Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sorting nexin-4

Gene

SNX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei108Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei132Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei154Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: UniProtKB
  • insulin receptor binding Source: UniProtKB
  • leptin receptor binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB
  • transferrin receptor binding Source: UniProtKB

GO - Biological processi

  • endocytic recycling Source: UniProtKB
  • endocytosis Source: GO_Central
  • positive regulation of histamine secretion by mast cell Source: UniProtKB
  • protein transport Source: UniProtKB
  • vesicle organization Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-4
Gene namesi
Name:SNX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114520.10.
HGNCiHGNC:11175. SNX4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi132K → A: Abolishes phosphatidylinositol phosphate binding. Abolishes endosomal location. 1 Publication1

Organism-specific databases

DisGeNETi8723.
OpenTargetsiENSG00000114520.
PharmGKBiPA36014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138421 – 450Sorting nexin-4Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei22PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95219.
MaxQBiO95219.
PaxDbiO95219.
PeptideAtlasiO95219.
PRIDEiO95219.

2D gel databases

DOSAC-COBS-2DPAGEiO95219.

PTM databases

iPTMnetiO95219.
PhosphoSitePlusiO95219.

Expressioni

Gene expression databases

BgeeiENSG00000114520.
CleanExiHS_SNX4.
ExpressionAtlasiO95219. baseline and differential.
GenevisibleiO95219. HS.

Organism-specific databases

HPAiHPA005709.

Interactioni

Subunit structurei

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: UniProtKB
  • insulin receptor binding Source: UniProtKB
  • leptin receptor binding Source: UniProtKB
  • transferrin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114262. 25 interactors.
CORUMiO95219.
DIPiDIP-36719N.
IntActiO95219. 26 interactors.
MINTiMINT-263255.
STRINGi9606.ENSP00000251775.

Structurei

3D structure databases

ProteinModelPortaliO95219.
SMRiO95219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 187PXPROSITE-ProRule annotationAdd BLAST127

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00900000140874.
HOGENOMiHOG000007933.
HOVERGENiHBG017826.
InParanoidiO95219.
KOiK17919.
OMAiRYTEFEL.
OrthoDBiEOG091G0CLA.
PhylomeDBiO95219.
TreeFamiTF328543.

Family and domain databases

CDDicd06864. PX_SNX4. 1 hit.
Gene3Di1.20.1270.60. 1 hit.
3.30.1520.10. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR_dom_sf.
IPR001683. Phox.
IPR036871. PX_dom_sf.
IPR034902. PX_SNX4.
IPR034783. SNX4.
PANTHERiPTHR10555:SF139. PTHR10555:SF139. 1 hit.
PfamiView protein in Pfam
PF00787. PX. 1 hit.
SMARTiView protein in SMART
SM00312. PX. 1 hit.
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiView protein in PROSITE
PS50195. PX. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95219-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQAPPDPER QLQPAPLEPL GSPDAGLGAA VGKEAEGAGE ESSGVDTMTH
60 70 80 90 100
NNFWLKKIEI SVSEAEKRTG RNAMNMQETY TAYLIETRSV EHTDGQSVLT
110 120 130 140 150
DSLWRRYSEF ELLRSYLLVY YPHIVVPPLP EKRAEFVWHK LSADNMDPDF
160 170 180 190 200
VERRRIGLEN FLLRIASHPI LCRDKIFYLF LTQEGNWKET VNETGFQLKA
210 220 230 240 250
DSRLKALNAT FRVKNPDKRF TDLKHYSDEL QSVISHLLRV RARVADRLYG
260 270 280 290 300
VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY
310 320 330 340 350
ADQLKEYLFY AEALRAVCRK HELMQYDLEM AAQDLASKKQ QCEELVTGTV
360 370 380 390 400
RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV
410 420 430 440 450
KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM
Length:450
Mass (Da):51,909
Last modified:May 1, 1999 - v1
Checksum:i3D5B52AC52A07686
GO
Isoform 2 (identifier: O95219-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: Missing.

Note: No experimental confirmation available.
Show »
Length:305
Mass (Da):35,611
Checksum:i2A82E353F65B99BB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566651 – 145Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065485 mRNA. Translation: AAC83149.1.
AK001835 mRNA. Translation: BAG50982.1.
AK298972 mRNA. Translation: BAG61066.1.
AC080096 Genomic DNA. No translation available.
AC117487 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79390.1.
CH471052 Genomic DNA. Translation: EAW79391.1.
CH471052 Genomic DNA. Translation: EAW79393.1.
BC018762 mRNA. Translation: AAH18762.1.
CCDSiCCDS3032.1. [O95219-1]
RefSeqiNP_003785.1. NM_003794.3. [O95219-1]
UniGeneiHs.507243.

Genome annotation databases

EnsembliENST00000251775; ENSP00000251775; ENSG00000114520. [O95219-1]
GeneIDi8723.
KEGGihsa:8723.
UCSCiuc003eib.5. human. [O95219-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNX4_HUMAN
AccessioniPrimary (citable) accession number: O95219
Secondary accession number(s): B3KMH0, B4DQV4, D3DNA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families