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Protein

Arginyl-tRNA--protein transferase 1

Gene

ATE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-37 is the initiator.Curated

Catalytic activityi

L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein].

GO - Molecular functioni

  • arginyltransferase activity Source: UniProtKB

GO - Biological processi

  • proteasomal protein catabolic process Source: MGI
  • protein arginylation Source: GO_Central

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciMetaCyc:HS03017-MONOMER
BRENDAi2.3.2.8 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Arginyl-tRNA--protein transferase 1 (EC:2.3.2.8)
Short name:
Arginyltransferase 1
Short name:
R-transferase 1
Alternative name(s):
Arginine-tRNA--protein transferase 1
Gene namesi
Name:ATE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107669.17
HGNCiHGNC:782 ATE1
MIMi607103 gene
neXtProtiNX_O95260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11101
OpenTargetsiENSG00000107669
PharmGKBiPA25082

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950881 – 518Arginyl-tRNA--protein transferase 1Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei169PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95260
MaxQBiO95260
PaxDbiO95260
PeptideAtlasiO95260
PRIDEiO95260

PTM databases

iPTMnetiO95260
PhosphoSitePlusiO95260

Expressioni

Gene expression databases

BgeeiENSG00000107669
CleanExiHS_ATE1
ExpressionAtlasiO95260 baseline and differential
GenevisibleiO95260 HS

Organism-specific databases

HPAiHPA038444
HPA057549

Interactioni

Subunit structurei

Monomer. Interacts with LIAT1 (By similarity).By similarityCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-1043378,EBI-349968

Protein-protein interaction databases

BioGridi116282, 38 interactors
IntActiO95260, 4 interactors
MINTiO95260
STRINGi9606.ENSP00000224652

Structurei

3D structure databases

ProteinModelPortaliO95260
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the R-transferase family.Curated

Phylogenomic databases

eggNOGiKOG1193 Eukaryota
COG2935 LUCA
GeneTreeiENSGT00500000044926
HOGENOMiHOG000007968
HOVERGENiHBG004299
InParanoidiO95260
KOiK00685
OrthoDBiEOG091G09MU
PhylomeDBiO95260
TreeFamiTF105976

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR017137 Arg-tRNA-P_Trfase_1_euk
IPR030700 N-end_Aminoacyl_Trfase
IPR007472 N-end_Aminoacyl_Trfase_C
IPR007471 N-end_Aminoacyl_Trfase_N
PANTHERiPTHR21367 PTHR21367, 1 hit
PfamiView protein in Pfam
PF04377 ATE_C, 1 hit
PF04376 ATE_N, 1 hit
PIRSFiPIRSF037207 ATE1_euk, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform ATE1-1 (identifier: O95260-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFWAGGSPS VVDYFPSEDF YRCGYCKNES GSRSNGMWAH SMTVQDYQDL
60 70 80 90 100
IDRGWRRSGK YVYKPVMNQT CCPQYTIRCR PLQFQPSKSH KKVLKKMLKF
110 120 130 140 150
LAKGEVPKGS CEDEPMDSTM DDAVAGDFAL INKLDIQCDL KTLSDDIKES
160 170 180 190 200
LESEGKNSKK EEPQELLQSQ DFVGEKLGSG EPSHSVKVHT VPKPGKGADL
210 220 230 240 250
SKPPCRKAKE IRKERKRLKL MQQNPAGELE GFQAQGHPPS LFPPKAKSNQ
260 270 280 290 300
PKSLEDLIFE SLPENASHKL EVRVVRSSPP SSQFKATLLE SYQVYKRYQM
310 320 330 340 350
VIHKNPPDTP TESQFTRFLC SSPLEAETPP NGPDCGYGSF HQQYWLDGKI
360 370 380 390 400
IAVGVIDILP NCVSSVYLYY DPDYSFLSLG VYSALREIAF TRQLHEKTSQ
410 420 430 440 450
LSYYYMGFYI HSCPKMKYKG QYRPSDLLCP ETYVWVPIEQ CLPSLENSKY
460 470 480 490 500
CRFNQDPEAV DEDRSTEPDR LQVFHKRAIM PYGVYKKQQK DPSEEAAVLQ
510
YASLVGQKCS ERMLLFRN
Length:518
Mass (Da):59,090
Last modified:July 26, 2002 - v2
Checksum:iBFD1CF8925CF5820
GO
Isoform ATE1-2 (identifier: O95260-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-314: VVRSSPPSSQ...NPPDTPTESQ → LVPVSFEDPE...DPPDECGKTE

Show »
Length:518
Mass (Da):59,032
Checksum:iD01E1D6024F04565
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 11AGGSPSV → GGGFAAS in AAD12366 (PubMed:9858543).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000336274 – 314VVRSS…PTESQ → LVPVSFEDPEFKSSFSQSFS LYVKYQVAIHQDPPDECGKT E in isoform ATE1-2. 2 PublicationsAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025947 Genomic DNA No translation available.
AL731542 Genomic DNA No translation available.
AL731566 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49334.1
BC022026 mRNA Translation: AAH22026.2
AF079098 mRNA Translation: AAD12366.1
AF079099 mRNA Translation: AAD12367.1
CCDSiCCDS31299.1 [O95260-2]
CCDS31300.1 [O95260-1]
RefSeqiNP_001001976.1, NM_001001976.2 [O95260-1]
NP_001275663.1, NM_001288734.1
NP_001275664.1, NM_001288735.1
NP_001275665.1, NM_001288736.1
NP_008972.2, NM_007041.3 [O95260-2]
UniGeneiHs.632080

Genome annotation databases

EnsembliENST00000224652; ENSP00000224652; ENSG00000107669 [O95260-1]
ENST00000369043; ENSP00000358039; ENSG00000107669 [O95260-2]
GeneIDi11101
KEGGihsa:11101
UCSCiuc001lfp.5 human [O95260-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATE1_HUMAN
AccessioniPrimary (citable) accession number: O95260
Secondary accession number(s): O95261, Q5SQQ3, Q8WW04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 26, 2002
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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