O95258 (UCP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain mitochondrial carrier protein 1
Short name=BMCP-1

Alternative name(s):
Mitochondrial uncoupling protein 5
Short name=UCP 5
Solute carrier family 25 member 14

Gene names

Name:	SLC25A14
Synonyms:	BMCP1, UCP5
ORF Names:	UNQ791/PRO1682

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Participates in the mitochondrial proton leak measured in brain mitochondria.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Mainly expressed in brain. Some expression in testis and pituitary. Ref.2
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic respiration Traceable author statement Ref.1. Source: ProtInc mitochondrial transport Inferred from electronic annotation. Source: InterPro transport Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95258-1)

Also known as: UCP5L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95258-2)

Also known as: UCP5S;

The sequence of this isoform differs from the canonical sequence as follows:
     23-25: Missing.

Isoform 3 (identifier: O95258-3)

Also known as: UCP5SI;

The sequence of this isoform differs from the canonical sequence as follows:
     23-25: Missing.
     198-198: R → RCLCSKAVTGCVLWLMPVIPALWEANAGGSLE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Brain mitochondrial carrier protein 1		PRO_0000090677
Regions
	Transmembrane	38 – 54	17	Helical; Name=1; Potential
	Transmembrane	112 – 128	17	Helical; Name=2; Potential
	Transmembrane	141 – 161	21	Helical; Name=3; Potential
	Transmembrane	199 – 215	17	Helical; Name=4; Potential
	Transmembrane	240 – 256	17	Helical; Name=5; Potential
	Transmembrane	298 – 315	18	Helical; Name=6; Potential
	Repeat	42 – 131	90	Solcar 1
	Repeat	139 – 224	86	Solcar 2
	Repeat	233 – 323	91	Solcar 3
Natural variations
	Alternative sequence	23 – 25	3	Missing in isoform 2 and isoform 3.		VSP_003272
	Alternative sequence	198	1	R → RCLCSKAVTGCVLWLMPVIP ALWEANAGGSLE in isoform 3.		VSP_003273
	Natural variant	55	1	E → A. Corresponds to variant rs2143598 [ dbSNP | Ensembl ].		VAR_050138

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (UCP5L) [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 0447E8E3B5374982	FASTA	325	36,202
	10 20 30 40 50 60 MGIFPGIILI FLRVKFATAA VIVSGHQKST TVSHEMSGLN WKPFVYGGLA SIVAEFGTFP 70 80 90 100 110 120 VDLTKTRLQV QGQSIDARFK EIKYRGMFHA LFRICKEEGV LALYSGIAPA LLRQASYGTI 130 140 150 160 170 180 KIGIYQSLKR LFVERLEDET LLINMICGVV SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM 190 200 210 220 230 240 IGSFIDIYQQ EGTRGLWRGV VPTAQRAAIV VGVELPVYDI TKKHLILSGM MGDTILTHFV 250 260 270 280 290 300 SSFTCGLAGA LASNPVDVVR TRMMNQRAIV GHVDLYKGTV DGILKMWKHE GFFALYKGFW 310 320 PNWLRLGPWN IIFFITYEQL KRLQI
	Isoform 2 (UCP5S) [UniParc]. Checksum: F3C186B06ADC0F6A	FASTA	322	35,958
	10 20 30 40 50 60 MGIFPGIILI FLRVKFATAA VIHQKSTTVS HEMSGLNWKP FVYGGLASIV AEFGTFPVDL 70 80 90 100 110 120 TKTRLQVQGQ SIDARFKEIK YRGMFHALFR ICKEEGVLAL YSGIAPALLR QASYGTIKIG 130 140 150 160 170 180 IYQSLKRLFV ERLEDETLLI NMICGVVSGV ISSTIANPTD VLKIRMQAQG SLFQGSMIGS 190 200 210 220 230 240 FIDIYQQEGT RGLWRGVVPT AQRAAIVVGV ELPVYDITKK HLILSGMMGD TILTHFVSSF 250 260 270 280 290 300 TCGLAGALAS NPVDVVRTRM MNQRAIVGHV DLYKGTVDGI LKMWKHEGFF ALYKGFWPNW 310 320 LRLGPWNIIF FITYEQLKRL QI
	Isoform 3 (UCP5SI) [UniParc]. Checksum: 8A66113E6FAE9C7B	FASTA	353	39,173
	10 20 30 40 50 60 MGIFPGIILI FLRVKFATAA VIHQKSTTVS HEMSGLNWKP FVYGGLASIV AEFGTFPVDL 70 80 90 100 110 120 TKTRLQVQGQ SIDARFKEIK YRGMFHALFR ICKEEGVLAL YSGIAPALLR QASYGTIKIG 130 140 150 160 170 180 IYQSLKRLFV ERLEDETLLI NMICGVVSGV ISSTIANPTD VLKIRMQAQG SLFQGSMIGS 190 200 210 220 230 240 FIDIYQQEGT RGLWRCLCSK AVTGCVLWLM PVIPALWEAN AGGSLEGVVP TAQRAAIVVG 250 260 270 280 290 300 VELPVYDITK KHLILSGMMG DTILTHFVSS FTCGLAGALA SNPVDVVRTR MMNQRAIVGH 310 320 330 340 350 VDLYKGTVDG ILKMWKHEGF FALYKGFWPN WLRLGPWNII FFITYEQLKR LQI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast." Sanchis D., Fleury C., Chomiki N., Goubern M., Huang Q., Neverova M., Gregoire F., Easlick J., Raimbault S., Levi-Meyrueis C., Miroux B., Collins S., Seldin M., Richard D., Warden C., Bouillaud F., Ricquier D. J. Biol. Chem. 273:34611-34615(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation." Yu X.X., Mao W., Zhong A., Schow P., Brush J., Sherwood S.W., Adams S.H., Pan G. FASEB J. 14:1611-1618(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF078544 mRNA. Translation: AAD04346.1. AF155809 mRNA. Translation: AAG29582.1. AF155810 mRNA. Translation: AAG29583.1. AF155811 mRNA. Translation: AAG29584.1. AY358099 mRNA. Translation: AAQ88466.1. AL035423 Genomic DNA. Translation: CAI42440.1. AL035423 Genomic DNA. Translation: CAI42441.1. AL035423 Genomic DNA. Translation: CAB41251.1. CH471107 Genomic DNA. Translation: EAX11804.1. BC119666 mRNA. Translation: AAI19667.1. BC119667 mRNA. Translation: AAI19668.1.
IPI	IPI00010162. IPI00029460. IPI00221084.
RefSeq	NP_003942.1. NM_003951.2. NP_073721.1. NM_022810.1.
UniGene	Hs.194686.
3D structure databases
ProteinModelPortal	O95258.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000218197.
Protein family/group databases
TCDB	2.A.29.24.1. mitochondrial carrier (MC) family.
PTM databases
PhosphoSite	O95258.
Proteomic databases
PaxDb	O95258.
PRIDE	O95258.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000218197; ENSP00000218197; ENSG00000102078. ENST00000339231; ENSP00000342797; ENSG00000102078. ENST00000361980; ENSP00000354455; ENSG00000102078.
GeneID	9016.
KEGG	hsa:9016.
UCSC	uc004evp.1. human. uc004evq.1. human. uc004evr.1. human.
Organism-specific databases
CTD	9016.
GeneCards	GC0XP129473.
HGNC	HGNC:10984. SLC25A14.
MIM	300242. gene.
neXtProt	NX_O95258.
PharmGKB	PA35860.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG240642.
HOGENOM	HOG000165140.
HOVERGEN	HBG009528.
KO	K15106.
OMA	WRCLCSK.
OrthoDB	EOG4V9TR9.
Gene expression databases
ArrayExpress	O95258.
Bgee	O95258.
CleanEx	HS_SLC25A14.
Genevestigator	O95258.
GermOnline	ENSG00000102078. Homo sapiens.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR002030. Mit_uncoupling. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00784. MTUNCOUPLING.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9016.
NextBio	33781.
SOURCE	Search...

Entry information

Entry name

UCP5_HUMAN

Accession

Primary (citable) accession number: O95258
Secondary accession number(s): D3DTG2 , Q0VDH7, Q9HC60, Q9HC61

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.