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Protein

Olfactory receptor 6A2

Gene

OR6A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33234-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6A2
Alternative name(s):
Olfactory receptor 11-55
Short name:
OR11-55
Olfactory receptor 6A1
Olfactory receptor OR11-83
hP2 olfactory receptor
Gene namesi
Name:OR6A2
Synonyms:OR6A1, OR6A2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15301. OR6A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 104ExtracellularSequence analysisAdd BLAST28
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 144CytoplasmicSequence analysisAdd BLAST19
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 201ExtracellularSequence analysisAdd BLAST36
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 242CytoplasmicSequence analysisAdd BLAST20
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 276ExtracellularSequence analysisAdd BLAST13
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 327CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184933.
PharmGKBiPA32574.

Polymorphism and mutation databases

BioMutaiOR6A2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506191 – 327Olfactory receptor 6A2Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi102 ↔ 194PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95222.
PeptideAtlasiO95222.
PRIDEiO95222.

Expressioni

Gene expression databases

CleanExiHS_OR6A2.
ExpressionAtlasiO95222. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330384.

Structurei

3D structure databases

ProteinModelPortaliO95222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9G. Eukaryota.
ENOG410YB1I. LUCA.
GeneTreeiENSGT00800000124041.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO95222.
KOiK04257.
OMAiLHLYQGQ.
OrthoDBiEOG091G0DAJ.
PhylomeDBiO95222.
TreeFamiTF337475.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95222-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWRNHSGRV SEFVLLGFPA PAPLQVLLFA LLLLAYVLVL TENTLIIMAI
60 70 80 90 100
RNHSTLHKPM YFFLANMSFL EIWYVTVTIP KMLAGFVGSK QDHGQLISFE
110 120 130 140 150
GCMTQLYFFL GLGCTECVLL AVMAYDRYMA ICYPLHYPVI VSGRLCVQMA
160 170 180 190 200
AGSWAGGFGI SMVKVFLISG LSYCGPNIIN HFFCDVSPLL NLSCTDMSTA
210 220 230 240 250
ELTDFILAIF ILLGPLSVTG ASYVAITGAV MHIPSAAGRY KAFSTCASHL
260 270 280 290 300
TVVIIFYAAS IFIYARPKAL SAFDTNKLVS VLYAVIVPLL NPIIYCLRNQ
310 320
EVKRALCCTL HLYQHQDPDP KKASRNV
Length:327
Mass (Da):36,154
Last modified:August 16, 2004 - v2
Checksum:i9C11914D3F069FC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22 – 27APLQVL → VPIQVI in AAC70018 (PubMed:9787077).Curated6
Sequence conflicti125Y → N in AAC70018 (PubMed:9787077).Curated1
Sequence conflicti125Y → N in DAA04825 (PubMed:9787077).Curated1
Sequence conflicti134P → L in AAC70018 (PubMed:9787077).Curated1
Sequence conflicti134P → L in DAA04825 (PubMed:9787077).Curated1
Sequence conflicti137Y → N in AAC70018 (PubMed:9787077).Curated1
Sequence conflicti137Y → N in DAA04825 (PubMed:9787077).Curated1
Sequence conflicti173 – 174YC → NG in AAC70018 (PubMed:9787077).Curated2
Sequence conflicti173 – 174YC → NG in DAA04825 (PubMed:9787077).Curated2
Sequence conflicti250 – 251LT → FN in AAC70018 (PubMed:9787077).Curated2
Sequence conflicti250 – 251LT → FN in DAA04825 (PubMed:9787077).Curated2
Sequence conflicti309T → I in AAC70018 (PubMed:9787077).Curated1
Sequence conflicti309T → I in DAA04825 (PubMed:9787077).Curated1
Sequence conflicti323A → G in AAC70018 (PubMed:9787077).Curated1
Sequence conflicti323A → G in DAA04825 (PubMed:9787077).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05321722A → V.Corresponds to variant rs7122644dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065870 Genomic DNA. Translation: AAC70018.1.
AF321237 Genomic DNA. Translation: AAG45208.1.
AB065822 Genomic DNA. Translation: BAC06041.1.
BC101489 mRNA. Translation: AAI01490.1.
BC101491 mRNA. Translation: AAI01492.1.
BK004427 Genomic DNA. Translation: DAA04825.1.
CCDSiCCDS7772.1.
RefSeqiNP_003687.2. NM_003696.2.
UniGeneiHs.652252.

Genome annotation databases

EnsembliENST00000332601; ENSP00000330384; ENSG00000184933.
GeneIDi8590.
KEGGihsa:8590.
UCSCiuc001mes.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065870 Genomic DNA. Translation: AAC70018.1.
AF321237 Genomic DNA. Translation: AAG45208.1.
AB065822 Genomic DNA. Translation: BAC06041.1.
BC101489 mRNA. Translation: AAI01490.1.
BC101491 mRNA. Translation: AAI01492.1.
BK004427 Genomic DNA. Translation: DAA04825.1.
CCDSiCCDS7772.1.
RefSeqiNP_003687.2. NM_003696.2.
UniGeneiHs.652252.

3D structure databases

ProteinModelPortaliO95222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000330384.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR6A2.

Proteomic databases

PaxDbiO95222.
PeptideAtlasiO95222.
PRIDEiO95222.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332601; ENSP00000330384; ENSG00000184933.
GeneIDi8590.
KEGGihsa:8590.
UCSCiuc001mes.2. human.

Organism-specific databases

CTDi8590.
GeneCardsiOR6A2.
HGNCiHGNC:15301. OR6A2.
MIMi608495. gene.
neXtProtiNX_O95222.
OpenTargetsiENSG00000184933.
PharmGKBiPA32574.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9G. Eukaryota.
ENOG410YB1I. LUCA.
GeneTreeiENSGT00800000124041.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO95222.
KOiK04257.
OMAiLHLYQGQ.
OrthoDBiEOG091G0DAJ.
PhylomeDBiO95222.
TreeFamiTF337475.

Enzyme and pathway databases

BioCyciZFISH:G66-33234-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6A2.
GenomeRNAii8590.
PROiO95222.
SOURCEiSearch...

Gene expression databases

CleanExiHS_OR6A2.
ExpressionAtlasiO95222. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR6A2_HUMAN
AccessioniPrimary (citable) accession number: O95222
Secondary accession number(s): Q3MJC7, Q6IF35, Q9H206
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.