ID   OR5F1_HUMAN             Reviewed;         314 AA.
AC   O95221; Q495D1; Q6IFB9;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 2.
DT   24-JAN-2024, entry version 170.
DE   RecName: Full=Olfactory receptor 5F1;
DE   AltName: Full=Olfactory receptor 11-10;
DE            Short=OR11-10;
DE   AltName: Full=Olfactory receptor OR11-167;
GN   Name=OR5F1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-294.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-294.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=9787077; DOI=10.1006/geno.1998.5422;
RA   Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.;
RT   "Organization and evolution of olfactory receptor genes on human chromosome
RT   11.";
RL   Genomics 53:56-68(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5F1";
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DR   EMBL; CH471076; EAW73694.1; -; Genomic_DNA.
DR   EMBL; BC101239; AAI01240.1; -; mRNA.
DR   EMBL; BC101241; AAI01242.1; -; mRNA.
DR   EMBL; AF065863; AAC70017.1; -; Genomic_DNA.
DR   EMBL; AF399527; AAK95012.1; -; Genomic_DNA.
DR   EMBL; BK004343; DAA04741.1; -; Genomic_DNA.
DR   CCDS; CCDS31515.1; -.
DR   RefSeq; NP_003688.1; NM_003697.1.
DR   AlphaFoldDB; O95221; -.
DR   SMR; O95221; -.
DR   BioGRID; 130779; 12.
DR   IntAct; O95221; 9.
DR   STRING; 9606.ENSP00000278409; -.
DR   GlyCosmos; O95221; 1 site, No reported glycans.
DR   GlyGen; O95221; 1 site.
DR   iPTMnet; O95221; -.
DR   PhosphoSitePlus; O95221; -.
DR   BioMuta; OR5F1; -.
DR   MassIVE; O95221; -.
DR   PaxDb; 9606-ENSP00000278409; -.
DR   PeptideAtlas; O95221; -.
DR   ProteomicsDB; 50725; -.
DR   Antibodypedia; 58954; 115 antibodies from 21 providers.
DR   DNASU; 338674; -.
DR   Ensembl; ENST00000278409.1; ENSP00000278409.1; ENSG00000149133.1.
DR   GeneID; 338674; -.
DR   KEGG; hsa:338674; -.
DR   MANE-Select; ENST00000278409.1; ENSP00000278409.1; NM_003697.1; NP_003688.1.
DR   UCSC; uc010riv.2; human.
DR   AGR; HGNC:8343; -.
DR   CTD; 338674; -.
DR   GeneCards; OR5F1; -.
DR   HGNC; HGNC:8343; OR5F1.
DR   HPA; ENSG00000149133; Not detected.
DR   MIM; 608492; gene.
DR   neXtProt; NX_O95221; -.
DR   PharmGKB; PA32526; -.
DR   VEuPathDB; HostDB:ENSG00000149133; -.
DR   eggNOG; ENOG502SJ0I; Eukaryota.
DR   GeneTree; ENSGT01100000263503; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; O95221; -.
DR   OMA; FYATCIY; -.
DR   OrthoDB; 4634131at2759; -.
DR   PhylomeDB; O95221; -.
DR   TreeFam; TF352753; -.
DR   PathwayCommons; O95221; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; O95221; -.
DR   BioGRID-ORCS; 338674; 12 hits in 707 CRISPR screens.
DR   GeneWiki; OR5F1; -.
DR   GenomeRNAi; 338674; -.
DR   Pharos; O95221; Tdark.
DR   PRO; PR:O95221; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; O95221; Protein.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   CDD; cd15411; 7tmA_OR8H-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48018:SF105; OLFACTORY RECEPTOR; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 5F1"
FT                   /id="PRO_0000150595"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         192
FT                   /note="T -> A (in dbSNP:rs35607186)"
FT                   /id="VAR_062043"
FT   VARIANT         278
FT                   /note="Y -> H (in dbSNP:rs11825964)"
FT                   /id="VAR_053194"
FT   VARIANT         294
FT                   /note="S -> N (in dbSNP:rs2449134)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT                   /id="VAR_034225"
SQ   SEQUENCE   314 AA;  35132 MW;  C14A9A35CD76E3A3 CRC64;
     MTRKNYTSLT EFVLLGLADT LELQIILFLF FLVIYTLTVL GNLGMILLIR IDSQLHTPMY
     FFLANLSFVD VCNSTTITPK MLADLLSEKK TISFAGCFLQ MYFFISLATT ECILFGLMAY
     DRYAAICRPL LYSLIMSRTV YLKMAAGAFA AGLLNFMVNT SHVSSLSFCD SNVIHHFFCD
     SPPLFKLSCS DTILKESISS ILAGVNIVGT LLVILSSYSY VLFSIFSMHS GEGRHRAFST
     CASHLTAIIL FYATCIYTYL RPSSSYSLNQ DKVASVFYTV VIPMLNPLIY SLRSKEVKKA
     LANVISRKRT SSFL
//