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O95221 (OR5F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5F1
Alternative name(s):
Olfactory receptor 11-10
Short name=OR11-10
Olfactory receptor OR11-167
Gene names
Name:OR5F1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Olfactory receptor 5F1
PRO_0000150595

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19636Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31422Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant1921T → A.
Corresponds to variant rs35607186 [ dbSNP | Ensembl ].
VAR_062043
Natural variant2781Y → H.
Corresponds to variant rs11825964 [ dbSNP | Ensembl ].
VAR_053194
Natural variant2941S → N. Ref.1 Ref.2
Corresponds to variant rs2449134 [ dbSNP | Ensembl ].
VAR_034225

Sequences

Sequence LengthMass (Da)Tools
O95221 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: C14A9A35CD76E3A3

FASTA31435,132
        10         20         30         40         50         60 
MTRKNYTSLT EFVLLGLADT LELQIILFLF FLVIYTLTVL GNLGMILLIR IDSQLHTPMY 

        70         80         90        100        110        120 
FFLANLSFVD VCNSTTITPK MLADLLSEKK TISFAGCFLQ MYFFISLATT ECILFGLMAY 

       130        140        150        160        170        180 
DRYAAICRPL LYSLIMSRTV YLKMAAGAFA AGLLNFMVNT SHVSSLSFCD SNVIHHFFCD 

       190        200        210        220        230        240 
SPPLFKLSCS DTILKESISS ILAGVNIVGT LLVILSSYSY VLFSIFSMHS GEGRHRAFST 

       250        260        270        280        290        300 
CASHLTAIIL FYATCIYTYL RPSSSYSLNQ DKVASVFYTV VIPMLNPLIY SLRSKEVKKA 

       310 
LANVISRKRT SSFL 

« Hide

References

« Hide 'large scale' references
[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-294.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-294.
[3]"Organization and evolution of olfactory receptor genes on human chromosome 11."
Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.
Genomics 53:56-68(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471076 Genomic DNA. Translation: EAW73694.1.
BC101239 mRNA. Translation: AAI01240.1.
BC101241 mRNA. Translation: AAI01242.1.
AF065863 Genomic DNA. Translation: AAC70017.1.
AF399527 Genomic DNA. Translation: AAK95012.1.
BK004343 Genomic DNA. Translation: DAA04741.1.
RefSeqNP_003688.1. NM_003697.1.
UniGeneHs.553702.

3D structure databases

ProteinModelPortalO95221.
SMRO95221. Positions 109-140, 279-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000278409.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO95221.

Proteomic databases

PaxDbO95221.
PRIDEO95221.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278409; ENSP00000278409; ENSG00000149133.
GeneID338674.
KEGGhsa:338674.
UCSCuc010riv.2. human.

Organism-specific databases

CTD338674.
GeneCardsGC11M055761.
HGNCHGNC:8343. OR5F1.
HPAHPA059360.
MIM608492. gene.
neXtProtNX_O95221.
PharmGKBPA32526.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG73596.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidO95221.
KOK04257.
OMASCSDTIL.
OrthoDBEOG71K63J.
PhylomeDBO95221.
TreeFamTF352753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5F1.
GenevestigatorO95221.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5F1.
GenomeRNAi338674.
NextBio97095.
PROO95221.
SOURCESearch...

Entry information

Entry nameOR5F1_HUMAN
AccessionPrimary (citable) accession number: O95221
Secondary accession number(s): Q495D1, Q6IFB9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries