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Protein

Histone acetyltransferase KAT7

Gene

KAT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.4 Publications

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei508 – 5081Proton donor/acceptorBy similarity
Binding sitei512 – 5121Acetyl-CoABy similarity
Binding sitei521 – 5211Acetyl-CoABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 21944CCHHC-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 39026C2HC MYST-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: UniProtKB
  • histone H3 acetylation Source: UniProtKB
  • histone H4-K12 acetylation Source: UniProtKB
  • histone H4-K5 acetylation Source: UniProtKB
  • histone H4-K8 acetylation Source: UniProtKB
  • positive regulation of protein localization to nucleus Source: GO_Central
  • regulation of transcription, DNA-templated Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA replication, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.
SIGNORiO95251.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase KAT7 (EC:2.3.1.481 Publication)
Alternative name(s):
Histone acetyltransferase binding to ORC1
Lysine acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Short name:
MYST-2
Gene namesi
Name:KAT7
Synonyms:HBO1, HBOa, MYST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:17016. KAT7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • histone acetyltransferase complex Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi371 – 3711C → A: No interaction with MCM2 and ORC1L. 1 Publication

Organism-specific databases

PharmGKBiPA134886407.

Polymorphism and mutation databases

BioMutaiKAT7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 611611Histone acetyltransferase KAT7PRO_0000051569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineCombined sources
Modified residuei50 – 501PhosphoserineCombined sources
Modified residuei57 – 571Phosphoserine; by PLK1Combined sources1 Publication
Modified residuei64 – 641PhosphoserineCombined sources
Modified residuei85 – 851Phosphothreonine; by CDK1Combined sources1 Publication
Modified residuei88 – 881Phosphothreonine; by CDK1Combined sources1 Publication
Modified residuei102 – 1021PhosphoserineCombined sources
Modified residuei104 – 1041PhosphothreonineBy similarity
Modified residuei111 – 1111PhosphoserineCombined sources
Modified residuei124 – 1241PhosphoserineCombined sources
Modified residuei128 – 1281PhosphothreonineBy similarity
Modified residuei158 – 1581PhosphoserineCombined sources
Modified residuei162 – 1621PhosphoserineCombined sources
Modified residuei164 – 1641PhosphoserineCombined sources
Modified residuei178 – 1781PhosphoserineCombined sources
Modified residuei199 – 1991N6-acetyllysineCombined sources
Modified residuei277 – 2771N6-acetyllysineBy similarity
Modified residuei432 – 4321N6-acetyllysine; by autocatalysisBy similarity
Modified residuei506 – 5061PhosphoserineCombined sources

Post-translational modificationi

Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior Phosphorylation at Thr-85 and Thr-88 by CDK1.1 Publication
Autoacetylation at Lys-432 is required for proper function.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95251.
MaxQBiO95251.
PaxDbiO95251.
PeptideAtlasiO95251.
PRIDEiO95251.

PTM databases

iPTMnetiO95251.
PhosphoSiteiO95251.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in testis.2 Publications

Gene expression databases

BgeeiENSG00000136504.
CleanExiHS_MYST2.
ExpressionAtlasiO95251. baseline and differential.
GenevisibleiO95251. HS.

Organism-specific databases

HPAiHPA044470.

Interactioni

Subunit structurei

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102755EBI-473199,EBI-608057
BARD1Q997282EBI-473199,EBI-473181
CEP126Q9P2H02EBI-473199,EBI-473176
VIMP086704EBI-473199,EBI-353844

Protein-protein interaction databases

BioGridi116315. 66 interactions.
DIPiDIP-29697N.
IntActiO95251. 43 interactions.
MINTiMINT-141769.
STRINGi9606.ENSP00000259021.

Structurei

3D structure databases

ProteinModelPortaliO95251.
SMRiO95251. Positions 182-210, 340-607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini332 – 607276MYST-type HATPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni475 – 4773Acetyl-CoA bindingBy similarity
Regioni482 – 4887Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 5748Ser-richAdd
BLAST

Domaini

The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1L.1 Publication
The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated
Contains 1 C2HC MYST-type zinc finger.PROSITE-ProRule annotation
Contains 1 CCHHC-type zinc finger.PROSITE-ProRule annotation
Contains 1 MYST-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 21944CCHHC-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 39026C2HC MYST-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2747. Eukaryota.
COG5027. LUCA.
GeneTreeiENSGT00550000074503.
HOGENOMiHOG000182457.
HOVERGENiHBG053268.
InParanoidiO95251.
KOiK11307.
OMAiVYSTRRV.
OrthoDBiEOG091G00D2.
PhylomeDBiO95251.
TreeFamiTF317619.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR002717. HAT_MYST-type.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51726. MYST_HAT. 1 hit.
PS51802. ZF_CCHHC. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95251-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRRKRNAGS SSDGTEDSDF STDLEHTDSS ESDGTSRRSA RVTRSSARLS
60 70 80 90 100
QSSQDSSPVR NLQSFGTEEP AYSTRRVTRS QQQPTPVTPK KYPLRQTRSS
110 120 130 140 150
GSETEQVVDF SDRETKNTAD HDESPPRTPT GNAPSSESDI DISSPNVSHD
160 170 180 190 200
ESIAKDMSLK DSGSDLSHRP KRRRFHESYN FNMKCPTPGC NSLGHLTGKH
210 220 230 240 250
ERHFSISGCP LYHNLSADEC KVRAQSRDKQ IEERMLSHRQ DDNNRHATRH
260 270 280 290 300
QAPTERQLRY KEKVAELRKK RNSGLSKEQK EKYMEHRQTY GNTREPLLEN
310 320 330 340 350
LTSEYDLDLF RRAQARASED LEKLRLQGQI TEGSNMIKTI AFGRYELDTW
360 370 380 390 400
YHSPYPEEYA RLGRLYMCEF CLKYMKSQTI LRRHMAKCVW KHPPGDEIYR
410 420 430 440 450
KGSISVFEVD GKKNKIYCQN LCLLAKLFLD HKTLYYDVEP FLFYVMTEAD
460 470 480 490 500
NTGCHLIGYF SKEKNSFLNY NVSCILTMPQ YMRQGYGKML IDFSYLLSKV
510 520 530 540 550
EEKVGSPERP LSDLGLISYR SYWKEVLLRY LHNFQGKEIS IKEISQETAV
560 570 580 590 600
NPVDIVSTLQ ALQMLKYWKG KHLVLKRQDL IDEWIAKEAK RSNSNKTMDP
610
SCLKWTPPKG T
Length:611
Mass (Da):70,642
Last modified:May 1, 1999 - v1
Checksum:i8368E7C4F07D8D7C
GO
Isoform 2 (identifier: O95251-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-193: Missing.
     222-251: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):58,136
Checksum:i005414956B922380
GO
Isoform 3 (identifier: O95251-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-113: Missing.
     114-193: Missing.
     222-251: Missing.

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):51,440
Checksum:iEF5AA3D8E63B35D0
GO
Isoform 4 (identifier: O95251-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-251: Missing.

Note: No experimental confirmation available.
Show »
Length:581
Mass (Da):66,947
Checksum:i30A3E4C3E47EFBED
GO
Isoform 5 (identifier: O95251-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-113: Missing.
     114-193: Missing.

Note: No experimental confirmation available.
Show »
Length:472
Mass (Da):55,135
Checksum:i906F630E44BAFD2B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 447Missing in BAG57945 (PubMed:14702039).Curated
Sequence conflicti41 – 411R → Q in BAG57346 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 11359Missing in isoform 3 and isoform 5. 1 PublicationVSP_042552Add
BLAST
Alternative sequencei114 – 19380Missing in isoform 2, isoform 3 and isoform 5. 1 PublicationVSP_042553Add
BLAST
Alternative sequencei222 – 25130Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationVSP_042554Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074606 mRNA. Translation: AAC99368.1.
AF140360 mRNA. Translation: AAD42348.1.
AF217502 mRNA. Translation: AAL56649.1.
AK023890 mRNA. Translation: BAG51236.1.
AK293976 mRNA. Translation: BAG57346.1.
AK294014 mRNA. Translation: BAG57375.1.
AK294052 mRNA. Translation: BAG57401.1.
AK294836 mRNA. Translation: BAG57945.1.
AC015795 Genomic DNA. No translation available.
AC027801 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94658.1.
CH471109 Genomic DNA. Translation: EAW94659.1.
BC032640 mRNA. Translation: AAH32640.1.
CCDSiCCDS11554.1. [O95251-1]
CCDS56035.1. [O95251-4]
CCDS56036.1. [O95251-2]
CCDS56037.1. [O95251-5]
CCDS56038.1. [O95251-3]
RefSeqiNP_001186084.1. NM_001199155.1. [O95251-4]
NP_001186085.1. NM_001199156.1. [O95251-5]
NP_001186086.1. NM_001199157.1. [O95251-2]
NP_001186087.1. NM_001199158.1. [O95251-3]
NP_008998.1. NM_007067.4. [O95251-1]
UniGeneiHs.21907.

Genome annotation databases

EnsembliENST00000259021; ENSP00000259021; ENSG00000136504. [O95251-1]
ENST00000424009; ENSP00000398961; ENSG00000136504. [O95251-4]
ENST00000454930; ENSP00000413415; ENSG00000136504. [O95251-5]
ENST00000509773; ENSP00000424577; ENSG00000136504. [O95251-2]
ENST00000510819; ENSP00000423385; ENSG00000136504. [O95251-3]
GeneIDi11143.
KEGGihsa:11143.
UCSCiuc002ipl.3. human. [O95251-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074606 mRNA. Translation: AAC99368.1.
AF140360 mRNA. Translation: AAD42348.1.
AF217502 mRNA. Translation: AAL56649.1.
AK023890 mRNA. Translation: BAG51236.1.
AK293976 mRNA. Translation: BAG57346.1.
AK294014 mRNA. Translation: BAG57375.1.
AK294052 mRNA. Translation: BAG57401.1.
AK294836 mRNA. Translation: BAG57945.1.
AC015795 Genomic DNA. No translation available.
AC027801 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94658.1.
CH471109 Genomic DNA. Translation: EAW94659.1.
BC032640 mRNA. Translation: AAH32640.1.
CCDSiCCDS11554.1. [O95251-1]
CCDS56035.1. [O95251-4]
CCDS56036.1. [O95251-2]
CCDS56037.1. [O95251-5]
CCDS56038.1. [O95251-3]
RefSeqiNP_001186084.1. NM_001199155.1. [O95251-4]
NP_001186085.1. NM_001199156.1. [O95251-5]
NP_001186086.1. NM_001199157.1. [O95251-2]
NP_001186087.1. NM_001199158.1. [O95251-3]
NP_008998.1. NM_007067.4. [O95251-1]
UniGeneiHs.21907.

3D structure databases

ProteinModelPortaliO95251.
SMRiO95251. Positions 182-210, 340-607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116315. 66 interactions.
DIPiDIP-29697N.
IntActiO95251. 43 interactions.
MINTiMINT-141769.
STRINGi9606.ENSP00000259021.

PTM databases

iPTMnetiO95251.
PhosphoSiteiO95251.

Polymorphism and mutation databases

BioMutaiKAT7.

Proteomic databases

EPDiO95251.
MaxQBiO95251.
PaxDbiO95251.
PeptideAtlasiO95251.
PRIDEiO95251.

Protocols and materials databases

DNASUi11143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259021; ENSP00000259021; ENSG00000136504. [O95251-1]
ENST00000424009; ENSP00000398961; ENSG00000136504. [O95251-4]
ENST00000454930; ENSP00000413415; ENSG00000136504. [O95251-5]
ENST00000509773; ENSP00000424577; ENSG00000136504. [O95251-2]
ENST00000510819; ENSP00000423385; ENSG00000136504. [O95251-3]
GeneIDi11143.
KEGGihsa:11143.
UCSCiuc002ipl.3. human. [O95251-1]

Organism-specific databases

CTDi11143.
GeneCardsiKAT7.
HGNCiHGNC:17016. KAT7.
HPAiHPA044470.
MIMi609880. gene.
neXtProtiNX_O95251.
PharmGKBiPA134886407.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2747. Eukaryota.
COG5027. LUCA.
GeneTreeiENSGT00550000074503.
HOGENOMiHOG000182457.
HOVERGENiHBG053268.
InParanoidiO95251.
KOiK11307.
OMAiVYSTRRV.
OrthoDBiEOG091G00D2.
PhylomeDBiO95251.
TreeFamiTF317619.

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.
SIGNORiO95251.

Miscellaneous databases

GeneWikiiMYST2.
GenomeRNAii11143.
PROiO95251.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136504.
CleanExiHS_MYST2.
ExpressionAtlasiO95251. baseline and differential.
GenevisibleiO95251. HS.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR002717. HAT_MYST-type.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51726. MYST_HAT. 1 hit.
PS51802. ZF_CCHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKAT7_HUMAN
AccessioniPrimary (citable) accession number: O95251
Secondary accession number(s): B3KN74
, B4DF85, B4DFB4, B4DFE0, B4DGY4, E7ER15, G5E9K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.