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Protein

Sorting nexin-4

Gene

SNX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.1 Publication

Caution

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei108Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei132Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei154Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: UniProtKB
  • insulin receptor binding Source: UniProtKB
  • leptin receptor binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB
  • transferrin receptor binding Source: UniProtKB

GO - Biological processi

  • endocytic recycling Source: UniProtKB
  • endocytosis Source: GO_Central
  • positive regulation of histamine secretion by mast cell Source: UniProtKB
  • protein transport Source: UniProtKB
  • vesicle organization Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-4
Gene namesi
Name:SNX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114520.10
HGNCiHGNC:11175 SNX4
MIMi605931 gene
neXtProtiNX_O95219

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi132K → A: Abolishes phosphatidylinositol phosphate binding. Abolishes endosomal location. 1 Publication1

Organism-specific databases

DisGeNETi8723
OpenTargetsiENSG00000114520
PharmGKBiPA36014

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138421 – 450Sorting nexin-4Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei22PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95219
MaxQBiO95219
PaxDbiO95219
PeptideAtlasiO95219
PRIDEiO95219

2D gel databases

DOSAC-COBS-2DPAGEiO95219

PTM databases

iPTMnetiO95219
PhosphoSitePlusiO95219

Expressioni

Gene expression databases

BgeeiENSG00000114520
CleanExiHS_SNX4
ExpressionAtlasiO95219 baseline and differential
GenevisibleiO95219 HS

Organism-specific databases

HPAiHPA005709

Interactioni

Subunit structurei

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: UniProtKB
  • insulin receptor binding Source: UniProtKB
  • leptin receptor binding Source: UniProtKB
  • transferrin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi11426226 interactors.
CORUMiO95219
DIPiDIP-36719N
IntActiO95219 27 interactors.
MINTiO95219
STRINGi9606.ENSP00000251775

Structurei

3D structure databases

ProteinModelPortaliO95219
SMRiO95219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 187PXPROSITE-ProRule annotationAdd BLAST127

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2273 Eukaryota
COG5391 LUCA
GeneTreeiENSGT00910000144107
HOGENOMiHOG000007933
HOVERGENiHBG017826
InParanoidiO95219
KOiK17919
OMAiRYTEFEL
OrthoDBiEOG091G0CLA
PhylomeDBiO95219
TreeFamiTF328543

Family and domain databases

CDDicd07622 BAR_SNX4, 1 hit
cd06864 PX_SNX4, 1 hit
Gene3Di1.20.1270.601 hit
3.30.1520.101 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR034902 PX_SNX4
IPR034783 SNX4
IPR037430 SNX4_BAR
PANTHERiPTHR10555:SF139 PTHR10555:SF139, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95219-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQAPPDPER QLQPAPLEPL GSPDAGLGAA VGKEAEGAGE ESSGVDTMTH
60 70 80 90 100
NNFWLKKIEI SVSEAEKRTG RNAMNMQETY TAYLIETRSV EHTDGQSVLT
110 120 130 140 150
DSLWRRYSEF ELLRSYLLVY YPHIVVPPLP EKRAEFVWHK LSADNMDPDF
160 170 180 190 200
VERRRIGLEN FLLRIASHPI LCRDKIFYLF LTQEGNWKET VNETGFQLKA
210 220 230 240 250
DSRLKALNAT FRVKNPDKRF TDLKHYSDEL QSVISHLLRV RARVADRLYG
260 270 280 290 300
VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY
310 320 330 340 350
ADQLKEYLFY AEALRAVCRK HELMQYDLEM AAQDLASKKQ QCEELVTGTV
360 370 380 390 400
RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV
410 420 430 440 450
KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM
Length:450
Mass (Da):51,909
Last modified:May 1, 1999 - v1
Checksum:i3D5B52AC52A07686
GO
Isoform 2 (identifier: O95219-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: Missing.

Note: No experimental confirmation available.
Show »
Length:305
Mass (Da):35,611
Checksum:i2A82E353F65B99BB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566651 – 145Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065485 mRNA Translation: AAC83149.1
AK001835 mRNA Translation: BAG50982.1
AK298972 mRNA Translation: BAG61066.1
AC080096 Genomic DNA No translation available.
AC117487 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79390.1
CH471052 Genomic DNA Translation: EAW79391.1
CH471052 Genomic DNA Translation: EAW79393.1
BC018762 mRNA Translation: AAH18762.1
CCDSiCCDS3032.1 [O95219-1]
RefSeqiNP_003785.1, NM_003794.3 [O95219-1]
UniGeneiHs.507243

Genome annotation databases

EnsembliENST00000251775; ENSP00000251775; ENSG00000114520 [O95219-1]
GeneIDi8723
KEGGihsa:8723
UCSCiuc003eib.5 human [O95219-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNX4_HUMAN
AccessioniPrimary (citable) accession number: O95219
Secondary accession number(s): B3KMH0, B4DQV4, D3DNA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome