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O95238

- SPDEF_HUMAN

UniProt

O95238 - SPDEF_HUMAN

Protein

SAM pointed domain-containing Ets transcription factor

Gene

SPDEF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi249 – 33284ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. intestinal epithelial cell development Source: Ensembl
    3. lung goblet cell differentiation Source: Ensembl
    4. multicellular organismal development Source: ProtInc
    5. negative regulation of cell fate commitment Source: Ensembl
    6. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    7. positive regulation of apoptotic process Source: BHF-UCL
    8. positive regulation of cell fate commitment Source: Ensembl
    9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    10. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SAM pointed domain-containing Ets transcription factor
    Alternative name(s):
    Prostate epithelium-specific Ets transcription factor
    Short name:
    Prostate-specific Ets
    Prostate-derived Ets factor
    Gene namesi
    Name:SPDEF
    Synonyms:PDEF, PSE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:17257. SPDEF.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134993886.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335SAM pointed domain-containing Ets transcription factorPRO_0000223958Add
    BLAST

    Proteomic databases

    MaxQBiO95238.
    PaxDbiO95238.
    PRIDEiO95238.

    PTM databases

    PhosphoSiteiO95238.

    Expressioni

    Tissue specificityi

    Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells.1 Publication

    Gene expression databases

    BgeeiO95238.
    CleanExiHS_SPDEF.
    GenevestigatoriO95238.

    Organism-specific databases

    HPAiHPA055707.

    Interactioni

    Subunit structurei

    Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1.3 Publications

    Protein-protein interaction databases

    BioGridi117335. 3 interactions.
    STRINGi9606.ENSP00000363149.

    Structurei

    Secondary structure

    1
    335
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi132 – 1398
    Turni140 – 1423
    Helixi147 – 1493
    Helixi155 – 16511
    Helixi172 – 1754
    Helixi180 – 1856
    Helixi188 – 1947
    Beta strandi196 – 1983
    Helixi200 – 21314
    Helixi251 – 26010
    Helixi262 – 2654
    Turni266 – 2683
    Beta strandi269 – 2735
    Turni274 – 2774
    Beta strandi278 – 2825
    Helixi284 – 29512
    Helixi302 – 31110
    Turni312 – 3165
    Beta strandi317 – 3193
    Beta strandi328 – 3325

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YO5X-ray2.00C247-335[»]
    2DKXNMR-A131-213[»]
    ProteinModelPortaliO95238.
    SMRiO95238. Positions 131-213, 247-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95238.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini129 – 21385PNTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG243414.
    HOGENOMiHOG000237327.
    HOVERGENiHBG080776.
    InParanoidiO95238.
    KOiK09442.
    OMAiMLYPEDS.
    OrthoDBiEOG76X60D.
    PhylomeDBiO95238.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95238-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSASPGLSS VSPSHLLLPP DTVSRTGLEK AAAGAVGLER RDWSPSPPAT    50
    PEQGLSAFYL SYFDMLYPED SSWAAKAPGA SSREEPPEEP EQCPVIDSQA 100
    PAGSLDLVPG GLTLEEHSLE QVQSMVVGEV LKDIETACKL LNITADPMDW 150
    SPSNVQKWLL WTEHQYRLPP MGKAFQELAG KELCAMSEEQ FRQRSPLGGD 200
    VLHAHLDIWK SAAWMKERTS PGAIHYCAST SEESWTDSEV DSSCSGQPIH 250
    LWQFLKELLL KPHSYGRFIR WLNKEKGIFK IEDSAQVARL WGIRKNRPAM 300
    NYDKLSRSIR QYYKKGIIRK PDISQRLVYQ FVHPI 335
    Length:335
    Mass (Da):37,518
    Last modified:May 1, 1999 - v1
    Checksum:iD3117E1AEEBA95EC
    GO
    Isoform 2 (identifier: O95238-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         212-227: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:319
    Mass (Da):35,715
    Checksum:i5C6B944F4885B2B2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491A → G in BAG63040. (PubMed:14702039)Curated
    Sequence conflicti76 – 761K → N in BAG63040. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571A → T.
    Corresponds to variant rs2233639 [ dbSNP | Ensembl ].
    VAR_048955

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei212 – 22716Missing in isoform 2. 1 PublicationVSP_044722Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031549 mRNA. Translation: BAA89543.1.
    AF071538 mRNA. Translation: AAC95296.1.
    AK301543 mRNA. Translation: BAG63040.1.
    BX255971, AL157372 Genomic DNA. Translation: CAI23605.1.
    BX255972 Genomic DNA. No translation available.
    BX255973 Genomic DNA. No translation available.
    BC021299 mRNA. Translation: AAH21299.1.
    CCDSiCCDS4794.1. [O95238-1]
    CCDS59013.1. [O95238-2]
    RefSeqiNP_001239223.1. NM_001252294.1. [O95238-2]
    NP_036523.1. NM_012391.2. [O95238-1]
    XP_005249045.1. XM_005248988.2. [O95238-1]
    XP_006715111.1. XM_006715048.1. [O95238-1]
    UniGeneiHs.485158.

    Genome annotation databases

    EnsembliENST00000374037; ENSP00000363149; ENSG00000124664. [O95238-1]
    ENST00000544425; ENSP00000442715; ENSG00000124664. [O95238-2]
    GeneIDi25803.
    KEGGihsa:25803.
    UCSCiuc003ojq.2. human. [O95238-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031549 mRNA. Translation: BAA89543.1 .
    AF071538 mRNA. Translation: AAC95296.1 .
    AK301543 mRNA. Translation: BAG63040.1 .
    BX255971 , AL157372 Genomic DNA. Translation: CAI23605.1 .
    BX255972 Genomic DNA. No translation available.
    BX255973 Genomic DNA. No translation available.
    BC021299 mRNA. Translation: AAH21299.1 .
    CCDSi CCDS4794.1. [O95238-1 ]
    CCDS59013.1. [O95238-2 ]
    RefSeqi NP_001239223.1. NM_001252294.1. [O95238-2 ]
    NP_036523.1. NM_012391.2. [O95238-1 ]
    XP_005249045.1. XM_005248988.2. [O95238-1 ]
    XP_006715111.1. XM_006715048.1. [O95238-1 ]
    UniGenei Hs.485158.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YO5 X-ray 2.00 C 247-335 [» ]
    2DKX NMR - A 131-213 [» ]
    ProteinModelPortali O95238.
    SMRi O95238. Positions 131-213, 247-334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117335. 3 interactions.
    STRINGi 9606.ENSP00000363149.

    PTM databases

    PhosphoSitei O95238.

    Proteomic databases

    MaxQBi O95238.
    PaxDbi O95238.
    PRIDEi O95238.

    Protocols and materials databases

    DNASUi 25803.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374037 ; ENSP00000363149 ; ENSG00000124664 . [O95238-1 ]
    ENST00000544425 ; ENSP00000442715 ; ENSG00000124664 . [O95238-2 ]
    GeneIDi 25803.
    KEGGi hsa:25803.
    UCSCi uc003ojq.2. human. [O95238-1 ]

    Organism-specific databases

    CTDi 25803.
    GeneCardsi GC06M034505.
    HGNCi HGNC:17257. SPDEF.
    HPAi HPA055707.
    MIMi 608144. gene.
    neXtProti NX_O95238.
    PharmGKBi PA134993886.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG243414.
    HOGENOMi HOG000237327.
    HOVERGENi HBG080776.
    InParanoidi O95238.
    KOi K09442.
    OMAi MLYPEDS.
    OrthoDBi EOG76X60D.
    PhylomeDBi O95238.
    TreeFami TF318679.

    Miscellaneous databases

    EvolutionaryTracei O95238.
    GeneWikii SPDEF.
    GenomeRNAii 25803.
    NextBioi 47011.
    PROi O95238.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95238.
    CleanExi HS_SPDEF.
    Genevestigatori O95238.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the mouse Pse gene encoding a novel Ets family member."
      Yamada N., Tamai Y., Miyamoto H., Nozaki M.
      Gene 241:267-274(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Prostatic carcinoma.
    2. "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression."
      Oettgen P., Finger E., Sun Z., Akbarali Y., Thamrongsak U., Boltax J., Grall F., Dube A., Weiss A., Brown L., Quinn G., Kas K., Endress G., Kunsch C., Libermann T.A.
      J. Biol. Chem. 275:1216-1225(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH AR.
      Tissue: Prostate.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Mammary gland.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    6. "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter."
      Chen H., Nandi A.K., Li X., Bieberich C.J.
      Cancer Res. 62:338-340(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NKX3-1.
    7. "Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site."
      Wang Y., Feng L., Said M., Balderman S., Fayazi Z., Liu Y., Ghosh D., Gulick A.M.
      Biochemistry 44:7095-7106(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 247-335 IN COMPLEX WITH DNA.
    8. "Solution structure of the SAM_pnt-domain of ETS transcription factor PDEF (prostate Ets)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 131-213.

    Entry informationi

    Entry nameiSPDEF_HUMAN
    AccessioniPrimary (citable) accession number: O95238
    Secondary accession number(s): B4DWH8, F5H778
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3