Reviewed, UniProtKB/Swiss-Prot O95236 (APOL3_HUMAN)

Names and origin

Protein names

Recommended name:
    Apolipoprotein L3
Alternative name(s):
    Apolipoprotein L-III
      Short name=ApoL-III
    TNF-inducible protein CG12-1
      Short name=CG12_1

Gene names

Name:

APOL3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
Subcellular location	Cytoplasm Probable.
Tissue specificity	Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and testis.
Induction	In vitro, is responsive to tumor necrosis factor.
Sequence similarities	Belongs to the apolipoprotein L family.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inflammatory response Ref.1 Traceable author statement. Source: ProtInc lipid transport Inferred from electronic annotation. Source: UniProtKB-KW lipoprotein metabolic process Inferred from electronic annotation. Source: InterPro positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: InterPro
Molecular function	lipid binding Inferred from electronic annotation. Source: InterPro lipid transporter activity Ref.1 Traceable author statement. Source: ProtInc signal transducer activity Inferred from mutant phenotype. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95236-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95236-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: MGLGQGWGWE...CSHSFKRSFL → MDS

Isoform 3 (identifier: O95236-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Apolipoprotein L3		PRO_0000137602
Natural variations
	Alternative sequence	1 – 200	200	Missing in isoform 3.		VSP_000294
	Alternative sequence	1 – 74	74	MGLGQ…KRSFL → MDS in isoform 2.		VSP_000293
	Natural variant	39	1	S → R: dbSNP rs132653. Ref.2		VAR_053007
	Natural variant	135	1	A → V: dbSNP rs6000152.		VAR_047488

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: 8356C8247817F66A	FASTA	402	44,278
	10 20 30 40 50 60 MGLGQGWGWE ASCFACLIRS CCQVVTFTFP FGFQGISQSL ENVSGYYADA RLEVGSTQLR 70 80 90 100 110 120 TAGSCSHSFK RSFLEKKRFT EEATKYFRER VSPVHLQILL TNNEAWKRFV TAAELPRDEA 130 140 150 160 170 180 DALYEALKKL RTYAAIEDEY VQQKDEQFRE WFLKEFPQVK RKIQESIEKL RALANGIEEV 190 200 210 220 230 240 HRGCTISNVV SSSTGAASGI MSLAGLVLAP FTAGTSLALT AAGVGLGAAS AVTGITTSIV 250 260 270 280 290 300 EHSYTSSAEA EASRLTATSI DRLKVFKEVM RDITPNLLSL LNNYYEATQT IGSEIRAIRQ 310 320 330 340 350 360 ARARARLPVT TWRISAGSGG QAERTIAGTT RAVSRGARIL SATTSGIFLA LDVVNLVYES 370 380 390 400 KHLHEGAKSA SAEELRRQAQ ELEENLMELT QIYQRLNPCH TH
	Isoform 2. Checksum: C7703BAE5D0302FA	FASTA	331	36,545
	10 20 30 40 50 60 MDSEKKRFTE EATKYFRERV SPVHLQILLT NNEAWKRFVT AAELPRDEAD ALYEALKKLR 70 80 90 100 110 120 TYAAIEDEYV QQKDEQFREW FLKEFPQVKR KIQESIEKLR ALANGIEEVH RGCTISNVVS 130 140 150 160 170 180 SSTGAASGIM SLAGLVLAPF TAGTSLALTA AGVGLGAASA VTGITTSIVE HSYTSSAEAE 190 200 210 220 230 240 ASRLTATSID RLKVFKEVMR DITPNLLSLL NNYYEATQTI GSEIRAIRQA RARARLPVTT 250 260 270 280 290 300 WRISAGSGGQ AERTIAGTTR AVSRGARILS ATTSGIFLAL DVVNLVYESK HLHEGAKSAS 310 320 330 AEELRRQAQE LEENLMELTQ IYQRLNPCHT H
	Isoform 3. Checksum: 3C560B4F74CE837E	FASTA	202	21,597
	10 20 30 40 50 60 MSLAGLVLAP FTAGTSLALT AAGVGLGAAS AVTGITTSIV EHSYTSSAEA EASRLTATSI 70 80 90 100 110 120 DRLKVFKEVM RDITPNLLSL LNNYYEATQT IGSEIRAIRQ ARARARLPVT TWRISAGSGG 130 140 150 160 170 180 QAERTIAGTT RAVSRGARIL SATTSGIFLA LDVVNLVYES KHLHEGAKSA SAEELRRQAQ 190 200 ELEENLMELT QIYQRLNPCH TH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes." Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M., ten Cate J.W., Pannekoek H. Blood 93:3418-3431(1999) [PubMed: 10233894] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Endothelial cell.
[2]	"Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene." Duchateau P.N., Pullinger C.R., Cho M.H., Eng C., Kane J.P. J. Lipid Res. 42:620-630(2001) [PubMed: 11290834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ARG-39. Tissue: Pancreas.
[3]	"The human apolipoprotein L gene cluster: identification, classification, and sites of distribution." Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J. Genomics 74:71-78(2001) [PubMed: 11374903] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Placenta.
[4]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Blood and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF070675 mRNA. Translation: AAC83233.1. AF324238, AF324233, AF324237 Genomic DNA. Translation: AAK26528.1. AY014904 mRNA. Translation: AAG50346.1. AF324238, AF324236, AF324237 Genomic DNA. Translation: AAK26529.1. AY014902 mRNA. Translation: AAG50344.1. AY014903 mRNA. Translation: AAG50345.1. AY014905 mRNA. Translation: AAG50347.1. AF324238 Genomic DNA. Translation: AAK26527.1. AY014906 mRNA. Translation: AAG50348.1. AY014907 mRNA. Translation: AAG50349.1. AF305227 mRNA. Translation: AAK20213.1. CR456379 mRNA. Translation: CAG30265.1. Z95114 Genomic DNA. Translation: CAQ08518.1. Z95114 Genomic DNA. Translation: CAQ08519.1. CH471095 Genomic DNA. Translation: EAW60080.1. BC042918 mRNA. Translation: AAH42918.1. BC050596 mRNA. Translation: AAH50596.1.
IPI	IPI00157607. IPI00302796. IPI00335164.
RefSeq	NP_663615.1. NP_663616.1. NP_663617.1.
UniGene	Hs.474737
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O95236.
Proteomic databases
PRIDE	O95236.
Genome annotation databases
Ensembl	ENST00000349314; ENSP00000344577; ENSG00000128284; Homo sapiens. [Genome view]
GeneID	80833.
KEGG	hsa:80833.
UCSC	uc003aoq.1. human.
Organism-specific databases
CTD	80833.
GeneCards	GC22M034860.
HGNC	HGNC:14868. APOL3.
MIM	607253. gene.
PharmGKB	PA24906.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O95236.
HOVERGEN	O95236.
OMA	TIGSEIR
Gene expression databases
ArrayExpress	O95236.
Bgee	O95236.
CleanEx	HS_APOL3.
Genevestigator	O95236.
GermOnline	ENSG00000128284. Homo sapiens.
Family and domain databases
InterPro	IPR008405. ApoL. [Graphical view]
PANTHER	PTHR14096. ApoL. 1 hit.
Pfam	PF05461. ApoL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	71256.
SOURCE	Search...

Entry information

Entry name

APOL3_HUMAN

Accession

Primary (citable) accession number: O95236
Secondary accession number(s): B1AHI4 , B1AHI5, Q5U5N4, Q9BQ82, Q9BQA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 25, 2008
Last modified:	November 24, 2009
This is version 77 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.