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O95221

- OR5F1_HUMAN

UniProt

O95221 - OR5F1_HUMAN

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Protein

Olfactory receptor 5F1

Gene

OR5F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5F1
Alternative name(s):
Olfactory receptor 11-10
Short name:
OR11-10
Olfactory receptor OR11-167
Gene namesi
Name:OR5F1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8343. OR5F1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 5F1PRO_0000150595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95221.
PRIDEiO95221.

PTM databases

PhosphoSiteiO95221.

Expressioni

Gene expression databases

CleanExiHS_OR5F1.
GenevestigatoriO95221.

Organism-specific databases

HPAiHPA059360.

Interactioni

Protein-protein interaction databases

BioGridi130779. 7 interactions.
STRINGi9606.ENSP00000278409.

Structurei

3D structure databases

ProteinModelPortaliO95221.
SMRiO95221. Positions 109-140.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG73596.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiO95221.
KOiK04257.
OMAiSCSDTIL.
OrthoDBiEOG71K63J.
PhylomeDBiO95221.
TreeFamiTF352753.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95221-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRKNYTSLT EFVLLGLADT LELQIILFLF FLVIYTLTVL GNLGMILLIR
60 70 80 90 100
IDSQLHTPMY FFLANLSFVD VCNSTTITPK MLADLLSEKK TISFAGCFLQ
110 120 130 140 150
MYFFISLATT ECILFGLMAY DRYAAICRPL LYSLIMSRTV YLKMAAGAFA
160 170 180 190 200
AGLLNFMVNT SHVSSLSFCD SNVIHHFFCD SPPLFKLSCS DTILKESISS
210 220 230 240 250
ILAGVNIVGT LLVILSSYSY VLFSIFSMHS GEGRHRAFST CASHLTAIIL
260 270 280 290 300
FYATCIYTYL RPSSSYSLNQ DKVASVFYTV VIPMLNPLIY SLRSKEVKKA
310
LANVISRKRT SSFL
Length:314
Mass (Da):35,132
Last modified:June 20, 2001 - v2
Checksum:iC14A9A35CD76E3A3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti192 – 1921T → A.
Corresponds to variant rs35607186 [ dbSNP | Ensembl ].
VAR_062043
Natural varianti278 – 2781Y → H.
Corresponds to variant rs11825964 [ dbSNP | Ensembl ].
VAR_053194
Natural varianti294 – 2941S → N.2 Publications
Corresponds to variant rs2449134 [ dbSNP | Ensembl ].
VAR_034225

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471076 Genomic DNA. Translation: EAW73694.1.
BC101239 mRNA. Translation: AAI01240.1.
BC101241 mRNA. Translation: AAI01242.1.
AF065863 Genomic DNA. Translation: AAC70017.1.
AF399527 Genomic DNA. Translation: AAK95012.1.
BK004343 Genomic DNA. Translation: DAA04741.1.
CCDSiCCDS31515.1.
RefSeqiNP_003688.1. NM_003697.1.
UniGeneiHs.553702.

Genome annotation databases

EnsembliENST00000278409; ENSP00000278409; ENSG00000149133.
GeneIDi338674.
KEGGihsa:338674.
UCSCiuc010riv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471076 Genomic DNA. Translation: EAW73694.1 .
BC101239 mRNA. Translation: AAI01240.1 .
BC101241 mRNA. Translation: AAI01242.1 .
AF065863 Genomic DNA. Translation: AAC70017.1 .
AF399527 Genomic DNA. Translation: AAK95012.1 .
BK004343 Genomic DNA. Translation: DAA04741.1 .
CCDSi CCDS31515.1.
RefSeqi NP_003688.1. NM_003697.1.
UniGenei Hs.553702.

3D structure databases

ProteinModelPortali O95221.
SMRi O95221. Positions 109-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130779. 7 interactions.
STRINGi 9606.ENSP00000278409.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O95221.

Proteomic databases

PaxDbi O95221.
PRIDEi O95221.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278409 ; ENSP00000278409 ; ENSG00000149133 .
GeneIDi 338674.
KEGGi hsa:338674.
UCSCi uc010riv.2. human.

Organism-specific databases

CTDi 338674.
GeneCardsi GC11M055761.
HGNCi HGNC:8343. OR5F1.
HPAi HPA059360.
MIMi 608492. gene.
neXtProti NX_O95221.
PharmGKBi PA32526.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73596.
GeneTreei ENSGT00760000118941.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi O95221.
KOi K04257.
OMAi SCSDTIL.
OrthoDBi EOG71K63J.
PhylomeDBi O95221.
TreeFami TF352753.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR5F1.
GenomeRNAii 338674.
NextBioi 97095.
PROi O95221.
SOURCEi Search...

Gene expression databases

CleanExi HS_OR5F1.
Genevestigatori O95221.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-294.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-294.
  3. "Organization and evolution of olfactory receptor genes on human chromosome 11."
    Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.
    Genomics 53:56-68(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5F1_HUMAN
AccessioniPrimary (citable) accession number: O95221
Secondary accession number(s): Q495D1, Q6IFB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3