Growth arrest and DNA damage-inducible protein GADD45 gamma

Contribute

Send feedback

Read comments (?) or add your own

O95257 (GA45G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 gamma

Alternative name(s):
Cytokine-responsive protein CR6
DNA damage-inducible transcript 2 protein
Short name=DDIT-2

Gene names

Name:	GADD45G
Synonyms:	CR6, DDIT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
Subunit structure	Interacts with GADD45GIP1. Ref.8
Sequence similarities	Belongs to the GADD45 family.

Ontologies

Keywords
Biological process	Apoptosis Differentiation
Coding sequence diversity	Polymorphism
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Traceable author statement Ref.1. Source: ProtInc activation of MAPKK activity Inferred from electronic annotation. Source: Compara activation of MAPKKK activity Traceable author statement Ref.1. Source: ProtInc apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of protein kinase activity Inferred from electronic annotation. Source: Compara regulation of cell cycle Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
GADD45GIP1	Q8TAE8	4	EBI-448202,EBI-372506
KAT5	Q92993	2	EBI-448202,EBI-399080
KIAA1377	Q9P2H0	2	EBI-448202,EBI-473176
MED31	Q9Y3C7	2	EBI-448202,EBI-394707
UTP14A	Q9BVJ6	2	EBI-448202,EBI-473284

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 159

159

Growth arrest and DNA damage-inducible protein GADD45 gamma

PRO_0000148336

Natural variations

Natural variant

112

G → S. Ref.4 Ref.6
Corresponds to variant rs3138505 [ dbSNP | Ensembl ].

VAR_018888

Experimental info

Sequence conflict

34 – 35

QR → HG in AAK00414. Ref.4

Sequence conflict

113 – 115

APG → CAC in AAK00414. Ref.4

Secondary structure

159

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

O95257 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 26427E5881941E64
Show »

FASTA

159

17,121

        10         20         30         40         50         60 
MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL NVDPDNVTFC 

        70         80         90        100        110        120 
VLAAGEEDEG DIALQIHFTL IQAFCCENDI DIVRVGDVQR LAAIVGAGEE AGAPGDLHCI 

       130        140        150 
LISNPNEDAW KDPALEKLSL FCEESRSVND WVPSITLPE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK." Takekawa M., Saito H. Cell 95:521-530(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cytokine response gene 6 induces p21 and regulates both cell growth and arrest." Fan W., Richter G., Cereseto A., Beadling C., Smith K.A. Oncogene 18:6573-6582(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and characterization of Gadd45 gamma gene and its regulation by C/EBP." Jung N., Yi Y., Kim D., Shong M., Hong S., Lee H., Bae I. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping." Gong R., Yu L., Zhang H., Tu Q., Zhao Y., Yang J., Xu Y., Zhao S. Cytogenet. Cell Genet. 88:95-96(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-112.
[5]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	NIEHS SNPs program Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-112.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[8]	"CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle." Chung H.K., Yi Y.-W., Jung N.-C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.-H., Bae Y.-S., Kim J.M., Bae I., Shong M. J. Biol. Chem. 278:28079-28088(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GADD45GIP1. Tissue: Colon carcinoma.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Wikipedia

GADD45G entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF078078 mRNA. Translation: AAC83329.1.
AF079806 mRNA. Translation: AAD28544.1.
AF265659 Genomic DNA. Translation: AAF73468.1.
AF087883 mRNA. Translation: AAK00414.1.
BT007234 mRNA. Translation: AAP35898.1.
AF494037 Genomic DNA. Translation: AAM00007.1.
BC000465 mRNA. Translation: AAH00465.1.
BC019325 mRNA. Translation: AAH19325.1.

IPI

IPI00029458.

RefSeq

NP_006696.1. NM_006705.3.

UniGene

Hs.9701.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WAL	X-ray	2.40	A/B	1-159	[»]
3FFM	X-ray	2.30	A	1-159	[»]

ProteinModelPortal

O95257.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-24218N.

IntAct

O95257. 27 interactions.

MINT

MINT-265043.

STRING

9606.ENSP00000252506.

Proteomic databases

PaxDb

O95257.

PRIDE

O95257.

Protocols and materials databases

DNASU

10912.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000252506; ENSP00000252506; ENSG00000130222.

GeneID

10912.

KEGG

hsa:10912.

UCSC

uc004aqq.3. human.

Organism-specific databases

CTD

10912.

GeneCards

GC09P092219.

H-InvDB

HIX0169359.

HGNC

HGNC:4097. GADD45G.

HPA

HPA023606.

MIM

604949. gene.

neXtProt

NX_O95257.

PharmGKB

PA28512.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG79725.

HOGENOM

HOG000013221.

HOVERGEN

HBG051684.

InParanoid

O95257.

K04402.

OMA

DWVPTIT.

OrthoDB

EOG4KWJV5.

PhylomeDB

O95257.

Enzyme and pathway databases

Pathway_Interaction_DB

il12_2pathway. IL12-mediated signaling events.
p38_mkk3_6pathway. p38 MAPK signaling pathway.

Gene expression databases

ArrayExpress

O95257.

Bgee

O95257.

CleanEx

HS_GADD45G.

Genevestigator

O95257.

GermOnline

ENSG00000130222. Homo sapiens.

Family and domain databases

InterPro

IPR024824. GADD45.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]

PANTHER

PTHR10411. PTHR10411. 1 hit.

Pfam

PF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

GADD45G. human.

EvolutionaryTrace

O95257.

GenomeRNAi

10912.

NextBio

41445.

SOURCE

Search...

Entry information

Entry name

GA45G_HUMAN

Accession

Primary (citable) accession number: O95257
Secondary accession number(s): Q9C076

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Natural variations

Experimental info

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents