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Protein

ZW10 interactor

Gene

ZWINT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.4 Publications

GO - Molecular functioni

  • protein N-terminus binding Source: HGNC

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • establishment of localization in cell Source: HGNC
  • mitotic cell cycle checkpoint Source: HGNC
  • mitotic sister chromatid segregation Source: HGNC
  • sister chromatid cohesion Source: Reactome

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-141444. Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
R-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
ZW10 interactor
Alternative name(s):
ZW10-interacting protein 1
Short name:
Zwint-1
Gene namesi
Name:ZWINT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000122952.16.
HGNCiHGNC:13195. ZWINT.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11130.
OpenTargetsiENSG00000122952.
PharmGKBiPA37761.

Polymorphism and mutation databases

BioMutaiZWINT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665941 – 277ZW10 interactorAdd BLAST277

Proteomic databases

EPDiO95229.
MaxQBiO95229.
PaxDbiO95229.
PeptideAtlasiO95229.
PRIDEiO95229.

PTM databases

iPTMnetiO95229.
PhosphoSitePlusiO95229.

Expressioni

Gene expression databases

BgeeiENSG00000122952.
CleanExiHS_ZWINT.
ExpressionAtlasiO95229. baseline and differential.
GenevisibleiO95229. HS.

Organism-specific databases

HPAiCAB033926.
HPA005757.
HPA022264.

Interactioni

Subunit structurei

Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with KNL1, CETN3, DSN1 and PMF1.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein N-terminus binding Source: HGNC

Protein-protein interaction databases

BioGridi116303. 101 interactors.
CORUMiO95229.
IntActiO95229. 84 interactors.
MINTiMINT-4990180.
STRINGi9606.ENSP00000363055.

Structurei

3D structure databases

ProteinModelPortaliO95229.
SMRiO95229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 155Interaction with NDC80 and ZW10Add BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili104 – 217Sequence analysisAdd BLAST114

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ58. Eukaryota.
ENOG4111831. LUCA.
GeneTreeiENSGT00390000017639.
HOGENOMiHOG000293254.
HOVERGENiHBG079391.
InParanoidiO95229.
KOiK19943.
OMAiIAAKEQW.
OrthoDBiEOG091G0GKM.
PhylomeDBiO95229.
TreeFamiTF338101.

Family and domain databases

InterProiView protein in InterPro
IPR029092. Zwint-1.
PANTHERiPTHR31504. PTHR31504. 1 hit.
PfamiView protein in Pfam
PF15556. Zwint. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95229-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAAETEAEA AALEVLAEVA GILEPVGLQE EAELPAKILV EFVVDSQKKD
60 70 80 90 100
KLLCSQLQVA DFLQNILAQE DTAKGLDPLA SEDTSRQKAI AAKEQWKELK
110 120 130 140 150
ATYREHVEAI KIGLTKALTQ MEEAQRKRTQ LREAFEQLQA KKQMAMEKRR
160 170 180 190 200
AVQNQWQLQQ EKHLQHLAEV SAEVRERKTG TQQELDRVFQ KLGNLKQQAE
210 220 230 240 250
QERDKLQRYQ TFLQLLYTLQ GKLLFPEAEA EAENLPDDKP QQPTRPQEQS
260 270
TGDTMGRDPG VSFKAVGLQP AGDVNLP
Length:277
Mass (Da):31,293
Last modified:October 31, 2006 - v2
Checksum:i3335FBA5731AD0DC
GO
Isoform 2 (identifier: O95229-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-220: Missing.

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):25,544
Checksum:i673BAD09107D7E3B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0287834A → S. Corresponds to variant dbSNP:rs11005328Ensembl.1
Natural variantiVAR_051505187R → G2 PublicationsCorresponds to variant dbSNP:rs2241666Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047660174 – 220Missing in isoform 2. CuratedAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067656 mRNA. Translation: AAC78629.1.
AC010996 Genomic DNA. No translation available.
BC000411 mRNA. Translation: AAH00411.1.
BC020979 mRNA. Translation: AAH20979.1.
BC110399 mRNA. Translation: AAI10400.1.
CCDSiCCDS31205.1. [O95229-2]
CCDS7249.1. [O95229-1]
RefSeqiNP_001005413.1. NM_001005413.1. [O95229-2]
NP_008988.2. NM_007057.3. [O95229-1]
NP_127490.1. NM_032997.2. [O95229-1]
UniGeneiHs.591363.

Genome annotation databases

EnsembliENST00000361148; ENSP00000354921; ENSG00000122952. [O95229-2]
ENST00000373944; ENSP00000363055; ENSG00000122952. [O95229-1]
ENST00000395405; ENSP00000378801; ENSG00000122952. [O95229-1]
GeneIDi11130.
KEGGihsa:11130.
UCSCiuc001jjx.2. human. [O95229-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZWINT_HUMAN
AccessioniPrimary (citable) accession number: O95229
Secondary accession number(s): A6NNV6, Q0D2I3, Q9BWD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 31, 2006
Last modified: September 27, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot