O95239 (KIF4A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosome-associated kinesin KIF4A

Alternative name(s):
Chromokinesin-A

Gene names

Name:	KIF4A
Synonyms:	KIF4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1232 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. Ref.10 Ref.11
Subunit structure	Interacts with unphosphorylated PRC1 during late mitosis. Ref.10 Ref.11
Subcellular location	Nucleus matrix. Cytoplasm › cytoskeleton › spindle. Midbody. Chromosome. Note: Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis. Ref.9 Ref.10 Ref.11
Tissue specificity	Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung. Ref.2
Sequence similarities	Belongs to the kinesin-like protein family. Chromokinesin subfamily. Contains 1 kinesin-motor domain.
Sequence caution	The sequence AAH49218.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Chromosome Cytoplasm Cytoskeleton Microtubule Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anterograde axon cargo transport Traceable author statement. Source: ProtInc axon guidance Traceable author statement. Source: Reactome blood coagulation Traceable author statement. Source: Reactome organelle organization Traceable author statement. Source: ProtInc
Cellular component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Traceable author statement. Source: Reactome midbody Inferred from direct assay. Source: UniProtKB nuclear matrix Inferred from electronic annotation. Source: UniProtKB-SubCell spindle microtubule Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95239-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95239-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1086-1127: CSCKGWCGNK...RNRQQGKDSL → VLLLTPVISA...RDPVSTKPKN
     1128-1232: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1232	1232	Chromosome-associated kinesin KIF4A		PRO_0000125437
Regions
	Domain	1 – 349	349	Kinesin-motor
	Nucleotide binding	88 – 95	8	ATP By similarity
	Region	663 – 1232	570	Interaction with PRC1
	Region	1000 – 1232	233	Globular
	Coiled coil	350 – 999	650	Potential
	Motif	793 – 798	6	Nuclear localization signal
Amino acid modifications
	Modified residue	394	1	Phosphoserine Ref.12 Ref.15 Ref.19
	Modified residue	501	1	Phosphoserine Ref.15
	Modified residue	507	1	Phosphoserine Ref.14
	Modified residue	544	1	Phosphothreonine Ref.12
	Modified residue	799	1	Phosphothreonine Ref.12 Ref.16
	Modified residue	801	1	Phosphoserine Ref.12 Ref.13 Ref.14 Ref.16 Ref.18 Ref.19
	Modified residue	810	1	Phosphoserine Ref.14 Ref.15
	Modified residue	815	1	Phosphoserine Ref.15
	Modified residue	951	1	Phosphoserine Ref.14 Ref.16
	Modified residue	995	1	Phosphothreonine Ref.17
	Modified residue	1001	1	Phosphoserine Ref.16 Ref.17 Ref.19
	Modified residue	1010	1	Phosphothreonine Ref.12
	Modified residue	1013	1	Phosphoserine Ref.12 Ref.14 Ref.16
	Modified residue	1016	1	Phosphoserine Ref.12 Ref.16
	Modified residue	1017	1	Phosphoserine Ref.14 Ref.16
	Modified residue	1020	1	Phosphotyrosine Ref.16
	Modified residue	1028	1	Phosphoserine Ref.16
	Modified residue	1038	1	Phosphoserine Ref.12 Ref.14 Ref.19
	Modified residue	1048	1	Phosphoserine Ref.12
	Modified residue	1051	1	Phosphoserine Ref.12
	Modified residue	1126	1	Phosphoserine Ref.14 Ref.15
	Modified residue	1129	1	Phosphothreonine Ref.15
	Modified residue	1161	1	Phosphothreonine Ref.14 Ref.18
	Modified residue	1181	1	Phosphothreonine Ref.13 Ref.14 Ref.16
	Modified residue	1186	1	Phosphoserine Ref.14 Ref.16
	Modified residue	1225	1	Phosphoserine Ref.12 Ref.14 Ref.16 Ref.18
Natural variations
	Alternative sequence	1086 – 1127	42	CSCKG…GKDSL → VLLLTPVISALWEAEARGLL EARSSRPAWATWRDPVSTKP KN in isoform 2.		VSP_013375
	Alternative sequence	1128 – 1232	105	Missing in isoform 2.		VSP_013376
	Natural variant	422	1	L → W. Ref.2 Ref.7 Corresponds to variant rs1199457 [ dbSNP | Ensembl ].		VAR_021828
	Natural variant	491	1	A → V. Corresponds to variant rs2297871 [ dbSNP | Ensembl ].		VAR_049693
	Natural variant	1193	1	L → S. Corresponds to variant rs1046485 [ dbSNP | Ensembl ].		VAR_049694
Experimental info
	Sequence conflict	223	1	R → G in AAD05492. Ref.2
	Sequence conflict	231	1	S → T in AAF86334. Ref.8
	Sequence conflict	286	1	V → A in AAD05492. Ref.2
	Sequence conflict	564	1	L → H in AAF86334. Ref.8
	Sequence conflict	564	1	L → P in AAD05492. Ref.2
	Sequence conflict	600	1	K → E in CAB75427. Ref.3
	Sequence conflict	668	1	K → R Ref.1
	Sequence conflict	668	1	K → R Ref.2
	Sequence conflict	928	1	Q → P in AAD51855. Ref.1
	Sequence conflict	958	1	Q → R in CAB75427. Ref.3
	Sequence conflict	960	1	L → Q in AAD51855. Ref.1
	Sequence conflict	996 – 997	2	LL → S in AAF86334. Ref.8
	Sequence conflict	1003 – 1014	12	QKHLP…TLLSP → RTLPRIPFYLQ in AAF86334. Ref.8
	Sequence conflict	1022	1	P → Q in AAD05492. Ref.2
	Sequence conflict	1077	1	K → N in AAD05492. Ref.2
	Sequence conflict	1138	1	G → S in AAD05492. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 12, 2005. Version 3. Checksum: AD1B7C2A10AB24DB	FASTA	1,232	139,881
	10 20 30 40 50 60 MKEEVKGIPV RVALRCRPLV PKEISEGCQM CLSFVPGEPQ VVVGTDKSFT YDFVFDPSTE 70 80 90 100 110 120 QEEVFNTAVA PLIKGVFKGY NATVLAYGQT GSGKTYSMGG AYTAEQENEP TVGVIPRVIQ 130 140 150 160 170 180 LLFKEIDKKS DFEFTLKVSY LEIYNEEILD LLCPSREKAQ INIREDPKEG IKIVGLTEKT 190 200 210 220 230 240 VLVALDTVSC LEQGNNSRTV ASTAMNSQSS RSHAIFTISL EQRKKSDKNS SFRSKLHLVD 250 260 270 280 290 300 LAGSERQKKT KAEGDRLKEG ININRGLLCL GNVISALGDD KKGGFVPYRD SKLTRLLQDS 310 320 330 340 350 360 LGGNSHTLMI ACVSPADSNL EETLNTLRYA DRARKIKNKP IVNIDPQTAE LNHLKQQVQQ 370 380 390 400 410 420 LQVLLLQAHG GTLPGSITVE PSENLQSLME KNQSLVEENE KLSRGLSEAA GQTAQMLERI 430 440 450 460 470 480 ILTEQANEKM NAKLEELRQH AACKLDLQKL VETLEDQELK ENVEIICNLQ QLITQLSDET 490 500 510 520 530 540 VACMAAAIDT AVEQEAQVET SPETSRSSDA FTTQHALRQA QMSKELVELN KALALKEALA 550 560 570 580 590 600 RKMTQNDSQL QPIQYQYQDN IKELELEVIN LQKEKEELVL ELQTAKKDAN QAKLSERRRK 610 620 630 640 650 660 RLQELEGQIA DLKKKLNEQS KLLKLKESTE RTVSKLNQEI RMMKNQRVQL MRQMKEDAEK 670 680 690 700 710 720 FRQWKQKKDK EVIQLKERDR KRQYELLKLE RNFQKQSNVL RRKTEEAAAA NKRLKDALQK 730 740 750 760 770 780 QREVADKRKE TQSRGMEGTA ARVKNWLGNE IEVMVSTEEA KRHLNDLLED RKILAQDVAQ 790 800 810 820 830 840 LKEKKESGEN PPPKLRRRTF SLTEVRGQVS ESEDSITKQI ESLETEMEFR SAQIADLQQK 850 860 870 880 890 900 LLDAESEDRP KQRWENIATI LEAKCALKYL IGELVSSKIQ VSKLESSLKQ SKTSCADMQK 910 920 930 940 950 960 MLFEERNHFA EIETELQAEL VRMEQQHQEK VLYLLSQLQQ SQMAEKQLEE SVSEKEQQLL 970 980 990 1000 1010 1020 STLKCQDEEL EKMREVCEQN QQLLRENEII KQKLTLLQVA SRQKHLPKDT LLSPDSSFEY 1030 1040 1050 1060 1070 1080 VPPKPKPSRV KEKFLEQSMD IEDLKYCSEH SVNEHEDGDG DDDEGDDEEW KPTKLVKVSR 1090 1100 1110 1120 1130 1140 KNIQGCSCKG WCGNKQCGCR KQKSDCGVDC CCDPTKCRNR QQGKDSLGTV ERTQDSEGSF 1150 1160 1170 1180 1190 1200 KLEDPTEVTP GLSFFNPVCA TPNSKILKEM CDVEQVLSKK TPPAPSPFDL PELKHVATEY 1210 1220 1230 QENKAPGKKK KRALASNTSF FSGCSPIEEE AH
	Isoform 2 [UniParc]. Checksum: 84D7ABE2CE39697A	FASTA	1,127	128,459
	10 20 30 40 50 60 MKEEVKGIPV RVALRCRPLV PKEISEGCQM CLSFVPGEPQ VVVGTDKSFT YDFVFDPSTE 70 80 90 100 110 120 QEEVFNTAVA PLIKGVFKGY NATVLAYGQT GSGKTYSMGG AYTAEQENEP TVGVIPRVIQ 130 140 150 160 170 180 LLFKEIDKKS DFEFTLKVSY LEIYNEEILD LLCPSREKAQ INIREDPKEG IKIVGLTEKT 190 200 210 220 230 240 VLVALDTVSC LEQGNNSRTV ASTAMNSQSS RSHAIFTISL EQRKKSDKNS SFRSKLHLVD 250 260 270 280 290 300 LAGSERQKKT KAEGDRLKEG ININRGLLCL GNVISALGDD KKGGFVPYRD SKLTRLLQDS 310 320 330 340 350 360 LGGNSHTLMI ACVSPADSNL EETLNTLRYA DRARKIKNKP IVNIDPQTAE LNHLKQQVQQ 370 380 390 400 410 420 LQVLLLQAHG GTLPGSITVE PSENLQSLME KNQSLVEENE KLSRGLSEAA GQTAQMLERI 430 440 450 460 470 480 ILTEQANEKM NAKLEELRQH AACKLDLQKL VETLEDQELK ENVEIICNLQ QLITQLSDET 490 500 510 520 530 540 VACMAAAIDT AVEQEAQVET SPETSRSSDA FTTQHALRQA QMSKELVELN KALALKEALA 550 560 570 580 590 600 RKMTQNDSQL QPIQYQYQDN IKELELEVIN LQKEKEELVL ELQTAKKDAN QAKLSERRRK 610 620 630 640 650 660 RLQELEGQIA DLKKKLNEQS KLLKLKESTE RTVSKLNQEI RMMKNQRVQL MRQMKEDAEK 670 680 690 700 710 720 FRQWKQKKDK EVIQLKERDR KRQYELLKLE RNFQKQSNVL RRKTEEAAAA NKRLKDALQK 730 740 750 760 770 780 QREVADKRKE TQSRGMEGTA ARVKNWLGNE IEVMVSTEEA KRHLNDLLED RKILAQDVAQ 790 800 810 820 830 840 LKEKKESGEN PPPKLRRRTF SLTEVRGQVS ESEDSITKQI ESLETEMEFR SAQIADLQQK 850 860 870 880 890 900 LLDAESEDRP KQRWENIATI LEAKCALKYL IGELVSSKIQ VSKLESSLKQ SKTSCADMQK 910 920 930 940 950 960 MLFEERNHFA EIETELQAEL VRMEQQHQEK VLYLLSQLQQ SQMAEKQLEE SVSEKEQQLL 970 980 990 1000 1010 1020 STLKCQDEEL EKMREVCEQN QQLLRENEII KQKLTLLQVA SRQKHLPKDT LLSPDSSFEY 1030 1040 1050 1060 1070 1080 VPPKPKPSRV KEKFLEQSMD IEDLKYCSEH SVNEHEDGDG DDDEGDDEEW KPTKLVKVSR 1090 1100 1110 1120 KNIQGVLLLT PVISALWEAE ARGLLEARSS RPAWATWRDP VSTKPKN

References

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[1]	"Human KIF4 mRNA, complete coding sequence." Villard L. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Lymphocyte.
[2]	"Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein." Oh S.J., Hahn H., Torrey T.A., Shin H., Choi W., Lee Y.M., Morse H.C. III, Kim W. Biochim. Biophys. Acta 1493:219-224(2000) [PubMed: 10978527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT TRP-422.
[3]	Rentsch A., Neumann T., Rommerskirch W. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Retinoblastoma.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Tongue.
[5]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-668 (ISOFORM 1), VARIANT TRP-422. Tissue: Lymph and Testis.
[8]	"Increased chromokinesin immunoreactivity in retinoblastoma cells." Yan R.-T., Wang S.-Z. Gene 189:263-267(1997) [PubMed: 9168136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-1232. Tissue: Retinoblastoma.
[9]	"Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis." Lee Y.M., Lee S., Lee E., Shin H., Hahn H., Choi W., Kim W. Biochem. J. 360:549-556(2001) [PubMed: 11736643] [Abstract] Cited for: SUBCELLULAR LOCATION.
[10]	"Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation." Kurasawa Y., Earnshaw W.C., Mochizuki Y., Dohmae N., Todokoro K. EMBO J. 23:3237-3248(2004) [PubMed: 15297875] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PRC1.
[11]	"Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis." Zhu C., Jiang W. Proc. Natl. Acad. Sci. U.S.A. 102:343-348(2005) [PubMed: 15625105] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PRC1.
[12]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394; THR-544; THR-799; SER-801; THR-1010; SER-1013; SER-1016; SER-1038; SER-1048; SER-1051 AND SER-1225, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-801 AND THR-1181, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507; SER-801; SER-810; SER-951; SER-1013; SER-1017; SER-1038; SER-1126; THR-1161; THR-1181; SER-1186 AND SER-1225, MASS SPECTROMETRY. Tissue: Cervix adenocarcinoma.
[15]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394; SER-501; SER-810; SER-815; SER-1126 AND THR-1129, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-799; SER-801; SER-951; SER-1001; SER-1013; SER-1016; SER-1017; TYR-1020; SER-1028; THR-1181; SER-1186 AND SER-1225, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-995 AND SER-1001, MASS SPECTROMETRY. Tissue: Liver.
[18]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-801; THR-1161 AND SER-1225, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[19]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394; SER-801; SER-1001 AND SER-1038, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[20]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF179308 mRNA. Translation: AAD51855.1. AF071592 mRNA. Translation: AAD05492.2. AJ271784 mRNA. Translation: CAB75427.1. AK313133 mRNA. Translation: BAG35952.1. AL139398, AL357752 Genomic DNA. Translation: CAI41024.1. AL357752, AL139398 Genomic DNA. Translation: CAI41487.1. CH471132 Genomic DNA. Translation: EAX05341.1. CH471132 Genomic DNA. Translation: EAX05342.1. BC049218 mRNA. Translation: AAH49218.1. Sequence problems. BC050548 mRNA. Translation: AAH50548.1. AF277375 mRNA. Translation: AAF86334.1.
IPI	IPI00178150. IPI00556059.
RefSeq	NP_036442.3. NM_012310.4.
UniGene	Hs.648326.
3D structure databases
ProteinModelPortal	O95239.
SMR	O95239. Positions 9-345.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95239. 1 interaction.
STRING	O95239.
PTM databases
PhosphoSite	O95239.
Proteomic databases
PRIDE	O95239.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374403; ENSP00000363524; ENSG00000090889.
GeneID	24137.
KEGG	hsa:24137.
NMPDR	fig|9606.3.peg.32949.
UCSC	uc004dyg.1. human.
Organism-specific databases
CTD	24137.
GeneCards	GC0XP069509.
H-InvDB	HIX0016851.
HGNC	HGNC:13339. KIF4A.
HPA	HPA034745. HPA034746.
MIM	300521. gene.
neXtProt	NX_O95239.
PharmGKB	PA30105.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14466.
HOVERGEN	HBG052256.
InParanoid	O95239.
OMA	LAKKMTQ.
OrthoDB	EOG40S0DV.
PhylomeDB	O95239.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	O95239.
Bgee	O95239.
CleanEx	HS_KIF4A.
Genevestigator	O95239.
GermOnline	ENSG00000090889. Homo sapiens.
Family and domain databases
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view]
Gene3D	G3DSA:3.40.850.10. kinesin_motor. 1 hit.
KO	K10395.
Pfam	PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	46801.
SOURCE	Search...

Entry information

Entry name

KIF4A_HUMAN

Accession

Primary (citable) accession number: O95239
Secondary accession number(s): B2R7V5 , D3DVU4, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	April 12, 2005
Last modified:	January 25, 2012
This is version 113 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.