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O95273

- CCDB1_HUMAN

UniProt

O95273 - CCDB1_HUMAN

Protein

Cyclin-D1-binding protein 1

Gene

CCNDBP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. regulation of cell cycle Source: InterPro

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-D1-binding protein 1
    Alternative name(s):
    Grap2 and cyclin-D-interacting protein
    Human homolog of Maid
    Gene namesi
    Name:CCNDBP1
    Synonyms:DIP1, GCIP, HHM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:1587. CCNDBP1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26154.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 360359Cyclin-D1-binding protein 1PRO_0000323372Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Post-translational modificationi

    Phosphorylated.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO95273.
    PaxDbiO95273.
    PRIDEiO95273.

    PTM databases

    PhosphoSiteiO95273.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.5 Publications

    Developmental stagei

    Expression may increase during differentiation.1 Publication

    Inductioni

    Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation.1 Publication

    Gene expression databases

    ArrayExpressiO95273.
    BgeeiO95273.
    GenevestigatoriO95273.

    Organism-specific databases

    HPAiCAB020664.
    HPA041065.

    Interactioni

    Subunit structurei

    Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    COPS5Q929055EBI-748961,EBI-594661
    ID2Q023634EBI-748961,EBI-713450
    Neurod1Q608674EBI-748961,EBI-309315From a different organism.
    RRADP550425EBI-748961,EBI-3911502
    TCF3P15923-13EBI-748961,EBI-769645

    Protein-protein interaction databases

    BioGridi117117. 10 interactions.
    IntActiO95273. 21 interactions.
    MINTiMINT-1411177.

    Structurei

    Secondary structure

    1
    360
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi17 – 2913
    Helixi31 – 366
    Helixi49 – 7325
    Beta strandi76 – 783
    Helixi82 – 10322
    Helixi108 – 1103
    Helixi112 – 13726
    Helixi154 – 1607
    Turni161 – 1644
    Helixi169 – 19729
    Helixi235 – 26531
    Helixi271 – 29525
    Beta strandi296 – 2983
    Helixi301 – 32424
    Helixi335 – 35218
    Helixi353 – 3586

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3AY5X-ray2.50A1-360[»]
    ProteinModelPortaliO95273.
    SMRiO95273. Positions 14-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 208207Required for interaction with CCND1Add
    BLAST
    Regioni2 – 190189Interaction with RPLP0Add
    BLAST
    Regioni2 – 184183Interaction with TCF3Add
    BLAST
    Regioni150 – 360211Interaction with TCF3Add
    BLAST
    Regioni240 – 360121Interaction with RPLP0Add
    BLAST

    Sequence similaritiesi

    Belongs to the CCNDBP1 family.Curated

    Phylogenomic databases

    eggNOGiNOG19167.
    HOVERGENiHBG107623.
    InParanoidiO95273.
    OMAiCMNRIKE.
    OrthoDBiEOG70S75V.
    PhylomeDBiO95273.
    TreeFamiTF336444.

    Family and domain databases

    InterProiIPR026907. CCNDBP1.
    [Graphical view]
    PANTHERiPTHR15492. PTHR15492. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95273-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASATAPAAA VPTLASPLEQ LRHLAEELRL LLPRVRVGEA QETTEEFNRE    50
    MFWRRLNEAA VTVSREATTL TIVFSQLPLP SPQETQKFCE QVHAAIKAFI 100
    AVYYLLPKDQ GITLRKLVRG ATLDIVDGMA QLMEVLSVTP TQSPENNDLI 150
    SYNSVWVACQ QMPQIPRDNK AAALLMLTKN VDFVKDAHEE MEQAVEECDP 200
    YSGLLNDTEE NNSDNHNHED DVLGFPSNQD LYWSEDDQEL IIPCLALVRA 250
    SKACLKKIRM LVAENGKKDQ VAQLDDIVDI SDEISPSVDD LALSIYPPMC 300
    HLTVRINSAK LVSVLKKALE ITKASHVTPQ PEDSWIPLLI NAIDHCMNRI 350
    KELTQSELEL 360
    Length:360
    Mass (Da):40,262
    Last modified:March 18, 2008 - v2
    Checksum:i40C7C3686632F6A7
    GO
    Isoform 2 (identifier: O95273-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         308-309: SA → EP
         310-360: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:309
    Mass (Da):34,553
    Checksum:iAD95CB0FFA840BED
    GO
    Isoform 3 (identifier: O95273-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-128: Missing.

    Show »
    Length:232
    Mass (Da):26,038
    Checksum:i358E6410BEF74DB4
    GO
    Isoform 4 (identifier: O95273-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-128: Missing.
         308-333: SAKLVSVLKKALEITKASHVTPQPED → VSTGFEGIATEQMGRISLITSISCK
         334-360: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:204
    Mass (Da):22,714
    Checksum:iBA2C46B96005794A
    GO

    Sequence cautioni

    The sequence AAD11777.1 differs from that shown. Reason: Frameshift at positions 8, 14 and 18.
    The sequence AAP97163.1 differs from that shown. Reason: Frameshift at positions 17 and 40.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401A → D in AAD11777. (PubMed:10854051)Curated
    Sequence conflicti41 – 411Q → R in AAP97163. 1 PublicationCurated
    Sequence conflicti74 – 741F → S in BAC11433. (PubMed:16303743)Curated
    Sequence conflicti211 – 2111N → S in BAC11433. (PubMed:16303743)Curated
    Sequence conflicti235 – 2351E → G in BAF83396. (PubMed:14702039)Curated
    Sequence conflicti267 – 2671K → R in BAC87645. (PubMed:14702039)Curated
    Sequence conflicti274 – 2741L → M in AAD11777. (PubMed:10854051)Curated
    Sequence conflicti274 – 2741L → M in AAF67182. (PubMed:10801854)Curated
    Sequence conflicti310 – 3101K → R in BAC11530. (PubMed:14702039)Curated
    Sequence conflicti334 – 3341S → I in BAF83354. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 128128Missing in isoform 3 and isoform 4. 2 PublicationsVSP_032012Add
    BLAST
    Alternative sequencei308 – 33326SAKLV…PQPED → VSTGFEGIATEQMGRISLIT SISCK in isoform 4. 1 PublicationVSP_032013Add
    BLAST
    Alternative sequencei308 – 3092SA → EP in isoform 2. 1 PublicationVSP_032014
    Alternative sequencei310 – 36051Missing in isoform 2. 1 PublicationVSP_032015Add
    BLAST
    Alternative sequencei334 – 36027Missing in isoform 4. 1 PublicationVSP_032016Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF082569 mRNA. Translation: AAD11777.1. Frameshift.
    AF132034 mRNA. Translation: AAF77613.1.
    AF246144 mRNA. Translation: AAF67182.1.
    AF087852 mRNA. Translation: AAP97163.1. Frameshift.
    AF113535 mRNA. Translation: AAF14872.1.
    CR450331 mRNA. Translation: CAG29327.1.
    AK075296 mRNA. Translation: BAC11530.1.
    AK128849 mRNA. Translation: BAC87645.1.
    AK290665 mRNA. Translation: BAF83354.1.
    AK290707 mRNA. Translation: BAF83396.1.
    AK075146 mRNA. Translation: BAC11433.1.
    CH471125 Genomic DNA. Translation: EAW92588.1.
    CH471125 Genomic DNA. Translation: EAW92590.1.
    BC009689 mRNA. Translation: AAH09689.1.
    CCDSiCCDS10092.1. [O95273-1]
    RefSeqiNP_036274.3. NM_012142.4. [O95273-1]
    UniGeneiHs.36794.

    Genome annotation databases

    EnsembliENST00000300213; ENSP00000300213; ENSG00000166946. [O95273-1]
    ENST00000565296; ENSP00000455419; ENSG00000166946. [O95273-2]
    ENST00000566515; ENSP00000456797; ENSG00000166946. [O95273-2]
    GeneIDi23582.
    KEGGihsa:23582.
    UCSCiuc001zqv.3. human. [O95273-1]
    uc021sjs.1. human. [O95273-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF082569 mRNA. Translation: AAD11777.1 . Frameshift.
    AF132034 mRNA. Translation: AAF77613.1 .
    AF246144 mRNA. Translation: AAF67182.1 .
    AF087852 mRNA. Translation: AAP97163.1 . Frameshift.
    AF113535 mRNA. Translation: AAF14872.1 .
    CR450331 mRNA. Translation: CAG29327.1 .
    AK075296 mRNA. Translation: BAC11530.1 .
    AK128849 mRNA. Translation: BAC87645.1 .
    AK290665 mRNA. Translation: BAF83354.1 .
    AK290707 mRNA. Translation: BAF83396.1 .
    AK075146 mRNA. Translation: BAC11433.1 .
    CH471125 Genomic DNA. Translation: EAW92588.1 .
    CH471125 Genomic DNA. Translation: EAW92590.1 .
    BC009689 mRNA. Translation: AAH09689.1 .
    CCDSi CCDS10092.1. [O95273-1 ]
    RefSeqi NP_036274.3. NM_012142.4. [O95273-1 ]
    UniGenei Hs.36794.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3AY5 X-ray 2.50 A 1-360 [» ]
    ProteinModelPortali O95273.
    SMRi O95273. Positions 14-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117117. 10 interactions.
    IntActi O95273. 21 interactions.
    MINTi MINT-1411177.

    PTM databases

    PhosphoSitei O95273.

    Proteomic databases

    MaxQBi O95273.
    PaxDbi O95273.
    PRIDEi O95273.

    Protocols and materials databases

    DNASUi 23582.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300213 ; ENSP00000300213 ; ENSG00000166946 . [O95273-1 ]
    ENST00000565296 ; ENSP00000455419 ; ENSG00000166946 . [O95273-2 ]
    ENST00000566515 ; ENSP00000456797 ; ENSG00000166946 . [O95273-2 ]
    GeneIDi 23582.
    KEGGi hsa:23582.
    UCSCi uc001zqv.3. human. [O95273-1 ]
    uc021sjs.1. human. [O95273-4 ]

    Organism-specific databases

    CTDi 23582.
    GeneCardsi GC15P043477.
    HGNCi HGNC:1587. CCNDBP1.
    HPAi CAB020664.
    HPA041065.
    MIMi 607089. gene.
    neXtProti NX_O95273.
    PharmGKBi PA26154.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG19167.
    HOVERGENi HBG107623.
    InParanoidi O95273.
    OMAi CMNRIKE.
    OrthoDBi EOG70S75V.
    PhylomeDBi O95273.
    TreeFami TF336444.

    Miscellaneous databases

    ChiTaRSi CCNDBP1. human.
    GeneWikii CCNDBP1.
    GenomeRNAii 23582.
    NextBioi 46190.
    PROi O95273.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95273.
    Bgeei O95273.
    Genevestigatori O95273.

    Family and domain databases

    InterProi IPR026907. CCNDBP1.
    [Graphical view ]
    PANTHERi PTHR15492. PTHR15492. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins."
      Yao Y., Doki Y., Jiang W., Imoto M., Venkatraj V.S., Warburton D., Santella R.M., Lu B., Yan L., Sun X.-H., Su T., Luo J., Weinstein I.B.
      Exp. Cell Res. 257:22-32(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CCND1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, PHOSPHORYLATION.
    2. "Human homologue of maid: a dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression."
      Terai S., Aoki H., Thorgeirsson S.S.
      Hepatology 32:357-366(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TCF3, TISSUE SPECIFICITY.
      Tissue: Liver.
    3. "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity."
      Xia C., Bao Z., Tabassam F., Ma W., Qiu M., Hua S., Liu M.
      J. Biol. Chem. 275:20942-20948(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CCND1 AND GRAP2, TISSUE SPECIFICITY.
      Tissue: Liver.
    4. "Cloning and characterization of a novel human cDNA homologous to murine Maid mRNA."
      Gao J., Yu L., Mao N.H., Wan Y.Z., Yang Y.M., Zhao S.Y.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Hypothalamus.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: Hair follicle dermal papilla, Lung, Retinoblastoma and Trachea.
    8. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreas.
    11. "p29, a novel GCIP-interacting protein, localizes in the nucleus."
      Chang M.-S., Chang C.-L., Huang C.-J., Yang Y.-C.
      Biochem. Biophys. Res. Commun. 279:732-737(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SYF2.
    12. Cited for: TISSUE SPECIFICITY, INTERACTION WITH COPS5.
    13. "GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis."
      Ma W., Stafford L.J., Li D., Luo J., Li X., Ning G., Liu M.
      J. Cell. Biochem. 100:1376-1386(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SIRT6, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    14. "Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells."
      Chang T.-W., Chen C.-C., Chen K.-Y., Su J.-H., Chang J.-H., Chang M.-C.
      Oncogene 27:332-338(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RPLP0, SUBCELLULAR LOCATION.
    15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCCDB1_HUMAN
    AccessioniPrimary (citable) accession number: O95273
    Secondary accession number(s): A8K3Q0
    , A8K3U2, Q6ZQN9, Q7Z519, Q8NBS7, Q8NBY2, Q9NS19, Q9NYH3, Q9UHX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3