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O95239

- KIF4A_HUMAN

UniProt

O95239 - KIF4A_HUMAN

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Protein

Chromosome-associated kinesin KIF4A

Gene

KIF4A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi88 – 958ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. DNA binding Source: UniProtKB-KW
  4. microtubule motor activity Source: ProtInc
  5. plus-end-directed microtubule motor activity Source: RefGenome

GO - Biological processi

  1. anterograde axon cargo transport Source: ProtInc
  2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  3. ATP catabolic process Source: GOC
  4. axon guidance Source: Reactome
  5. blood coagulation Source: Reactome
  6. metabolic process Source: GOC
  7. microtubule-based movement Source: RefGenome
  8. organelle organization Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_22365. Recycling pathway of L1.
REACT_25201. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome-associated kinesin KIF4A
Alternative name(s):
Chromokinesin-A
Gene namesi
Name:KIF4A
Synonyms:KIF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:13339. KIF4A.

Subcellular locationi

Nucleus matrix. Cytoplasmcytoskeletonspindle. Midbody. Chromosome
Note: Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis.

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. cytoplasm Source: ProtInc
  3. cytosol Source: Reactome
  4. kinesin complex Source: RefGenome
  5. membrane Source: UniProtKB
  6. midbody Source: UniProtKB
  7. nucleus Source: HPA
  8. spindle microtubule Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12321232Chromosome-associated kinesin KIF4APRO_0000125437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei799 – 7991Phosphothreonine2 Publications
Modified residuei801 – 8011Phosphoserine2 Publications
Modified residuei951 – 9511Phosphoserine1 Publication
Modified residuei995 – 9951Phosphothreonine1 Publication
Modified residuei1001 – 10011Phosphoserine3 Publications
Modified residuei1013 – 10131Phosphoserine1 Publication
Modified residuei1017 – 10171Phosphoserine1 Publication
Modified residuei1028 – 10281Phosphoserine1 Publication
Modified residuei1181 – 11811Phosphothreonine2 Publications
Modified residuei1186 – 11861Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95239.
PaxDbiO95239.
PRIDEiO95239.

PTM databases

PhosphoSiteiO95239.

Expressioni

Tissue specificityi

Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung.1 Publication

Gene expression databases

BgeeiO95239.
CleanExiHS_KIF4A.
GenevestigatoriO95239.

Organism-specific databases

HPAiHPA034745.
HPA034746.

Interactioni

Subunit structurei

Interacts with unphosphorylated PRC1 during late mitosis.2 Publications

Protein-protein interaction databases

BioGridi117288. 16 interactions.
IntActiO95239. 5 interactions.
MINTiMINT-3002743.
STRINGi9606.ENSP00000363524.

Structurei

3D structure databases

ProteinModelPortaliO95239.
SMRiO95239. Positions 4-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 336328Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni663 – 1232570Interaction with PRC1Add
BLAST
Regioni1000 – 1232233GlobularAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili350 – 999650Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi793 – 7986Nuclear localization signal

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00770000120453.
HOVERGENiHBG052256.
InParanoidiO95239.
KOiK10395.
OMAiEVEVMVS.
OrthoDBiEOG7P8P9J.
PhylomeDBiO95239.
TreeFamiTF105224.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95239-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEEVKGIPV RVALRCRPLV PKEISEGCQM CLSFVPGEPQ VVVGTDKSFT
60 70 80 90 100
YDFVFDPSTE QEEVFNTAVA PLIKGVFKGY NATVLAYGQT GSGKTYSMGG
110 120 130 140 150
AYTAEQENEP TVGVIPRVIQ LLFKEIDKKS DFEFTLKVSY LEIYNEEILD
160 170 180 190 200
LLCPSREKAQ INIREDPKEG IKIVGLTEKT VLVALDTVSC LEQGNNSRTV
210 220 230 240 250
ASTAMNSQSS RSHAIFTISL EQRKKSDKNS SFRSKLHLVD LAGSERQKKT
260 270 280 290 300
KAEGDRLKEG ININRGLLCL GNVISALGDD KKGGFVPYRD SKLTRLLQDS
310 320 330 340 350
LGGNSHTLMI ACVSPADSNL EETLNTLRYA DRARKIKNKP IVNIDPQTAE
360 370 380 390 400
LNHLKQQVQQ LQVLLLQAHG GTLPGSITVE PSENLQSLME KNQSLVEENE
410 420 430 440 450
KLSRGLSEAA GQTAQMLERI ILTEQANEKM NAKLEELRQH AACKLDLQKL
460 470 480 490 500
VETLEDQELK ENVEIICNLQ QLITQLSDET VACMAAAIDT AVEQEAQVET
510 520 530 540 550
SPETSRSSDA FTTQHALRQA QMSKELVELN KALALKEALA RKMTQNDSQL
560 570 580 590 600
QPIQYQYQDN IKELELEVIN LQKEKEELVL ELQTAKKDAN QAKLSERRRK
610 620 630 640 650
RLQELEGQIA DLKKKLNEQS KLLKLKESTE RTVSKLNQEI RMMKNQRVQL
660 670 680 690 700
MRQMKEDAEK FRQWKQKKDK EVIQLKERDR KRQYELLKLE RNFQKQSNVL
710 720 730 740 750
RRKTEEAAAA NKRLKDALQK QREVADKRKE TQSRGMEGTA ARVKNWLGNE
760 770 780 790 800
IEVMVSTEEA KRHLNDLLED RKILAQDVAQ LKEKKESGEN PPPKLRRRTF
810 820 830 840 850
SLTEVRGQVS ESEDSITKQI ESLETEMEFR SAQIADLQQK LLDAESEDRP
860 870 880 890 900
KQRWENIATI LEAKCALKYL IGELVSSKIQ VSKLESSLKQ SKTSCADMQK
910 920 930 940 950
MLFEERNHFA EIETELQAEL VRMEQQHQEK VLYLLSQLQQ SQMAEKQLEE
960 970 980 990 1000
SVSEKEQQLL STLKCQDEEL EKMREVCEQN QQLLRENEII KQKLTLLQVA
1010 1020 1030 1040 1050
SRQKHLPKDT LLSPDSSFEY VPPKPKPSRV KEKFLEQSMD IEDLKYCSEH
1060 1070 1080 1090 1100
SVNEHEDGDG DDDEGDDEEW KPTKLVKVSR KNIQGCSCKG WCGNKQCGCR
1110 1120 1130 1140 1150
KQKSDCGVDC CCDPTKCRNR QQGKDSLGTV ERTQDSEGSF KLEDPTEVTP
1160 1170 1180 1190 1200
GLSFFNPVCA TPNSKILKEM CDVEQVLSKK TPPAPSPFDL PELKHVATEY
1210 1220 1230
QENKAPGKKK KRALASNTSF FSGCSPIEEE AH
Length:1,232
Mass (Da):139,881
Last modified:April 12, 2005 - v3
Checksum:iAD1B7C2A10AB24DB
GO
Isoform 2 (identifier: O95239-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1086-1127: CSCKGWCGNK...RNRQQGKDSL → VLLLTPVISA...RDPVSTKPKN
     1128-1232: Missing.

Note: No experimental confirmation available.

Show »
Length:1,127
Mass (Da):128,459
Checksum:i84D7ABE2CE39697A
GO

Sequence cautioni

The sequence AAH49218.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231R → G in AAD05492. (PubMed:10978527)Curated
Sequence conflicti231 – 2311S → T in AAF86334. (PubMed:9168136)Curated
Sequence conflicti286 – 2861V → A in AAD05492. (PubMed:10978527)Curated
Sequence conflicti564 – 5641L → H in AAF86334. (PubMed:9168136)Curated
Sequence conflicti564 – 5641L → P in AAD05492. (PubMed:10978527)Curated
Sequence conflicti600 – 6001K → E in CAB75427. 1 PublicationCurated
Sequence conflicti668 – 6681K → R1 PublicationCurated
Sequence conflicti668 – 6681K → R(PubMed:10978527)Curated
Sequence conflicti928 – 9281Q → P in AAD51855. 1 PublicationCurated
Sequence conflicti958 – 9581Q → R in CAB75427. 1 PublicationCurated
Sequence conflicti960 – 9601L → Q in AAD51855. 1 PublicationCurated
Sequence conflicti996 – 9972LL → S in AAF86334. (PubMed:9168136)Curated
Sequence conflicti1003 – 101412QKHLP…TLLSP → RTLPRIPFYLQ in AAF86334. (PubMed:9168136)CuratedAdd
BLAST
Sequence conflicti1022 – 10221P → Q in AAD05492. (PubMed:10978527)Curated
Sequence conflicti1077 – 10771K → N in AAD05492. (PubMed:10978527)Curated
Sequence conflicti1138 – 11381G → S in AAD05492. (PubMed:10978527)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti422 – 4221L → W.2 Publications
Corresponds to variant rs1199457 [ dbSNP | Ensembl ].
VAR_021828
Natural varianti491 – 4911A → V.
Corresponds to variant rs2297871 [ dbSNP | Ensembl ].
VAR_049693
Natural varianti1193 – 11931L → S.
Corresponds to variant rs1046485 [ dbSNP | Ensembl ].
VAR_049694

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1086 – 112742CSCKG…GKDSL → VLLLTPVISALWEAEARGLL EARSSRPAWATWRDPVSTKP KN in isoform 2. 1 PublicationVSP_013375Add
BLAST
Alternative sequencei1128 – 1232105Missing in isoform 2. 1 PublicationVSP_013376Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179308 mRNA. Translation: AAD51855.1.
AF071592 mRNA. Translation: AAD05492.2.
AJ271784 mRNA. Translation: CAB75427.1.
AK313133 mRNA. Translation: BAG35952.1.
AL139398, AL357752 Genomic DNA. Translation: CAI41024.1.
AL357752, AL139398 Genomic DNA. Translation: CAI41487.1.
CH471132 Genomic DNA. Translation: EAX05341.1.
CH471132 Genomic DNA. Translation: EAX05342.1.
BC049218 mRNA. Translation: AAH49218.1. Sequence problems.
BC050548 mRNA. Translation: AAH50548.1.
AF277375 mRNA. Translation: AAF86334.1.
CCDSiCCDS14401.1. [O95239-1]
RefSeqiNP_036442.3. NM_012310.4. [O95239-1]
UniGeneiHs.648326.

Genome annotation databases

EnsembliENST00000374403; ENSP00000363524; ENSG00000090889. [O95239-1]
GeneIDi24137.
KEGGihsa:24137.
UCSCiuc004dyf.2. human. [O95239-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179308 mRNA. Translation: AAD51855.1 .
AF071592 mRNA. Translation: AAD05492.2 .
AJ271784 mRNA. Translation: CAB75427.1 .
AK313133 mRNA. Translation: BAG35952.1 .
AL139398 , AL357752 Genomic DNA. Translation: CAI41024.1 .
AL357752 , AL139398 Genomic DNA. Translation: CAI41487.1 .
CH471132 Genomic DNA. Translation: EAX05341.1 .
CH471132 Genomic DNA. Translation: EAX05342.1 .
BC049218 mRNA. Translation: AAH49218.1 . Sequence problems.
BC050548 mRNA. Translation: AAH50548.1 .
AF277375 mRNA. Translation: AAF86334.1 .
CCDSi CCDS14401.1. [O95239-1 ]
RefSeqi NP_036442.3. NM_012310.4. [O95239-1 ]
UniGenei Hs.648326.

3D structure databases

ProteinModelPortali O95239.
SMRi O95239. Positions 4-343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117288. 16 interactions.
IntActi O95239. 5 interactions.
MINTi MINT-3002743.
STRINGi 9606.ENSP00000363524.

Chemistry

ChEMBLi CHEMBL6163.

PTM databases

PhosphoSitei O95239.

Proteomic databases

MaxQBi O95239.
PaxDbi O95239.
PRIDEi O95239.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374403 ; ENSP00000363524 ; ENSG00000090889 . [O95239-1 ]
GeneIDi 24137.
KEGGi hsa:24137.
UCSCi uc004dyf.2. human. [O95239-1 ]

Organism-specific databases

CTDi 24137.
GeneCardsi GC0XP069509.
H-InvDB HIX0016851.
HGNCi HGNC:13339. KIF4A.
HPAi HPA034745.
HPA034746.
MIMi 300521. gene.
neXtProti NX_O95239.
PharmGKBi PA30105.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00770000120453.
HOVERGENi HBG052256.
InParanoidi O95239.
KOi K10395.
OMAi EVEVMVS.
OrthoDBi EOG7P8P9J.
PhylomeDBi O95239.
TreeFami TF105224.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_22365. Recycling pathway of L1.
REACT_25201. Kinesins.

Miscellaneous databases

ChiTaRSi KIF4A. human.
GeneWikii KIF4A.
GenomeRNAii 24137.
NextBioi 46801.
PROi O95239.
SOURCEi Search...

Gene expression databases

Bgeei O95239.
CleanExi HS_KIF4A.
Genevestigatori O95239.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human KIF4 mRNA, complete coding sequence."
    Villard L.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymphocyte.
  2. "Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein."
    Oh S.J., Hahn H., Torrey T.A., Shin H., Choi W., Lee Y.M., Morse H.C. III, Kim W.
    Biochim. Biophys. Acta 1493:219-224(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT TRP-422.
  3. Rentsch A., Neumann T., Rommerskirch W.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retinoblastoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Tongue.
  5. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-668 (ISOFORM 1), VARIANT TRP-422.
    Tissue: Lymph and Testis.
  8. "Increased chromokinesin immunoreactivity in retinoblastoma cells."
    Yan R.-T., Wang S.-Z.
    Gene 189:263-267(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-1232.
    Tissue: Retinoblastoma.
  9. "Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis."
    Lee Y.M., Lee S., Lee E., Shin H., Hahn H., Choi W., Kim W.
    Biochem. J. 360:549-556(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation."
    Kurasawa Y., Earnshaw W.C., Mochizuki Y., Dohmae N., Todokoro K.
    EMBO J. 23:3237-3248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PRC1.
  11. "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis."
    Zhu C., Jiang W.
    Proc. Natl. Acad. Sci. U.S.A. 102:343-348(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PRC1.
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1181, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-799; SER-801; SER-951; SER-1001; SER-1013; SER-1017 AND SER-1028, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-995 AND SER-1001, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-799; SER-801; SER-1001; THR-1181 AND SER-1186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKIF4A_HUMAN
AccessioniPrimary (citable) accession number: O95239
Secondary accession number(s): B2R7V5
, D3DVU4, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 12, 2005
Last modified: November 26, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3