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Protein

Interleukin-18 receptor accessory protein

Gene

IL18RAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation.Curated1 Publication

GO - Molecular functioni

  • receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • cellular response to cytokine stimulus Source: Ensembl
  • cellular response to hydrogen peroxide Source: Ensembl
  • immune response Source: ProtInc
  • inflammatory response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115607-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18 receptor accessory protein
Short name:
IL-18 receptor accessory protein
Short name:
IL-18RAcP
Alternative name(s):
Accessory protein-like
Short name:
AcPL
CD218 antigen-like family member B
CDw218b
IL-1R accessory protein-like
Short name:
IL-1RAcPL
Interleukin-1 receptor 7
Short name:
IL-1R-7
Short name:
IL-1R7
Interleukin-18 receptor accessory protein-like
Interleukin-18 receptor beta
Short name:
IL-18R-beta
Short name:
IL-18Rbeta
CD_antigen: CD218b
Gene namesi
Name:IL18RAP
Synonyms:IL1R7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5989. IL18RAP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 356ExtracellularSequence analysisAdd BLAST337
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Topological domaini378 – 599CytoplasmicSequence analysisAdd BLAST222

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8807.
OpenTargetsiENSG00000115607.
PharmGKBiPA29805.

Polymorphism and mutation databases

BioMutaiIL18RAP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000004218520 – 599Interleukin-18 receptor accessory proteinAdd BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi180 ↔ 221PROSITE-ProRule annotation
Disulfide bondi273 ↔ 337PROSITE-ProRule annotation
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95256.
PRIDEiO95256.

PTM databases

iPTMnetiO95256.
PhosphoSitePlusiO95256.

Expressioni

Tissue specificityi

Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.3 Publications

Inductioni

Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells.1 Publication

Gene expression databases

BgeeiENSG00000115607.
CleanExiHS_IL18RAP.
ExpressionAtlasiO95256. baseline and differential.
GenevisibleiO95256. HS.

Organism-specific databases

HPAiCAB025270.

Interactioni

Subunit structurei

Heterodimer with IL18R1; within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation.Curated

Protein-protein interaction databases

BioGridi114335. 3 interactors.
STRINGi9606.ENSP00000264260.

Structurei

Secondary structure

1599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 36Combined sources5
Beta strandi41 – 44Combined sources4
Beta strandi110 – 115Combined sources6
Beta strandi117 – 120Combined sources4
Beta strandi122 – 126Combined sources5
Beta strandi141 – 149Combined sources9
Beta strandi154 – 157Combined sources4
Beta strandi161 – 166Combined sources6
Beta strandi171 – 174Combined sources4
Helixi176 – 178Combined sources3
Turni180 – 183Combined sources4
Beta strandi189 – 193Combined sources5
Beta strandi203 – 210Combined sources8
Helixi213 – 215Combined sources3
Beta strandi217 – 224Combined sources8
Beta strandi233 – 243Combined sources11
Beta strandi252 – 255Combined sources4
Beta strandi258 – 263Combined sources6
Beta strandi269 – 278Combined sources10
Beta strandi286 – 293Combined sources8
Beta strandi296 – 299Combined sources4
Beta strandi306 – 310Combined sources5
Beta strandi312 – 325Combined sources14
Helixi328 – 331Combined sources4
Beta strandi333 – 341Combined sources9
Beta strandi344 – 354Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WO4X-ray3.10C15-356[»]
ProteinModelPortaliO95256.
SMRiO95256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 235Ig-like C2-type 1Add BLAST87
Domaini251 – 353Ig-like C2-type 2Add BLAST103
Domaini406 – 562TIRPROSITE-ProRule annotationAdd BLAST157

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGUG. Eukaryota.
ENOG410Y9SN. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000060101.
HOVERGENiHBG081778.
InParanoidiO95256.
KOiK05174.
OMAiPTVTWRG.
OrthoDBiEOG091G0GXW.
PhylomeDBiO95256.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 2 hits.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95256-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE
60 70 80 90 100
PQKSHFCHRN RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS
110 120 130 140 150
YPHIIQDKCT LHFLTPGVNN SGSYICRPKM IKSPYDVACC VKMILEVKPQ
160 170 180 190 200
TNASCEYSAS HKQDLLLGST GSISCPSLSC QSDAQSPAVT WYKNGKLLSV
210 220 230 240 250
ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV RTIVGDTKLK
260 270 280 290 300
PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV
310 320 330 340 350
SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV
360 370 380 390 400
QLKEKRGVVL LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ
410 420 430 440 450
TLGDKKDFDA FVSYAKWSSF PSEATSSLSE EHLALSLFPD VLENKYGYSL
460 470 480 490 500
CLLERDVAPG GVYAEDIVSI IKRSRRGIFI LSPNYVNGPS IFELQAAVNL
510 520 530 540 550
ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR GLKSVPPNSR
560 570 580 590
FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW
Length:599
Mass (Da):68,310
Last modified:May 1, 1999 - v1
Checksum:i54807DA3E05462F1
GO
Isoform 2 (identifier: O95256-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Note: No experimental confirmation available.
Show »
Length:457
Mass (Da):51,945
Checksum:iD18892A9D90312DA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034005350V → I.Corresponds to variant rs11465716dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562951 – 142Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077346 mRNA. Translation: AAC72196.1.
AC007278 Genomic DNA. Translation: AAY15080.1.
AC007248 Genomic DNA. Translation: AAY15049.1.
CH471127 Genomic DNA. Translation: EAX01791.1.
BC069630 mRNA. Translation: AAH69630.1.
BC106764 mRNA. Translation: AAI06765.1.
BC106765 mRNA. Translation: AAI06766.1.
BC137474 mRNA. Translation: AAI37475.1.
BC137475 mRNA. Translation: AAI37476.1.
CCDSiCCDS2061.1. [O95256-1]
RefSeqiNP_003844.1. NM_003853.3. [O95256-1]
XP_011510389.1. XM_011512087.2. [O95256-2]
XP_011510390.1. XM_011512088.2. [O95256-2]
UniGeneiHs.158315.

Genome annotation databases

EnsembliENST00000264260; ENSP00000264260; ENSG00000115607. [O95256-1]
ENST00000409369; ENSP00000387201; ENSG00000115607. [O95256-2]
GeneIDi8807.
KEGGihsa:8807.
UCSCiuc002tbx.4. human. [O95256-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077346 mRNA. Translation: AAC72196.1.
AC007278 Genomic DNA. Translation: AAY15080.1.
AC007248 Genomic DNA. Translation: AAY15049.1.
CH471127 Genomic DNA. Translation: EAX01791.1.
BC069630 mRNA. Translation: AAH69630.1.
BC106764 mRNA. Translation: AAI06765.1.
BC106765 mRNA. Translation: AAI06766.1.
BC137474 mRNA. Translation: AAI37475.1.
BC137475 mRNA. Translation: AAI37476.1.
CCDSiCCDS2061.1. [O95256-1]
RefSeqiNP_003844.1. NM_003853.3. [O95256-1]
XP_011510389.1. XM_011512087.2. [O95256-2]
XP_011510390.1. XM_011512088.2. [O95256-2]
UniGeneiHs.158315.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WO4X-ray3.10C15-356[»]
ProteinModelPortaliO95256.
SMRiO95256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114335. 3 interactors.
STRINGi9606.ENSP00000264260.

PTM databases

iPTMnetiO95256.
PhosphoSitePlusiO95256.

Polymorphism and mutation databases

BioMutaiIL18RAP.

Proteomic databases

PaxDbiO95256.
PRIDEiO95256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264260; ENSP00000264260; ENSG00000115607. [O95256-1]
ENST00000409369; ENSP00000387201; ENSG00000115607. [O95256-2]
GeneIDi8807.
KEGGihsa:8807.
UCSCiuc002tbx.4. human. [O95256-1]

Organism-specific databases

CTDi8807.
DisGeNETi8807.
GeneCardsiIL18RAP.
HGNCiHGNC:5989. IL18RAP.
HPAiCAB025270.
MIMi604509. gene.
neXtProtiNX_O95256.
OpenTargetsiENSG00000115607.
PharmGKBiPA29805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGUG. Eukaryota.
ENOG410Y9SN. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000060101.
HOVERGENiHBG081778.
InParanoidiO95256.
KOiK05174.
OMAiPTVTWRG.
OrthoDBiEOG091G0GXW.
PhylomeDBiO95256.
TreeFamiTF325519.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115607-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.

Miscellaneous databases

GeneWikiiIL18RAP.
GenomeRNAii8807.
PROiO95256.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115607.
CleanExiHS_IL18RAP.
ExpressionAtlasiO95256. baseline and differential.
GenevisibleiO95256. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 2 hits.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI18RA_HUMAN
AccessioniPrimary (citable) accession number: O95256
Secondary accession number(s): B2RPJ3
, Q3KPE7, Q3KPE8, Q53TT4, Q53TU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.