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Protein

Olfactory receptor 5F1

Gene

OR5F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149133-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5F1
Alternative name(s):
Olfactory receptor 11-10
Short name:
OR11-10
Olfactory receptor OR11-167
Gene namesi
Name:OR5F1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8343. OR5F1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149133.
PharmGKBiPA32526.

Polymorphism and mutation databases

BioMutaiOR5F1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505951 – 314Olfactory receptor 5F1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95221.
PeptideAtlasiO95221.
PRIDEiO95221.

PTM databases

iPTMnetiO95221.
PhosphoSitePlusiO95221.

Expressioni

Gene expression databases

CleanExiHS_OR5F1.

Organism-specific databases

HPAiHPA059360.

Interactioni

Protein-protein interaction databases

BioGridi130779. 10 interactors.
STRINGi9606.ENSP00000278409.

Structurei

3D structure databases

ProteinModelPortaliO95221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU6. Eukaryota.
ENOG4111BJM. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO95221.
KOiK04257.
OMAiSCSDTIL.
OrthoDBiEOG091G0AZH.
PhylomeDBiO95221.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKNYTSLT EFVLLGLADT LELQIILFLF FLVIYTLTVL GNLGMILLIR
60 70 80 90 100
IDSQLHTPMY FFLANLSFVD VCNSTTITPK MLADLLSEKK TISFAGCFLQ
110 120 130 140 150
MYFFISLATT ECILFGLMAY DRYAAICRPL LYSLIMSRTV YLKMAAGAFA
160 170 180 190 200
AGLLNFMVNT SHVSSLSFCD SNVIHHFFCD SPPLFKLSCS DTILKESISS
210 220 230 240 250
ILAGVNIVGT LLVILSSYSY VLFSIFSMHS GEGRHRAFST CASHLTAIIL
260 270 280 290 300
FYATCIYTYL RPSSSYSLNQ DKVASVFYTV VIPMLNPLIY SLRSKEVKKA
310
LANVISRKRT SSFL
Length:314
Mass (Da):35,132
Last modified:June 20, 2001 - v2
Checksum:iC14A9A35CD76E3A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062043192T → A.Corresponds to variant rs35607186dbSNPEnsembl.1
Natural variantiVAR_053194278Y → H.Corresponds to variant rs11825964dbSNPEnsembl.1
Natural variantiVAR_034225294S → N.2 PublicationsCorresponds to variant rs2449134dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW73694.1.
BC101239 mRNA. Translation: AAI01240.1.
BC101241 mRNA. Translation: AAI01242.1.
AF065863 Genomic DNA. Translation: AAC70017.1.
AF399527 Genomic DNA. Translation: AAK95012.1.
BK004343 Genomic DNA. Translation: DAA04741.1.
CCDSiCCDS31515.1.
RefSeqiNP_003688.1. NM_003697.1.
UniGeneiHs.553702.

Genome annotation databases

EnsembliENST00000278409; ENSP00000278409; ENSG00000149133.
GeneIDi338674.
KEGGihsa:338674.
UCSCiuc010riv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW73694.1.
BC101239 mRNA. Translation: AAI01240.1.
BC101241 mRNA. Translation: AAI01242.1.
AF065863 Genomic DNA. Translation: AAC70017.1.
AF399527 Genomic DNA. Translation: AAK95012.1.
BK004343 Genomic DNA. Translation: DAA04741.1.
CCDSiCCDS31515.1.
RefSeqiNP_003688.1. NM_003697.1.
UniGeneiHs.553702.

3D structure databases

ProteinModelPortaliO95221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130779. 10 interactors.
STRINGi9606.ENSP00000278409.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95221.
PhosphoSitePlusiO95221.

Polymorphism and mutation databases

BioMutaiOR5F1.

Proteomic databases

PaxDbiO95221.
PeptideAtlasiO95221.
PRIDEiO95221.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278409; ENSP00000278409; ENSG00000149133.
GeneIDi338674.
KEGGihsa:338674.
UCSCiuc010riv.2. human.

Organism-specific databases

CTDi338674.
GeneCardsiOR5F1.
HGNCiHGNC:8343. OR5F1.
HPAiHPA059360.
MIMi608492. gene.
neXtProtiNX_O95221.
OpenTargetsiENSG00000149133.
PharmGKBiPA32526.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIU6. Eukaryota.
ENOG4111BJM. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO95221.
KOiK04257.
OMAiSCSDTIL.
OrthoDBiEOG091G0AZH.
PhylomeDBiO95221.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149133-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5F1.
GenomeRNAii338674.
PROiO95221.
SOURCEiSearch...

Gene expression databases

CleanExiHS_OR5F1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5F1_HUMAN
AccessioniPrimary (citable) accession number: O95221
Secondary accession number(s): Q495D1, Q6IFB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.