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O95219

- SNX4_HUMAN

UniProt

O95219 - SNX4_HUMAN

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Protein
Sorting nexin-4
Gene
SNX4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Phosphatidylinositol 3-phosphate By similarity
Binding sitei108 – 1081Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei132 – 1321Phosphatidylinositol 3-phosphate By similarity
Binding sitei154 – 1541Phosphatidylinositol 3-phosphate By similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. endocytic recycling Source: UniProtKB
  2. endocytosis Source: ProtInc
  3. intracellular protein transport Source: RefGenome
  4. protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-4
Gene namesi
Name:SNX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11175. SNX4.

Subcellular locationi

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side
Note: Also detected on a juxtanuclear endocytic recycling compartment (ERC).1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HGNC
  2. cytoplasmic dynein complex Source: UniProtKB
  3. early endosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi132 – 1321K → A: Abolishes phosphatidylinositol phosphate binding. Abolishes endosomal location. 1 Publication

Organism-specific databases

PharmGKBiPA36014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Sorting nexin-4
PRO_0000213842Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei22 – 221Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95219.
PaxDbiO95219.
PRIDEiO95219.

2D gel databases

DOSAC-COBS-2DPAGEO95219.

PTM databases

PhosphoSiteiO95219.

Expressioni

Gene expression databases

ArrayExpressiO95219.
BgeeiO95219.
CleanExiHS_SNX4.
GenevestigatoriO95219.

Organism-specific databases

HPAiHPA005709.

Interactioni

Subunit structurei

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BIN1O004993EBI-724909,EBI-719094
SNX30Q5VWJ92EBI-724909,EBI-8099676
SNX7Q9UNH62EBI-724909,EBI-751422

Protein-protein interaction databases

BioGridi114262. 17 interactions.
DIPiDIP-36719N.
IntActiO95219. 12 interactions.
MINTiMINT-263255.
STRINGi9606.ENSP00000251775.

Structurei

3D structure databases

ProteinModelPortaliO95219.
SMRiO95219. Positions 55-185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 187127PX
Add
BLAST

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

Sequence similaritiesi

Belongs to the sorting nexin family.

Phylogenomic databases

eggNOGiCOG5391.
HOGENOMiHOG000007933.
HOVERGENiHBG017826.
InParanoidiO95219.
KOiK17919.
OMAiMDVYAAS.
OrthoDBiEOG76HQ1H.
PhylomeDBiO95219.
TreeFamiTF328543.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95219-1 [UniParc]FASTAAdd to Basket

« Hide

MEQAPPDPER QLQPAPLEPL GSPDAGLGAA VGKEAEGAGE ESSGVDTMTH    50
NNFWLKKIEI SVSEAEKRTG RNAMNMQETY TAYLIETRSV EHTDGQSVLT 100
DSLWRRYSEF ELLRSYLLVY YPHIVVPPLP EKRAEFVWHK LSADNMDPDF 150
VERRRIGLEN FLLRIASHPI LCRDKIFYLF LTQEGNWKET VNETGFQLKA 200
DSRLKALNAT FRVKNPDKRF TDLKHYSDEL QSVISHLLRV RARVADRLYG 250
VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY 300
ADQLKEYLFY AEALRAVCRK HELMQYDLEM AAQDLASKKQ QCEELVTGTV 350
RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV 400
KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM 450
Length:450
Mass (Da):51,909
Last modified:May 1, 1999 - v1
Checksum:i3D5B52AC52A07686
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF065485 mRNA. Translation: AAC83149.1.
AK001835 mRNA. Translation: BAG50982.1.
CH471052 Genomic DNA. Translation: EAW79390.1.
CH471052 Genomic DNA. Translation: EAW79391.1.
CH471052 Genomic DNA. Translation: EAW79393.1.
BC018762 mRNA. Translation: AAH18762.1.
CCDSiCCDS3032.1.
RefSeqiNP_003785.1. NM_003794.3.
UniGeneiHs.507243.

Genome annotation databases

EnsembliENST00000251775; ENSP00000251775; ENSG00000114520.
GeneIDi8723.
KEGGihsa:8723.
UCSCiuc003eib.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF065485 mRNA. Translation: AAC83149.1 .
AK001835 mRNA. Translation: BAG50982.1 .
CH471052 Genomic DNA. Translation: EAW79390.1 .
CH471052 Genomic DNA. Translation: EAW79391.1 .
CH471052 Genomic DNA. Translation: EAW79393.1 .
BC018762 mRNA. Translation: AAH18762.1 .
CCDSi CCDS3032.1.
RefSeqi NP_003785.1. NM_003794.3.
UniGenei Hs.507243.

3D structure databases

ProteinModelPortali O95219.
SMRi O95219. Positions 55-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114262. 17 interactions.
DIPi DIP-36719N.
IntActi O95219. 12 interactions.
MINTi MINT-263255.
STRINGi 9606.ENSP00000251775.

PTM databases

PhosphoSitei O95219.

2D gel databases

DOSAC-COBS-2DPAGE O95219.

Proteomic databases

MaxQBi O95219.
PaxDbi O95219.
PRIDEi O95219.

Protocols and materials databases

DNASUi 8723.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251775 ; ENSP00000251775 ; ENSG00000114520 .
GeneIDi 8723.
KEGGi hsa:8723.
UCSCi uc003eib.4. human.

Organism-specific databases

CTDi 8723.
GeneCardsi GC03M125196.
HGNCi HGNC:11175. SNX4.
HPAi HPA005709.
MIMi 605931. gene.
neXtProti NX_O95219.
PharmGKBi PA36014.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5391.
HOGENOMi HOG000007933.
HOVERGENi HBG017826.
InParanoidi O95219.
KOi K17919.
OMAi MDVYAAS.
OrthoDBi EOG76HQ1H.
PhylomeDBi O95219.
TreeFami TF328543.

Miscellaneous databases

ChiTaRSi SNX4. human.
GeneWikii SNX4.
GenomeRNAii 8723.
NextBioi 32719.
PROi O95219.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95219.
Bgeei O95219.
CleanExi HS_SNX4.
Genevestigatori O95219.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
[Graphical view ]
Pfami PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a family of sorting nexin molecules and characterization of their association with receptors."
    Haft C.R., de la Luz Sierra M., Barr V.A., Haft D.H., Taylor S.I.
    Mol. Cell. Biol. 18:7278-7287(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment."
    Traer C.J., Rutherford A.C., Palmer K.J., Wassmer T., Oakley J., Attar N., Carlton J.G., Kremerskothen J., Stephens D.J., Cullen P.J.
    Nat. Cell Biol. 9:1370-1380(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH WWC1/KIBRA, MUTAGENESIS OF LYS-132, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNX4_HUMAN
AccessioniPrimary (citable) accession number: O95219
Secondary accession number(s): B3KMH0, D3DNA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi