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O95259

- KCNH1_HUMAN

UniProt

O95259 - KCNH1_HUMAN

Protein

Potassium voltage-gated channel subfamily H member 1

Gene

KCNH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi581 – 698118cNMPAdd
    BLAST

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: ProtInc
    2. phosphorelay sensor kinase activity Source: InterPro
    3. protein binding Source: IntAct

    GO - Biological processi

    1. myoblast fusion Source: ProtInc
    2. potassium ion transmembrane transport Source: RefGenome
    3. potassium ion transport Source: ProtInc
    4. regulation of membrane potential Source: RefGenome
    5. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Calmodulin-binding, Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily H member 1
    Alternative name(s):
    Ether-a-go-go potassium channel 1
    Short name:
    EAG channel 1
    Short name:
    h-eag
    Short name:
    hEAG1
    Voltage-gated potassium channel subunit Kv10.1
    Gene namesi
    Name:KCNH1
    Synonyms:EAG, EAG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6250. KCNH1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Nucleus inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Perinuclear KCNH1 is located to NPC-free islands.

    GO - Cellular componenti

    1. nuclear inner membrane Source: UniProtKB-SubCell
    2. plasma membrane Source: Reactome
    3. voltage-gated potassium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30037.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 989989Potassium voltage-gated channel subfamily H member 1PRO_0000053994Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO95259.
    PRIDEiO95259.

    PTM databases

    PhosphoSiteiO95259.

    Expressioni

    Tissue specificityi

    Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.

    Gene expression databases

    BgeeiO95259.
    CleanExiHS_KCNH1.
    GenevestigatoriO95259.

    Organism-specific databases

    HPAiHPA019445.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. Interacts with ALG10B By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CALM3P621584EBI-2909270,EBI-397435
    S100BP026383EBI-2909270,EBI-458452From a different organism.

    Protein-protein interaction databases

    BioGridi109958. 4 interactions.
    IntActiO95259. 7 interactions.
    MINTiMINT-138319.
    STRINGi9606.ENSP00000271751.

    Structurei

    3D structure databases

    ProteinModelPortaliO95259.
    SMRiO95259. Positions 28-137, 449-503, 509-720.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 220220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini242 – 2487ExtracellularSequence Analysis
    Topological domaini270 – 29425CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini316 – 34934ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini371 – 3766CytoplasmicSequence Analysis
    Topological domaini398 – 45053ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini472 – 4776ExtracellularSequence Analysis
    Topological domaini499 – 989491CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei451 – 47121Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei221 – 24121Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 9481PASPROSITE-ProRule annotationAdd
    BLAST
    Domaini93 – 14553PACPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni673 – 77098Calmodulin-bindingAdd
    BLAST
    Regioni924 – 96441CAD (involved in subunit assembly)By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi463 – 4686Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2202.
    HOGENOMiHOG000230794.
    HOVERGENiHBG101348.
    InParanoidiO95259.
    KOiK04904.
    OMAiHAKLHAP.
    OrthoDBiEOG7QG43V.
    PhylomeDBiO95259.
    TreeFamiTF313130.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003949. K_chnl_volt-dep_EAG.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01464. EAGCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: O95259-1) [UniParc]FASTAAdd to Basket

    Also known as: hEAGB

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTMAGGRRGL VAPQNTFLEN IVRRSNDTNF VLGNAQIVDW PIVYSNDGFC    50
    KLSGYHRAEV MQKSSTCSFM YGELTDKDTI EKVRQTFENY EMNSFEILMY 100
    KKNRTPVWFF VKIAPIRNEQ DKVVLFLCTF SDITAFKQPI EDDSCKGWGK 150
    FARLTRALTS SRGVLQQLAP SVQKGENVHK HSRLAEVLQL GSDILPQYKQ 200
    EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS FKTRQNNVAW 250
    LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL 300
    LSCLPYDVIN AFENVDEVSA FMGDPGKIGF ADQIPPPLEG RESQGISSLF 350
    SSLKVVRLLR LGRVARKLDH YIEYGAAVLV LLVCVFGLAA HWMACIWYSI 400
    GDYEIFDEDT KTIRNNSWLY QLAMDIGTPY QFNGSGSGKW EGGPSKNSVY 450
    ISSLYFTMTS LTSVGFGNIA PSTDIEKIFA VAIMMIGSLL YATIFGNVTT 500
    IFQQMYANTN RYHEMLNSVR DFLKLYQVPK GLSERVMDYI VSTWSMSRGI 550
    DTEKVLQICP KDMRADICVH LNRKVFKEHP AFRLASDGCL RALAMEFQTV 600
    HCAPGDLIYH AGESVDSLCF VVSGSLEVIQ DDEVVAILGK GDVFGDVFWK 650
    EATLAQSCAN VRALTYCDLH VIKRDALQKV LEFYTAFSHS FSRNLILTYN 700
    LRKRIVFRKI SDVKREEEER MKRKNEAPLI LPPDHPVRRL FQRFRQQKEA 750
    RLAAERGGRD LDDLDVEKGN VLTEHASANH SLVKASVVTV RESPATPVSF 800
    QAASTSGVPD HAKLQAPGSE CLGPKGGGGD CAKRKSWARF KDACGKSEDW 850
    NKVSKAESME TLPERTKASG EATLKKTDSC DSGITKSDLR LDNVGEARSP 900
    QDRSPILAEV KHSFYPIPEQ TLQATVLEVR HELKEDIKAL NAKMTNIEKQ 950
    LSEILRILTS RRSSQSPQEL FEISRPQSPE SERDIFGAS 989
    Length:989
    Mass (Da):111,423
    Last modified:May 1, 1999 - v1
    Checksum:iCAA8CB251300C7E5
    GO
    Isoform 1 (identifier: O95259-2) [UniParc]FASTAAdd to Basket

    Also known as: hEAG

    The sequence of this isoform differs from the canonical sequence as follows:
         318-344: Missing.

    Show »
    Length:962
    Mass (Da):108,597
    Checksum:i9CC995AFF156582D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei318 – 34427Missing in isoform 1. 2 PublicationsVSP_000964Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001366 mRNA. Translation: CAA04700.1.
    AF078741 mRNA. Translation: AAC68668.1.
    AF078742 mRNA. Translation: AAC68669.1.
    AL590132
    , AC092017, AC096636, AC099755 Genomic DNA. Translation: CAH71752.1.
    AL590132
    , AC092017, AC096636, AC099755 Genomic DNA. Translation: CAH71753.1.
    CH471100 Genomic DNA. Translation: EAW93424.1.
    CH471100 Genomic DNA. Translation: EAW93425.1.
    BC113709 mRNA. Translation: AAI13710.1.
    BC143599 mRNA. Translation: AAI43600.1.
    CCDSiCCDS1496.1. [O95259-1]
    CCDS31015.1. [O95259-2]
    RefSeqiNP_002229.1. NM_002238.3. [O95259-2]
    NP_758872.1. NM_172362.2. [O95259-1]
    UniGeneiHs.553187.

    Genome annotation databases

    EnsembliENST00000271751; ENSP00000271751; ENSG00000143473. [O95259-1]
    ENST00000367007; ENSP00000355974; ENSG00000143473. [O95259-2]
    GeneIDi3756.
    KEGGihsa:3756.
    UCSCiuc001hib.2. human. [O95259-1]
    uc001hic.2. human. [O95259-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001366 mRNA. Translation: CAA04700.1 .
    AF078741 mRNA. Translation: AAC68668.1 .
    AF078742 mRNA. Translation: AAC68669.1 .
    AL590132
    , AC092017 , AC096636 , AC099755 Genomic DNA. Translation: CAH71752.1 .
    AL590132
    , AC092017 , AC096636 , AC099755 Genomic DNA. Translation: CAH71753.1 .
    CH471100 Genomic DNA. Translation: EAW93424.1 .
    CH471100 Genomic DNA. Translation: EAW93425.1 .
    BC113709 mRNA. Translation: AAI13710.1 .
    BC143599 mRNA. Translation: AAI43600.1 .
    CCDSi CCDS1496.1. [O95259-1 ]
    CCDS31015.1. [O95259-2 ]
    RefSeqi NP_002229.1. NM_002238.3. [O95259-2 ]
    NP_758872.1. NM_172362.2. [O95259-1 ]
    UniGenei Hs.553187.

    3D structure databases

    ProteinModelPortali O95259.
    SMRi O95259. Positions 28-137, 449-503, 509-720.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109958. 4 interactions.
    IntActi O95259. 7 interactions.
    MINTi MINT-138319.
    STRINGi 9606.ENSP00000271751.

    Chemistry

    BindingDBi O95259.
    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 570.

    PTM databases

    PhosphoSitei O95259.

    Proteomic databases

    PaxDbi O95259.
    PRIDEi O95259.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271751 ; ENSP00000271751 ; ENSG00000143473 . [O95259-1 ]
    ENST00000367007 ; ENSP00000355974 ; ENSG00000143473 . [O95259-2 ]
    GeneIDi 3756.
    KEGGi hsa:3756.
    UCSCi uc001hib.2. human. [O95259-1 ]
    uc001hic.2. human. [O95259-2 ]

    Organism-specific databases

    CTDi 3756.
    GeneCardsi GC01M210851.
    HGNCi HGNC:6250. KCNH1.
    HPAi HPA019445.
    MIMi 603305. gene.
    neXtProti NX_O95259.
    PharmGKBi PA30037.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2202.
    HOGENOMi HOG000230794.
    HOVERGENi HBG101348.
    InParanoidi O95259.
    KOi K04904.
    OMAi HAKLHAP.
    OrthoDBi EOG7QG43V.
    PhylomeDBi O95259.
    TreeFami TF313130.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNH1.
    GenomeRNAii 3756.
    NextBioi 14711.
    PROi O95259.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95259.
    CleanExi HS_KCNH1.
    Genevestigatori O95259.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003949. K_chnl_volt-dep_EAG.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01464. EAGCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion."
      Occhiodoro T., Bernheim L., Liu J.-H., Bijlenga P., Sinnreich M., Bader C.R., Fischer-Lougheed J.
      FEBS Lett. 434:177-182(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Myoblast.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. "Inhibition of human ether a go-go potassium channels by Ca(2+)/calmodulin."
      Schoenherr R., Lober K., Heinemann S.H.
      EMBO J. 19:3263-3271(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CALMODULIN-BINDING DOMAIN.
    7. "Functional distinction of human EAG1 and EAG2 potassium channels."
      Schoenherr R., Gessner G., Loeber K., Heinemann S.H.
      FEBS Lett. 514:204-208(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KCNH5.
    8. "Functional K(v)10.1 channels localize to the inner nuclear membrane."
      Chen Y., Sanchez A., Rubio M.E., Kohl T., Pardo L.A., Stuhmer W.
      PLoS ONE 6:E19257-E19257(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiKCNH1_HUMAN
    AccessioniPrimary (citable) accession number: O95259
    Secondary accession number(s): B1AQ26, O76035, Q14CL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3