Reviewed,
UniProtKB/Swiss-Prot O95251 (MYST2_HUMAN)
Last modified
November 25, 2008.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone acetyltransferase MYST2 Short name=MYST protein 2 EC=2.3.1.48 Alternative name(s): MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 Histone acetyltransferase binding to ORC1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 611 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Histone acetyltransferase which specifically represses AR-mediated transcription. May play a role in DNA replication. |
| Catalytic activity | Acetyl-CoA + histone = CoA + acetylhistone. |
| Subunit structure | Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. |
| Subcellular location | |
| Tissue specificity | Ubiquitously expressed, with highest levels in testis. |
| Domain | The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction By similarity. |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Sequence similarities | Belongs to the MYST (SAS/MOZ) family. Contains 1 C2HC-type zinc finger. |
Ontologies
Keywords | |
|---|---|
| Biological process | DNA replication Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Zinc-finger |
| Ligand | Metal-binding Zinc |
| Molecular function | Acyltransferase Chromatin regulator Repressor Transferase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | DNA replication Ref.1 Traceable author statement. Source: ProtInc chromatin modificationInferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | nucleus Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | H3/H4 histone acetyltransferase activity Ref.1 Traceable author statement. Source: ProtInc protein binding Ref.1 Ref.2Inferred from physical interaction. Source: IntAct transcription factor activityInferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| AR | P10275 | 3 | EBI-473199,EBI-608057 | |
| BARD1 | Q99728 | 1 | EBI-473199,EBI-473181 | |
| KIAA1377 | Q9P2H0 | 1 | EBI-473199,EBI-473176 | |
| VIM | P08670 | 2 | EBI-473199,EBI-353844 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 611 | 611 | Histone acetyltransferase MYST2 | PRO_0000051569 | |||||
Regions | |||||||||
| Zinc finger | 366 – 388 | 23 | C2HC-type | ||||||
| Compositional bias | 10 – 57 | 48 | Ser-rich | ||||||
Sites | |||||||||
| Active site | 474 | 1 | By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 50 | 1 | Phosphoserine | ||||||
| Modified residue | 52 | 1 | Phosphoserine | ||||||
| Modified residue | 53 | 1 | Phosphoserine | ||||||
| Modified residue | 56 | 1 | Phosphoserine | ||||||
| Modified residue | 57 | 1 | Phosphoserine | ||||||
| Modified residue | 88 | 1 | Phosphothreonine | ||||||
| Modified residue | 99 | 1 | Phosphoserine | ||||||
| Modified residue | 100 | 1 | Phosphoserine | ||||||
| Modified residue | 102 | 1 | Phosphoserine | ||||||
| Modified residue | 124 | 1 | Phosphoserine | ||||||
| Modified residue | 128 | 1 | Phosphothreonine | ||||||
Experimental info | |||||||||
| Mutagenesis | 371 | 1 | C → A: No interaction with MCM2 and ORC1L | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein." Iizuka M., Stillman B. J. Biol. Chem. 274:23027-23034(1999) [PubMed: 10438470] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ORC1L, FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY. Tissue: Epithelium. |
| [2] | "Androgen receptor interacts with a novel MYST protein, HBO1." Sharma M., Zarnegar M., Li X., Lim B., Sun Z. J. Biol. Chem. 275:35200-35208(2000) [PubMed: 10930412] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH AR, FUNCTION. Tissue: Prostate. |
| [3] | "Cloning and identifying histone acetyltransferase HBOa." Jian J., Guangtao L., Guangwei D., Yan Z., Jianhe C., Jiangang Y., Boqin Q. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Structure and function of the human MYST family: MOZ2, MYST1 and MYST2." Borrow J., Housman D.E. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph. |
| [6] | "Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1." Burke T.W., Cook J.G., Asano M., Nevins J.R. J. Biol. Chem. 276:15397-15408(2001) [PubMed: 11278932] [Abstract] Cited for: INTERACTION WITH MCM2 AND ORC1L, DOMAIN, SUBCELLULAR LOCATION, FUNCTION, MUTAGENESIS OF CYS-371. |
| [7] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99; SER-100; SER-102; SER-124 AND THR-128, MASS SPECTROMETRY. Tissue: Epithelium. |
| [8] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-88, MASS SPECTROMETRY. Tissue: Epithelium. |
| [9] | "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-52; SER-53; SER-56 AND SER-57, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AF074606 mRNA. Translation: AAC99368.1. AF140360 mRNA. Translation: AAD42348.1. AF217502 mRNA. Translation: AAL56649.1. BC032640 mRNA. Translation: AAH32640.1. | |
| RefSeq | NP_008998.1. |
| UniGene | Hs.21907 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1M36 based on UniProtKB Q92794. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O95251. |
PTM databases | |
| PhosphoSite | O95251. |
Genome annotation databases | |
| Ensembl | ENSG00000136504. Homo sapiens. [Contig view] |
| GeneID | 11143. |
| KEGG | hsa:11143. |
Organism-specific databases | |
| H-InvDB | HIX0013964. |
| HGNC | HGNC:17016. MYST2. |
| MIM | 609880. gene. |
| PharmGKB | PA134886407. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | O95251. |
| HOVERGEN | O95251. |
Gene expression databases | |
| ArrayExpress | O95251. |
| CleanEx | HS_MYST2. |
| GermOnline | ENSG00000136504. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR002717. MOZ_SAS. IPR011991. Wing_hlx_DNA_bd. IPR015880. Znf_C2H2-like. IPR002515. Znf_C2HC. [Graphical view] |
| Gene3D | G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. |
| Pfam | PF01853. MOZ_SAS. 1 hit. PF01530. zf-C2HC. 1 hit. [Graphical view] |
| SMART | SM00355. ZnF_C2H2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | O95251. |
| NextBio | 42360. |
| SOURCE | Search... |
Entry information
| Entry name | MYST2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O95251 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


