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Protein

Cyclin-D1-binding protein 1

Gene

CCNDBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-D1-binding protein 1
Alternative name(s):
Grap2 and cyclin-D-interacting protein
Human homolog of Maid
Gene namesi
Name:CCNDBP1
Synonyms:DIP1, GCIP, HHM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:1587. CCNDBP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23582.
OpenTargetsiENSG00000166946.
PharmGKBiPA26154.

Polymorphism and mutation databases

BioMutaiCCNDBP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003233722 – 360Cyclin-D1-binding protein 1Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95273.
MaxQBiO95273.
PaxDbiO95273.
PeptideAtlasiO95273.
PRIDEiO95273.

PTM databases

iPTMnetiO95273.
PhosphoSitePlusiO95273.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.5 Publications

Developmental stagei

Expression may increase during differentiation.1 Publication

Inductioni

Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation.1 Publication

Gene expression databases

BgeeiENSG00000166946.
ExpressionAtlasiO95273. baseline and differential.
GenevisibleiO95273. HS.

Organism-specific databases

HPAiCAB020664.
HPA041065.

Interactioni

Subunit structurei

Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
B0FTY23EBI-748961,EBI-10175366
B2R4U63EBI-748961,EBI-10175477
F4ZW623EBI-748961,EBI-10177680
Q5XG853EBI-748961,EBI-10248413
Q8N9J23EBI-748961,EBI-10268244
Q96BA23EBI-748961,EBI-10282278
AMPD2Q014333EBI-748961,EBI-8796759
ARHGAP22Q7Z5H33EBI-748961,EBI-3866859
ATP4BP511643EBI-748961,EBI-3904463
C22orf23Q9BZE73EBI-748961,EBI-10303102
C6orf226Q5I0X43EBI-748961,EBI-10244057
CCDC108Q6ZU64-33EBI-748961,EBI-10255250
CCDC146Q8IYE0-23EBI-748961,EBI-10247802
CDK18Q070023EBI-748961,EBI-746238
CNNM3Q8NE013EBI-748961,EBI-741032
COPS5Q929055EBI-748961,EBI-594661
CUL5Q930343EBI-748961,EBI-1057139
DMRT3Q9NQL93EBI-748961,EBI-9679045
DOCK2Q926083EBI-748961,EBI-448771
FAM110AQ9BQ893EBI-748961,EBI-1752811
FAM161AQ3B8204EBI-748961,EBI-719941
FAM64AQ9BSJ63EBI-748961,EBI-2568609
FAM74A6Q5TZK35EBI-748961,EBI-10247271
GSTK1Q9Y2Q33EBI-748961,EBI-1053767
ID2Q023634EBI-748961,EBI-713450
IMP3Q9NV315EBI-748961,EBI-747481
MAP2K2P365073EBI-748961,EBI-1056930
MOSP005403EBI-748961,EBI-1757866
MRPL15Q9P0156EBI-748961,EBI-2371967
NAIF1Q69YI73EBI-748961,EBI-10249231
NANOS2P603213EBI-748961,EBI-10216569
Neurod1Q608674EBI-748961,EBI-309315From a different organism.
PIAS2O759284EBI-748961,EBI-348555
PMP2P026893EBI-748961,EBI-10193858
PRPF31Q8WWY34EBI-748961,EBI-1567797
PSMB10P403064EBI-748961,EBI-603329
RBP5P829803EBI-748961,EBI-3941274
RPL28P467796EBI-748961,EBI-366357
RPL39LQ96EH53EBI-748961,EBI-6658607
RPLP0P053883EBI-748961,EBI-354101
RPS28P628573EBI-748961,EBI-353027
RRADP550425EBI-748961,EBI-3911502
SPG7Q9UQ903EBI-748961,EBI-717201
SYF2O959263EBI-748961,EBI-2557644
TCF3P15923-13EBI-748961,EBI-769645
TEAD4D3DUQ63EBI-748961,EBI-10176734
TFPTA0A024R4Q53EBI-748961,EBI-11527449
THAP10Q9P2Z04EBI-748961,EBI-745404
THAP7Q9BT493EBI-748961,EBI-741350
TMEM120BA0PK003EBI-748961,EBI-10171534
TRAPPC5Q8IUR05EBI-748961,EBI-3246160
TTC23Q5W5X93EBI-748961,EBI-6447954
TYMSOSQ8TAI13EBI-748961,EBI-742060
ZBTB24O431673EBI-748961,EBI-744471
ZGPATQ8N5A54EBI-748961,EBI-3439227
ZNF124Q159733EBI-748961,EBI-2555767
ZNF136P527374EBI-748961,EBI-749129
ZNF169Q149293EBI-748961,EBI-10234472
ZNF20P170245EBI-748961,EBI-717634
ZNF230Q9UIE03EBI-748961,EBI-1105361
ZNF334Q9HCZ13EBI-748961,EBI-748965
ZNF394Q53GI33EBI-748961,EBI-10211248
ZNF417Q8TAU33EBI-748961,EBI-740727
ZNF439Q8NDP43EBI-748961,EBI-747580
ZNF490Q9ULM23EBI-748961,EBI-1105370
ZNF555Q8NEP93EBI-748961,EBI-10270752
ZNF564Q8TBZ83EBI-748961,EBI-10273713
ZNF581Q9P0T43EBI-748961,EBI-745520
ZNF627Q7L9453EBI-748961,EBI-2797561
ZNF670Q9BS345EBI-748961,EBI-745276
ZNF697Q8N5083EBI-748961,EBI-10265733
ZNF707Q96C283EBI-748961,EBI-748111
ZSCAN26Q166703EBI-748961,EBI-3920053

Protein-protein interaction databases

BioGridi117117. 88 interactors.
IntActiO95273. 113 interactors.
MINTiMINT-1411177.
STRINGi9606.ENSP00000300213.

Structurei

Secondary structure

1360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 29Combined sources13
Helixi31 – 36Combined sources6
Helixi49 – 73Combined sources25
Beta strandi76 – 78Combined sources3
Helixi82 – 103Combined sources22
Helixi108 – 110Combined sources3
Helixi112 – 137Combined sources26
Helixi154 – 160Combined sources7
Turni161 – 164Combined sources4
Helixi169 – 197Combined sources29
Helixi235 – 265Combined sources31
Helixi271 – 295Combined sources25
Beta strandi296 – 298Combined sources3
Helixi301 – 324Combined sources24
Helixi335 – 352Combined sources18
Helixi353 – 358Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AY5X-ray2.50A1-360[»]
ProteinModelPortaliO95273.
SMRiO95273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 208Required for interaction with CCND1Add BLAST207
Regioni2 – 190Interaction with RPLP01 PublicationAdd BLAST189
Regioni2 – 184Interaction with TCF31 PublicationAdd BLAST183
Regioni150 – 360Interaction with TCF31 PublicationAdd BLAST211
Regioni240 – 360Interaction with RPLP01 PublicationAdd BLAST121

Sequence similaritiesi

Belongs to the CCNDBP1 family.Curated

Phylogenomic databases

eggNOGiENOG410II9T. Eukaryota.
ENOG410ZPHZ. LUCA.
GeneTreeiENSGT00390000018016.
HOVERGENiHBG107623.
InParanoidiO95273.
OMAiCMNRIKE.
OrthoDBiEOG091G0HT3.
PhylomeDBiO95273.
TreeFamiTF336444.

Family and domain databases

InterProiIPR026907. CCNDBP1.
[Graphical view]
PANTHERiPTHR15492. PTHR15492. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95273-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASATAPAAA VPTLASPLEQ LRHLAEELRL LLPRVRVGEA QETTEEFNRE
60 70 80 90 100
MFWRRLNEAA VTVSREATTL TIVFSQLPLP SPQETQKFCE QVHAAIKAFI
110 120 130 140 150
AVYYLLPKDQ GITLRKLVRG ATLDIVDGMA QLMEVLSVTP TQSPENNDLI
160 170 180 190 200
SYNSVWVACQ QMPQIPRDNK AAALLMLTKN VDFVKDAHEE MEQAVEECDP
210 220 230 240 250
YSGLLNDTEE NNSDNHNHED DVLGFPSNQD LYWSEDDQEL IIPCLALVRA
260 270 280 290 300
SKACLKKIRM LVAENGKKDQ VAQLDDIVDI SDEISPSVDD LALSIYPPMC
310 320 330 340 350
HLTVRINSAK LVSVLKKALE ITKASHVTPQ PEDSWIPLLI NAIDHCMNRI
360
KELTQSELEL
Length:360
Mass (Da):40,262
Last modified:March 18, 2008 - v2
Checksum:i40C7C3686632F6A7
GO
Isoform 2 (identifier: O95273-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-309: SA → EP
     310-360: Missing.

Note: No experimental confirmation available.
Show »
Length:309
Mass (Da):34,553
Checksum:iAD95CB0FFA840BED
GO
Isoform 3 (identifier: O95273-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Show »
Length:232
Mass (Da):26,038
Checksum:i358E6410BEF74DB4
GO
Isoform 4 (identifier: O95273-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.
     308-333: SAKLVSVLKKALEITKASHVTPQPED → VSTGFEGIATEQMGRISLITSISCK
     334-360: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):22,714
Checksum:iBA2C46B96005794A
GO

Sequence cautioni

The sequence AAD11777 differs from that shown. Reason: Frameshift at positions 8, 14 and 18.Curated
The sequence AAP97163 differs from that shown. Reason: Frameshift at positions 17 and 40.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40A → D in AAD11777 (PubMed:10854051).Curated1
Sequence conflicti41Q → R in AAP97163 (Ref. 4) Curated1
Sequence conflicti74F → S in BAC11433 (PubMed:16303743).Curated1
Sequence conflicti211N → S in BAC11433 (PubMed:16303743).Curated1
Sequence conflicti235E → G in BAF83396 (PubMed:14702039).Curated1
Sequence conflicti267K → R in BAC87645 (PubMed:14702039).Curated1
Sequence conflicti274L → M in AAD11777 (PubMed:10854051).Curated1
Sequence conflicti274L → M in AAF67182 (PubMed:10801854).Curated1
Sequence conflicti310K → R in BAC11530 (PubMed:14702039).Curated1
Sequence conflicti334S → I in BAF83354 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0320121 – 128Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST128
Alternative sequenceiVSP_032013308 – 333SAKLV…PQPED → VSTGFEGIATEQMGRISLIT SISCK in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_032014308 – 309SA → EP in isoform 2. 1 Publication2
Alternative sequenceiVSP_032015310 – 360Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_032016334 – 360Missing in isoform 4. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082569 mRNA. Translation: AAD11777.1. Frameshift.
AF132034 mRNA. Translation: AAF77613.1.
AF246144 mRNA. Translation: AAF67182.1.
AF087852 mRNA. Translation: AAP97163.1. Frameshift.
AF113535 mRNA. Translation: AAF14872.1.
CR450331 mRNA. Translation: CAG29327.1.
AK075296 mRNA. Translation: BAC11530.1.
AK128849 mRNA. Translation: BAC87645.1.
AK290665 mRNA. Translation: BAF83354.1.
AK290707 mRNA. Translation: BAF83396.1.
AK075146 mRNA. Translation: BAC11433.1.
CH471125 Genomic DNA. Translation: EAW92588.1.
CH471125 Genomic DNA. Translation: EAW92590.1.
BC009689 mRNA. Translation: AAH09689.1.
CCDSiCCDS10092.1. [O95273-1]
RefSeqiNP_036274.3. NM_012142.4. [O95273-1]
UniGeneiHs.36794.

Genome annotation databases

EnsembliENST00000300213; ENSP00000300213; ENSG00000166946. [O95273-1]
ENST00000565296; ENSP00000455419; ENSG00000166946. [O95273-2]
ENST00000566515; ENSP00000456797; ENSG00000166946. [O95273-2]
GeneIDi23582.
KEGGihsa:23582.
UCSCiuc001zqv.4. human. [O95273-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082569 mRNA. Translation: AAD11777.1. Frameshift.
AF132034 mRNA. Translation: AAF77613.1.
AF246144 mRNA. Translation: AAF67182.1.
AF087852 mRNA. Translation: AAP97163.1. Frameshift.
AF113535 mRNA. Translation: AAF14872.1.
CR450331 mRNA. Translation: CAG29327.1.
AK075296 mRNA. Translation: BAC11530.1.
AK128849 mRNA. Translation: BAC87645.1.
AK290665 mRNA. Translation: BAF83354.1.
AK290707 mRNA. Translation: BAF83396.1.
AK075146 mRNA. Translation: BAC11433.1.
CH471125 Genomic DNA. Translation: EAW92588.1.
CH471125 Genomic DNA. Translation: EAW92590.1.
BC009689 mRNA. Translation: AAH09689.1.
CCDSiCCDS10092.1. [O95273-1]
RefSeqiNP_036274.3. NM_012142.4. [O95273-1]
UniGeneiHs.36794.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AY5X-ray2.50A1-360[»]
ProteinModelPortaliO95273.
SMRiO95273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117117. 88 interactors.
IntActiO95273. 113 interactors.
MINTiMINT-1411177.
STRINGi9606.ENSP00000300213.

PTM databases

iPTMnetiO95273.
PhosphoSitePlusiO95273.

Polymorphism and mutation databases

BioMutaiCCNDBP1.

Proteomic databases

EPDiO95273.
MaxQBiO95273.
PaxDbiO95273.
PeptideAtlasiO95273.
PRIDEiO95273.

Protocols and materials databases

DNASUi23582.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300213; ENSP00000300213; ENSG00000166946. [O95273-1]
ENST00000565296; ENSP00000455419; ENSG00000166946. [O95273-2]
ENST00000566515; ENSP00000456797; ENSG00000166946. [O95273-2]
GeneIDi23582.
KEGGihsa:23582.
UCSCiuc001zqv.4. human. [O95273-1]

Organism-specific databases

CTDi23582.
DisGeNETi23582.
GeneCardsiCCNDBP1.
HGNCiHGNC:1587. CCNDBP1.
HPAiCAB020664.
HPA041065.
MIMi607089. gene.
neXtProtiNX_O95273.
OpenTargetsiENSG00000166946.
PharmGKBiPA26154.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II9T. Eukaryota.
ENOG410ZPHZ. LUCA.
GeneTreeiENSGT00390000018016.
HOVERGENiHBG107623.
InParanoidiO95273.
OMAiCMNRIKE.
OrthoDBiEOG091G0HT3.
PhylomeDBiO95273.
TreeFamiTF336444.

Miscellaneous databases

ChiTaRSiCCNDBP1. human.
GeneWikiiCCNDBP1.
GenomeRNAii23582.
PROiO95273.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166946.
ExpressionAtlasiO95273. baseline and differential.
GenevisibleiO95273. HS.

Family and domain databases

InterProiIPR026907. CCNDBP1.
[Graphical view]
PANTHERiPTHR15492. PTHR15492. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCDB1_HUMAN
AccessioniPrimary (citable) accession number: O95273
Secondary accession number(s): A8K3Q0
, A8K3U2, Q6ZQN9, Q7Z519, Q8NBS7, Q8NBY2, Q9NS19, Q9NYH3, Q9UHX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.