O95256 (I18RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-18 receptor accessory protein
Short name=IL-18 receptor accessory protein
Short name=IL-18RAcP

Alternative name(s):
Accessory protein-like
Short name=AcPL
CD218 antigen-like family member B
CDw218b
IL-1R accessory protein-like
Short name=IL-1RAcPL
Interleukin-1 receptor 7
Short name=IL-1R-7
Short name=IL-1R7
Interleukin-18 receptor accessory protein-like
Interleukin-18 receptor beta
Short name=IL-18R-beta
Short name=IL-18Rbeta
CD_antigen=CD218b

Gene names

Name:	IL18RAP
Synonyms:	IL1R7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	599 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex By similarity. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Ref.1
Subunit structure	Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18. Ref.1
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells. Ref.1 Ref.5 Ref.6
Induction	Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells. Ref.5
Sequence similarities	Belongs to the interleukin-1 receptor family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell surface receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc immune response Traceable author statement Ref.1. Source: ProtInc inflammatory response Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 599	580	Interleukin-18 receptor accessory protein		PRO_0000042185
Regions
	Topological domain	20 – 356	337	Extracellular Potential
	Transmembrane	357 – 377	21	Helical; Potential
	Topological domain	378 – 599	222	Cytoplasmic Potential
	Domain	149 – 235	87	Ig-like C2-type 1
	Domain	251 – 353	103	Ig-like C2-type 2
	Domain	406 – 562	157	TIR
Amino acid modifications
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Glycosylation	119	1	N-linked (GlcNAc...) Potential
	Glycosylation	152	1	N-linked (GlcNAc...) Potential
	Glycosylation	345	1	N-linked (GlcNAc...) Potential
	Disulfide bond	180 ↔ 221		By similarity
	Disulfide bond	273 ↔ 337		By similarity
Natural variations
	Natural variant	350	1	V → I. Corresponds to variant rs11465716 [ dbSNP | Ensembl ].		VAR_034005

Sequences

	Sequence		Length	Mass (Da)
	O95256 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 54807DA3E05462F1	FASTA	599	68,310
	10 20 30 40 50 60 MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE PQKSHFCHRN 70 80 90 100 110 120 RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS YPHIIQDKCT LHFLTPGVNN 130 140 150 160 170 180 SGSYICRPKM IKSPYDVACC VKMILEVKPQ TNASCEYSAS HKQDLLLGST GSISCPSLSC 190 200 210 220 230 240 QSDAQSPAVT WYKNGKLLSV ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV 250 260 270 280 290 300 RTIVGDTKLK PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV 310 320 330 340 350 360 SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV QLKEKRGVVL 370 380 390 400 410 420 LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ TLGDKKDFDA FVSYAKWSSF 430 440 450 460 470 480 PSEATSSLSE EHLALSLFPD VLENKYGYSL CLLERDVAPG GVYAEDIVSI IKRSRRGIFI 490 500 510 520 530 540 LSPNYVNGPS IFELQAAVNL ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR 550 560 570 580 590 GLKSVPPNSR FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling." Born T.L., Thomassen E., Bird T.A., Sims J.E. J. Biol. Chem. 273:29445-29450(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells." Sareneva T., Julkunen I., Matikainen S. J. Immunol. 165:1933-1938(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INDUCTION.
[6]	"IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18." Debets R., Timans J.C., Churakowa T., Zurawski S., de Waal Malefyt R., Moore K.W., Abrams J.S., O'Garra A., Bazan J.F., Kastelein R.A. J. Immunol. 165:4950-4956(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF077346 mRNA. Translation: AAC72196.1. AC007278 Genomic DNA. Translation: AAY15080.1. AC007248 Genomic DNA. Translation: AAY15049.1. CH471127 Genomic DNA. Translation: EAX01791.1. BC069630 mRNA. Translation: AAH69630.1. BC106765 mRNA. Translation: AAI06766.1. BC137474 mRNA. Translation: AAI37475.1. BC137475 mRNA. Translation: AAI37476.1.
IPI	IPI00021998.
RefSeq	NP_003844.1. NM_003853.2.
UniGene	Hs.158315.
3D structure databases
ProteinModelPortal	O95256.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000264260.
PTM databases
PhosphoSite	O95256.
Proteomic databases
PaxDb	O95256.
PRIDE	O95256.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264260; ENSP00000264260; ENSG00000115607.
GeneID	8807.
KEGG	hsa:8807.
UCSC	uc002tbx.3. human.
Organism-specific databases
CTD	8807.
GeneCards	GC02P103035.
HGNC	HGNC:5989. IL18RAP.
HPA	CAB025270.
MIM	604509. gene.
neXtProt	NX_O95256.
PharmGKB	PA29805.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40454.
HOGENOM	HOG000060101.
HOVERGEN	HBG081778.
InParanoid	O95256.
KO	K05174.
OMA	YVCDYTQ.
OrthoDB	EOG4CG087.
PhylomeDB	O95256.
Enzyme and pathway databases
Pathway_Interaction_DB	il12_stat4pathway. IL12 signaling mediated by STAT4. il12_2pathway. IL12-mediated signaling events. il23pathway. IL23-mediated signaling events.
Gene expression databases
ArrayExpress	O95256.
Bgee	O95256.
CleanEx	HS_IL18RAP.
Genevestigator	O95256.
GermOnline	ENSG00000115607. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR015621. IL1-receptor_fam. IPR000157. TIR_dom. [Graphical view]
PANTHER	PTHR11890. PTHR11890. 1 hit.
Pfam	PF01582. TIR. 1 hit. [Graphical view]
SMART	SM00409. IG. 2 hits. SM00255. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS50835. IG_LIKE. 2 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8807.
NextBio	33036.
SOURCE	Search...

Entry information

Entry name

I18RA_HUMAN

Accession

Primary (citable) accession number: O95256
Secondary accession number(s): B2RPJ3 , Q3KPE7, Q53TT4, Q53TU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.