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O95256 (I18RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-18 receptor accessory protein

Short name=IL-18 receptor accessory protein
Short name=IL-18RAcP
Alternative name(s):
Accessory protein-like
Short name=AcPL
CD218 antigen-like family member B
CDw218b
IL-1R accessory protein-like
Short name=IL-1RAcPL
Interleukin-1 receptor 7
Short name=IL-1R-7
Short name=IL-1R7
Interleukin-18 receptor accessory protein-like
Interleukin-18 receptor beta
Short name=IL-18R-beta
Short name=IL-18Rbeta
CD_antigen=CD218b
Gene names
Name:IL18RAP
Synonyms:IL1R7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex By similarity. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Ref.1

Subunit structure

Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18. Ref.1

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells. Ref.1 Ref.5 Ref.6

Induction

Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells. Ref.5

Sequence similarities

Belongs to the interleukin-1 receptor family.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 TIR domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell surface receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

immune response

Traceable author statement Ref.1. Source: ProtInc

inflammatory response

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionreceptor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 599580Interleukin-18 receptor accessory protein
PRO_0000042185

Regions

Topological domain20 – 356337Extracellular Potential
Transmembrane357 – 37721Helical; Potential
Topological domain378 – 599222Cytoplasmic Potential
Domain149 – 23587Ig-like C2-type 1
Domain251 – 353103Ig-like C2-type 2
Domain406 – 562157TIR

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation3451N-linked (GlcNAc...) Potential
Disulfide bond180 ↔ 221 By similarity
Disulfide bond273 ↔ 337 By similarity

Natural variations

Natural variant3501V → I.
Corresponds to variant rs11465716 [ dbSNP | Ensembl ].
VAR_034005

Sequences

Sequence LengthMass (Da)Tools
O95256 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 54807DA3E05462F1

FASTA59968,310
        10         20         30         40         50         60 
MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE PQKSHFCHRN 

        70         80         90        100        110        120 
RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS YPHIIQDKCT LHFLTPGVNN 

       130        140        150        160        170        180 
SGSYICRPKM IKSPYDVACC VKMILEVKPQ TNASCEYSAS HKQDLLLGST GSISCPSLSC 

       190        200        210        220        230        240 
QSDAQSPAVT WYKNGKLLSV ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV 

       250        260        270        280        290        300 
RTIVGDTKLK PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV 

       310        320        330        340        350        360 
SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV QLKEKRGVVL 

       370        380        390        400        410        420 
LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ TLGDKKDFDA FVSYAKWSSF 

       430        440        450        460        470        480 
PSEATSSLSE EHLALSLFPD VLENKYGYSL CLLERDVAPG GVYAEDIVSI IKRSRRGIFI 

       490        500        510        520        530        540 
LSPNYVNGPS IFELQAAVNL ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR 

       550        560        570        580        590 
GLKSVPPNSR FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling."
Born T.L., Thomassen E., Bird T.A., Sims J.E.
J. Biol. Chem. 273:29445-29450(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells."
Sareneva T., Julkunen I., Matikainen S.
J. Immunol. 165:1933-1938(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION.
[6]"IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18."
Debets R., Timans J.C., Churakowa T., Zurawski S., de Waal Malefyt R., Moore K.W., Abrams J.S., O'Garra A., Bazan J.F., Kastelein R.A.
J. Immunol. 165:4950-4956(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF077346 mRNA. Translation: AAC72196.1.
AC007278 Genomic DNA. Translation: AAY15080.1.
AC007248 Genomic DNA. Translation: AAY15049.1.
CH471127 Genomic DNA. Translation: EAX01791.1.
BC069630 mRNA. Translation: AAH69630.1.
BC106765 mRNA. Translation: AAI06766.1.
BC137474 mRNA. Translation: AAI37475.1.
BC137475 mRNA. Translation: AAI37476.1.
RefSeqNP_003844.1. NM_003853.2.
UniGeneHs.158315.

3D structure databases

ProteinModelPortalO95256.
SMRO95256. Positions 82-354, 406-560.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114335. 1 interaction.
STRING9606.ENSP00000264260.

PTM databases

PhosphoSiteO95256.

Proteomic databases

PaxDbO95256.
PRIDEO95256.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264260; ENSP00000264260; ENSG00000115607.
GeneID8807.
KEGGhsa:8807.
UCSCuc002tbx.3. human.

Organism-specific databases

CTD8807.
GeneCardsGC02P103035.
HGNCHGNC:5989. IL18RAP.
HPACAB025270.
MIM604509. gene.
neXtProtNX_O95256.
PharmGKBPA29805.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40454.
HOGENOMHOG000060101.
HOVERGENHBG081778.
InParanoidO95256.
KOK05174.
OMAYVCDYTQ.
OrthoDBEOG7CVPXJ.
PhylomeDBO95256.
TreeFamTF325519.

Gene expression databases

ArrayExpressO95256.
BgeeO95256.
CleanExHS_IL18RAP.
GenevestigatorO95256.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR000157. TIR_dom.
[Graphical view]
PANTHERPTHR11890. PTHR11890. 1 hit.
PfamPF01582. TIR. 1 hit.
[Graphical view]
SMARTSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. SSF52200. 1 hit.
PROSITEPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIL18RAP.
GenomeRNAi8807.
NextBio33036.
PROO95256.
SOURCESearch...

Entry information

Entry nameI18RA_HUMAN
AccessionPrimary (citable) accession number: O95256
Secondary accession number(s): B2RPJ3 expand/collapse secondary AC list , Q3KPE7, Q53TT4, Q53TU5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries