O95255 (MRP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Multidrug resistance-associated protein 6

Alternative name(s):
ATP-binding cassette sub-family C member 6
Anthracycline resistance-associated protein
Multi-specific organic anion transporter E
Short name=MOAT-E

Gene names

Name:	ABCC6
Synonyms:	ARA, MRP6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1503 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Ref.5
Subcellular location	Membrane; Multi-pass membrane protein By similarity. Note: Localized to the basolateral membrane. Ref.7
Tissue specificity	Expressed in kidney and liver. Very low expression in other tissues.
Involvement in disease	Pseudoxanthoma elasticum (PXE) [MIM:264800]: A multisystem disorder characterized by accumulation of mineralized and fragmented elastic fibers in the skin, vascular walls, and Burch membrane in the eye. Clinically, patients exhibit characteristic lesions of the posterior segment of the eye including peau d'orange, angioid streaks, and choroidal neovascularizations, of the skin including soft, ivory colored papules in a reticular pattern that predominantly affect the neck and large flexor surfaces, and of the cardiovascular system with peripheral and coronary arterial occlusive disease as well as gastrointestinal bleedings. Note: The disease is caused by mutations affecting the gene represented in this entry. Homozygous or compound heterozygous ABCC6 mutations have been found in the overwhelming majority of cases. Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype. Ref.5 Ref.6 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.22 Ref.23 Arterial calcification of infancy, generalized, 2 (GACI2) [MIM:614473]: A severe autosomal recessive disorder characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. The disorder is often fatal within the first 6 months of life because of myocardial ischemia resulting in refractory heart failure. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.24
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.
Sequence caution	The sequence AAC15785.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Sensory transduction Transport Vision
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Disease	Disease mutation
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to drug Traceable author statement PubMed 8912525. Source: ProtInc visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW lateral plasma membrane Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement. Source: Reactome
Molecular_function	ATP binding Traceable author statement PubMed 8912525. Source: ProtInc ATPase activity, coupled to transmembrane movement of substances Traceable author statement PubMed 8912525. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1503	1503	Multidrug resistance-associated protein 6		PRO_0000093366
Regions
	Topological domain	1 – 31	31	Extracellular By similarity
	Transmembrane	32 – 52	21	Helical; Name=1; By similarity
	Topological domain	53 – 72	20	Cytoplasmic By similarity
	Transmembrane	73 – 93	21	Helical; Name=2; By similarity
	Topological domain	94 – 98	5	Extracellular By similarity
	Transmembrane	99 – 119	21	Helical; Name=3; By similarity
	Topological domain	120 – 131	12	Cytoplasmic By similarity
	Transmembrane	132 – 149	18	Helical; Name=4; By similarity
	Topological domain	150 – 167	18	Extracellular By similarity
	Transmembrane	168 – 188	21	Helical; Name=5; By similarity
	Topological domain	189 – 302	114	Cytoplasmic By similarity
	Transmembrane	303 – 323	21	Helical; Name=6; By similarity
	Topological domain	324 – 349	26	Extracellular By similarity
	Transmembrane	350 – 370	21	Helical; Name=7; By similarity
	Topological domain	371 – 426	56	Cytoplasmic By similarity
	Transmembrane	427 – 447	21	Helical; Name=8; By similarity
	Topological domain	448 – 450	3	Extracellular By similarity
	Transmembrane	451 – 471	21	Helical; Name=9; By similarity
	Topological domain	472 – 533	62	Cytoplasmic By similarity
	Transmembrane	534 – 554	21	Helical; Name=10; By similarity
	Topological domain	555 – 575	21	Extracellular By similarity
	Transmembrane	576 – 596	21	Helical; Name=11; By similarity
	Topological domain	597 – 939	343	Cytoplasmic By similarity
	Transmembrane	940 – 960	21	Helical; Name=12; By similarity
	Topological domain	961 – 997	37	Extracellular By similarity
	Transmembrane	998 – 1018	21	Helical; Name=13; By similarity
	Topological domain	1019 – 1061	43	Cytoplasmic By similarity
	Transmembrane	1062 – 1082	21	Helical; Name=14; By similarity
	Topological domain	1083	1	Extracellular By similarity
	Transmembrane	1084 – 1104	21	Helical; Name=15; By similarity
	Topological domain	1105 – 1175	71	Cytoplasmic By similarity
	Transmembrane	1176 – 1196	21	Helical; Name=16; By similarity
	Topological domain	1197 – 1198	2	Extracellular By similarity
	Transmembrane	1199 – 1219	21	Helical; Name=17; By similarity
	Topological domain	1220 – 1503	284	Cytoplasmic By similarity
	Domain	311 – 593	283	ABC transmembrane type-1 1
	Domain	629 – 853	225	ABC transporter 1
	Domain	947 – 1228	282	ABC transmembrane type-1 2
	Domain	1265 – 1499	235	ABC transporter 2
	Nucleotide binding	663 – 670	8	ATP 1 Potential
	Nucleotide binding	1299 – 1306	8	ATP 2 Potential
Amino acid modifications
	Modified residue	244	1	Phosphoserine By similarity
	Modified residue	902	1	Phosphoserine By similarity
	Glycosylation	15	1	N-linked (GlcNAc...) Probable
Natural variations
	Natural variant	60 – 62	3	Missing in PXE; autosomal recessive.		VAR_013363
	Natural variant	61	1	G → D. Ref.13		VAR_013364
	Natural variant	64	1	R → W. Ref.1 Ref.3 Ref.9		VAR_013365
	Natural variant	74	1	Missing in PXE. Ref.18		VAR_067840
	Natural variant	78	1	A → T. Ref.19 Ref.22		VAR_067841
	Natural variant	125	1	E → K. Ref.19 Corresponds to variant rs3853814 [ dbSNP | Ensembl ].		VAR_067842
	Natural variant	129	1	G → E in PXE; autosomal recessive. Ref.19		VAR_067843
	Natural variant	158	1	A → V. Ref.19		VAR_067844
	Natural variant	207	1	G → R. Ref.13		VAR_013366
	Natural variant	265	1	R → G. Ref.13 Ref.14 Ref.19 Ref.22 Corresponds to variant rs78629019 [ dbSNP | Ensembl ].		VAR_013367
	Natural variant	281	1	K → E. Ref.13 Ref.19 Corresponds to variant rs4780606 [ dbSNP | Ensembl ].		VAR_013368
	Natural variant	317	1	S → R in PXE; autosomal recessive. Ref.19 Ref.20 Corresponds to variant rs78678589 [ dbSNP | Ensembl ].		VAR_067845
	Natural variant	319	1	I → V. Ref.13 Ref.19 Corresponds to variant rs72657699 [ dbSNP | Ensembl ].		VAR_013369
	Natural variant	355	1	L → R in GACI2 and PXE; autosomal recessive. Ref.19 Ref.24 Corresponds to variant rs72653758 [ dbSNP | Ensembl ].		VAR_067846
	Natural variant	363 – 373	11	Missing in PXE.		VAR_067847
	Natural variant	364	1	T → R in PXE; autosomal recessive. Ref.14 Ref.17 Ref.19 Ref.20		VAR_013370
	Natural variant	370	1	N → D in PXE; autosomal recessive. Ref.19 Corresponds to variant rs72653760 [ dbSNP | Ensembl ].		VAR_067848
	Natural variant	382	1	R → W in PXE. Ref.20 Corresponds to variant rs72653761 [ dbSNP | Ensembl ].		VAR_067849
	Natural variant	391	1	R → G in GACI2 and PXE; autosomal recessive. Ref.18 Ref.19 Ref.20 Ref.24 Corresponds to variant rs72653762 [ dbSNP | Ensembl ].		VAR_067850
	Natural variant	392	1	K → N in PXE. Ref.20		VAR_067851
	Natural variant	398	1	S → G in PXE; autosomal recessive. Ref.19 Corresponds to variant rs72653764 [ dbSNP | Ensembl ].		VAR_067852
	Natural variant	411	1	N → K in PXE; autosomal dominant. Ref.13 Ref.17 Corresponds to variant rs9930886 [ dbSNP | Ensembl ].		VAR_013371
	Natural variant	417	1	V → M. Ref.22		VAR_067853
	Natural variant	440	1	C → G in PXE; autosomal recessive. Ref.17 Corresponds to variant rs72653766 [ dbSNP | Ensembl ].		VAR_067854
	Natural variant	455	1	A → P in PXE; autosomal dominant. Ref.6 Corresponds to variant rs67996819 [ dbSNP | Ensembl ].		VAR_013372
	Natural variant	463	1	L → H in PXE. Ref.20 Corresponds to variant rs72653767 [ dbSNP | Ensembl ].		VAR_067855
	Natural variant	495	1	L → H in PXE; autosomal recessive. Ref.19 Ref.20 Corresponds to variant rs72653769 [ dbSNP | Ensembl ].		VAR_067856
	Natural variant	497	1	N → K. Ref.13 Corresponds to variant rs72653770 [ dbSNP | Ensembl ].		VAR_013373
	Natural variant	514	1	V → I. Ref.19 Corresponds to variant rs59157279 [ dbSNP | Ensembl ].		VAR_067857
	Natural variant	518	1	R → Q in PXE; autosomal recessive. Ref.13 Ref.17 Ref.18 Ref.19 Ref.20 Ref.22 Corresponds to variant rs72653772 [ dbSNP | Ensembl ].		VAR_013374
	Natural variant	535	1	S → P in PXE. Ref.20 Corresponds to variant rs72653773 [ dbSNP | Ensembl ].		VAR_067858
	Natural variant	551	1	F → S in PXE; autosomal recessive. Ref.19 Corresponds to variant rs72653774 [ dbSNP | Ensembl ].		VAR_067859
	Natural variant	568	1	F → S in PXE; autosomal dominant. Ref.13 Ref.20 Corresponds to variant rs66864704 [ dbSNP | Ensembl ].		VAR_013375
	Natural variant	590	1	S → F in GACI2. Ref.24		VAR_067860
	Natural variant	594	1	A → V in PXE; autosomal recessive. Ref.19 Corresponds to variant rs72653776 [ dbSNP | Ensembl ].		VAR_067861
	Natural variant	600	1	R → C in PXE; autosomal recessive. Ref.17 Ref.20 Corresponds to variant rs72653777 [ dbSNP | Ensembl ].		VAR_067862
	Natural variant	614	1	V → A. Ref.11 Ref.13 Ref.15 Ref.19 Ref.22 Corresponds to variant rs12931472 [ dbSNP | Ensembl ].		VAR_011490
	Natural variant	632	1	H → Q. Ref.10 Ref.13 Ref.15 Ref.19 Ref.22 Corresponds to variant rs8058694 [ dbSNP | Ensembl ].		VAR_013376
	Natural variant	663	1	G → C in PXE. Ref.20 Corresponds to variant rs72653780 [ dbSNP | Ensembl ].		VAR_067863
	Natural variant	665	1	V → A. Corresponds to variant rs4341770 [ dbSNP | Ensembl ].		VAR_055477
	Natural variant	673	1	L → P in PXE; autosomal dominant. Ref.13 Corresponds to variant rs67470842 [ dbSNP | Ensembl ].		VAR_013377
	Natural variant	677	1	L → P in PXE; autosomal recessive. Ref.19 Corresponds to variant rs72653782 [ dbSNP | Ensembl ].		VAR_067864
	Natural variant	698	1	Q → P in PXE. Ref.20 Corresponds to variant rs72653783 [ dbSNP | Ensembl ].		VAR_067865
	Natural variant	699	1	E → D in PXE. Ref.20 Corresponds to variant rs72653784 [ dbSNP | Ensembl ].		VAR_067866
	Natural variant	724	1	R → K. Ref.19 Corresponds to variant rs58073789 [ dbSNP | Ensembl ].		VAR_067867
	Natural variant	724	1	R → L. Ref.22		VAR_067868
	Natural variant	726	1	L → P in PXE. Ref.20 Ref.22 Corresponds to variant rs72653785 [ dbSNP | Ensembl ].		VAR_067869
	Natural variant	742	1	I → V. Ref.19 Ref.22 Corresponds to variant rs59593133 [ dbSNP | Ensembl ].		VAR_067870
	Natural variant	751	1	M → K in PXE. Ref.20 Corresponds to variant rs72653786 [ dbSNP | Ensembl ].		VAR_067871
	Natural variant	755	1	G → R in PXE. Ref.20 Corresponds to variant rs72653787 [ dbSNP | Ensembl ].		VAR_067872
	Natural variant	760	1	R → W in PXE; autosomal recessive. Ref.19 Ref.20 Corresponds to variant rs72653788 [ dbSNP | Ensembl ].		VAR_067873
	Natural variant	765	1	R → Q in PXE; autosomal dominant and autosomal recessive. Ref.13 Ref.19 Ref.20 Ref.23 Corresponds to variant rs67561842 [ dbSNP | Ensembl ].		VAR_013378
	Natural variant	766	1	A → D in PXE; autosomal recessive. Ref.18 Corresponds to variant rs72653789 [ dbSNP | Ensembl ].		VAR_067874
	Natural variant	777	1	D → N in PXE. Ref.20 Corresponds to variant rs72653790 [ dbSNP | Ensembl ].		VAR_067875
	Natural variant	807	1	R → Q in PXE; autosomal recessive. Ref.19 Corresponds to variant rs72653794 [ dbSNP | Ensembl ].		VAR_067876
	Natural variant	807	1	R → W in PXE; autosomal recessive. Ref.19 Corresponds to variant rs72653793 [ dbSNP | Ensembl ].		VAR_067877
	Natural variant	810	1	V → M in PXE; autosomal recessive. Ref.17 Corresponds to variant rs72653795 [ dbSNP | Ensembl ].		VAR_067878
	Natural variant	811	1	T → M in PXE. Ref.20 Corresponds to variant rs72653796 [ dbSNP | Ensembl ].		VAR_067879
	Natural variant	820	1	A → P in PXE; autosomal recessive. Ref.17 Corresponds to variant rs72653797 [ dbSNP | Ensembl ].		VAR_067880
	Natural variant	848	1	M → V. Ref.1 Ref.3 Ref.4 Ref.22 Corresponds to variant rs6416668 [ dbSNP | Ensembl ].		VAR_059108
	Natural variant	881	1	R → S in PXE. Ref.20 Corresponds to variant rs72653800 [ dbSNP | Ensembl ].		VAR_067881
	Natural variant	944	1	T → I in PXE. Ref.20 Corresponds to variant rs72653801 [ dbSNP | Ensembl ].		VAR_067882
	Natural variant	946	1	L → I. Ref.19 Ref.22 Corresponds to variant rs61340537 [ dbSNP | Ensembl ].		VAR_067883
	Natural variant	950	1	A → T in PXE. Ref.20 Corresponds to variant rs72657689 [ dbSNP | Ensembl ].		VAR_067884
	Natural variant	953	1	L → H. Ref.13 Corresponds to variant rs72657700 [ dbSNP | Ensembl ].		VAR_013379
	Natural variant	992	1	G → R in PXE. Ref.20 Corresponds to variant rs72657692 [ dbSNP | Ensembl ].		VAR_067885
	Natural variant	1036	1	Missing in GACI2 and PXE; autosomal recessive. Ref.19 Ref.24		VAR_067886
	Natural variant	1048	1	Missing in PXE; autosomal recessive. Ref.19		VAR_067887
	Natural variant	1056	1	D → E in PXE. Ref.19 Corresponds to variant rs72657694 [ dbSNP | Ensembl ].		VAR_067888
	Natural variant	1064	1	R → W. Ref.19 Corresponds to variant rs41278174 [ dbSNP | Ensembl ].		VAR_067889
	Natural variant	1097	1	L → I. Corresponds to variant rs60707953 [ dbSNP | Ensembl ].		VAR_060988
	Natural variant	1114	1	R → C in GACI2 and PXE; autosomal recessive. Ref.17 Ref.19 Ref.20 Ref.24 Corresponds to variant rs63749794 [ dbSNP | Ensembl ].		VAR_067890
	Natural variant	1114	1	R → P in PXE; autosomal recessive. Ref.11 Ref.13		VAR_011491
	Natural variant	1121	1	S → L in PXE. Ref.19		VAR_067891
	Natural variant	1121	1	S → W in PXE; autosomal dominant. Ref.13		VAR_013380
	Natural variant	1130	1	T → M in PXE; autosomal recessive. Ref.17 Ref.18 Ref.20 Corresponds to variant rs63750459 [ dbSNP | Ensembl ].		VAR_067892
	Natural variant	1133	1	G → A in PXE. Ref.20 Corresponds to variant rs63750473 [ dbSNP | Ensembl ].		VAR_067893
	Natural variant	1138	1	R → P in PXE; autosomal dominant. Ref.13		VAR_013381
	Natural variant	1138	1	R → Q in PXE; autosomal recessive. Ref.11 Ref.13 Ref.17 Ref.18 Ref.19 Ref.20 Ref.22 Corresponds to variant rs60791294 [ dbSNP | Ensembl ].		VAR_011492
	Natural variant	1138	1	R → W in PXE; autosomal recessive. Ref.12 Ref.19 Ref.20 Corresponds to variant rs28939701 [ dbSNP | Ensembl ].		VAR_011493
	Natural variant	1139	1	A → T in PXE. Ref.20 Corresponds to variant rs63750146 [ dbSNP | Ensembl ].		VAR_067894
	Natural variant	1164	1	R → Q in PXE; autosomal recessive. Ref.19 Ref.20 Corresponds to variant rs63750457 [ dbSNP | Ensembl ].		VAR_067895
	Natural variant	1203	1	G → D in PXE; autosomal dominant. Ref.13 Corresponds to variant rs63750607 [ dbSNP | Ensembl ].		VAR_013382
	Natural variant	1221	1	R → C in PXE; autosomal recessive. Ref.19 Ref.20 Corresponds to variant rs63751215 [ dbSNP | Ensembl ].		VAR_067896
	Natural variant	1221	1	R → H in GACI2. Ref.20 Ref.24 Corresponds to variant rs63751001 [ dbSNP | Ensembl ].		VAR_067897
	Natural variant	1226	1	L → I in PXE. Ref.20 Corresponds to variant rs63750125 [ dbSNP | Ensembl ].		VAR_067898
	Natural variant	1235	1	R → W in PXE; autosomal recessive. Ref.19 Corresponds to variant rs63750402 [ dbSNP | Ensembl ].		VAR_067899
	Natural variant	1238	1	D → H in PXE; pseudodominant. Ref.18 Corresponds to variant rs63749796 [ dbSNP | Ensembl ].		VAR_067900
	Natural variant	1241	1	W → C. Ref.13 Corresponds to variant rs72657701 [ dbSNP | Ensembl ].		VAR_013383
	Natural variant	1268	1	R → Q Associated with lower plasma triglycerides and higher plasma HDL cholesterol. Ref.8 Ref.12 Ref.13 Ref.15 Ref.19 Ref.21 Corresponds to variant rs2238472 [ dbSNP | Ensembl ].		VAR_011494
	Natural variant	1298	1	V → F in PXE; autosomal dominant; abolishes LTC4 and NEM-GS transport. Ref.5 Ref.13 Ref.20		VAR_013384
	Natural variant	1301	1	T → I in PXE; autosomal dominant. Ref.13 Corresponds to variant rs63750494 [ dbSNP | Ensembl ].		VAR_013385
	Natural variant	1302	1	G → R in PXE; autosomal dominant and autosomal recessive; abolishes LTC4 and NEM-GS transport. Ref.5 Ref.13 Ref.19 Ref.20 Ref.22 Corresponds to variant rs63749856 [ dbSNP | Ensembl ].		VAR_013386
	Natural variant	1303	1	A → P in PXE; autosomal dominant and autosomal recessive. Ref.13 Ref.19 Ref.20		VAR_013387
	Natural variant	1314	1	R → Q in PXE; autosomal dominant and autosomal recessive. Ref.13 Ref.19 Ref.20		VAR_013388
	Natural variant	1314	1	R → W in GACI2 and PXE; autosomal recessive. Ref.11 Ref.13 Ref.20 Ref.24 Corresponds to variant rs63750759 [ dbSNP | Ensembl ].		VAR_011495
	Natural variant	1321	1	G → S in PXE; autosomal dominant; abolishes LTC4 and NEM-GS transport. Ref.5 Ref.13 Corresponds to variant rs63749823 [ dbSNP | Ensembl ].		VAR_013389
	Natural variant	1335	1	L → P in PXE; autosomal recessive. Ref.18 Ref.22		VAR_067901
	Natural variant	1335	1	L → Q in PXE. Ref.20 Corresponds to variant rs63750414 [ dbSNP | Ensembl ].		VAR_067902
	Natural variant	1339	1	R → C in PXE; autosomal recessive. Ref.10 Ref.13 Ref.17 Ref.19 Ref.20 Ref.22 Corresponds to variant rs28939702 [ dbSNP | Ensembl ].		VAR_013390
	Natural variant	1339	1	R → H in PXE; autosomal recessive. Ref.20 Corresponds to variant rs63750622 [ dbSNP | Ensembl ].		VAR_067904
	Natural variant	1339	1	R → L in PXE; autosomal recessive. Ref.19		VAR_067903
	Natural variant	1346	1	P → S in PXE; autosomal recessive. Ref.17 Corresponds to variant rs63751112 [ dbSNP | Ensembl ].		VAR_067905
	Natural variant	1347	1	Q → H in PXE; autosomal dominant. Ref.13 Corresponds to variant rs67720869 [ dbSNP | Ensembl ].		VAR_013391
	Natural variant	1354	1	G → R in PXE; autosomal recessive. Ref.14 Corresponds to variant rs63750018 [ dbSNP | Ensembl ].		VAR_013392
	Natural variant	1357	1	R → W in PXE; autosomal recessive. Ref.19 Corresponds to variant rs63750428 [ dbSNP | Ensembl ].		VAR_067906
	Natural variant	1361	1	D → N in PXE; autosomal dominant. Ref.13 Corresponds to variant rs58695352 [ dbSNP | Ensembl ].		VAR_013393
	Natural variant	1400	1	E → K in PXE; autosomal recessive. Ref.17 Ref.18 Corresponds to variant rs63751241 [ dbSNP | Ensembl ].		VAR_067907
	Natural variant	1406	1	Q → K in PXE; autosomal recessive. Ref.23		VAR_067908
	Natural variant	1424	1	I → T in PXE; autosomal dominant. Ref.13 Corresponds to variant rs63750295 [ dbSNP | Ensembl ].		VAR_013394
	Natural variant	1459	1	R → C in PXE; putative autosomal dominant. Ref.16 Corresponds to variant rs72547524 [ dbSNP | Ensembl ].		VAR_067909
Experimental info
	Sequence conflict	377	1	L → P in AAD51293. Ref.4
	Sequence conflict	1274	1	Y → C in AAD51293. Ref.4
	Sequence conflict	1455	1	L → P in AAD51293. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O95255 [UniParc]. Last modified November 24, 2009. Version 2. Checksum: 2107BE13B1547B39	FASTA	1,503	164,906
	10 20 30 40 50 60 MAAPAEPCAG QGVWNQTEPE PAATSLLSLC FLRTAGVWVP PMYLWVLGPI YLLFIHHHGR 70 80 90 100 110 120 GYLRMSPLFK AKMVLGFALI VLCTSSVAVA LWKIQQGTPE APEFLIHPTV WLTTMSFAVF 130 140 150 160 170 180 LIHTERKKGV QSSGVLFGYW LLCFVLPATN AAQQASGAGF QSDPVRHLST YLCLSLVVAQ 190 200 210 220 230 240 FVLSCLADQP PFFPEDPQQS NPCPETGAAF PSKATFWWVS GLVWRGYRRP LRPKDLWSLG 250 260 270 280 290 300 RENSSEELVS RLEKEWMRNR SAARRHNKAI AFKRKGGSGM KAPETEPFLR QEGSQWRPLL 310 320 330 340 350 360 KAIWQVFHST FLLGTLSLII SDVFRFTVPK LLSLFLEFIG DPKPPAWKGY LLAVLMFLSA 370 380 390 400 410 420 CLQTLFEQQN MYRLKVLQMR LRSAITGLVY RKVLALSSGS RKASAVGDVV NLVSVDVQRL 430 440 450 460 470 480 TESVLYLNGL WLPLVWIVVC FVYLWQLLGP SALTAIAVFL SLLPLNFFIS KKRNHHQEEQ 490 500 510 520 530 540 MRQKDSRARL TSSILRNSKT IKFHGWEGAF LDRVLGIRGQ ELGALRTSGL LFSVSLVSFQ 550 560 570 580 590 600 VSTFLVALVV FAVHTLVAEN AMNAEKAFVT LTVLNILNKA QAFLPFSIHS LVQARVSFDR 610 620 630 640 650 660 LVTFLCLEEV DPGVVDSSSS GSAAGKDCIT IHSATFAWSQ ESPPCLHRIN LTVPQGCLLA 670 680 690 700 710 720 VVGPVGAGKS SLLSALLGEL SKVEGFVSIE GAVAYVPQEA WVQNTSVVEN VCFGQELDPP 730 740 750 760 770 780 WLERVLEACA LQPDVDSFPE GIHTSIGEQG MNLSGGQKQR LSLARAVYRK AAVYLLDDPL 790 800 810 820 830 840 AALDAHVGQH VFNQVIGPGG LLQGTTRILV THALHILPQA DWIIVLANGA IAEMGSYQEL 850 860 870 880 890 900 LQRKGALMCL LDQARQPGDR GEGETEPGTS TKDPRGTSAG RRPELRRERS IKSVPEKDRT 910 920 930 940 950 960 TSEAQTEVPL DDPDRAGWPA GKDSIQYGRV KATVHLAYLR AVGTPLCLYA LFLFLCQQVA 970 980 990 1000 1010 1020 SFCRGYWLSL WADDPAVGGQ QTQAALRGGI FGLLGCLQAI GLFASMAAVL LGGARASRLL 1030 1040 1050 1060 1070 1080 FQRLLWDVVR SPISFFERTP IGHLLNRFSK ETDTVDVDIP DKLRSLLMYA FGLLEVSLVV 1090 1100 1110 1120 1130 1140 AVATPLATVA ILPLFLLYAG FQSLYVVSSC QLRRLESASY SSVCSHMAET FQGSTVVRAF 1150 1160 1170 1180 1190 1200 RTQAPFVAQN NARVDESQRI SFPRLVADRW LAANVELLGN GLVFAAATCA VLSKAHLSAG 1210 1220 1230 1240 1250 1260 LVGFSVSAAL QVTQTLQWVV RNWTDLENSI VSVERMQDYA WTPKEAPWRL PTCAAQPPWP 1270 1280 1290 1300 1310 1320 QGGQIEFRDF GLRYRPELPL AVQGVSFKIH AGEKVGIVGR TGAGKSSLAS GLLRLQEAAE 1330 1340 1350 1360 1370 1380 GGIWIDGVPI AHVGLHTLRS RISIIPQDPI LFPGSLRMNL DLLQEHSDEA IWAALETVQL 1390 1400 1410 1420 1430 1440 KALVASLPGQ LQYKCADRGE DLSVGQKQLL CLARALLRKT QILILDEATA AVDPGTELQM 1450 1460 1470 1480 1490 1500 QAMLGSWFAQ CTVLLIAHRL RSVMDCARVL VMDKGQVAES GSPAQLLAQK GLFYRLAQES GLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells." Kool M., van der Linden M., de Haas M., Baas F., Borst P. Cancer Res. 59:175-182(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS TRP-64 AND VAL-848.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D. Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS TRP-64 AND VAL-848.
[4]	"MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver." Belinsky M.G., Kruh G.D. Br. J. Cancer 80:1342-1349(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-848.
[5]	"Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6)." Ilias A., Urban Z., Seidl T.L., Le Saux O., Sinko E., Boyd C.D., Sarkadi B., Varadi A. J. Biol. Chem. 277:16860-16867(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CHARACTERIZATION OF VARIANTS PXE PHE-1298; ARG-1302 AND SER-1321.
[6]	"Molecular genetics of pseudoxanthoma elasticum: a metabolic disorder at the environment-genome interface?" Uitto J., Pulkkinen L., Ringpfeil F. Trends Mol. Med. 7:13-17(2001) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW, VARIANT PXE PRO-455.
[7]	"Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells." Sinko E., Ilias A., Ujhelly O., Homolya L., Scheffer G.L., Bergen A.A., Sarkadi B., Varadi A. Biochem. Biophys. Res. Commun. 308:263-269(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION AT ASN-15.
[8]	"Homozygosity for the R1268Q mutation in MRP6, the pseudoxanthoma elasticum gene, is not disease-causing." Germain D.P., Perdu J., Remones V., Jeunemaitre X. Biochem. Biophys. Res. Commun. 274:297-301(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLN-1268.
[9]	"Identification of two polymorphisms (c189G>C; c190T>C) in exon 2 of the human MRP6 gene (ABCC6) by screening of Pseudoxanthoma elasticum patients: possible sequence correction?" Germain D.P., Perdu J., Remones V., Manzoni K., Jeunemaitre X. Hum. Mutat. 16:449-449(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT TRP-64.
[10]	"Mutations of the gene encoding the transmembrane transporter protein ABC-C6 cause pseudoxanthoma elasticum." Struk B., Cai L., Zaech S., Ji W., Chung J., Lumsden A., Stumm M., Huber M., Schaen L., Kim C.-A., Goldsmith L.A., Viljoen D., Figuera L.E., Fuchs W., Munier F., Ramesar R., Hohl D., Richards R., Neldner K.H., Lindpaintner K. J. Mol. Med. 78:282-286(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT PXE CYS-1339, VARIANT GLN-632.
[11]	"Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum." Le Saux O., Urban Z., Tschuch C., Csiszar K., Bacchelli B., Quaglino D., Pasquali-Ronchetti I., Pope F.M., Richards A., Terry S., Bercovitch L., de Paepe A., Boyd C.D. Nat. Genet. 25:223-227(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PXE PRO-1114; GLN-1138 AND TRP-1314, VARIANT ALA-614.
[12]	"Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter." Ringpfeil F., Lebwohl M.G., Christiano A.M., Uitto J. Proc. Natl. Acad. Sci. U.S.A. 97:6001-6006(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT PXE TRP-1138, VARIANT GLN-1268.
[13]	"A spectrum of ABCC6 mutations is responsible for pseudoxanthoma elasticum." Le Saux O., Beck K., Sachsinger C., Silvestri C., Treiber C., Goering H.H.H., Johnson E.W., De Paepe A., Pope F.M., Pasquali-Ronchetti I., Bercovitch L., Terry S., Boyd C.D. Am. J. Hum. Genet. 69:749-764(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PXE LYS-411; GLN-518; SER-568; PRO-673; GLN-765; PRO-1114; TRP-1121; PRO-1138; GLN-1138; ASP-1203; PHE-1298; ILE-1301; ARG-1302; PRO-1303; GLN-1314; TRP-1314; SER-1321; CYS-1339; HIS-1347; ASN-1361 AND THR-1424, VARIANTS ASP-61; ARG-207; GLY-265; GLU-281; VAL-319; LYS-497; ALA-614; GLN-632; HIS-953; CYS-1241 AND GLN-1268.
[14]	"Identification of ABCC6 pseudogenes on human chromosome 16p: implications for mutation detection in pseudoxanthoma elasticum." Pulkkinen L., Nakano A., Ringpfeil F., Uitto J. Hum. Genet. 109:356-365(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PXE 60-ARG--TYR-62 DEL; ARG-364 AND ARG-1354, VARIANT GLY-265.
[15]	"ABCC6 gene polymorphism associated with variation in plasma lipoproteins." Wang J., Near S., Young K., Connelly P.W., Hegele R.A. J. Hum. Genet. 46:699-705(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ALA-614; GLN-632 AND GLN-1268.
[16]	"Does autosomal dominant pseudoxanthoma elasticum exist?" Plomp A.S., Hu X., de Jong P.T., Bergen A.A. Am. J. Med. Genet. A 126:403-412(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT PXE CYS-1459.
[17]	"ABCC6 mutations in Italian families affected by pseudoxanthoma elasticum (PXE)." Gheduzzi D., Guidetti R., Anzivino C., Tarugi P., Di Leo E., Quaglino D., Ronchetti I.P. Hum. Mutat. 24:438-439(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PXE ARG-364; LYS-411; GLY-440; GLN-518; CYS-600; MET-810; PRO-820; CYS-1114; MET-1130; GLN-1138; CYS-1339; SER-1346 AND LYS-1400.
[18]	"Novel ABCC6 mutations in pseudoxanthoma elasticum." Chassaing N., Martin L., Mazereeuw J., Barrie L., Nizard S., Bonafe J.L., Calvas P., Hovnanian A. J. Invest. Dermatol. 122:608-613(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PXE VAL-74 DEL; 363-GLN--ARG-373 DEL; GLY-391; GLN-518; ASP-766; MET-1130; GLN-1138 HIS-1238; PRO-1335 AND LYS-1400.
[19]	"Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations in ABCC6." Miksch S., Lumsden A., Guenther U.P., Foernzler D., Christen-Zach S., Daugherty C., Ramesar R.K., Lebwohl M., Hohl D., Neldner K.H., Lindpaintner K., Richards R.I., Struk B. Hum. Mutat. 26:235-248(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PXE 60-ARG--TYR-62 DEL; GLU-129; ARG-317; ARG-355; ARG-364; ASP-370; GLY-391; GLY-398; HIS-495; GLN-518; SER-551; VAL-594; PRO-677; TRP-760; GLN-765; GLN-807; TRP-807; GLU-1056; PHE-1036 DEL; PHE-1048 DEL; CYS-1114; LEU-1121; GLN-1138; TRP-1138; GLN-1164; CYS-1221; TRP-1235; ARG-1302; PRO-1303; GLN-1314; CYS-1339; LEU-1339 AND TRP-1357, VARIANTS THR-78; LYS-125; VAL-158; GLY-265; GLU-281; VAL-319; ILE-514; ALA-614; GLN-632; LYS-724; VAL-742; ILE-946; TRP-1064 AND GLN-1268.
[20]	"Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum." Pfendner E.G., Vanakker O.M., Terry S.F., Vourthis S., McAndrew P.E., McClain M.R., Fratta S., Marais A.S., Hariri S., Coucke P.J., Ramsay M., Viljoen D., Terry P.F., De Paepe A., Uitto J., Bercovitch L.G. J. Med. Genet. 44:621-628(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PXE 60-ARG--TYR-62 DEL; ARG-317; ARG-364; TRP-382; GLY-391; ASN-392; HIS-463 HIS-495; GLN-518; PRO-535; SER-568; CYS-600; CYS-663; PRO-698; ASP-699; PRO-726; LYS-751; ARG-755; TRP-760; GLN-765; ASN-777; MET-811; SER-881; ILE-944; THR-950; ARG-992; CYS-1114; MET-1130; ALA-1133; GLN-1138; TRP-1138; THR-1139; GLN-1164; CYS-1221; HIS-1221; ILE-1226; PHE-1298; ARG-1302; PRO-1303; GLN-1314; TRP-1314; GLN-1335; CYS-1339; HIS-1339 AND THR-1342.
[21]	"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K. Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-1268.
[22]	"Spectrum of genetic variation at the ABCC6 locus in South Africans: Pseudoxanthoma elasticum patients and healthy individuals." Ramsay M., Greenberg T., Lombard Z., Labrum R., Lubbe S., Aron S., Marais A.S., Terry S., Bercovitch L., Viljoen D. J. Dermatol. Sci. 54:198-204(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PXE GLN-518; PRO-726; GLN-1138; ARG-1302; PRO-1335 AND CYS-1339, VARIANTS THR-78; GLY-265; MET-417; ALA-614; GLN-632; LEU-724; VAL-742; VAL-848 AND ILE-946.
[23]	"An unusual severe vascular case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy." Le Boulanger G., Labreze C., Croue A., Schurgers L.J., Chassaing N., Wittkampf T., Rutsch F., Martin L. Am. J. Med. Genet. A 152:118-123(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PXE GLN-765 AND LYS-1406.
[24]	"Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6." Nitschke Y., Baujat G., Botschen U., Wittkampf T., du Moulin M., Stella J., Le Merrer M., Guest G., Lambot K., Tazarourte-Pinturier M.F., Chassaing N., Roche O., Feenstra I., Loechner K., Deshpande C., Garber S.J., Chikarmane R., Steinmann B. , Shahinyan T., Martorell L., Davies J., Smith W.E., Kahler S.G., McCulloch M., Wraige E., Loidi L., Hohne W., Martin L., Hadj-Rabia S., Terkeltaub R., Rutsch F. Am. J. Hum. Genet. 90:25-39(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS GACI2 ARG-355; GLY-391; PHE-590; PHE-1036 DEL; CYS-1114; HIS-1221 AND TRP-1314.
+	Additional computationally mapped references.

Web resources

Mutations of the ABCC6 gene

Retina International's Scientific Newsletter

GeneReviews

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF076622 mRNA. Translation: AAC79696.1. AC136624 Genomic DNA. No translation available. U91318 Genomic DNA. Translation: AAC15785.1. Sequence problems. AF168791 mRNA. Translation: AAD51293.1.
IPI	IPI00029455.
RefSeq	NP_001162.4. NM_001171.5.
UniGene	Hs.442182.
3D structure databases
ProteinModelPortal	O95255.
SMR	O95255. Positions 627-847.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95255. 5 interactions.
STRING	9606.ENSP00000205557.
Protein family/group databases
TCDB	3.A.1.208.10. ATP-binding cassette (ABC) superfamily.
PTM databases
PhosphoSite	O95255.
Proteomic databases
PaxDb	O95255.
PRIDE	O95255.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000205557; ENSP00000205557; ENSG00000091262.
GeneID	368.
KEGG	hsa:368.
UCSC	uc002den.4. human.
Organism-specific databases
CTD	368.
GeneCards	GC16M016243.
H-InvDB	HIX0026937. HIX0038600.
HGNC	HGNC:57. ABCC6.
MIM	177850. phenotype. 264800. phenotype. 603234. gene. 614473. phenotype.
neXtProt	NX_O95255.
Orphanet	51608. Generalized arterial calcification of infancy. 758. Pseudoxanthoma elasticum.
PharmGKB	PA58.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1132.
HOVERGEN	HBG108314.
InParanoid	O95255.
KO	K05669.
OMA	KVLQMRL.
OrthoDB	EOG4868BN.
PhylomeDB	O95255.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	O95255.
Bgee	O95255.
CleanEx	HS_ABCC6.
Genevestigator	O95255.
GermOnline	ENSG00000091262. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR005292. Multidrug-R_assoc. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits. SSF52540. SSF52540. 2 hits.
TIGRFAMs	TIGR00957. MRP_assoc_pro. 1 hit.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ABCC6. human.
GenomeRNAi	368.
NextBio	1537.
SOURCE	Search...

Entry information

Entry name

MRP6_HUMAN

Accession

Primary (citable) accession number: O95255
Secondary accession number(s): P78420, Q9UMZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 24, 2009
Last modified:	May 29, 2013
This is version 142 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.