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O95264

- 5HT3B_HUMAN

UniProt

O95264 - 5HT3B_HUMAN

Protein

5-hydroxytryptamine receptor 3B

Gene

HTR3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.1 Publication

    GO - Molecular functioni

    1. ion channel activity Source: ProtInc
    2. serotonin-activated cation-selective channel activity Source: ProtInc
    3. serotonin receptor activity Source: ProtInc

    GO - Biological processi

    1. cation transport Source: GOC
    2. ion transmembrane transport Source: Reactome
    3. synaptic transmission Source: ProtInc
    4. transmembrane transport Source: Reactome
    5. transport Source: ProtInc

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_25387. Ligand-gated ion channel transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 3B
    Short name:
    5-HT3-B
    Short name:
    5-HT3B
    Alternative name(s):
    Serotonin receptor 3B
    Gene namesi
    Name:HTR3B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:5298. HTR3B.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome
    3. postsynaptic membrane Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi52 – 521N → S: Reduced molecular weight. Very little expression in the cell membrane. 1 Publication
    Mutagenesisi96 – 961N → S: Reduced molecular weight. Very little expression in the cell membrane. 1 Publication
    Mutagenesisi138 – 1381N → S: Reduced molecular weight. Very little expression in the cell membrane. 1 Publication
    Mutagenesisi168 – 1681N → S: Reduced molecular weight and cell membrane expression. 1 Publication
    Mutagenesisi203 – 2031N → S: Reduced molecular weight. Very little expression in the cell membrane. 1 Publication

    Organism-specific databases

    PharmGKBiPA29556.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 4414205-hydroxytryptamine receptor 3BPRO_0000312289Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)1 Publication
    Glycosylationi96 – 961N-linked (GlcNAc...)1 Publication
    Glycosylationi138 – 1381N-linked (GlcNAc...)1 Publication
    Disulfide bondi155 ↔ 169By similarity
    Glycosylationi168 – 1681N-linked (GlcNAc...)1 Publication
    Glycosylationi203 – 2031N-linked (GlcNAc...)1 Publication
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylation required for membrane localization.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95264.
    PRIDEiO95264.

    PTM databases

    PhosphoSiteiO95264.

    Expressioni

    Tissue specificityi

    Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.2 Publications

    Gene expression databases

    ArrayExpressiO95264.
    BgeeiO95264.
    CleanExiHS_HTR3B.
    GenevestigatoriO95264.

    Organism-specific databases

    HPAiHPA039559.

    Interactioni

    Subunit structurei

    Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.2 Publications

    Protein-protein interaction databases

    STRINGi9606.ENSP00000260191.

    Structurei

    3D structure databases

    ProteinModelPortaliO95264.
    SMRiO95264. Positions 35-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 238217ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 2689CytoplasmicSequence Analysis
    Topological domaini287 – 30317ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini325 – 41490CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini436 – 4416ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei239 – 25921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28618Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei415 – 43521Helical; Name=4Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni381 – 41333HA-stretchAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260507.
    HOGENOMiHOG000241519.
    HOVERGENiHBG106638.
    InParanoidiO95264.
    KOiK04819.
    OMAiEVWNDEF.
    OrthoDBiEOG7FXZZK.
    PhylomeDBiO95264.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR008132. 5HT3_rcpt.
    IPR008134. 5HT3_rcpt_B.
    IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR01710. 5HT3BRECEPTR.
    PR01708. 5HT3RECEPTOR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95264-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSSVMAPLW ACILVAAGIL ATDTHHPQDS ALYHLSKQLL QKYHKEVRPV    50
    YNWTKATTVY LDLFVHAILD VDAENQILKT SVWYQEVWND EFLSWNSSMF 100
    DEIREISLPL SAIWAPDIII NEFVDIERYP DLPYVYVNSS GTIENYKPIQ 150
    VVSACSLETY AFPFDVQNCS LTFKSILHTV EDVDLAFLRS PEDIQHDKKA 200
    FLNDSEWELL SVSSTYSILQ SSAGGFAQIQ FNVVMRRHPL VYVVSLLIPS 250
    IFLMLVDLGS FYLPPNCRAR IVFKTSVLVG YTVFRVNMSN QVPRSVGSTP 300
    LIGHFFTICM AFLVLSLAKS IVLVKFLHDE QRGGQEQPFL CLRGDTDADR 350
    PRVEPRAQRA VVTESSLYGE HLAQPGTLKE VWSQLQSISN YLQTQDQTDQ 400
    QEAEWLVLLS RFDRLLFQSY LFMLGIYTIT LCSLWALWGG V 441
    Length:441
    Mass (Da):50,292
    Last modified:May 1, 1999 - v1
    Checksum:i2ED59E4E11400648
    GO
    Isoform 2 (identifier: O95264-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: MLSSVMAPLWACILVAA → MIVYFP

    Show »
    Length:430
    Mass (Da):49,285
    Checksum:i8C69BE27437D6D03
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti129 – 1291Y → S.4 Publications
    Corresponds to variant rs1176744 [ dbSNP | Ensembl ].
    VAR_037472
    Natural varianti143 – 1431I → T.1 Publication
    Corresponds to variant rs34550504 [ dbSNP | Ensembl ].
    VAR_037473
    Natural varianti156 – 1561S → R.3 Publications
    Corresponds to variant rs72466469 [ dbSNP | Ensembl ].
    VAR_037474
    Natural varianti183 – 1831V → I.3 Publications
    Corresponds to variant rs17116138 [ dbSNP | Ensembl ].
    VAR_037475

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1717MLSSV…ILVAA → MIVYFP in isoform 2. 1 PublicationVSP_029796Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169255 mRNA. Translation: AAF03691.1.
    AF080582 mRNA. Translation: AAD12242.1.
    AM293589 mRNA. Translation: CAL25321.1.
    EF444985 Genomic DNA. Translation: ACA06001.1.
    AK314268 mRNA. Translation: BAG36930.1.
    CCDSiCCDS8364.1. [O95264-1]
    RefSeqiNP_006019.1. NM_006028.4. [O95264-1]
    UniGeneiHs.241377.

    Genome annotation databases

    EnsembliENST00000260191; ENSP00000260191; ENSG00000149305. [O95264-1]
    ENST00000537778; ENSP00000443118; ENSG00000149305. [O95264-2]
    GeneIDi9177.
    KEGGihsa:9177.
    UCSCiuc001pok.3. human. [O95264-1]
    uc001pol.3. human. [O95264-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169255 mRNA. Translation: AAF03691.1 .
    AF080582 mRNA. Translation: AAD12242.1 .
    AM293589 mRNA. Translation: CAL25321.1 .
    EF444985 Genomic DNA. Translation: ACA06001.1 .
    AK314268 mRNA. Translation: BAG36930.1 .
    CCDSi CCDS8364.1. [O95264-1 ]
    RefSeqi NP_006019.1. NM_006028.4. [O95264-1 ]
    UniGenei Hs.241377.

    3D structure databases

    ProteinModelPortali O95264.
    SMRi O95264. Positions 35-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000260191.

    Chemistry

    BindingDBi O95264.
    ChEMBLi CHEMBL2094132.
    DrugBanki DB01049. Ergoloid mesylate.
    GuidetoPHARMACOLOGYi 374.

    PTM databases

    PhosphoSitei O95264.

    Proteomic databases

    PaxDbi O95264.
    PRIDEi O95264.

    Protocols and materials databases

    DNASUi 9177.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260191 ; ENSP00000260191 ; ENSG00000149305 . [O95264-1 ]
    ENST00000537778 ; ENSP00000443118 ; ENSG00000149305 . [O95264-2 ]
    GeneIDi 9177.
    KEGGi hsa:9177.
    UCSCi uc001pok.3. human. [O95264-1 ]
    uc001pol.3. human. [O95264-2 ]

    Organism-specific databases

    CTDi 9177.
    GeneCardsi GC11P113775.
    HGNCi HGNC:5298. HTR3B.
    HPAi HPA039559.
    MIMi 604654. gene.
    neXtProti NX_O95264.
    PharmGKBi PA29556.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG260507.
    HOGENOMi HOG000241519.
    HOVERGENi HBG106638.
    InParanoidi O95264.
    KOi K04819.
    OMAi EVWNDEF.
    OrthoDBi EOG7FXZZK.
    PhylomeDBi O95264.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_25387. Ligand-gated ion channel transport.

    Miscellaneous databases

    GeneWikii HTR3B.
    GenomeRNAii 9177.
    NextBioi 34409.
    PROi O95264.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95264.
    Bgeei O95264.
    CleanExi HS_HTR3B.
    Genevestigatori O95264.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR008132. 5HT3_rcpt.
    IPR008134. 5HT3_rcpt_B.
    IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR01710. 5HT3BRECEPTR.
    PR01708. 5HT3RECEPTOR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit."
      Dubin A.E., Huvar R., D'Andrea M.R., Pyati J., Zhu J.Y., Joy K.C., Wilson S.J., Galindo J.E., Glass C.A., Luo L., Jackson M.R., Lovenberg T.W., Erlander M.G.
      J. Biol. Chem. 274:30799-30810(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Small intestine.
    2. "The 5-HT3B subunit is a major determinant of serotonin-receptor function."
      Davies P.A., Pistis M., Hanna M.C., Peters J.A., Lambert J.J., Hales T.G., Kirkness E.F.
      Nature 397:359-363(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBUNIT.
    3. "Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine."
      Tzvetkov M.V., Meineke C., Oetjen E., Hirsch-Ernst K., Brockmoller J.
      Gene 386:52-62(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT SER-129.
      Tissue: Brain.
    4. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors."
      Kelley S.P., Dunlop J.I., Kirkness E.F., Lambert J.J., Peters J.A.
      Nature 424:321-324(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, REGION.
    7. "Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E."
      Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M.
      Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    8. "The identification of N-glycosylated residues of the human 5-HT3B receptor subunit: importance for cell membrane expression."
      Massoura A.N., Dover T.J., Newman A.S., Barnes N.M.
      J. Neurochem. 116:975-983(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-52; ASN-96; ASN-138; ASN-168 AND ASN-203, MUTAGENESIS OF ASN-52; ASN-96; ASN-138; ASN-168 AND ASN-203.
    9. "Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients."
      Frank B., Niesler B., Noethen M.M., Neidt H., Propping P., Bondy B., Rietschel M., Maier W., Albus M., Rappold G.
      Am. J. Med. Genet. B Neuropsychiatr. Genet. 131:1-5(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SER-129; ARG-156 AND ILE-183.
    10. "Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."
      Frank B., Niesler B., Bondy B., Spaeth M., Pongratz D.E., Ackenheil M., Fischer C., Rappold G.
      Clin. Rheumatol. 23:338-344(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SER-129; ARG-156 AND ILE-183.
    11. "Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."
      Yamada K., Hattori E., Iwayama Y., Ohnishi T., Ohba H., Toyota T., Takao H., Minabe Y., Nakatani N., Higuchi T., Detera-Wadleigh S.D., Yoshikawa T.
      Biol. Psychiatry 60:192-201(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SER-129; THR-143 AND ILE-183.
    12. Cited for: VARIANT ARG-156.

    Entry informationi

    Entry namei5HT3B_HUMAN
    AccessioniPrimary (citable) accession number: O95264
    Secondary accession number(s): B0YJ23, Q0VJC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The HA-stretch region of HTR3B seems to confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3