Reviewed, UniProtKB/Swiss-Prot O95263 (PDE8B_HUMAN)

Names and origin

Protein names

Recommended name:
    High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
      Short name=HsPDE8B
    EC=3.1.4.17

Gene names

Name:

PDE8B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	885 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase has high affinity for cAMP and may be involved in specific signaling in the thyroid gland.
Catalytic activity	Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. Ref.2
Cofactor	Divalent cations.
Enzyme regulation	Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and milrinone as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP. Ref.2
Pathway	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Tissue specificity	Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates. Ref.2 Ref.1
Domain	Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family. Contains 1 PAS (PER-ARNT-SIM) domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	Magnesium Manganese Metal-binding cAMP
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cAMP catabolic process Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro two-component signal transduction system (phosphorelay) Inferred from electronic annotation. Source: InterPro
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity Ref.4 Non-traceable author statement. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW two-component response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95263-1)

Also known as: PDE8B1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Major isoform.

Isoform 2 (identifier: O95263-2)

Also known as: PDE8B2; PDE8B3;

The sequence of this isoform differs from the canonical sequence as follows:
     293-389: Missing.

Isoform 3 (identifier: O95263-3)

Also known as: PDE8B3;

The sequence of this isoform differs from the canonical sequence as follows:
     456-510: Missing.

Isoform 4 (identifier: O95263-4)

Also known as: PDE8B4;

The sequence of this isoform differs from the canonical sequence as follows:
     114-133: Missing.

Isoform 5 (identifier: O95263-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-535: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: O95263-6)

Also known as: PDE8B2;

The sequence of this isoform differs from the canonical sequence as follows:
     293-339: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 885	885	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B		PRO_0000198840
Regions
	Domain	267 – 338	72	PAS
	Region	590 – 868	279	Catalytic By similarity
Sites
	Metal binding	615	1	Magnesium or manganese 1 Potential
	Metal binding	619	1	Magnesium or manganese 1 Potential
	Metal binding	644	1	Magnesium or manganese 1 Potential
	Metal binding	655	1	Magnesium or manganese 2 Potential
	Metal binding	659	1	Magnesium or manganese 2 Potential
	Metal binding	685	1	Magnesium or manganese 2 Potential
Amino acid modifications
	Modified residue	517	1	Phosphoserine Ref.6 Ref.7
Natural variations
	Alternative sequence	1 – 535	535	Missing in isoform 5.		VSP_008081
	Alternative sequence	114 – 133	20	Missing in isoform 4.		VSP_008082
	Alternative sequence	293 – 389	97	Missing in isoform 2.		VSP_008084
	Alternative sequence	293 – 339	47	Missing in isoform 6.		VSP_008083
	Alternative sequence	456 – 510	55	Missing in isoform 3.		VSP_008085
Experimental info
	Sequence conflict	147	1	G → R in CAD38584. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PDE8B1) [UniParc]. Last modified August 22, 2003. Version 2. Checksum: DB4F763E51F745A3	FASTA	885	98,979
	10 20 30 40 50 60 MGCAPSIHVS QSGVIYCRDS DESSSPRQTT SVSQGPAAPL PGLFVQTDAA DAIPPSRASG 70 80 90 100 110 120 PPSVARVRRA RTELGSGSSA GSAAPAATTS RGRRRHCCSS AEAETQTCYT SVKQVSSAEV 130 140 150 160 170 180 RIGPMRLTQD PIQVLLIFAK EDSQSDGFWW ACDRAGYRCN IARTPESALE CFLDKHHEII 190 200 210 220 230 240 VIDHRQTQNF DAEAVCRSIR ATNPSEHTVI LAVVSRVSDD HEEASVLPLL HAGFNRRFME 250 260 270 280 290 300 NSSIIACYNE LIQIEHGEVR SQFKLRACNS VFTALDHCHE AIEITSDDHV IQYVNPAFER 310 320 330 340 350 360 MMGYHKGELL GKELADLPKS DKNRADLLDT INTCIKKGKE WQGVYYARRK SGDSIQQHVK 370 380 390 400 410 420 ITPVIGQGGK IRHFVSLKKL CCTTDNNKQI HKIHRDSGDN SQTEPHSFRY KNRRKESIDV 430 440 450 460 470 480 KSISSRGSDA PSLQNRRYPS MARIHSMTIE APITKVINII NAAQENSPVT VAEALDRVLE 490 500 510 520 530 540 ILRTTELYSP QLGTKDEDPH TSDLVGGLMT DGLRRLSGNE YVFTKNVHQS HSHLAMPITI 550 560 570 580 590 600 NDVPPCISQL LDNEESWDFN IFELEAITHK RPLVYLGLKV FSRFGVCEFL NCSETTLRAW 610 620 630 640 650 660 FQVIEANYHS SNAYHNSTHA ADVLHATAFF LGKERVKGSL DQLDEVAALI AATVHDVDHP 670 680 690 700 710 720 GRTNSFLCNA GSELAVLYND TAVLESHHTA LAFQLTVKDT KCNIFKNIDR NHYRTLRQAI 730 740 750 760 770 780 IDMVLATEMT KHFEHVNKFV NSINKPMAAE IEGSDCECNP AGKNFPENQI LIKRMMIKCA 790 800 810 820 830 840 DVANPCRPLD LCIEWAGRIS EEYFAQTDEE KRQGLPVVMP VFDRNTCSIP KSQISFIDYF 850 860 870 880 ITDMFDAWDA FAHLPALMQH LADNYKHWKT LDDLKCKSLR LPSDS
	Isoform 2 (PDE8B2) (PDE8B3). Checksum: 816AECACCAE45447	FASTA	788	87,974
	10 20 30 40 50 60 MGCAPSIHVS QSGVIYCRDS DESSSPRQTT SVSQGPAAPL PGLFVQTDAA DAIPPSRASG 70 80 90 100 110 120 PPSVARVRRA RTELGSGSSA GSAAPAATTS RGRRRHCCSS AEAETQTCYT SVKQVSSAEV 130 140 150 160 170 180 RIGPMRLTQD PIQVLLIFAK EDSQSDGFWW ACDRAGYRCN IARTPESALE CFLDKHHEII 190 200 210 220 230 240 VIDHRQTQNF DAEAVCRSIR ATNPSEHTVI LAVVSRVSDD HEEASVLPLL HAGFNRRFME 250 260 270 280 290 300 NSSIIACYNE LIQIEHGEVR SQFKLRACNS VFTALDHCHE AIEITSDDHV IQIHKIHRDS 310 320 330 340 350 360 GDNSQTEPHS FRYKNRRKES IDVKSISSRG SDAPSLQNRR YPSMARIHSM TIEAPITKVI 370 380 390 400 410 420 NIINAAQENS PVTVAEALDR VLEILRTTEL YSPQLGTKDE DPHTSDLVGG LMTDGLRRLS 430 440 450 460 470 480 GNEYVFTKNV HQSHSHLAMP ITINDVPPCI SQLLDNEESW DFNIFELEAI THKRPLVYLG 490 500 510 520 530 540 LKVFSRFGVC EFLNCSETTL RAWFQVIEAN YHSSNAYHNS THAADVLHAT AFFLGKERVK 550 560 570 580 590 600 GSLDQLDEVA ALIAATVHDV DHPGRTNSFL CNAGSELAVL YNDTAVLESH HTALAFQLTV 610 620 630 640 650 660 KDTKCNIFKN IDRNHYRTLR QAIIDMVLAT EMTKHFEHVN KFVNSINKPM AAEIEGSDCE 670 680 690 700 710 720 CNPAGKNFPE NQILIKRMMI KCADVANPCR PLDLCIEWAG RISEEYFAQT DEEKRQGLPV 730 740 750 760 770 780 VMPVFDRNTC SIPKSQISFI DYFITDMFDA WDAFAHLPAL MQHLADNYKH WKTLDDLKCK SLRLPSDS
	Isoform 3 (PDE8B3). Checksum: 5A39ED08E2A877E4	FASTA	830	93,047
	10 20 30 40 50 60 MGCAPSIHVS QSGVIYCRDS DESSSPRQTT SVSQGPAAPL PGLFVQTDAA DAIPPSRASG 70 80 90 100 110 120 PPSVARVRRA RTELGSGSSA GSAAPAATTS RGRRRHCCSS AEAETQTCYT SVKQVSSAEV 130 140 150 160 170 180 RIGPMRLTQD PIQVLLIFAK EDSQSDGFWW ACDRAGYRCN IARTPESALE CFLDKHHEII 190 200 210 220 230 240 VIDHRQTQNF DAEAVCRSIR ATNPSEHTVI LAVVSRVSDD HEEASVLPLL HAGFNRRFME 250 260 270 280 290 300 NSSIIACYNE LIQIEHGEVR SQFKLRACNS VFTALDHCHE AIEITSDDHV IQYVNPAFER 310 320 330 340 350 360 MMGYHKGELL GKELADLPKS DKNRADLLDT INTCIKKGKE WQGVYYARRK SGDSIQQHVK 370 380 390 400 410 420 ITPVIGQGGK IRHFVSLKKL CCTTDNNKQI HKIHRDSGDN SQTEPHSFRY KNRRKESIDV 430 440 450 460 470 480 KSISSRGSDA PSLQNRRYPS MARIHSMTIE APITKDGLRR LSGNEYVFTK NVHQSHSHLA 490 500 510 520 530 540 MPITINDVPP CISQLLDNEE SWDFNIFELE AITHKRPLVY LGLKVFSRFG VCEFLNCSET 550 560 570 580 590 600 TLRAWFQVIE ANYHSSNAYH NSTHAADVLH ATAFFLGKER VKGSLDQLDE VAALIAATVH 610 620 630 640 650 660 DVDHPGRTNS FLCNAGSELA VLYNDTAVLE SHHTALAFQL TVKDTKCNIF KNIDRNHYRT 670 680 690 700 710 720 LRQAIIDMVL ATEMTKHFEH VNKFVNSINK PMAAEIEGSD CECNPAGKNF PENQILIKRM 730 740 750 760 770 780 MIKCADVANP CRPLDLCIEW AGRISEEYFA QTDEEKRQGL PVVMPVFDRN TCSIPKSQIS 790 800 810 820 830 FIDYFITDMF DAWDAFAHLP ALMQHLADNY KHWKTLDDLK CKSLRLPSDS
	Isoform 4 (PDE8B4). Checksum: DDC83E5525C7E7B7	FASTA	865	96,771
	10 20 30 40 50 60 MGCAPSIHVS QSGVIYCRDS DESSSPRQTT SVSQGPAAPL PGLFVQTDAA DAIPPSRASG 70 80 90 100 110 120 PPSVARVRRA RTELGSGSSA GSAAPAATTS RGRRRHCCSS AEAETQTCYT SVKVLLIFAK 130 140 150 160 170 180 EDSQSDGFWW ACDRAGYRCN IARTPESALE CFLDKHHEII VIDHRQTQNF DAEAVCRSIR 190 200 210 220 230 240 ATNPSEHTVI LAVVSRVSDD HEEASVLPLL HAGFNRRFME NSSIIACYNE LIQIEHGEVR 250 260 270 280 290 300 SQFKLRACNS VFTALDHCHE AIEITSDDHV IQYVNPAFER MMGYHKGELL GKELADLPKS 310 320 330 340 350 360 DKNRADLLDT INTCIKKGKE WQGVYYARRK SGDSIQQHVK ITPVIGQGGK IRHFVSLKKL 370 380 390 400 410 420 CCTTDNNKQI HKIHRDSGDN SQTEPHSFRY KNRRKESIDV KSISSRGSDA PSLQNRRYPS 430 440 450 460 470 480 MARIHSMTIE APITKVINII NAAQENSPVT VAEALDRVLE ILRTTELYSP QLGTKDEDPH 490 500 510 520 530 540 TSDLVGGLMT DGLRRLSGNE YVFTKNVHQS HSHLAMPITI NDVPPCISQL LDNEESWDFN 550 560 570 580 590 600 IFELEAITHK RPLVYLGLKV FSRFGVCEFL NCSETTLRAW FQVIEANYHS SNAYHNSTHA 610 620 630 640 650 660 ADVLHATAFF LGKERVKGSL DQLDEVAALI AATVHDVDHP GRTNSFLCNA GSELAVLYND 670 680 690 700 710 720 TAVLESHHTA LAFQLTVKDT KCNIFKNIDR NHYRTLRQAI IDMVLATEMT KHFEHVNKFV 730 740 750 760 770 780 NSINKPMAAE IEGSDCECNP AGKNFPENQI LIKRMMIKCA DVANPCRPLD LCIEWAGRIS 790 800 810 820 830 840 EEYFAQTDEE KRQGLPVVMP VFDRNTCSIP KSQISFIDYF ITDMFDAWDA FAHLPALMQH 850 860 LADNYKHWKT LDDLKCKSLR LPSDS
	Isoform 5. Checksum: A6D4F19BE26C045F	FASTA	350	39,791
	10 20 30 40 50 60 MPITINDVPP CISQLLDNEE SWDFNIFELE AITHKRPLVY LGLKVFSRFG VCEFLNCSET 70 80 90 100 110 120 TLRAWFQVIE ANYHSSNAYH NSTHAADVLH ATAFFLGKER VKGSLDQLDE VAALIAATVH 130 140 150 160 170 180 DVDHPGRTNS FLCNAGSELA VLYNDTAVLE SHHTALAFQL TVKDTKCNIF KNIDRNHYRT 190 200 210 220 230 240 LRQAIIDMVL ATEMTKHFEH VNKFVNSINK PMAAEIEGSD CECNPAGKNF PENQILIKRM 250 260 270 280 290 300 MIKCADVANP CRPLDLCIEW AGRISEEYFA QTDEEKRQGL PVVMPVFDRN TCSIPKSQIS 310 320 330 340 350 FIDYFITDMF DAWDAFAHLP ALMQHLADNY KHWKTLDDLK CKSLRLPSDS
	Isoform 6 (PDE8B2). Checksum: 013C790AC0F24F92	FASTA	838	93,674
	10 20 30 40 50 60 MGCAPSIHVS QSGVIYCRDS DESSSPRQTT SVSQGPAAPL PGLFVQTDAA DAIPPSRASG 70 80 90 100 110 120 PPSVARVRRA RTELGSGSSA GSAAPAATTS RGRRRHCCSS AEAETQTCYT SVKQVSSAEV 130 140 150 160 170 180 RIGPMRLTQD PIQVLLIFAK EDSQSDGFWW ACDRAGYRCN IARTPESALE CFLDKHHEII 190 200 210 220 230 240 VIDHRQTQNF DAEAVCRSIR ATNPSEHTVI LAVVSRVSDD HEEASVLPLL HAGFNRRFME 250 260 270 280 290 300 NSSIIACYNE LIQIEHGEVR SQFKLRACNS VFTALDHCHE AIEITSDDHV IQEWQGVYYA 310 320 330 340 350 360 RRKSGDSIQQ HVKITPVIGQ GGKIRHFVSL KKLCCTTDNN KQIHKIHRDS GDNSQTEPHS 370 380 390 400 410 420 FRYKNRRKES IDVKSISSRG SDAPSLQNRR YPSMARIHSM TIEAPITKVI NIINAAQENS 430 440 450 460 470 480 PVTVAEALDR VLEILRTTEL YSPQLGTKDE DPHTSDLVGG LMTDGLRRLS GNEYVFTKNV 490 500 510 520 530 540 HQSHSHLAMP ITINDVPPCI SQLLDNEESW DFNIFELEAI THKRPLVYLG LKVFSRFGVC 550 560 570 580 590 600 EFLNCSETTL RAWFQVIEAN YHSSNAYHNS THAADVLHAT AFFLGKERVK GSLDQLDEVA 610 620 630 640 650 660 ALIAATVHDV DHPGRTNSFL CNAGSELAVL YNDTAVLESH HTALAFQLTV KDTKCNIFKN 670 680 690 700 710 720 IDRNHYRTLR QAIIDMVLAT EMTKHFEHVN KFVNSINKPM AAEIEGSDCE CNPAGKNFPE 730 740 750 760 770 780 NQILIKRMMI KCADVANPCR PLDLCIEWAG RISEEYFAQT DEEKRQGLPV VMPVFDRNTC 790 800 810 820 830 SIPKSQISFI DYFITDMFDA WDAFAHLPAL MQHLADNYKH WKTLDDLKCK SLRLPSDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene." Hayashi M., Shimada Y., Nishimura Y., Hama T., Tanaka T. Biochem. Biophys. Res. Commun. 297:1253-1258(2002) [PubMed: 12372422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 6), TISSUE SPECIFICITY.
[2]	"Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans." Gamanuma M., Yuasa K., Sasaki T., Sakurai N., Kotera J., Omori K. Cell. Signal. 15:565-574(2003) [PubMed: 12681444] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), CATALYTIC ACTIVITY, ENZYME REGULATION, TISSUE SPECIFICITY. Tissue: Thyroid.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Testis.
[4]	"Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase." Hayashi M., Matsushima K., Ohashi H., Tsunoda H., Murase S., Kawarada Y., Tanaka T. Biochem. Biophys. Res. Commun. 250:751-756(1998) [PubMed: 9784418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 227-885 (ISOFORM 1).
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-885 (ISOFORM 1). Tissue: Amygdala.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, MASS SPECTROMETRY.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY129948 mRNA. Translation: AAN71723.1. AY129949 mRNA. Translation: AAN71724.1. AY129950 Genomic DNA. Translation: AAN71725.1. AY129950 Genomic DNA. Translation: AAN71726.1. AY129950 Genomic DNA. Translation: AAN71727.1. AB085824 mRNA. Translation: BAC53762.1. AB085825 mRNA. Translation: BAC53763.1. AB085826 mRNA. Translation: BAC53764.1. AB085827 mRNA. Translation: BAC53765.1. BC043209 mRNA. No translation available. AF079529 mRNA. Translation: AAC69564.2. AL831924 mRNA. Translation: CAD38584.1.
IPI	IPI00216767. IPI00216768. IPI00294049. IPI00337505. IPI00337506. IPI00337507.
PIR	JE0293.
RefSeq	NP_001025022.1. NP_001025023.1. NP_001025024.1. NP_001025025.1. NP_003710.1.
UniGene	Hs.584830
3D structure databases
HSSP	HSSP built from PDB template 1F0J based on UniProtKB Q07343.
ModBase	Search...
Protein-protein interaction databases
STRING	O95263.
PTM databases
PhosphoSite	O95263.
Proteomic databases
PRIDE	O95263.
Genome annotation databases
Ensembl	ENST00000264917; ENSP00000264917; ENSG00000113231; Homo sapiens. [Genome view] ENST00000333194; ENSP00000331336; ENSG00000113231; Homo sapiens. [Genome view] ENST00000340978; ENSP00000345446; ENSG00000113231; Homo sapiens. [Genome view] ENST00000342343; ENSP00000345646; ENSG00000113231; Homo sapiens. [Genome view] ENST00000346042; ENSP00000330428; ENSG00000113231; Homo sapiens. [Genome view]
GeneID	8622.
KEGG	hsa:8622.
UCSC	uc003kfa.1. human. uc003kfb.1. human. uc003kfc.1. human. uc003kfd.1. human. uc003kfe.1. human.
Organism-specific databases
CTD	8622.
GeneCards	GC05P076542.
H-InvDB	HIX0004968. HIX0078031.
HGNC	HGNC:8794. PDE8B.
MIM	603390. gene.
PharmGKB	PA33142.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O95263.
OMA	AEIEGSD.
Enzyme and pathway databases
BRENDA	3.1.4.17. 247.
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	O95263.
Bgee	O95263.
CleanEx	HS_PDE8B.
Genevestigator	O95263.
GermOnline	ENSG00000113231. Homo sapiens.
Family and domain databases
InterPro	IPR003607. Met-dep_phosphohydro_HD. IPR000014. PAS. IPR013767. PAS_fold. IPR002073. PDEase. IPR013938. PDEase_PDE8. IPR001789. Sig_transdc_resp-reg_receiver. [Graphical view]
Pfam	PF00989. PAS. 1 hit. PF08629. PDE8. 1 hit. PF00233. PDEase_I. 1 hit. PF00072. Response_reg. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00471. HDc. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
TIGRFAMs	TIGR00229. sensory_box. 1 hit.
PROSITE	PS50112. PAS. 1 hit. PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	32309.
SOURCE	Search...

Entry information

Entry name

PDE8B_HUMAN

Accession

Primary (citable) accession number: O95263
Secondary accession number(s): Q86XK8 , Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 22, 2003
Last modified:	November 3, 2009
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.