O95231 (VENTX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein VENTX

Alternative name(s):
VENT homeobox homolog
VENT-like homeobox protein 2

Gene names

Name:	VENTX
Synonyms:	HPX42B, VENTX2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in ventralization.
Subcellular location	Nucleus Probable.
Tissue specificity	Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line. Ref.1
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Homeobox protein VENTX		PRO_0000305938
Regions
	DNA binding	91 – 150	60	Homeobox
Natural variations
	Natural variant	42	1	L → P. Ref.3 Corresponds to variant rs2240892 [ dbSNP | Ensembl ].		VAR_035243
	Natural variant	79	1	M → V. Corresponds to variant rs2240891 [ dbSNP | Ensembl ].		VAR_035244
	Natural variant	101	1	E → K. Corresponds to variant rs2270192 [ dbSNP | Ensembl ].		VAR_049591
	Natural variant	191	1	G → R. Corresponds to variant rs9418952 [ dbSNP | Ensembl ].		VAR_049592
	Natural variant	247	1	G → D. Corresponds to variant rs9418953 [ dbSNP | Ensembl ].		VAR_061269

Sequences

	Sequence		Length	Mass (Da)
	O95231 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 6F611169122D8244	FASTA	258	27,552
	10 20 30 40 50 60 MRLSSSPPRG PQQLSSFGSV DWLSQSSCSG PTHTPRPADF SLGSLPGPGQ TSGAREPPQA 70 80 90 100 110 120 VSIKEAAGSS NLPAPERTMA GLSKEPNTLR APRVRTAFTM EQVRTLEGVF QHHQYLSPLE 130 140 150 160 170 180 RKRLAREMQL SEVQIKTWFQ NRRMKHKRQM QDPQLHSPFS GSLHAPPAFY STSSGLANGL 190 200 210 220 230 240 QLLCPWAPLS GPQALMLPPG SFWGLCQVAQ EALASAGASC CGQPLASHPP TPGRPSLGPA 250 LSTGPRGLCA MPQTGDAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a human Vent-like homeobox gene." Moretti P.A.B., Davidson A.J., Baker E., Lilley B., Zon L.I., D'Andrea R.J. Genomics 76:21-29(2001) [PubMed: 11549314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY. Tissue: Bone marrow.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-42.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF068006 mRNA. Translation: AAC82375.1. AF288039 Genomic DNA. Translation: AAK83043.1. AL445199 Genomic DNA. Translation: CAI17343.1. BC108915 mRNA. Translation: AAI08916.1. BC108916 mRNA. Translation: AAI08917.1.
IPI	IPI00004447.
RefSeq	NP_055283.1. NM_014468.2.
UniGene	Hs.125231.
3D structure databases
HSSP	HSSP built from PDB template 1K61 based on UniProtKB Q6B2C0.
ProteinModelPortal	O95231.
SMR	O95231. Positions 93-149.
ModBase	Search...
Protein-protein interaction databases
STRING	O95231.
Proteomic databases
PRIDE	O95231.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325980; ENSP00000357556; ENSG00000151650.
GeneID	27287.
KEGG	hsa:27287.
UCSC	uc001lmd.1. human.
Organism-specific databases
CTD	27287.
GeneCards	GC10P135051.
H-InvDB	HIX0036778. HIX0201519.
HGNC	HGNC:13639. VENTX.
MIM	607158. gene.
neXtProt	NX_O95231.
PharmGKB	PA37803.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11121.
GeneTree	ENSGT00590000083002.
InParanoid	O95231.
OMA	DWLSQSS.
OrthoDB	EOG44TP97.
PhylomeDB	O95231.
Gene expression databases
ArrayExpress	O95231.
Bgee	O95231.
CleanEx	HS_VENTX.
Genevestigator	O95231.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	50228.
SOURCE	Search...

Entry information

Entry name

VENTX_HUMAN

Accession

Primary (citable) accession number: O95231
Secondary accession number(s): Q32MZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.