Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O95267

- GRP1_HUMAN

UniProt

O95267 - GRP1_HUMAN

Protein

RAS guanyl-releasing protein 1

Gene

RASGRP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation.7 Publications

    Enzyme regulationi

    Probably regulated by calcium By similarity. Regulated by PLC gamma, DGKA, DGKZ and by F-actin polymerization.By similarity3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi483 – 494121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi510 – 521122PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri541 – 59151Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: ProtInc
    2. guanyl-nucleotide exchange factor activity Source: Reactome
    3. lipid binding Source: ProtInc

    GO - Biological processi

    1. activation of Rho GTPase activity Source: Ensembl
    2. blood coagulation Source: Reactome
    3. cell differentiation Source: UniProtKB-KW
    4. cytokine production Source: Ensembl
    5. Fc-epsilon receptor signaling pathway Source: Reactome
    6. inflammatory response to antigenic stimulus Source: Ensembl
    7. innate immune response Source: Reactome
    8. mast cell degranulation Source: Ensembl
    9. platelet activation Source: Reactome
    10. Ras protein signal transduction Source: ProtInc
    11. regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    12. secretory granule localization Source: Ensembl
    13. signal transduction Source: ProtInc
    14. vesicle transport along microtubule Source: Ensembl

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_118778. Activation of RAS in B cells.
    REACT_15523. Integrin alphaIIb beta3 signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    REACT_2202. Effects of PIP2 hydrolysis.
    REACT_23898. Rap1 signalling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RAS guanyl-releasing protein 1
    Alternative name(s):
    Calcium and DAG-regulated guanine nucleotide exchange factor II
    Short name:
    CalDAG-GEFII
    Ras guanyl-releasing protein
    Gene namesi
    Name:RASGRP1
    Synonyms:RASGRP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:9878. RASGRP1.

    Subcellular locationi

    Cytoplasmcytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein
    Note: Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells By similarity.By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. Golgi membrane Source: UniProtKB-SubCell
    4. mast cell granule Source: GOC
    5. membrane Source: ProtInc
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi271 – 2711R → E: Loss of function; prevents Ras activation. 1 Publication
    Mutagenesisi549 – 5491Y → F: Loss of localization to the endoplasmic reticulum and the Golgi apparatus. 1 Publication

    Keywords - Diseasei

    Systemic lupus erythematosus

    Organism-specific databases

    MIMi152700. phenotype.
    PharmGKBiPA34240.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 797797RAS guanyl-releasing protein 1PRO_0000316978Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei184 – 1841Phosphothreonine; by PKC2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95267.
    PaxDbiO95267.
    PRIDEiO95267.

    PTM databases

    PhosphoSiteiO95267.

    Expressioni

    Tissue specificityi

    Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level).3 Publications

    Developmental stagei

    Expressed in fetal brain and kidney.1 Publication

    Gene expression databases

    ArrayExpressiO95267.
    BgeeiO95267.
    GenevestigatoriO95267.

    Interactioni

    Subunit structurei

    Forms a signaling complex with DGKZ and HRAS. Interacts with F-actin. Interacts with SKAP1.3 Publications

    Protein-protein interaction databases

    BioGridi115429. 5 interactions.
    IntActiO95267. 1 interaction.
    MINTiMINT-7970969.

    Structurei

    Secondary structure

    1
    797
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi62 – 7110
    Helixi84 – 929
    Helixi93 – 953
    Helixi99 – 11517
    Helixi119 – 13517
    Helixi138 – 1425
    Helixi144 – 16017
    Helixi164 – 1685
    Helixi172 – 1798
    Beta strandi201 – 2033
    Helixi206 – 22217
    Helixi226 – 2349
    Helixi242 – 26423
    Turni267 – 2693
    Helixi270 – 28718
    Helixi291 – 30111
    Helixi304 – 3074
    Helixi310 – 3156
    Helixi318 – 33114
    Turni335 – 3373
    Helixi338 – 3458
    Helixi355 – 36814
    Beta strandi376 – 3783
    Helixi380 – 39516
    Helixi396 – 3983
    Helixi407 – 41610
    Helixi423 – 43311
    Helixi464 – 48219
    Helixi492 – 5009
    Helixi519 – 53315
    Beta strandi544 – 5474
    Turni556 – 5583
    Beta strandi564 – 5663
    Beta strandi569 – 5724
    Turni573 – 5753
    Turni581 – 5833
    Beta strandi584 – 5863
    Helixi748 – 78235
    Turni783 – 7853
    Helixi788 – 7914

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4L9MX-ray3.00A50-607[»]
    4L9UX-ray1.60A/B739-793[»]
    ProteinModelPortaliO95267.
    SMRiO95267. Positions 53-593, 745-793.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 176124N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini205 – 436232Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini470 – 50536EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini497 – 53236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 11054Ras exchanger motif region; required for transforming activityBy similarityAdd
    BLAST
    Regioni686 – 6949Suppress the PT region-mediated translocation to plasma membraneBy similarity
    Regioni718 – 79780PT region; mediates the BCR-dependent translocation to plasma membraneBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili746 – 78641Sequence AnalysisAdd
    BLAST

    Domaini

    The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required for functional activation through DAG-binding.

    Sequence similaritiesi

    Belongs to the RASGRP family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri541 – 59151Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG256085.
    HOVERGENiHBG007513.
    InParanoidiO95267.
    KOiK04350.
    OrthoDBiEOG72G16V.
    PhylomeDBiO95267.
    TreeFamiTF312918.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.840.10. 1 hit.
    InterProiIPR020454. DAG/PE-bd.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF13405. EF-hand_6. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    PRINTSiPR00008. DAGPEDOMAIN.
    SMARTiSM00109. C1. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist. Several splicing events may be used independently in a modular way.

    Isoform 1 (identifier: O95267-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGTLGKAREA PRKPSHGCRA ASKARLEAKP ANSPFPSHPS LAHITQFRMM    50
    VSLGHLAKGA SLDDLIDSCI QSFDADGNLC RSNQLLQVML TMHRIVISSA 100
    ELLQKVITLY KDALAKNSPG LCLKICYFVR YWITEFWVMF KMDASLTDTM 150
    EEFQELVKAK GEELHCRLID TTQINARDWS RKLTQRIKSN TSKKRKVSLL 200
    FDHLEPEELS EHLTYLEFKS FRRISFSDYQ NYLVNSCVKE NPTMERSIAL 250
    CNGISQWVQL MVLSRPTPQL RAEVFIKFIQ VAQKLHQLQN FNTLMAVIGG 300
    LCHSSISRLK ETSSHVPHEI NKVLGEMTEL LSSSRNYDNY RRAYGECTDF 350
    KIPILGVHLK DLISLYEAMP DYLEDGKVNV HKLLALYNHI SELVQLQEVA 400
    PPLEANKDLV HLLTLSLDLY YTEDEIYELS YAREPRNHRA PPLTPSKPPV 450
    VVDWASGVSP KPDPKTISKH VQRMVDSVFK NYDHDQDGYI SQEEFEKIAA 500
    SFPFSFCVMD KDREGLISRD EITAYFMRAS SIYSKLGLGF PHNFQETTYL 550
    KPTFCDNCAG FLWGVIKQGY RCKDCGMNCH KQCKDLVVFE CKKRAKNPVA 600
    PTENNTSVGP VSNLCSLGAK DLLHAPEEGP FTFPNGEAVE HGEESKDRTI 650
    MLMGVSSQKI SLRLKRAVAH KATQTESQPW IGSEGPSGPF VLSSPRKTAQ 700
    DTLYVLPSPT SPCPSPVLVR KRAFVKWENK DSLIKSKEEL RHLRLPTYQE 750
    LEQEINTLKA DNDALKIQLK YAQKKIESLQ LEKSNHVLAQ MEQGDCS 797
    Length:797
    Mass (Da):90,402
    Last modified:February 5, 2008 - v2
    Checksum:i8ACDCF0F715ABAA9
    GO
    Isoform 2 (identifier: O95267-2) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         442-476: Missing.

    Show »
    Length:762
    Mass (Da):86,625
    Checksum:iC3ACFFF5888E3236
    GO
    Isoform 3 (identifier: O95267-3) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         442-476: Missing.
         625-632: APEEGPFT → GNKYSESR
         633-797: Missing.

    Show »
    Length:597
    Mass (Da):68,170
    Checksum:i979AEA31D0FBE5DC
    GO
    Isoform 4 (identifier: O95267-4) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         442-476: Missing.
         513-516: REGL → SSGE
         517-797: Missing.

    Show »
    Length:481
    Mass (Da):55,100
    Checksum:i11408850F4E84118
    GO
    Isoform 5 (identifier: O95267-5) [UniParc]FASTAAdd to Basket

    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         442-476: Missing.
         574-581: DCGMNCHK → GNKYSESR
         582-797: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:546
    Mass (Da):62,674
    Checksum:i54018A113532AF92
    GO

    Sequence cautioni

    The sequence AAH67298.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti374 – 3741E → G in AAC79699. (PubMed:9789079)Curated
    Sequence conflicti374 – 3741E → G in AAF21898. (PubMed:9789079)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei442 – 47635Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsVSP_030836Add
    BLAST
    Alternative sequencei513 – 5164REGL → SSGE in isoform 4. 1 PublicationVSP_030837
    Alternative sequencei517 – 797281Missing in isoform 4. 1 PublicationVSP_030838Add
    BLAST
    Alternative sequencei574 – 5818DCGMNCHK → GNKYSESR in isoform 5. 1 PublicationVSP_030839
    Alternative sequencei582 – 797216Missing in isoform 5. 1 PublicationVSP_030840Add
    BLAST
    Alternative sequencei625 – 6328APEEGPFT → GNKYSESR in isoform 3. 1 PublicationVSP_030841
    Alternative sequencei633 – 797165Missing in isoform 3. 1 PublicationVSP_030842Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081195 mRNA. Translation: AAC79699.1.
    AF081197 mRNA. Translation: AAF21898.1.
    AF106071 mRNA. Translation: AAC97349.1.
    AY634315 mRNA. Translation: AAT47482.2.
    AY858556 mRNA. Translation: AAW32406.2.
    AY954625 mRNA. Translation: AAX54699.4.
    AY966005 mRNA. Translation: AAX76907.1.
    BC067298 mRNA. Translation: AAH67298.1. Sequence problems.
    BC109296 mRNA. Translation: AAI09297.1.
    BC109297 mRNA. Translation: AAI09298.1.
    AB208848 mRNA. Translation: BAD92085.1.
    CCDSiCCDS45221.1. [O95267-2]
    CCDS45222.1. [O95267-1]
    RefSeqiNP_001122074.1. NM_001128602.1. [O95267-2]
    NP_005730.2. NM_005739.3. [O95267-1]
    UniGeneiHs.591127.

    Genome annotation databases

    GeneIDi10125.
    KEGGihsa:10125.
    UCSCiuc001zkd.4. human. [O95267-2]
    uc001zke.4. human. [O95267-1]
    uc010bbf.3. human. [O95267-3]
    uc010bbg.3. human. [O95267-5]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081195 mRNA. Translation: AAC79699.1 .
    AF081197 mRNA. Translation: AAF21898.1 .
    AF106071 mRNA. Translation: AAC97349.1 .
    AY634315 mRNA. Translation: AAT47482.2 .
    AY858556 mRNA. Translation: AAW32406.2 .
    AY954625 mRNA. Translation: AAX54699.4 .
    AY966005 mRNA. Translation: AAX76907.1 .
    BC067298 mRNA. Translation: AAH67298.1 . Sequence problems.
    BC109296 mRNA. Translation: AAI09297.1 .
    BC109297 mRNA. Translation: AAI09298.1 .
    AB208848 mRNA. Translation: BAD92085.1 .
    CCDSi CCDS45221.1. [O95267-2 ]
    CCDS45222.1. [O95267-1 ]
    RefSeqi NP_001122074.1. NM_001128602.1. [O95267-2 ]
    NP_005730.2. NM_005739.3. [O95267-1 ]
    UniGenei Hs.591127.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4L9M X-ray 3.00 A 50-607 [» ]
    4L9U X-ray 1.60 A/B 739-793 [» ]
    ProteinModelPortali O95267.
    SMRi O95267. Positions 53-593, 745-793.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115429. 5 interactions.
    IntActi O95267. 1 interaction.
    MINTi MINT-7970969.

    Chemistry

    ChEMBLi CHEMBL5953.

    PTM databases

    PhosphoSitei O95267.

    Proteomic databases

    MaxQBi O95267.
    PaxDbi O95267.
    PRIDEi O95267.

    Protocols and materials databases

    DNASUi 10125.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10125.
    KEGGi hsa:10125.
    UCSCi uc001zkd.4. human. [O95267-2 ]
    uc001zke.4. human. [O95267-1 ]
    uc010bbf.3. human. [O95267-3 ]
    uc010bbg.3. human. [O95267-5 ]

    Organism-specific databases

    CTDi 10125.
    GeneCardsi GC15M038780.
    H-InvDB HIX0038076.
    HGNCi HGNC:9878. RASGRP1.
    MIMi 152700. phenotype.
    603962. gene.
    neXtProti NX_O95267.
    PharmGKBi PA34240.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256085.
    HOVERGENi HBG007513.
    InParanoidi O95267.
    KOi K04350.
    OrthoDBi EOG72G16V.
    PhylomeDBi O95267.
    TreeFami TF312918.

    Enzyme and pathway databases

    Reactomei REACT_118778. Activation of RAS in B cells.
    REACT_15523. Integrin alphaIIb beta3 signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    REACT_2202. Effects of PIP2 hydrolysis.
    REACT_23898. Rap1 signalling.

    Miscellaneous databases

    GeneWikii RASGRP1.
    GenomeRNAii 10125.
    NextBioi 38299.
    PROi O95267.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95267.
    Bgeei O95267.
    Genevestigatori O95267.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.840.10. 1 hit.
    InterProi IPR020454. DAG/PE-bd.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF13405. EF-hand_6. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00008. DAGPEDOMAIN.
    SMARTi SM00109. C1. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Frontal cortex.
    2. "RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions."
      Bottorff D.A., Ebinu J.O., Stone J.C.
      Mamm. Genome 10:358-361(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: T-cell.
    3. "Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus."
      Yasuda S., Stevens R.L., Terada T., Takeda M., Hashimoto T., Fukae J., Horita T., Kataoka H., Atsumi T., Koike T.
      J. Immunol. 179:4890-4900(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS, TISSUE SPECIFICITY.
      Tissue: Peripheral blood.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-797 (ISOFORM 2).
      Tissue: Brain.
    6. "RasGRP links T-cell receptor signaling to Ras."
      Ebinu J.O., Stang S.L., Teixeira C., Bottorff D.A., Hooton J., Blumberg P.M., Barry M., Bleakley R.C., Ostergaard H.L., Stone J.C.
      Blood 95:3199-3203(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN T-CELL RECEPTOR SIGNALING, TOPOLOGY, TISSUE SPECIFICITY.
    7. "Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism."
      Topham M.K., Prescott S.M.
      J. Cell Biol. 152:1135-1143(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH DGKZ AND HRAS, ENZYME REGULATION.
    8. "Expression of a catalytically inactive form of diacylglycerol kinase alpha induces sustained signaling through RasGRP."
      Jones D.R., Sanjuan M.A., Stone J.C., Merida I.
      FASEB J. 16:595-597(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.
    9. "Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1."
      Caloca M.J., Zugaza J.L., Matallanas D., Crespo P., Bustelo X.R.
      EMBO J. 22:3326-3336(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN B-CELLS, SUBCELLULAR LOCATION, INTERACTION WITH F-ACTIN, ENZYME REGULATION.
    10. "Exchange factors of the RasGRP family mediate Ras activation in the Golgi."
      Caloca M.J., Zugaza J.L., Bustelo X.R.
      J. Biol. Chem. 278:33465-33473(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-549.
    11. Cited for: FUNCTION, MUTAGENESIS OF ARG-271.
    12. "Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus."
      Perez de Castro I., Bivona T.G., Philips M.R., Pellicer A.
      Mol. Cell. Biol. 24:3485-3496(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    13. "Inverted signaling hierarchy between RAS and RAC in T-lymphocytes."
      Zugaza J.L., Caloca M.J., Bustelo X.R.
      Oncogene 23:5823-5833(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    14. "Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells."
      Zheng Y., Liu H., Coughlin J.J., Zheng J., Li L., Stone J.C.
      Blood 105:3648-3654(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-184 BY PKC.
    15. "A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells."
      Roose J.P., Mollenauer M., Gupta V.A., Stone J.C., Weiss A.
      Mol. Cell. Biol. 25:4426-4441(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT THR-184.
    16. "SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1."
      Kosco K.A., Cerignoli F., Williams S., Abraham R.T., Mustelin T.
      Mol. Immunol. 45:510-522(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SKAP1.

    Entry informationi

    Entry nameiGRP1_HUMAN
    AccessioniPrimary (citable) accession number: O95267
    Secondary accession number(s): Q56CZ0
    , Q58G75, Q59HB1, Q5I3A8, Q6GV31, Q6NX39, Q7LDG6, Q9UI94, Q9UNN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3