O95221 (OR5F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 5F1

Alternative name(s):
Olfactory receptor 11-10
Short name=OR11-10
Olfactory receptor OR11-167

Gene names

Name:

OR5F1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.3. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Olfactory receptor 5F1		PRO_0000150595
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 196	36	Extracellular Potential
	Transmembrane	197 – 217	21	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 314	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	192	1	T → A. Corresponds to variant rs35607186 [ dbSNP | Ensembl ].		VAR_062043
	Natural variant	278	1	Y → H. Corresponds to variant rs11825964 [ dbSNP | Ensembl ].		VAR_053194
	Natural variant	294	1	S → N. Ref.1 Ref.2 Corresponds to variant rs2449134 [ dbSNP | Ensembl ].		VAR_034225

Sequences

	Sequence		Length	Mass (Da)
	O95221 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: C14A9A35CD76E3A3	FASTA	314	35,132
	10 20 30 40 50 60 MTRKNYTSLT EFVLLGLADT LELQIILFLF FLVIYTLTVL GNLGMILLIR IDSQLHTPMY 70 80 90 100 110 120 FFLANLSFVD VCNSTTITPK MLADLLSEKK TISFAGCFLQ MYFFISLATT ECILFGLMAY 130 140 150 160 170 180 DRYAAICRPL LYSLIMSRTV YLKMAAGAFA AGLLNFMVNT SHVSSLSFCD SNVIHHFFCD 190 200 210 220 230 240 SPPLFKLSCS DTILKESISS ILAGVNIVGT LLVILSSYSY VLFSIFSMHS GEGRHRAFST 250 260 270 280 290 300 CASHLTAIIL FYATCIYTYL RPSSSYSLNQ DKVASVFYTV VIPMLNPLIY SLRSKEVKKA 310 LANVISRKRT SSFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-294.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-294.
[3]	"Organization and evolution of olfactory receptor genes on human chromosome 11." Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A. Genomics 53:56-68(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[4]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471076 Genomic DNA. Translation: EAW73694.1. BC101239 mRNA. Translation: AAI01240.1. BC101241 mRNA. Translation: AAI01242.1. AF065863 Genomic DNA. Translation: AAC70017.1. AF399527 Genomic DNA. Translation: AAK95012.1. BK004343 Genomic DNA. Translation: DAA04741.1.
IPI	IPI00029411.
RefSeq	NP_003688.1. NM_003697.1.
UniGene	Hs.553702.
3D structure databases
ProteinModelPortal	O95221.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000278409.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O95221.
Proteomic databases
PaxDb	O95221.
PRIDE	O95221.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278409; ENSP00000278409; ENSG00000149133.
GeneID	338674.
KEGG	hsa:338674.
UCSC	uc010riv.2. human.
Organism-specific databases
CTD	338674.
GeneCards	GC11M055761.
HGNC	HGNC:8343. OR5F1.
MIM	608492. gene.
neXtProt	NX_O95221.
PharmGKB	PA32526.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG73596.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	O95221.
KO	K04257.
OMA	SCSDTIL.
OrthoDB	EOG4PRSR5.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR5F1.
Genevestigator	O95221.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	338674.
NextBio	97095.
SOURCE	Search...

Entry information

Entry name

OR5F1_HUMAN

Accession

Primary (citable) accession number: O95221
Secondary accession number(s): Q495D1, Q6IFB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 20, 2001
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.