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Protein

Golgi SNAP receptor complex member 1

Gene

GOSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.2 Publications

GO - Molecular functioni

  • SNAP receptor activity Source: HGNC
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi SNAP receptor complex member 1
Alternative name(s):
28 kDa Golgi SNARE protein
28 kDa cis-Golgi SNARE p28
Short name:
GOS-28
Gene namesi
Name:GOSR1
Synonyms:GS28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108587.14
HGNCiHGNC:4430 GOSR1
MIMi604026 gene
neXtProtiNX_O95249

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 229CytoplasmicSequence analysisAdd BLAST228
Transmembranei230 – 250Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9527
OpenTargetsiENSG00000108587
PharmGKBiPA28815

Polymorphism and mutation databases

BioMutaiGOSR1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002125422 – 250Golgi SNAP receptor complex member 1Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei141PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95249
MaxQBiO95249
PaxDbiO95249
PeptideAtlasiO95249
PRIDEiO95249

PTM databases

iPTMnetiO95249
PhosphoSitePlusiO95249

Expressioni

Inductioni

Expression induced by hydrogen peroxide in neuronal cells. By monocrotaline in pulmonary epithelial cells (at protein level). Negatively regulated by OSBPL7 via GABARAPL2 leading to degradation on proteasomes (at protein level).3 Publications

Gene expression databases

BgeeiENSG00000108587
CleanExiHS_GOSR1
ExpressionAtlasiO95249 baseline and differential
GenevisibleiO95249 HS

Organism-specific databases

HPAiHPA020590

Interactioni

Subunit structurei

Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2 (By similarity).By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: HGNC
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi114903, 51 interactors
IntActiO95249, 11 interactors
MINTiO95249
STRINGi9606.ENSP00000225724

Structurei

3D structure databases

ProteinModelPortaliO95249
SMRiO95249
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili9 – 30Sequence analysisAdd BLAST22
Coiled coili68 – 95Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the GOSR1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3208 Eukaryota
ENOG410YI1X LUCA
GeneTreeiENSGT00390000008688
HOGENOMiHOG000207760
HOVERGENiHBG051764
InParanoidiO95249
KOiK08495
PhylomeDBiO95249
TreeFamiTF105782

Family and domain databases

InterProiView protein in InterPro
IPR023601 Golgi_SNAP_su1
PANTHERiPTHR21094 PTHR21094, 1 hit
PIRSFiPIRSF027109 Golgi_SNARE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95249-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGTSSYWE DLRKQARQLE NELDLKLVSF SKLCTSYSHS STRDGRRDRY
60 70 80 90 100
SSDTTPLLNG SSQDRMFETM AIEIEQLLAR LTGVNDKMAE YTNSAGVPSL
110 120 130 140 150
NAALMHTLQR HRDILQDYTH EFHKTKANFM AIRERENLMG SVRKDIESYK
160 170 180 190 200
SGSGVNNRRT ELFLKEHDHL RNSDRLIEET ISIAMATKEN MTSQRGMLKS
210 220 230 240 250
IHSKMNTLAN RFPAVNSLIQ RINLRKRRDS LILGGVIGIC TILLLLYAFH
Length:250
Mass (Da):28,613
Last modified:May 1, 1999 - v1
Checksum:iEEDA4291436162F6
GO
Isoform 2 (identifier: O95249-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Note: Gene prediction based on EST data.
Show »
Length:185
Mass (Da):21,214
Checksum:i2FF672E5364FC52A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11D → GEARRPPD in AAC39889 (PubMed:9653160).Curated1
Sequence conflicti49 – 50Missing in AAC39889 (PubMed:9653160).Curated2
Sequence conflicti156 – 157NN → TT in AAC39889 (PubMed:9653160).Curated2
Sequence conflicti159R → G in AAC39889 (PubMed:9653160).Curated1
Sequence conflicti170L → F in AAC39889 (PubMed:9653160).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0473261 – 65Missing in isoform 2. CuratedAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047438 mRNA Translation: AAC39889.1
AF073926 mRNA Translation: AAD12945.1
AC006050 Genomic DNA No translation available.
AC011840 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51229.1
BC040471 mRNA Translation: AAH40471.1
CCDSiCCDS11258.1 [O95249-1]
CCDS45644.1 [O95249-2]
RefSeqiNP_001007025.1, NM_001007024.1 [O95249-2]
NP_001007026.1, NM_001007025.1
NP_004862.1, NM_004871.2 [O95249-1]
XP_005258129.1, XM_005258072.2 [O95249-2]
UniGeneiHs.462680

Genome annotation databases

EnsembliENST00000225724; ENSP00000225724; ENSG00000108587 [O95249-1]
ENST00000467337; ENSP00000462638; ENSG00000108587 [O95249-2]
GeneIDi9527
KEGGihsa:9527
UCSCiuc002hfe.4 human [O95249-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGOSR1_HUMAN
AccessioniPrimary (citable) accession number: O95249
Secondary accession number(s): J3KST5, O75392
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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