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Protein

Zinc finger Ran-binding domain-containing protein 2

Gene

ZRANB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 40RanBP2-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri65 – 94RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • zinc ion binding Source: InterPro

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • RNA splicing Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132485-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger Ran-binding domain-containing protein 2
Alternative name(s):
Zinc finger protein 265
Zinc finger, splicing
Gene namesi
Name:ZRANB2
Synonyms:ZIS, ZNF265
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13058. ZRANB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9406.
OpenTargetsiENSG00000132485.
PharmGKBiPA37636.

Polymorphism and mutation databases

BioMutaiZRANB2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665851 – 330Zinc finger Ran-binding domain-containing protein 2Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei18N6-acetyllysineBy similarity1
Modified residuei54N6-acetyllysineCombined sources1
Modified residuei92N6-acetyllysineBy similarity1
Modified residuei120PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Isoform 2 (identifier: O95218-2)
Modified residuei303PhosphothreonineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1

Post-translational modificationi

Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95218.
MaxQBiO95218.
PaxDbiO95218.
PeptideAtlasiO95218.
PRIDEiO95218.
TopDownProteomicsiO95218-1. [O95218-1]

PTM databases

iPTMnetiO95218.
PhosphoSitePlusiO95218.

Expressioni

Gene expression databases

BgeeiENSG00000132485.
CleanExiHS_ZRANB2.
GenevisibleiO95218. HS.

Organism-specific databases

HPAiHPA053960.
HPA061949.
HPA063298.

Interactioni

Subunit structurei

Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP17AQ020404EBI-1051583,EBI-1042725
ARRB1P494074EBI-1051583,EBI-743313
ARRB2P321214EBI-1051583,EBI-714559

Protein-protein interaction databases

BioGridi114802. 77 interactors.
IntActiO95218. 18 interactors.
STRINGi9606.ENSP00000359958.

Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 12Combined sources3
Turni18 – 20Combined sources3
Beta strandi32 – 34Combined sources3
Beta strandi65 – 68Combined sources4
Turni72 – 74Combined sources3
Turni86 – 88Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N0ZNMR-A1-40[»]
2K1PNMR-A65-95[»]
3G9YX-ray1.40A65-95[»]
ProteinModelPortaliO95218.
SMRiO95218.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95218.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni151 – 324Required for nuclear targetingAdd BLAST174

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 262Arg/Ser-richAdd BLAST65

Domaini

The RanBP2-type zinc fingers mediate binding to RNA.

Sequence similaritiesi

Belongs to the ZRANB2 family.Curated
Contains 2 RanBP2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 40RanBP2-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri65 – 94RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1995. Eukaryota.
ENOG4111QXA. LUCA.
GeneTreeiENSGT00730000111078.
HOVERGENiHBG066285.
InParanoidiO95218.
PhylomeDBiO95218.
TreeFamiTF105996.

Family and domain databases

Gene3Di4.10.1060.10. 2 hits.
InterProiIPR017337. UCP037956_Znf_RanB2.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00641. zf-RanBP. 2 hits.
[Graphical view]
PIRSFiPIRSF037956. UCP037956_ZnF_Ran. 1 hit.
SMARTiSM00547. ZnF_RBZ. 2 hits.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 2 hits.
PROSITEiPS01358. ZF_RANBP2_1. 2 hits.
PS50199. ZF_RANBP2_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95218-1) [UniParc]FASTAAdd to basket
Also known as: ZIS-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT
60 70 80 90 100
EIGKTLAEKS RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT
110 120 130 140 150
GYGGGFNERE NVEYIEREES DGEYDEFGRK KKKYRGKAVG PASILKEVED
160 170 180 190 200
KESEGEEEDE DEDLSKYKLD EDEDEDDADL SKYNLDASEE EDSNKKKSNR
210 220 230 240 250
RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR SRSSSRERSR
260 270 280 290 300
SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERNRKRSRS RSSSSGDRKK
310 320 330
RRTRSRSPER RHRSSSGSSH SGSRSSSKKK
Length:330
Mass (Da):37,404
Last modified:May 1, 2007 - v2
Checksum:i99BE2D12EBE0FF8E
GO
Isoform 2 (identifier: O95218-2) [UniParc]FASTAAdd to basket
Also known as: ZIS-2

The sequence of this isoform differs from the canonical sequence as follows:
     310-330: RRHRSSSGSSHSGSRSSSKKK → SQVIGENTKQP

Show »
Length:320
Mass (Da):36,318
Checksum:i15F1DFB7CD6CF611
GO

Sequence cautioni

The sequence AAD09746 differs from that shown. Reason: Frameshift at position 236.Curated
The sequence AAD09747 differs from that shown. Reason: Frameshift at position 236.Curated
The sequence BAD92805 differs from that shown. Intron retention.Curated
The sequence CAB66879 differs from that shown. Reason: Frameshift at position 236.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41E → G in BAD96578 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030783207R → G.2 PublicationsCorresponds to variant rs11583800dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024945310 – 330RRHRS…SSKKK → SQVIGENTKQP in isoform 2. 5 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065391 mRNA. Translation: AAD09746.1. Frameshift.
AF065392 mRNA. Translation: AAD09747.1. Frameshift.
AL136945 mRNA. Translation: CAB66879.1. Frameshift.
AB209568 mRNA. Translation: BAD92805.1. Sequence problems.
AK222858 mRNA. Translation: BAD96578.1.
AL512443 Genomic DNA. Translation: CAH70058.1.
AL512443 Genomic DNA. Translation: CAH70059.1.
CH471059 Genomic DNA. Translation: EAX06433.1.
CH471059 Genomic DNA. Translation: EAX06435.1.
BC039814 mRNA. Translation: AAH39814.1.
CCDSiCCDS659.1. [O95218-1]
CCDS660.1. [O95218-2]
RefSeqiNP_005446.2. NM_005455.4. [O95218-2]
NP_976225.1. NM_203350.2. [O95218-1]
UniGeneiHs.194718.

Genome annotation databases

EnsembliENST00000254821; ENSP00000254821; ENSG00000132485. [O95218-2]
ENST00000370920; ENSP00000359958; ENSG00000132485. [O95218-1]
ENST00000611683; ENSP00000482026; ENSG00000132485. [O95218-2]
GeneIDi9406.
KEGGihsa:9406.
UCSCiuc001dfs.4. human. [O95218-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065391 mRNA. Translation: AAD09746.1. Frameshift.
AF065392 mRNA. Translation: AAD09747.1. Frameshift.
AL136945 mRNA. Translation: CAB66879.1. Frameshift.
AB209568 mRNA. Translation: BAD92805.1. Sequence problems.
AK222858 mRNA. Translation: BAD96578.1.
AL512443 Genomic DNA. Translation: CAH70058.1.
AL512443 Genomic DNA. Translation: CAH70059.1.
CH471059 Genomic DNA. Translation: EAX06433.1.
CH471059 Genomic DNA. Translation: EAX06435.1.
BC039814 mRNA. Translation: AAH39814.1.
CCDSiCCDS659.1. [O95218-1]
CCDS660.1. [O95218-2]
RefSeqiNP_005446.2. NM_005455.4. [O95218-2]
NP_976225.1. NM_203350.2. [O95218-1]
UniGeneiHs.194718.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N0ZNMR-A1-40[»]
2K1PNMR-A65-95[»]
3G9YX-ray1.40A65-95[»]
ProteinModelPortaliO95218.
SMRiO95218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114802. 77 interactors.
IntActiO95218. 18 interactors.
STRINGi9606.ENSP00000359958.

PTM databases

iPTMnetiO95218.
PhosphoSitePlusiO95218.

Polymorphism and mutation databases

BioMutaiZRANB2.

Proteomic databases

EPDiO95218.
MaxQBiO95218.
PaxDbiO95218.
PeptideAtlasiO95218.
PRIDEiO95218.
TopDownProteomicsiO95218-1. [O95218-1]

Protocols and materials databases

DNASUi9406.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254821; ENSP00000254821; ENSG00000132485. [O95218-2]
ENST00000370920; ENSP00000359958; ENSG00000132485. [O95218-1]
ENST00000611683; ENSP00000482026; ENSG00000132485. [O95218-2]
GeneIDi9406.
KEGGihsa:9406.
UCSCiuc001dfs.4. human. [O95218-1]

Organism-specific databases

CTDi9406.
DisGeNETi9406.
GeneCardsiZRANB2.
HGNCiHGNC:13058. ZRANB2.
HPAiHPA053960.
HPA061949.
HPA063298.
MIMi604347. gene.
neXtProtiNX_O95218.
OpenTargetsiENSG00000132485.
PharmGKBiPA37636.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1995. Eukaryota.
ENOG4111QXA. LUCA.
GeneTreeiENSGT00730000111078.
HOVERGENiHBG066285.
InParanoidiO95218.
PhylomeDBiO95218.
TreeFamiTF105996.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132485-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO95218.
GeneWikiiZRANB2.
GenomeRNAii9406.
PROiO95218.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132485.
CleanExiHS_ZRANB2.
GenevisibleiO95218. HS.

Family and domain databases

Gene3Di4.10.1060.10. 2 hits.
InterProiIPR017337. UCP037956_Znf_RanB2.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00641. zf-RanBP. 2 hits.
[Graphical view]
PIRSFiPIRSF037956. UCP037956_ZnF_Ran. 1 hit.
SMARTiSM00547. ZnF_RBZ. 2 hits.
[Graphical view]
SUPFAMiSSF90209. SSF90209. 2 hits.
PROSITEiPS01358. ZF_RANBP2_1. 2 hits.
PS50199. ZF_RANBP2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZRAB2_HUMAN
AccessioniPrimary (citable) accession number: O95218
Secondary accession number(s): D3DQ75
, Q53GS3, Q59F92, Q5VV33, Q5VV34, Q8IXN6, Q9UP63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.