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Protein

Interleukin-18 receptor accessory protein

Gene

IL18RAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.By similarity1 Publication

GO - Molecular functioni

  1. receptor activity Source: ProtInc

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. immune response Source: ProtInc
  3. inflammatory response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18 receptor accessory protein
Short name:
IL-18 receptor accessory protein
Short name:
IL-18RAcP
Alternative name(s):
Accessory protein-like
Short name:
AcPL
CD218 antigen-like family member B
CDw218b
IL-1R accessory protein-like
Short name:
IL-1RAcPL
Interleukin-1 receptor 7
Short name:
IL-1R-7
Short name:
IL-1R7
Interleukin-18 receptor accessory protein-like
Interleukin-18 receptor beta
Short name:
IL-18R-beta
Short name:
IL-18Rbeta
CD_antigen: CD218b
Gene namesi
Name:IL18RAP
Synonyms:IL1R7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5989. IL18RAP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 356337ExtracellularSequence AnalysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence AnalysisAdd
BLAST
Topological domaini378 – 599222CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 599580Interleukin-18 receptor accessory proteinPRO_0000042185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi180 ↔ 221PROSITE-ProRule annotation
Disulfide bondi273 ↔ 337PROSITE-ProRule annotation
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95256.
PRIDEiO95256.

PTM databases

PhosphoSiteiO95256.

Expressioni

Tissue specificityi

Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.3 Publications

Inductioni

Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells.1 Publication

Gene expression databases

BgeeiO95256.
CleanExiHS_IL18RAP.
ExpressionAtlasiO95256. baseline and differential.
GenevestigatoriO95256.

Organism-specific databases

HPAiCAB025270.

Interactioni

Subunit structurei

Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18.1 Publication

Protein-protein interaction databases

BioGridi114335. 1 interaction.
STRINGi9606.ENSP00000264260.

Structurei

Secondary structure

1
599
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 365Combined sources
Beta strandi41 – 444Combined sources
Beta strandi110 – 1156Combined sources
Beta strandi117 – 1204Combined sources
Beta strandi122 – 1265Combined sources
Beta strandi141 – 1499Combined sources
Beta strandi154 – 1574Combined sources
Beta strandi161 – 1666Combined sources
Beta strandi171 – 1744Combined sources
Helixi176 – 1783Combined sources
Turni180 – 1834Combined sources
Beta strandi189 – 1935Combined sources
Beta strandi203 – 2108Combined sources
Helixi213 – 2153Combined sources
Beta strandi217 – 2248Combined sources
Beta strandi233 – 24311Combined sources
Beta strandi252 – 2554Combined sources
Beta strandi258 – 2636Combined sources
Beta strandi269 – 27810Combined sources
Beta strandi286 – 2938Combined sources
Beta strandi296 – 2994Combined sources
Beta strandi306 – 3105Combined sources
Beta strandi312 – 32514Combined sources
Helixi328 – 3314Combined sources
Beta strandi333 – 3419Combined sources
Beta strandi344 – 35411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WO4X-ray3.10C15-356[»]
ProteinModelPortaliO95256.
SMRiO95256. Positions 84-354, 406-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 23587Ig-like C2-type 1Add
BLAST
Domaini251 – 353103Ig-like C2-type 2Add
BLAST
Domaini406 – 562157TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40454.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000060101.
HOVERGENiHBG081778.
InParanoidiO95256.
KOiK05174.
OMAiYVCDYTQ.
OrthoDBiEOG7CVPXJ.
PhylomeDBiO95256.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95256-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE
60 70 80 90 100
PQKSHFCHRN RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS
110 120 130 140 150
YPHIIQDKCT LHFLTPGVNN SGSYICRPKM IKSPYDVACC VKMILEVKPQ
160 170 180 190 200
TNASCEYSAS HKQDLLLGST GSISCPSLSC QSDAQSPAVT WYKNGKLLSV
210 220 230 240 250
ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV RTIVGDTKLK
260 270 280 290 300
PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV
310 320 330 340 350
SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV
360 370 380 390 400
QLKEKRGVVL LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ
410 420 430 440 450
TLGDKKDFDA FVSYAKWSSF PSEATSSLSE EHLALSLFPD VLENKYGYSL
460 470 480 490 500
CLLERDVAPG GVYAEDIVSI IKRSRRGIFI LSPNYVNGPS IFELQAAVNL
510 520 530 540 550
ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR GLKSVPPNSR
560 570 580 590
FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW
Length:599
Mass (Da):68,310
Last modified:May 1, 1999 - v1
Checksum:i54807DA3E05462F1
GO
Isoform 2 (identifier: O95256-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Note: No experimental confirmation available.

Show »
Length:457
Mass (Da):51,945
Checksum:iD18892A9D90312DA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti350 – 3501V → I.
Corresponds to variant rs11465716 [ dbSNP | Ensembl ].
VAR_034005

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 142142Missing in isoform 2. 1 PublicationVSP_056295Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077346 mRNA. Translation: AAC72196.1.
AC007278 Genomic DNA. Translation: AAY15080.1.
AC007248 Genomic DNA. Translation: AAY15049.1.
CH471127 Genomic DNA. Translation: EAX01791.1.
BC069630 mRNA. Translation: AAH69630.1.
BC106764 mRNA. Translation: AAI06765.1.
BC106765 mRNA. Translation: AAI06766.1.
BC137474 mRNA. Translation: AAI37475.1.
BC137475 mRNA. Translation: AAI37476.1.
CCDSiCCDS2061.1. [O95256-1]
RefSeqiNP_003844.1. NM_003853.3. [O95256-1]
XP_005264091.1. XM_005264034.1. [O95256-2]
UniGeneiHs.158315.

Genome annotation databases

EnsembliENST00000264260; ENSP00000264260; ENSG00000115607. [O95256-1]
ENST00000409369; ENSP00000387201; ENSG00000115607. [O95256-2]
GeneIDi8807.
KEGGihsa:8807.
UCSCiuc002tbx.3. human. [O95256-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077346 mRNA. Translation: AAC72196.1.
AC007278 Genomic DNA. Translation: AAY15080.1.
AC007248 Genomic DNA. Translation: AAY15049.1.
CH471127 Genomic DNA. Translation: EAX01791.1.
BC069630 mRNA. Translation: AAH69630.1.
BC106764 mRNA. Translation: AAI06765.1.
BC106765 mRNA. Translation: AAI06766.1.
BC137474 mRNA. Translation: AAI37475.1.
BC137475 mRNA. Translation: AAI37476.1.
CCDSiCCDS2061.1. [O95256-1]
RefSeqiNP_003844.1. NM_003853.3. [O95256-1]
XP_005264091.1. XM_005264034.1. [O95256-2]
UniGeneiHs.158315.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WO4X-ray3.10C15-356[»]
ProteinModelPortaliO95256.
SMRiO95256. Positions 84-354, 406-560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114335. 1 interaction.
STRINGi9606.ENSP00000264260.

PTM databases

PhosphoSiteiO95256.

Proteomic databases

PaxDbiO95256.
PRIDEiO95256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264260; ENSP00000264260; ENSG00000115607. [O95256-1]
ENST00000409369; ENSP00000387201; ENSG00000115607. [O95256-2]
GeneIDi8807.
KEGGihsa:8807.
UCSCiuc002tbx.3. human. [O95256-1]

Organism-specific databases

CTDi8807.
GeneCardsiGC02P103035.
HGNCiHGNC:5989. IL18RAP.
HPAiCAB025270.
MIMi604509. gene.
neXtProtiNX_O95256.
PharmGKBiPA29805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40454.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000060101.
HOVERGENiHBG081778.
InParanoidiO95256.
KOiK05174.
OMAiYVCDYTQ.
OrthoDBiEOG7CVPXJ.
PhylomeDBiO95256.
TreeFamiTF325519.

Miscellaneous databases

GeneWikiiIL18RAP.
GenomeRNAii8807.
NextBioi33036.
PROiO95256.
SOURCEiSearch...

Gene expression databases

BgeeiO95256.
CleanExiHS_IL18RAP.
ExpressionAtlasiO95256. baseline and differential.
GenevestigatoriO95256.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling."
    Born T.L., Thomassen E., Bird T.A., Sims J.E.
    J. Biol. Chem. 273:29445-29450(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  5. "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells."
    Sareneva T., Julkunen I., Matikainen S.
    J. Immunol. 165:1933-1938(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  6. "IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18."
    Debets R., Timans J.C., Churakowa T., Zurawski S., de Waal Malefyt R., Moore K.W., Abrams J.S., O'Garra A., Bazan J.F., Kastelein R.A.
    J. Immunol. 165:4950-4956(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiI18RA_HUMAN
AccessioniPrimary (citable) accession number: O95256
Secondary accession number(s): B2RPJ3
, Q3KPE7, Q3KPE8, Q53TT4, Q53TU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.