Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O95267 (GRP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RAS guanyl-releasing protein 1
Alternative name(s):
Calcium and DAG-regulated guanine nucleotide exchange factor II
Short name=CalDAG-GEFII
Ras guanyl-releasing protein
Gene names
Name:RASGRP1
Synonyms:RASGRP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length797 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation. Ref.6 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.15

Enzyme regulation

Probably regulated by calcium By similarity. Regulated by PLC gamma, DGKA, DGKZ and by F-actin polymerization. Ref.7 Ref.8 Ref.9

Subunit structure

Forms a signaling complex with DGKZ and HRAS. Interacts with F-actin. Interacts with SKAP1. Ref.7 Ref.9 Ref.16

Subcellular location

Cytoplasmcytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note: Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells By similarity. Ref.9 Ref.10 Ref.12 Ref.13

Tissue specificity

Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Ref.1 Ref.3 Ref.6

Developmental stage

Expressed in fetal brain and kidney. Ref.1

Domain

The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required for functional activation through DAG-binding.

Involvement in disease

Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.

Sequence similarities

Belongs to the RASGRP family.

Contains 2 EF-hand domains.

Contains 1 N-terminal Ras-GEF domain.

Contains 1 phorbol-ester/DAG-type zinc finger.

Contains 1 Ras-GEF domain.

Sequence caution

The sequence AAH67298.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentCell membrane
Cytoplasm
Endoplasmic reticulum
Golgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
   DiseaseSystemic lupus erythematosus
   DomainCoiled coil
Repeat
Zinc-finger
   LigandCalcium
Metal-binding
Zinc
   Molecular functionGuanine-nucleotide releasing factor
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processFc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

Ras protein signal transduction

Traceable author statement PubMed 9582122. Source: ProtInc

activation of Rho GTPase activity

Inferred from electronic annotation. Source: Ensembl

blood coagulation

Traceable author statement. Source: Reactome

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

cytokine production

Inferred from electronic annotation. Source: Ensembl

inflammatory response to antigenic stimulus

Inferred from electronic annotation. Source: Ensembl

innate immune response

Traceable author statement. Source: Reactome

mast cell degranulation

Inferred from electronic annotation. Source: Ensembl

platelet activation

Traceable author statement. Source: Reactome

regulation of phosphatidylinositol 3-kinase signaling

Inferred from electronic annotation. Source: Ensembl

secretory granule localization

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement Ref.1. Source: ProtInc

vesicle transport along microtubule

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

cytosol

Traceable author statement. Source: Reactome

endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

mast cell granule

Inferred from electronic annotation. Source: GOC

membrane

Traceable author statement PubMed 9582122. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functioncalcium ion binding

Traceable author statement PubMed 9582122. Source: ProtInc

guanyl-nucleotide exchange factor activity

Traceable author statement. Source: Reactome

lipid binding

Traceable author statement PubMed 9582122. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist. Several splicing events may be used independently in a modular way.
Isoform 1 (identifier: O95267-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95267-2)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     442-476: Missing.
Isoform 3 (identifier: O95267-3)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     442-476: Missing.
     625-632: APEEGPFT → GNKYSESR
     633-797: Missing.
Isoform 4 (identifier: O95267-4)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     442-476: Missing.
     513-516: REGL → SSGE
     517-797: Missing.
Isoform 5 (identifier: O95267-5)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     442-476: Missing.
     574-581: DCGMNCHK → GNKYSESR
     582-797: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 797797RAS guanyl-releasing protein 1
PRO_0000316978

Regions

Domain53 – 176124N-terminal Ras-GEF
Domain205 – 436232Ras-GEF
Domain470 – 50536EF-hand 1
Domain497 – 53236EF-hand 2
Calcium binding483 – 494121 Potential
Calcium binding510 – 521122 Potential
Zinc finger541 – 59151Phorbol-ester/DAG-type
Region57 – 11054Ras exchanger motif region; required for transforming activity By similarity
Region686 – 6949Suppress the PT region-mediated translocation to plasma membrane By similarity
Region718 – 79780PT region; mediates the BCR-dependent translocation to plasma membrane By similarity
Coiled coil746 – 78641 Potential

Amino acid modifications

Modified residue1841Phosphothreonine; by PKC Ref.14 Ref.15

Natural variations

Alternative sequence442 – 47635Missing in isoform 2, isoform 3, isoform 4 and isoform 5.
VSP_030836
Alternative sequence513 – 5164REGL → SSGE in isoform 4.
VSP_030837
Alternative sequence517 – 797281Missing in isoform 4.
VSP_030838
Alternative sequence574 – 5818DCGMNCHK → GNKYSESR in isoform 5.
VSP_030839
Alternative sequence582 – 797216Missing in isoform 5.
VSP_030840
Alternative sequence625 – 6328APEEGPFT → GNKYSESR in isoform 3.
VSP_030841
Alternative sequence633 – 797165Missing in isoform 3.
VSP_030842

Experimental info

Mutagenesis2711R → E: Loss of function; prevents Ras activation. Ref.11
Mutagenesis5491Y → F: Loss of localization to the endoplasmic reticulum and the Golgi apparatus. Ref.10
Sequence conflict3741E → G in AAC79699. Ref.1
Sequence conflict3741E → G in AAF21898. Ref.1

Secondary structure

.......................................................................... 797
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 8ACDCF0F715ABAA9

FASTA79790,402
        10         20         30         40         50         60 
MGTLGKAREA PRKPSHGCRA ASKARLEAKP ANSPFPSHPS LAHITQFRMM VSLGHLAKGA 

        70         80         90        100        110        120 
SLDDLIDSCI QSFDADGNLC RSNQLLQVML TMHRIVISSA ELLQKVITLY KDALAKNSPG 

       130        140        150        160        170        180 
LCLKICYFVR YWITEFWVMF KMDASLTDTM EEFQELVKAK GEELHCRLID TTQINARDWS 

       190        200        210        220        230        240 
RKLTQRIKSN TSKKRKVSLL FDHLEPEELS EHLTYLEFKS FRRISFSDYQ NYLVNSCVKE 

       250        260        270        280        290        300 
NPTMERSIAL CNGISQWVQL MVLSRPTPQL RAEVFIKFIQ VAQKLHQLQN FNTLMAVIGG 

       310        320        330        340        350        360 
LCHSSISRLK ETSSHVPHEI NKVLGEMTEL LSSSRNYDNY RRAYGECTDF KIPILGVHLK 

       370        380        390        400        410        420 
DLISLYEAMP DYLEDGKVNV HKLLALYNHI SELVQLQEVA PPLEANKDLV HLLTLSLDLY 

       430        440        450        460        470        480 
YTEDEIYELS YAREPRNHRA PPLTPSKPPV VVDWASGVSP KPDPKTISKH VQRMVDSVFK 

       490        500        510        520        530        540 
NYDHDQDGYI SQEEFEKIAA SFPFSFCVMD KDREGLISRD EITAYFMRAS SIYSKLGLGF 

       550        560        570        580        590        600 
PHNFQETTYL KPTFCDNCAG FLWGVIKQGY RCKDCGMNCH KQCKDLVVFE CKKRAKNPVA 

       610        620        630        640        650        660 
PTENNTSVGP VSNLCSLGAK DLLHAPEEGP FTFPNGEAVE HGEESKDRTI MLMGVSSQKI 

       670        680        690        700        710        720 
SLRLKRAVAH KATQTESQPW IGSEGPSGPF VLSSPRKTAQ DTLYVLPSPT SPCPSPVLVR 

       730        740        750        760        770        780 
KRAFVKWENK DSLIKSKEEL RHLRLPTYQE LEQEINTLKA DNDALKIQLK YAQKKIESLQ 

       790 
LEKSNHVLAQ MEQGDCS 

« Hide

Isoform 2 (A) [UniParc].

Checksum: C3ACFFF5888E3236
Show »

FASTA76286,625
Isoform 3 (B) [UniParc].

Checksum: 979AEA31D0FBE5DC
Show »

FASTA59768,170
Isoform 4 (C) [UniParc].

Checksum: 11408850F4E84118
Show »

FASTA48155,100
Isoform 5 (D) [UniParc].

Checksum: 54018A113532AF92
Show »

FASTA54662,674

References

« Hide 'large scale' references
[1]"A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia."
Kawasaki H., Springett G.M., Toki S., Canales J.J., Harlan P., Blumenstiel J.P., Chen E.J., Bany I.A., Mochizuki N., Ashbacher A., Matsuda M., Housman D.E., Graybiel A.M.
Proc. Natl. Acad. Sci. U.S.A. 95:13278-13283(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Frontal cortex.
[2]"RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions."
Bottorff D.A., Ebinu J.O., Stone J.C.
Mamm. Genome 10:358-361(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: T-cell.
[3]"Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus."
Yasuda S., Stevens R.L., Terada T., Takeda M., Hashimoto T., Fukae J., Horita T., Kataoka H., Atsumi T., Koike T.
J. Immunol. 179:4890-4900(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS, TISSUE SPECIFICITY.
Tissue: Peripheral blood.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[5]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-797 (ISOFORM 2).
Tissue: Brain.
[6]"RasGRP links T-cell receptor signaling to Ras."
Ebinu J.O., Stang S.L., Teixeira C., Bottorff D.A., Hooton J., Blumberg P.M., Barry M., Bleakley R.C., Ostergaard H.L., Stone J.C.
Blood 95:3199-3203(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN T-CELL RECEPTOR SIGNALING, TOPOLOGY, TISSUE SPECIFICITY.
[7]"Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism."
Topham M.K., Prescott S.M.
J. Cell Biol. 152:1135-1143(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH DGKZ AND HRAS, ENZYME REGULATION.
[8]"Expression of a catalytically inactive form of diacylglycerol kinase alpha induces sustained signaling through RasGRP."
Jones D.R., Sanjuan M.A., Stone J.C., Merida I.
FASEB J. 16:595-597(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: ENZYME REGULATION.
[9]"Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1."
Caloca M.J., Zugaza J.L., Matallanas D., Crespo P., Bustelo X.R.
EMBO J. 22:3326-3336(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN B-CELLS, SUBCELLULAR LOCATION, INTERACTION WITH F-ACTIN, ENZYME REGULATION.
[10]"Exchange factors of the RasGRP family mediate Ras activation in the Golgi."
Caloca M.J., Zugaza J.L., Bustelo X.R.
J. Biol. Chem. 278:33465-33473(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-549.
[11]"Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1."
Bivona T.G., Perez De Castro I., Ahearn I.M., Grana T.M., Chiu V.K., Lockyer P.J., Cullen P.J., Pellicer A., Cox A.D., Philips M.R.
Nature 424:694-698(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF ARG-271.
[12]"Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus."
Perez de Castro I., Bivona T.G., Philips M.R., Pellicer A.
Mol. Cell. Biol. 24:3485-3496(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[13]"Inverted signaling hierarchy between RAS and RAC in T-lymphocytes."
Zugaza J.L., Caloca M.J., Bustelo X.R.
Oncogene 23:5823-5833(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[14]"Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells."
Zheng Y., Liu H., Coughlin J.J., Zheng J., Li L., Stone J.C.
Blood 105:3648-3654(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT THR-184 BY PKC.
[15]"A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells."
Roose J.P., Mollenauer M., Gupta V.A., Stone J.C., Weiss A.
Mol. Cell. Biol. 25:4426-4441(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION AT THR-184.
[16]"SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1."
Kosco K.A., Cerignoli F., Williams S., Abraham R.T., Mustelin T.
Mol. Immunol. 45:510-522(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SKAP1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF081195 mRNA. Translation: AAC79699.1.
AF081197 mRNA. Translation: AAF21898.1.
AF106071 mRNA. Translation: AAC97349.1.
AY634315 mRNA. Translation: AAT47482.2.
AY858556 mRNA. Translation: AAW32406.2.
AY954625 mRNA. Translation: AAX54699.4.
AY966005 mRNA. Translation: AAX76907.1.
BC067298 mRNA. Translation: AAH67298.1. Sequence problems.
BC109296 mRNA. Translation: AAI09297.1.
BC109297 mRNA. Translation: AAI09298.1.
AB208848 mRNA. Translation: BAD92085.1.
CCDSCCDS45221.1. [O95267-2]
CCDS45222.1. [O95267-1]
RefSeqNP_001122074.1. NM_001128602.1. [O95267-2]
NP_005730.2. NM_005739.3. [O95267-1]
UniGeneHs.591127.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4L9MX-ray3.00A50-607[»]
4L9UX-ray1.60A/B739-793[»]
ProteinModelPortalO95267.
SMRO95267. Positions 53-593, 745-793.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115429. 5 interactions.
IntActO95267. 1 interaction.
MINTMINT-7970969.

Chemistry

ChEMBLCHEMBL5953.

PTM databases

PhosphoSiteO95267.

Proteomic databases

MaxQBO95267.
PaxDbO95267.
PRIDEO95267.

Protocols and materials databases

DNASU10125.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310803; ENSP00000310244; ENSG00000172575. [O95267-1]
ENST00000414708; ENSP00000413105; ENSG00000172575. [O95267-4]
ENST00000450598; ENSP00000388540; ENSG00000172575. [O95267-2]
ENST00000558164; ENSP00000454164; ENSG00000172575. [O95267-5]
ENST00000559830; ENSP00000452721; ENSG00000172575. [O95267-3]
GeneID10125.
KEGGhsa:10125.
UCSCuc001zkd.4. human. [O95267-2]
uc001zke.4. human. [O95267-1]
uc010bbf.3. human. [O95267-3]
uc010bbg.3. human. [O95267-5]

Organism-specific databases

CTD10125.
GeneCardsGC15M038780.
H-InvDBHIX0038076.
HGNCHGNC:9878. RASGRP1.
MIM152700. phenotype.
603962. gene.
neXtProtNX_O95267.
PharmGKBPA34240.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256085.
HOVERGENHBG007513.
InParanoidO95267.
KOK04350.
OrthoDBEOG72G16V.
PhylomeDBO95267.
TreeFamTF312918.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_604. Hemostasis.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressO95267.
BgeeO95267.
GenevestigatorO95267.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.10.840.10. 1 hit.
InterProIPR020454. DAG/PE-bd.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamPF00130. C1_1. 1 hit.
PF13405. EF-hand_6. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSPR00008. DAGPEDOMAIN.
SMARTSM00109. C1. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMSSF48366. SSF48366. 1 hit.
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRASGRP1.
GenomeRNAi10125.
NextBio38299.
PROO95267.
SOURCESearch...

Entry information

Entry nameGRP1_HUMAN
AccessionPrimary (citable) accession number: O95267
Secondary accession number(s): Q56CZ0 expand/collapse secondary AC list , Q58G75, Q59HB1, Q5I3A8, Q6GV31, Q6NX39, Q7LDG6, Q9UI94, Q9UNN9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM