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Protein

Arginyl-tRNA--protein transferase 1

Gene

ATE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).By similarity

Catalytic activityi

L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein].

GO - Molecular functioni

  • arginyltransferase activity Source: UniProtKB

GO - Biological processi

  • proteasomal protein catabolic process Source: MGI
  • protein arginylation Source: GO_Central

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

BRENDAi2.3.2.8. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginyl-tRNA--protein transferase 1 (EC:2.3.2.8)
Short name:
Arginyltransferase 1
Short name:
R-transferase 1
Alternative name(s):
Arginine-tRNA--protein transferase 1
Gene namesi
Name:ATE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107669.17.
HGNCiHGNC:782. ATE1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11101.
OpenTargetsiENSG00000107669.
PharmGKBiPA25082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950881 – 518Arginyl-tRNA--protein transferase 1Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei169PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95260.
MaxQBiO95260.
PaxDbiO95260.
PeptideAtlasiO95260.
PRIDEiO95260.

PTM databases

iPTMnetiO95260.
PhosphoSitePlusiO95260.

Expressioni

Gene expression databases

BgeeiENSG00000107669.
CleanExiHS_ATE1.
ExpressionAtlasiO95260. baseline and differential.
GenevisibleiO95260. HS.

Organism-specific databases

HPAiHPA038444.
HPA057549.

Interactioni

Subunit structurei

Monomer. Interacts with LIAT1 (By similarity).By similarityCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-1043378,EBI-349968

Protein-protein interaction databases

BioGridi116282. 36 interactors.
IntActiO95260. 5 interactors.
MINTiMINT-4527548.
STRINGi9606.ENSP00000224652.

Structurei

3D structure databases

ProteinModelPortaliO95260.
SMRiO95260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the R-transferase family.Curated

Phylogenomic databases

eggNOGiKOG1193. Eukaryota.
COG2935. LUCA.
GeneTreeiENSGT00500000044926.
HOGENOMiHOG000007968.
HOVERGENiHBG004299.
InParanoidiO95260.
KOiK00685.
OrthoDBiEOG091G09MU.
PhylomeDBiO95260.
TreeFamiTF105976.

Family and domain databases

InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR017137. Arg-tRNA-P_Trfase_1_euk.
IPR007472. Arg-tRNA-P_Trfase_C.
IPR030700. Arg-tRNA_Trfase.
IPR007471. Arg_tRNA_PTrfase_N.
PANTHERiPTHR21367. PTHR21367. 1 hit.
PfamiView protein in Pfam
PF04377. ATE_C. 1 hit.
PF04376. ATE_N. 1 hit.
PIRSFiPIRSF037207. ATE1_euk. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform ATE1-1 (identifier: O95260-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFWAGGSPS VVDYFPSEDF YRCGYCKNES GSRSNGMWAH SMTVQDYQDL
60 70 80 90 100
IDRGWRRSGK YVYKPVMNQT CCPQYTIRCR PLQFQPSKSH KKVLKKMLKF
110 120 130 140 150
LAKGEVPKGS CEDEPMDSTM DDAVAGDFAL INKLDIQCDL KTLSDDIKES
160 170 180 190 200
LESEGKNSKK EEPQELLQSQ DFVGEKLGSG EPSHSVKVHT VPKPGKGADL
210 220 230 240 250
SKPPCRKAKE IRKERKRLKL MQQNPAGELE GFQAQGHPPS LFPPKAKSNQ
260 270 280 290 300
PKSLEDLIFE SLPENASHKL EVRVVRSSPP SSQFKATLLE SYQVYKRYQM
310 320 330 340 350
VIHKNPPDTP TESQFTRFLC SSPLEAETPP NGPDCGYGSF HQQYWLDGKI
360 370 380 390 400
IAVGVIDILP NCVSSVYLYY DPDYSFLSLG VYSALREIAF TRQLHEKTSQ
410 420 430 440 450
LSYYYMGFYI HSCPKMKYKG QYRPSDLLCP ETYVWVPIEQ CLPSLENSKY
460 470 480 490 500
CRFNQDPEAV DEDRSTEPDR LQVFHKRAIM PYGVYKKQQK DPSEEAAVLQ
510
YASLVGQKCS ERMLLFRN
Length:518
Mass (Da):59,090
Last modified:July 26, 2002 - v2
Checksum:iBFD1CF8925CF5820
GO
Isoform ATE1-2 (identifier: O95260-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-314: VVRSSPPSSQ...NPPDTPTESQ → LVPVSFEDPE...DPPDECGKTE

Show »
Length:518
Mass (Da):59,032
Checksum:iD01E1D6024F04565
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 11AGGSPSV → GGGFAAS in AAD12366 (PubMed:9858543).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000336274 – 314VVRSS…PTESQ → LVPVSFEDPEFKSSFSQSFS LYVKYQVAIHQDPPDECGKT E in isoform ATE1-2. 2 PublicationsAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731542, AC025947, AL731566 Genomic DNA. Translation: CAI12918.1.
AL731566, AC025947, AL731542 Genomic DNA. Translation: CAI14813.1.
CH471066 Genomic DNA. Translation: EAW49334.1.
BC022026 mRNA. Translation: AAH22026.2.
AF079098 mRNA. Translation: AAD12366.1.
AF079099 mRNA. Translation: AAD12367.1.
CCDSiCCDS31299.1. [O95260-2]
CCDS31300.1. [O95260-1]
RefSeqiNP_001001976.1. NM_001001976.2. [O95260-1]
NP_001275663.1. NM_001288734.1.
NP_001275664.1. NM_001288735.1.
NP_001275665.1. NM_001288736.1.
NP_008972.2. NM_007041.3. [O95260-2]
UniGeneiHs.632080.

Genome annotation databases

EnsembliENST00000224652; ENSP00000224652; ENSG00000107669. [O95260-1]
ENST00000369043; ENSP00000358039; ENSG00000107669. [O95260-2]
GeneIDi11101.
KEGGihsa:11101.
UCSCiuc001lfp.5. human. [O95260-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATE1_HUMAN
AccessioniPrimary (citable) accession number: O95260
Secondary accession number(s): O95261, Q5SQQ3, Q8WW04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 26, 2002
Last modified: September 27, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-37 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families