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Protein

Homeobox protein VENTX

Gene

VENTX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in ventralization.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi91 – 150HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein VENTX
Alternative name(s):
VENT homeobox homolog
VENT-like homeobox protein 2
Gene namesi
Name:VENTX
Synonyms:HPX42B, VENTX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151650.7.
HGNCiHGNC:13639. VENTX.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27287.
OpenTargetsiENSG00000151650.
PharmGKBiPA37803.

Polymorphism and mutation databases

BioMutaiVENTX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003059381 – 258Homeobox protein VENTXAdd BLAST258

Proteomic databases

EPDiO95231.
PaxDbiO95231.
PRIDEiO95231.

PTM databases

iPTMnetiO95231.
PhosphoSitePlusiO95231.

Expressioni

Tissue specificityi

Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line.1 Publication

Gene expression databases

BgeeiENSG00000151650.
CleanExiHS_VENTX.
GenevisibleiO95231. HS.

Organism-specific databases

HPAiHPA050955.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118111. 15 interactors.
IntActiO95231. 79 interactors.
STRINGi9606.ENSP00000357556.

Structurei

3D structure databases

ProteinModelPortaliO95231.
SMRiO95231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiENOG410J3ER. Eukaryota.
ENOG411280P. LUCA.
GeneTreeiENSGT00890000139333.
HOGENOMiHOG000154815.
InParanoidiO95231.
OMAiWLSQSSC.
OrthoDBiEOG091G0HNO.
PhylomeDBiO95231.
TreeFamiTF351607.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O95231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSSSPPRG PQQLSSFGSV DWLSQSSCSG PTHTPRPADF SLGSLPGPGQ
60 70 80 90 100
TSGAREPPQA VSIKEAAGSS NLPAPERTMA GLSKEPNTLR APRVRTAFTM
110 120 130 140 150
EQVRTLEGVF QHHQYLSPLE RKRLAREMQL SEVQIKTWFQ NRRMKHKRQM
160 170 180 190 200
QDPQLHSPFS GSLHAPPAFY STSSGLANGL QLLCPWAPLS GPQALMLPPG
210 220 230 240 250
SFWGLCQVAQ EALASAGASC CGQPLASHPP TPGRPSLGPA LSTGPRGLCA

MPQTGDAF
Length:258
Mass (Da):27,552
Last modified:May 1, 1999 - v1
Checksum:i6F611169122D8244
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03524342L → P1 PublicationCorresponds to variant dbSNP:rs2240892Ensembl.1
Natural variantiVAR_03524479M → V. Corresponds to variant dbSNP:rs2240891Ensembl.1
Natural variantiVAR_049591101E → K. Corresponds to variant dbSNP:rs2270192Ensembl.1
Natural variantiVAR_049592191G → R. Corresponds to variant dbSNP:rs9418952Ensembl.1
Natural variantiVAR_061269247G → D. Corresponds to variant dbSNP:rs9418953Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068006 mRNA. Translation: AAC82375.1.
AF288039 Genomic DNA. Translation: AAK83043.1.
AL445199 Genomic DNA. No translation available.
BC108915 mRNA. Translation: AAI08916.1.
BC108916 mRNA. Translation: AAI08917.1.
CCDSiCCDS7675.1.
RefSeqiNP_055283.1. NM_014468.3.
UniGeneiHs.125231.

Genome annotation databases

EnsembliENST00000325980; ENSP00000357556; ENSG00000151650.
GeneIDi27287.
KEGGihsa:27287.
UCSCiuc010quy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVENTX_HUMAN
AccessioniPrimary (citable) accession number: O95231
Secondary accession number(s): Q32MZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot