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Protein

Apolipoprotein L3

Gene

APOL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

GO - Molecular functioni

  • lipid binding Source: InterPro
  • lipid transporter activity Source: ProtInc
  • signal transducer activity Source: UniProtKB

GO - Biological processi

  • inflammatory response Source: ProtInc
  • lipoprotein metabolic process Source: InterPro
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128284-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L3
Alternative name(s):
Apolipoprotein L-III
Short name:
ApoL-III
TNF-inducible protein CG12-1
Short name:
CG12_1
Gene namesi
Name:APOL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:14868. APOL3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular region Source: InterPro
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi80833.
OpenTargetsiENSG00000128284.
PharmGKBiPA24906.

Polymorphism and mutation databases

BioMutaiAPOL3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001376021 – 402Apolipoprotein L3Add BLAST402

Proteomic databases

MaxQBiO95236.
PaxDbiO95236.
PeptideAtlasiO95236.
PRIDEiO95236.

PTM databases

iPTMnetiO95236.
PhosphoSitePlusiO95236.

Expressioni

Tissue specificityi

Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and testis.

Inductioni

In vitro, is responsive to TNF.

Gene expression databases

BgeeiENSG00000128284.
CleanExiHS_APOL3.
ExpressionAtlasiO95236. baseline and differential.
GenevisibleiO95236. HS.

Interactioni

Protein-protein interaction databases

IntActiO95236. 6 interactors.
MINTiMINT-6768689.

Structurei

3D structure databases

ProteinModelPortaliO95236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Phylogenomic databases

eggNOGiENOG410IWES. Eukaryota.
ENOG410Y0AF. LUCA.
GeneTreeiENSGT00510000046700.
HOGENOMiHOG000294132.
HOVERGENiHBG074468.
InParanoidiO95236.
KOiK14480.
OMAiDVVNLVY.
OrthoDBiEOG091G0IH5.
PhylomeDBiO95236.
TreeFamiTF334681.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95236-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLGQGWGWE ASCFACLIRS CCQVVTFTFP FGFQGISQSL ENVSGYYADA
60 70 80 90 100
RLEVGSTQLR TAGSCSHSFK RSFLEKKRFT EEATKYFRER VSPVHLQILL
110 120 130 140 150
TNNEAWKRFV TAAELPRDEA DALYEALKKL RTYAAIEDEY VQQKDEQFRE
160 170 180 190 200
WFLKEFPQVK RKIQESIEKL RALANGIEEV HRGCTISNVV SSSTGAASGI
210 220 230 240 250
MSLAGLVLAP FTAGTSLALT AAGVGLGAAS AVTGITTSIV EHSYTSSAEA
260 270 280 290 300
EASRLTATSI DRLKVFKEVM RDITPNLLSL LNNYYEATQT IGSEIRAIRQ
310 320 330 340 350
ARARARLPVT TWRISAGSGG QAERTIAGTT RAVSRGARIL SATTSGIFLA
360 370 380 390 400
LDVVNLVYES KHLHEGAKSA SAEELRRQAQ ELEENLMELT QIYQRLNPCH

TH
Length:402
Mass (Da):44,278
Last modified:November 25, 2008 - v3
Checksum:i8356C8247817F66A
GO
Isoform 2 (identifier: O95236-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: MGLGQGWGWE...CSHSFKRSFL → MDS

Show »
Length:331
Mass (Da):36,545
Checksum:iC7703BAE5D0302FA
GO
Isoform 3 (identifier: O95236-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.

Show »
Length:202
Mass (Da):21,597
Checksum:i3C560B4F74CE837E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05300739S → R.1 PublicationCorresponds to variant rs132653dbSNPEnsembl.1
Natural variantiVAR_047488135A → V.Corresponds to variant rs6000152dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0002941 – 200Missing in isoform 3. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_0002931 – 74MGLGQ…KRSFL → MDS in isoform 2. 5 PublicationsAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070675 mRNA. Translation: AAC83233.1.
AF324238, AF324233, AF324237 Genomic DNA. Translation: AAK26528.1.
AY014904 mRNA. Translation: AAG50346.1.
AF324238, AF324236, AF324237 Genomic DNA. Translation: AAK26529.1.
AY014902 mRNA. Translation: AAG50344.1.
AY014903 mRNA. Translation: AAG50345.1.
AY014905 mRNA. Translation: AAG50347.1.
AF324238 Genomic DNA. Translation: AAK26527.1.
AY014906 mRNA. Translation: AAG50348.1.
AY014907 mRNA. Translation: AAG50349.1.
AF305227 mRNA. Translation: AAK20213.1.
CR456379 mRNA. Translation: CAG30265.1.
Z95114 Genomic DNA. Translation: CAQ08518.1.
Z95114 Genomic DNA. Translation: CAQ08519.1.
CH471095 Genomic DNA. Translation: EAW60080.1.
BC042918 mRNA. Translation: AAH42918.1.
BC050596 mRNA. Translation: AAH50596.1.
CCDSiCCDS13922.1. [O95236-1]
CCDS13924.1. [O95236-3]
RefSeqiNP_055164.1. NM_014349.2. [O95236-2]
NP_085147.1. NM_030644.1. [O95236-2]
NP_663614.1. NM_145639.1. [O95236-2]
NP_663615.1. NM_145640.2. [O95236-1]
NP_663616.1. NM_145641.2. [O95236-3]
NP_663617.1. NM_145642.2. [O95236-3]
XP_006724387.1. XM_006724324.1. [O95236-2]
XP_006724388.1. XM_006724325.2. [O95236-2]
XP_016884441.1. XM_017028952.1. [O95236-3]
UniGeneiHs.474737.

Genome annotation databases

EnsembliENST00000349314; ENSP00000344577; ENSG00000128284. [O95236-1]
ENST00000361710; ENSP00000355164; ENSG00000128284. [O95236-3]
ENST00000397287; ENSP00000380456; ENSG00000128284. [O95236-3]
ENST00000397293; ENSP00000380461; ENSG00000128284. [O95236-3]
ENST00000424878; ENSP00000415779; ENSG00000128284. [O95236-2]
GeneIDi80833.
KEGGihsa:80833.
UCSCiuc003aot.4. human. [O95236-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070675 mRNA. Translation: AAC83233.1.
AF324238, AF324233, AF324237 Genomic DNA. Translation: AAK26528.1.
AY014904 mRNA. Translation: AAG50346.1.
AF324238, AF324236, AF324237 Genomic DNA. Translation: AAK26529.1.
AY014902 mRNA. Translation: AAG50344.1.
AY014903 mRNA. Translation: AAG50345.1.
AY014905 mRNA. Translation: AAG50347.1.
AF324238 Genomic DNA. Translation: AAK26527.1.
AY014906 mRNA. Translation: AAG50348.1.
AY014907 mRNA. Translation: AAG50349.1.
AF305227 mRNA. Translation: AAK20213.1.
CR456379 mRNA. Translation: CAG30265.1.
Z95114 Genomic DNA. Translation: CAQ08518.1.
Z95114 Genomic DNA. Translation: CAQ08519.1.
CH471095 Genomic DNA. Translation: EAW60080.1.
BC042918 mRNA. Translation: AAH42918.1.
BC050596 mRNA. Translation: AAH50596.1.
CCDSiCCDS13922.1. [O95236-1]
CCDS13924.1. [O95236-3]
RefSeqiNP_055164.1. NM_014349.2. [O95236-2]
NP_085147.1. NM_030644.1. [O95236-2]
NP_663614.1. NM_145639.1. [O95236-2]
NP_663615.1. NM_145640.2. [O95236-1]
NP_663616.1. NM_145641.2. [O95236-3]
NP_663617.1. NM_145642.2. [O95236-3]
XP_006724387.1. XM_006724324.1. [O95236-2]
XP_006724388.1. XM_006724325.2. [O95236-2]
XP_016884441.1. XM_017028952.1. [O95236-3]
UniGeneiHs.474737.

3D structure databases

ProteinModelPortaliO95236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO95236. 6 interactors.
MINTiMINT-6768689.

PTM databases

iPTMnetiO95236.
PhosphoSitePlusiO95236.

Polymorphism and mutation databases

BioMutaiAPOL3.

Proteomic databases

MaxQBiO95236.
PaxDbiO95236.
PeptideAtlasiO95236.
PRIDEiO95236.

Protocols and materials databases

DNASUi80833.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349314; ENSP00000344577; ENSG00000128284. [O95236-1]
ENST00000361710; ENSP00000355164; ENSG00000128284. [O95236-3]
ENST00000397287; ENSP00000380456; ENSG00000128284. [O95236-3]
ENST00000397293; ENSP00000380461; ENSG00000128284. [O95236-3]
ENST00000424878; ENSP00000415779; ENSG00000128284. [O95236-2]
GeneIDi80833.
KEGGihsa:80833.
UCSCiuc003aot.4. human. [O95236-1]

Organism-specific databases

CTDi80833.
DisGeNETi80833.
GeneCardsiAPOL3.
HGNCiHGNC:14868. APOL3.
MIMi607253. gene.
neXtProtiNX_O95236.
OpenTargetsiENSG00000128284.
PharmGKBiPA24906.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWES. Eukaryota.
ENOG410Y0AF. LUCA.
GeneTreeiENSGT00510000046700.
HOGENOMiHOG000294132.
HOVERGENiHBG074468.
InParanoidiO95236.
KOiK14480.
OMAiDVVNLVY.
OrthoDBiEOG091G0IH5.
PhylomeDBiO95236.
TreeFamiTF334681.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128284-MONOMER.

Miscellaneous databases

ChiTaRSiAPOL3. human.
GeneWikiiAPOL3.
GenomeRNAii80833.
PROiO95236.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128284.
CleanExiHS_APOL3.
ExpressionAtlasiO95236. baseline and differential.
GenevisibleiO95236. HS.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOL3_HUMAN
AccessioniPrimary (citable) accession number: O95236
Secondary accession number(s): B1AHI4
, B1AHI5, Q5U5N4, Q9BQ82, Q9BQA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.