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Protein

Homeobox protein VENTX

Gene

VENTX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in ventralization.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi91 – 150HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein VENTX
Alternative name(s):
VENT homeobox homolog
VENT-like homeobox protein 2
Gene namesi
Name:VENTX
Synonyms:HPX42B, VENTX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151650.7
HGNCiHGNC:13639 VENTX
MIMi607158 gene
neXtProtiNX_O95231

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27287
OpenTargetsiENSG00000151650
PharmGKBiPA37803

Polymorphism and mutation databases

BioMutaiVENTX

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003059381 – 258Homeobox protein VENTXAdd BLAST258

Proteomic databases

PaxDbiO95231
PRIDEiO95231

PTM databases

iPTMnetiO95231
PhosphoSitePlusiO95231

Expressioni

Tissue specificityi

Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line.1 Publication

Gene expression databases

BgeeiENSG00000151650
CleanExiHS_VENTX
GenevisibleiO95231 HS

Organism-specific databases

HPAiHPA050955

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118111, 15 interactors
IntActiO95231, 79 interactors
STRINGi9606.ENSP00000357556

Structurei

3D structure databases

ProteinModelPortaliO95231
SMRiO95231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiENOG410J3ER Eukaryota
ENOG411280P LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000154815
InParanoidiO95231
OMAiWLSQSSC
OrthoDBiEOG091G0HNO
PhylomeDBiO95231
TreeFamiTF351607

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSSSPPRG PQQLSSFGSV DWLSQSSCSG PTHTPRPADF SLGSLPGPGQ
60 70 80 90 100
TSGAREPPQA VSIKEAAGSS NLPAPERTMA GLSKEPNTLR APRVRTAFTM
110 120 130 140 150
EQVRTLEGVF QHHQYLSPLE RKRLAREMQL SEVQIKTWFQ NRRMKHKRQM
160 170 180 190 200
QDPQLHSPFS GSLHAPPAFY STSSGLANGL QLLCPWAPLS GPQALMLPPG
210 220 230 240 250
SFWGLCQVAQ EALASAGASC CGQPLASHPP TPGRPSLGPA LSTGPRGLCA

MPQTGDAF
Length:258
Mass (Da):27,552
Last modified:May 1, 1999 - v1
Checksum:i6F611169122D8244
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03524342L → P1 PublicationCorresponds to variant dbSNP:rs2240892Ensembl.1
Natural variantiVAR_03524479M → V. Corresponds to variant dbSNP:rs2240891Ensembl.1
Natural variantiVAR_049591101E → K. Corresponds to variant dbSNP:rs2270192Ensembl.1
Natural variantiVAR_049592191G → R. Corresponds to variant dbSNP:rs9418952Ensembl.1
Natural variantiVAR_061269247G → D. Corresponds to variant dbSNP:rs9418953Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068006 mRNA Translation: AAC82375.1
AF288039 Genomic DNA Translation: AAK83043.1
AL445199 Genomic DNA No translation available.
BC108915 mRNA Translation: AAI08916.1
BC108916 mRNA Translation: AAI08917.1
CCDSiCCDS7675.1
RefSeqiNP_055283.1, NM_014468.3
UniGeneiHs.125231

Genome annotation databases

EnsembliENST00000325980; ENSP00000357556; ENSG00000151650
GeneIDi27287
KEGGihsa:27287
UCSCiuc010quy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVENTX_HUMAN
AccessioniPrimary (citable) accession number: O95231
Secondary accession number(s): Q32MZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health