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O95221

- OR5F1_HUMAN

UniProt

O95221 - OR5F1_HUMAN

Protein

Olfactory receptor 5F1

Gene

OR5F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. sensory perception of smell Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5F1
    Alternative name(s):
    Olfactory receptor 11-10
    Short name:
    OR11-10
    Olfactory receptor OR11-167
    Gene namesi
    Name:OR5F1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8343. OR5F1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32526.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 5F1PRO_0000150595Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95221.
    PRIDEiO95221.

    PTM databases

    PhosphoSiteiO95221.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5F1.
    GenevestigatoriO95221.

    Organism-specific databases

    HPAiHPA059360.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000278409.

    Structurei

    3D structure databases

    ProteinModelPortaliO95221.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG73596.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiO95221.
    KOiK04257.
    OMAiSCSDTIL.
    OrthoDBiEOG71K63J.
    PhylomeDBiO95221.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95221-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRKNYTSLT EFVLLGLADT LELQIILFLF FLVIYTLTVL GNLGMILLIR    50
    IDSQLHTPMY FFLANLSFVD VCNSTTITPK MLADLLSEKK TISFAGCFLQ 100
    MYFFISLATT ECILFGLMAY DRYAAICRPL LYSLIMSRTV YLKMAAGAFA 150
    AGLLNFMVNT SHVSSLSFCD SNVIHHFFCD SPPLFKLSCS DTILKESISS 200
    ILAGVNIVGT LLVILSSYSY VLFSIFSMHS GEGRHRAFST CASHLTAIIL 250
    FYATCIYTYL RPSSSYSLNQ DKVASVFYTV VIPMLNPLIY SLRSKEVKKA 300
    LANVISRKRT SSFL 314
    Length:314
    Mass (Da):35,132
    Last modified:June 20, 2001 - v2
    Checksum:iC14A9A35CD76E3A3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti192 – 1921T → A.
    Corresponds to variant rs35607186 [ dbSNP | Ensembl ].
    VAR_062043
    Natural varianti278 – 2781Y → H.
    Corresponds to variant rs11825964 [ dbSNP | Ensembl ].
    VAR_053194
    Natural varianti294 – 2941S → N.2 Publications
    Corresponds to variant rs2449134 [ dbSNP | Ensembl ].
    VAR_034225

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471076 Genomic DNA. Translation: EAW73694.1.
    BC101239 mRNA. Translation: AAI01240.1.
    BC101241 mRNA. Translation: AAI01242.1.
    AF065863 Genomic DNA. Translation: AAC70017.1.
    AF399527 Genomic DNA. Translation: AAK95012.1.
    BK004343 Genomic DNA. Translation: DAA04741.1.
    CCDSiCCDS31515.1.
    RefSeqiNP_003688.1. NM_003697.1.
    UniGeneiHs.553702.

    Genome annotation databases

    EnsembliENST00000278409; ENSP00000278409; ENSG00000149133.
    GeneIDi338674.
    KEGGihsa:338674.
    UCSCiuc010riv.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471076 Genomic DNA. Translation: EAW73694.1 .
    BC101239 mRNA. Translation: AAI01240.1 .
    BC101241 mRNA. Translation: AAI01242.1 .
    AF065863 Genomic DNA. Translation: AAC70017.1 .
    AF399527 Genomic DNA. Translation: AAK95012.1 .
    BK004343 Genomic DNA. Translation: DAA04741.1 .
    CCDSi CCDS31515.1.
    RefSeqi NP_003688.1. NM_003697.1.
    UniGenei Hs.553702.

    3D structure databases

    ProteinModelPortali O95221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000278409.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O95221.

    Proteomic databases

    PaxDbi O95221.
    PRIDEi O95221.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278409 ; ENSP00000278409 ; ENSG00000149133 .
    GeneIDi 338674.
    KEGGi hsa:338674.
    UCSCi uc010riv.2. human.

    Organism-specific databases

    CTDi 338674.
    GeneCardsi GC11M055761.
    HGNCi HGNC:8343. OR5F1.
    HPAi HPA059360.
    MIMi 608492. gene.
    neXtProti NX_O95221.
    PharmGKBi PA32526.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73596.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi O95221.
    KOi K04257.
    OMAi SCSDTIL.
    OrthoDBi EOG71K63J.
    PhylomeDBi O95221.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5F1.
    GenomeRNAii 338674.
    NextBioi 97095.
    PROi O95221.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_OR5F1.
    Genevestigatori O95221.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-294.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-294.
    3. "Organization and evolution of olfactory receptor genes on human chromosome 11."
      Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.
      Genomics 53:56-68(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR5F1_HUMAN
    AccessioniPrimary (citable) accession number: O95221
    Secondary accession number(s): Q495D1, Q6IFB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3