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Protein

Homeobox protein VENTX

Gene

VENTX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in ventralization.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi91 – 15060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein VENTX
Alternative name(s):
VENT homeobox homolog
VENT-like homeobox protein 2
Gene namesi
Name:VENTX
Synonyms:HPX42B, VENTX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13639. VENTX.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37803.

Polymorphism and mutation databases

BioMutaiVENTX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Homeobox protein VENTXPRO_0000305938Add
BLAST

Proteomic databases

MaxQBiO95231.
PaxDbiO95231.
PRIDEiO95231.

PTM databases

iPTMnetiO95231.

Expressioni

Tissue specificityi

Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line.1 Publication

Gene expression databases

BgeeiO95231.
CleanExiHS_VENTX.
GenevisibleiO95231. HS.

Organism-specific databases

HPAiHPA050955.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf94Q6P1W53EBI-10191303,EBI-946029
DAB1O755533EBI-10191303,EBI-7875264
KRTAP12-2P599913EBI-10191303,EBI-10176379
KRTAP12-4P603293EBI-10191303,EBI-10176396
RBPMSQ930623EBI-10191303,EBI-740322
TBX15Q96SF73EBI-10191303,EBI-10191361
TBX22Q9Y4583EBI-10191303,EBI-6427217

Protein-protein interaction databases

BioGridi118111. 14 interactions.
IntActiO95231. 7 interactions.
STRINGi9606.ENSP00000357556.

Structurei

3D structure databases

ProteinModelPortaliO95231.
SMRiO95231. Positions 98-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiENOG410J3ER. Eukaryota.
ENOG411280P. LUCA.
GeneTreeiENSGT00840000129974.
HOGENOMiHOG000154815.
InParanoidiO95231.
OMAiWLSQSSC.
OrthoDBiEOG7F514H.
PhylomeDBiO95231.
TreeFamiTF351607.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSSSPPRG PQQLSSFGSV DWLSQSSCSG PTHTPRPADF SLGSLPGPGQ
60 70 80 90 100
TSGAREPPQA VSIKEAAGSS NLPAPERTMA GLSKEPNTLR APRVRTAFTM
110 120 130 140 150
EQVRTLEGVF QHHQYLSPLE RKRLAREMQL SEVQIKTWFQ NRRMKHKRQM
160 170 180 190 200
QDPQLHSPFS GSLHAPPAFY STSSGLANGL QLLCPWAPLS GPQALMLPPG
210 220 230 240 250
SFWGLCQVAQ EALASAGASC CGQPLASHPP TPGRPSLGPA LSTGPRGLCA

MPQTGDAF
Length:258
Mass (Da):27,552
Last modified:May 1, 1999 - v1
Checksum:i6F611169122D8244
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421L → P.1 Publication
Corresponds to variant rs2240892 [ dbSNP | Ensembl ].
VAR_035243
Natural varianti79 – 791M → V.
Corresponds to variant rs2240891 [ dbSNP | Ensembl ].
VAR_035244
Natural varianti101 – 1011E → K.
Corresponds to variant rs2270192 [ dbSNP | Ensembl ].
VAR_049591
Natural varianti191 – 1911G → R.
Corresponds to variant rs9418952 [ dbSNP | Ensembl ].
VAR_049592
Natural varianti247 – 2471G → D.
Corresponds to variant rs9418953 [ dbSNP | Ensembl ].
VAR_061269

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068006 mRNA. Translation: AAC82375.1.
AF288039 Genomic DNA. Translation: AAK83043.1.
AL445199 Genomic DNA. Translation: CAI17343.1.
BC108915 mRNA. Translation: AAI08916.1.
BC108916 mRNA. Translation: AAI08917.1.
CCDSiCCDS7675.1.
RefSeqiNP_055283.1. NM_014468.3.
UniGeneiHs.125231.

Genome annotation databases

EnsembliENST00000325980; ENSP00000357556; ENSG00000151650.
GeneIDi27287.
KEGGihsa:27287.
UCSCiuc010quy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068006 mRNA. Translation: AAC82375.1.
AF288039 Genomic DNA. Translation: AAK83043.1.
AL445199 Genomic DNA. Translation: CAI17343.1.
BC108915 mRNA. Translation: AAI08916.1.
BC108916 mRNA. Translation: AAI08917.1.
CCDSiCCDS7675.1.
RefSeqiNP_055283.1. NM_014468.3.
UniGeneiHs.125231.

3D structure databases

ProteinModelPortaliO95231.
SMRiO95231. Positions 98-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118111. 14 interactions.
IntActiO95231. 7 interactions.
STRINGi9606.ENSP00000357556.

PTM databases

iPTMnetiO95231.

Polymorphism and mutation databases

BioMutaiVENTX.

Proteomic databases

MaxQBiO95231.
PaxDbiO95231.
PRIDEiO95231.

Protocols and materials databases

DNASUi27287.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325980; ENSP00000357556; ENSG00000151650.
GeneIDi27287.
KEGGihsa:27287.
UCSCiuc010quy.3. human.

Organism-specific databases

CTDi27287.
GeneCardsiVENTX.
H-InvDBHIX0036778.
HGNCiHGNC:13639. VENTX.
HPAiHPA050955.
MIMi607158. gene.
neXtProtiNX_O95231.
PharmGKBiPA37803.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3ER. Eukaryota.
ENOG411280P. LUCA.
GeneTreeiENSGT00840000129974.
HOGENOMiHOG000154815.
InParanoidiO95231.
OMAiWLSQSSC.
OrthoDBiEOG7F514H.
PhylomeDBiO95231.
TreeFamiTF351607.

Miscellaneous databases

GenomeRNAii27287.
PROiO95231.
SOURCEiSearch...

Gene expression databases

BgeeiO95231.
CleanExiHS_VENTX.
GenevisibleiO95231. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-42.

Entry informationi

Entry nameiVENTX_HUMAN
AccessioniPrimary (citable) accession number: O95231
Secondary accession number(s): Q32MZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.