Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O95256

- I18RA_HUMAN

UniProt

O95256 - I18RA_HUMAN

Protein

Interleukin-18 receptor accessory protein

Gene

IL18RAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex By similarity. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.By similarity1 Publication

    GO - Molecular functioni

    1. receptor activity Source: ProtInc

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. immune response Source: ProtInc
    3. inflammatory response Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-18 receptor accessory protein
    Short name:
    IL-18 receptor accessory protein
    Short name:
    IL-18RAcP
    Alternative name(s):
    Accessory protein-like
    Short name:
    AcPL
    CD218 antigen-like family member B
    CDw218b
    IL-1R accessory protein-like
    Short name:
    IL-1RAcPL
    Interleukin-1 receptor 7
    Short name:
    IL-1R-7
    Short name:
    IL-1R7
    Interleukin-18 receptor accessory protein-like
    Interleukin-18 receptor beta
    Short name:
    IL-18R-beta
    Short name:
    IL-18Rbeta
    CD_antigen: CD218b
    Gene namesi
    Name:IL18RAP
    Synonyms:IL1R7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:5989. IL18RAP.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29805.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 599580Interleukin-18 receptor accessory proteinPRO_0000042185Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi180 ↔ 221PROSITE-ProRule annotation
    Disulfide bondi273 ↔ 337PROSITE-ProRule annotation
    Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95256.
    PRIDEiO95256.

    PTM databases

    PhosphoSiteiO95256.

    Expressioni

    Tissue specificityi

    Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.3 Publications

    Inductioni

    Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells.1 Publication

    Gene expression databases

    ArrayExpressiO95256.
    BgeeiO95256.
    CleanExiHS_IL18RAP.
    GenevestigatoriO95256.

    Organism-specific databases

    HPAiCAB025270.

    Interactioni

    Subunit structurei

    Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18.1 Publication

    Protein-protein interaction databases

    BioGridi114335. 1 interaction.
    STRINGi9606.ENSP00000264260.

    Structurei

    3D structure databases

    ProteinModelPortaliO95256.
    SMRiO95256. Positions 82-354, 406-560.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 356337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini378 – 599222CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei357 – 37721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini149 – 23587Ig-like C2-type 1Add
    BLAST
    Domaini251 – 353103Ig-like C2-type 2Add
    BLAST
    Domaini406 – 562157TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the interleukin-1 receptor family.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40454.
    HOGENOMiHOG000060101.
    HOVERGENiHBG081778.
    InParanoidiO95256.
    KOiK05174.
    OMAiYVCDYTQ.
    OrthoDBiEOG7CVPXJ.
    PhylomeDBiO95256.
    TreeFamiTF325519.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    3.40.50.10140. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR000157. TIR_dom.
    [Graphical view]
    PANTHERiPTHR11890. PTHR11890. 1 hit.
    PfamiPF01582. TIR. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS50835. IG_LIKE. 2 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95256-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE    50
    PQKSHFCHRN RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS 100
    YPHIIQDKCT LHFLTPGVNN SGSYICRPKM IKSPYDVACC VKMILEVKPQ 150
    TNASCEYSAS HKQDLLLGST GSISCPSLSC QSDAQSPAVT WYKNGKLLSV 200
    ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV RTIVGDTKLK 250
    PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV 300
    SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV 350
    QLKEKRGVVL LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ 400
    TLGDKKDFDA FVSYAKWSSF PSEATSSLSE EHLALSLFPD VLENKYGYSL 450
    CLLERDVAPG GVYAEDIVSI IKRSRRGIFI LSPNYVNGPS IFELQAAVNL 500
    ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR GLKSVPPNSR 550
    FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW 599
    Length:599
    Mass (Da):68,310
    Last modified:May 1, 1999 - v1
    Checksum:i54807DA3E05462F1
    GO
    Isoform 2 (identifier: O95256-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-142: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:457
    Mass (Da):51,945
    Checksum:iD18892A9D90312DA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti350 – 3501V → I.
    Corresponds to variant rs11465716 [ dbSNP | Ensembl ].
    VAR_034005

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 142142Missing in isoform 2. 1 PublicationVSP_056295Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077346 mRNA. Translation: AAC72196.1.
    AC007278 Genomic DNA. Translation: AAY15080.1.
    AC007248 Genomic DNA. Translation: AAY15049.1.
    CH471127 Genomic DNA. Translation: EAX01791.1.
    BC069630 mRNA. Translation: AAH69630.1.
    BC106764 mRNA. Translation: AAI06765.1.
    BC106765 mRNA. Translation: AAI06766.1.
    BC137474 mRNA. Translation: AAI37475.1.
    BC137475 mRNA. Translation: AAI37476.1.
    CCDSiCCDS2061.1.
    RefSeqiNP_003844.1. NM_003853.3.
    XP_005264091.1. XM_005264034.1.
    UniGeneiHs.158315.

    Genome annotation databases

    EnsembliENST00000264260; ENSP00000264260; ENSG00000115607.
    ENST00000409369; ENSP00000387201; ENSG00000115607.
    GeneIDi8807.
    KEGGihsa:8807.
    UCSCiuc002tbx.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077346 mRNA. Translation: AAC72196.1 .
    AC007278 Genomic DNA. Translation: AAY15080.1 .
    AC007248 Genomic DNA. Translation: AAY15049.1 .
    CH471127 Genomic DNA. Translation: EAX01791.1 .
    BC069630 mRNA. Translation: AAH69630.1 .
    BC106764 mRNA. Translation: AAI06765.1 .
    BC106765 mRNA. Translation: AAI06766.1 .
    BC137474 mRNA. Translation: AAI37475.1 .
    BC137475 mRNA. Translation: AAI37476.1 .
    CCDSi CCDS2061.1.
    RefSeqi NP_003844.1. NM_003853.3.
    XP_005264091.1. XM_005264034.1.
    UniGenei Hs.158315.

    3D structure databases

    ProteinModelPortali O95256.
    SMRi O95256. Positions 82-354, 406-560.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114335. 1 interaction.
    STRINGi 9606.ENSP00000264260.

    PTM databases

    PhosphoSitei O95256.

    Proteomic databases

    PaxDbi O95256.
    PRIDEi O95256.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264260 ; ENSP00000264260 ; ENSG00000115607 .
    ENST00000409369 ; ENSP00000387201 ; ENSG00000115607 .
    GeneIDi 8807.
    KEGGi hsa:8807.
    UCSCi uc002tbx.3. human.

    Organism-specific databases

    CTDi 8807.
    GeneCardsi GC02P103035.
    HGNCi HGNC:5989. IL18RAP.
    HPAi CAB025270.
    MIMi 604509. gene.
    neXtProti NX_O95256.
    PharmGKBi PA29805.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40454.
    HOGENOMi HOG000060101.
    HOVERGENi HBG081778.
    InParanoidi O95256.
    KOi K05174.
    OMAi YVCDYTQ.
    OrthoDBi EOG7CVPXJ.
    PhylomeDBi O95256.
    TreeFami TF325519.

    Miscellaneous databases

    GeneWikii IL18RAP.
    GenomeRNAii 8807.
    NextBioi 33036.
    PROi O95256.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95256.
    Bgeei O95256.
    CleanExi HS_IL18RAP.
    Genevestigatori O95256.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    3.40.50.10140. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR000157. TIR_dom.
    [Graphical view ]
    PANTHERi PTHR11890. PTHR11890. 1 hit.
    Pfami PF01582. TIR. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS50835. IG_LIKE. 2 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling."
      Born T.L., Thomassen E., Bird T.A., Sims J.E.
      J. Biol. Chem. 273:29445-29450(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    5. "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells."
      Sareneva T., Julkunen I., Matikainen S.
      J. Immunol. 165:1933-1938(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    6. "IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18."
      Debets R., Timans J.C., Churakowa T., Zurawski S., de Waal Malefyt R., Moore K.W., Abrams J.S., O'Garra A., Bazan J.F., Kastelein R.A.
      J. Immunol. 165:4950-4956(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiI18RA_HUMAN
    AccessioniPrimary (citable) accession number: O95256
    Secondary accession number(s): B2RPJ3
    , Q3KPE7, Q3KPE8, Q53TT4, Q53TU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3