogen binding%3B disrupts the interaction with PPP1R3C. G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11175283,ECO:0000269|PubMed:14532330,ECO:0000269|PubMed:25544560;Dbxref=PMID:11175283,PMID:14532330,PMID:25544560 O95278 UniProtKB Natural variant 279 279 . . . ID=VAR_019478;Note=In EPM2%3B results in ubiquitin-positive perinuclear aggregates%3B loss of phosphatase activity%3B affects glycogen binding%3B disrupts the interaction with PPP1R3C. G->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12019207,ECO:0000269|PubMed:14532330,ECO:0000269|PubMed:14722920,ECO:0000269|PubMed:9771710,ECO:0000269|PubMed:9931343;Dbxref=dbSNP:rs137852917,PMID:12019207,PMID:14532330,PMID:14722920,PMID:9771710,PMID:9931343 O95278 UniProtKB Natural variant 293 293 . . . ID=VAR_019479;Note=In EPM2%3B results in ubiquitin-positive perinuclear aggregates%3B may affect proper folding%3B loss of phosphatase activity%3B affects glycogen binding%3B disrupts the interaction with PPP1R3C. Q->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11001928,ECO:0000269|PubMed:12019207,ECO:0000269|PubMed:14532330,ECO:0000269|PubMed:9771710;Dbxref=dbSNP:rs796052427,PMID:11001928,PMID:12019207,PMID:14532330,PMID:9771710 O95278 UniProtKB Natural variant 294 294 . . . ID=VAR_019480;Note=In EPM2%3B results in ubiquitin-positive perinuclear aggregates%3B impairs phosphatase activity%3B affects glycogen binding%3B disrupts the interaction with PPP1R3C. Y->N;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12019207,ECO:0000269|PubMed:14532330,ECO:0000269|PubMed:25544560,ECO:0000269|PubMed:9931343;Dbxref=PMID:12019207,PMID:14532330,PMID:25544560,PMID:9931343 O95278 UniProtKB Natural variant 301 301 . . . ID=VAR_019481;Note=In EPM2%3B impairs protein stability%3B impairs phosphatase activity%3B affects glycogen binding%3B disrupts the interaction with PPP1R3C. P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11175283,ECO:0000269|PubMed:14532330,ECO:0000269|PubMed:25544560;Dbxref=dbSNP:rs796052428,PMID:11175283,PMID:14532330,PMID:25544560 O95278 UniProtKB Natural variant 310 310 . . . ID=VAR_046386;Note=In EPM2%3B causes location of isoform 1 at cytoplasmic punctae%3B does not affect homodimerization of isoform 1 but prevents heterodimerization of isoform 1 and isoform 2. L->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18311786;Dbxref=PMID:18311786 O95278 UniProtKB Mutagenesis 8 8 . . . Note=Loss of phosphatase activity. No effect on glycogen binding. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25544560;Dbxref=PMID:25544560 O95278 UniProtKB Mutagenesis 25 25 . . . Note=Partial loss of phosphatase activity. Abolishes homodimerization. Abolishes interaction with NHLRC1%2C PPP1R3C and PRKAA2. Does not affect glycogen binding. Reduces stability of the protein. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21728993;Dbxref=PMID:21728993 O95278 UniProtKB Mutagenesis 25 25 . . . Note=Partial loss of phosphatase activity. Increases interaction with NHLRC1. Does not affect interaction with NHLRC1%2C PPP1R3C or PRKAA2. Does not affect binding to carbohydrate. Does not affect homodimerization. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21728993;Dbxref=PMID:21728993 O95278 UniProtKB Mutagenesis 87 87 . . . Note=Loss of phosphatase activity. Abolishes glycogen binding. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11739371,ECO:0000269|PubMed:25544560;Dbxref=PMID:11739371,PMID:25544560 O95278 UniProtKB Mutagenesis 99 99 . . . Note=Strongly reduces phosphatase activity. Strongly reduces glycogen binding. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25544560;Dbxref=PMID:25544560 O95278 UniProtKB Mutagenesis 109 110 . . . Note=No effect on homodimerization or carbohydrate binding. Decreased phosphatase activity. CC->SS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23922729;Dbxref=PMID:23922729 O95278 UniProtKB Mutagenesis 123 123 . . . Note=No effect on homodimerization or carbohydrate binding. Decreased phosphatase activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23922729;Dbxref=PMID:23922729 O95278 UniProtKB Mutagenesis 126 126 . . . Note=Strongly decreased phosphatase activity. No effect on glycogen binding. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25544560;Dbxref=PMID:25544560 O95278 UniProtKB Mutagenesis 142 142 . . . Note=Strongly decreased phosphatase activity. No effect on glycogen binding. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25544560;Dbxref=PMID:25544560 O95278 UniProtKB Mutagenesis 168 168 . . . Note=Abolishes interaction with NHLRC1. S->A%2CD;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21728993;Dbxref=PMID:21728993 O95278 UniProtKB Mutagenesis 169 169 . . . Note=No effect on homodimerization or carbohydrate binding. Decreased phosphatase activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23922729;Dbxref=PMID:23922729 O95278 UniProtKB Mutagenesis 169 169 . . . Note=No effect on phosphatase activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25538239;Dbxref=PMID:25538239 O95278 UniProtKB Mutagenesis 171 171 . . . Note=No effect on phosphatase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25538239;Dbxref=PMID:25538239 O95278 UniProtKB Mutagenesis 187 187 . . . Note=Abolishes interaction with NHLRC1. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21728993;Dbxref=PMID:21728993 O95278 UniProtKB Mutagenesis 194 194 . . . Note=Does not affect interaction with NHLRC1%2C PPP1R3C or PRKAA2. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21728993;Dbxref=PMID:21728993 O95278 UniProtKB Mutagenesis 197 197 . . . Note=Strongly decreased phosphatase activity. No effect on glycogen binding. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25538239,ECO:0000269|PubMed:25544560;Dbxref=PMID:25538239,PMID:25544560 O95278 UniProtKB Mutagenesis 205 205 . . . Note=No effect on homodimerization or carbohydrate binding. Decreased phosphatase activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23922729;Dbxref=PMID:23922729 O95278 UniProtKB Mutagenesis 235 235 . . . Note=Complete loss of phosphatase activity. Does not affect glycogen binding. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14532330,ECO:0000269|PubMed:25538239;Dbxref=PMID:14532330,PMID:25538239 O95278 UniProtKB Mutagenesis 236 236 . . . Note=Complete loss of phosphatase activity. No effect on glycogen binding. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25544560;Dbxref=PMID:25544560 O95278 UniProtKB Mutagenesis 250 250 . . . Note=No effect on homodimerization or carbohydrate binding. Decreased phosphatase activity. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23922729;Dbxref=PMID:23922729 O95278 UniProtKB Mutagenesis 251 251 . . . Note=Impairs protein stability. Strongly reduces phosphatase activity. No effect on glycogen binding. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25544560;Dbxref=PMID:25544560 O95278 UniProtKB Mutagenesis 266 266 . . . Note=Complete loss of phosphatase activity. Does not affect glycogen binding. Does not affect self-interaction. Increases the interaction with PPP1R3C. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11220751,ECO:0000269|PubMed:11739371,ECO:0000269|PubMed:14532330,ECO:0000269|PubMed:22036712,ECO:0000269|PubMed:23922729,ECO:0000269|PubMed:25538239,ECO:0000269|PubMed:25544560;Dbxref=PMID:11220751,PMID:11739371,PMID:14532330,PMID:22036712,PMID:23922729,PMID:25538239,PMID:25544560 O95278 UniProtKB Mutagenesis 272 272 . . . Note=Complete loss of phosphatase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25538239;Dbxref=PMID:25538239 O95278 UniProtKB Mutagenesis 321 321 . . . Note=Impairs protein stability. Strongly reduces phosphatase activity. No effect on glycogen binding. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25544560;Dbxref=PMID:25544560 O95278 UniProtKB Mutagenesis 329 331 . . . Note=Fails to homodimerize. Does not affect carbohydrate binding or phosphatase activity. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23922729;Dbxref=PMID:23922729 O95278 UniProtKB Mutagenesis 329 329 . . . Note=Fails to homodimerize. Does not affect carbohydrate binding%2C interaction with NHLRC1%2C phosphatase activity%2C or ubiquitination by NHLRC1. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23922729;Dbxref=PMID:23922729 O95278 UniProtKB Mutagenesis 329 329 . . . Note=No effect on homodimerization. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25538239;Dbxref=PMID:25538239 O95278 UniProtKB Sequence conflict 193 193 . . . Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95278 UniProtKB Sequence conflict 248 248 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95278 UniProtKB Sequence conflict 258 258 . . . Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95278 UniProtKB Sequence conflict 294 294 . . . Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 O95278 UniProtKB Beta strand 1 9 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Helix 11 14 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Beta strand 19 26 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Helix 27 29 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Turn 30 32 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Helix 34 36 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Beta strand 58 67 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Beta strand 84 91 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Beta strand 97 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Helix 104 106 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Beta strand 108 110 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Helix 114 116 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Beta strand 121 123 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Helix 138 151 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RKK O95278 UniProtKB Beta strand 157 161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Beta strand 164 167 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Helix 173 177 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Helix 178 183 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Beta strand 188 191 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Helix 195 201 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Helix 203 205 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Beta strand 208 210 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Helix 214 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Beta strand 227 230 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Helix 238 258 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Beta strand 262 265 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Helix 271 283 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Helix 289 296 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Beta strand 303 305 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30 O95278 UniProtKB Helix 307 321 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4R30