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O95218 (ZRAB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger Ran-binding domain-containing protein 2
Alternative name(s):
Zinc finger protein 265
Zinc finger, splicing
Gene names
Name:ZRANB2
Synonyms:ZIS, ZNF265
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. Ref.8

Subunit structure

Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1. Ref.8 Ref.10

Subcellular location

Nucleus Ref.8.

Domain

The RanBP2-type zinc fingers mediate binding to RNA.

Post-translational modification

Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.

Sequence similarities

Belongs to the ZRANB2 family.

Contains 2 RanBP2-type zinc fingers.

Sequence caution

The sequence AAD09746.1 differs from that shown. Reason: Frameshift at position 236.

The sequence AAD09747.1 differs from that shown. Reason: Frameshift at position 236.

The sequence BAD92805.1 differs from that shown. Reason: Intron retention.

The sequence CAB66879.1 differs from that shown. Reason: Frameshift at position 236.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95218-1)

Also known as: ZIS-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95218-2)

Also known as: ZIS-2;

The sequence of this isoform differs from the canonical sequence as follows:
     310-330: RRHRSSSGSSHSGSRSSSKKK → SQVIGENTKQP
Note: Contains a phosphoserine at position 305. Contains a phosphoserine at position 307. Contains a phosphoserine at position 310. Contains a phosphothreonine at position 303.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Zinc finger Ran-binding domain-containing protein 2
PRO_0000066585

Regions

Zinc finger9 – 4032RanBP2-type 1
Zinc finger65 – 9430RanBP2-type 2
Region151 – 324174Required for nuclear targeting
Compositional bias198 – 26265Arg/Ser-rich

Amino acid modifications

Modified residue91Phosphoserine Ref.18
Modified residue181N6-acetyllysine By similarity
Modified residue541N6-acetyllysine Ref.17
Modified residue921N6-acetyllysine By similarity
Modified residue1201Phosphoserine Ref.9 Ref.12 Ref.13 Ref.14 Ref.16 Ref.18 Ref.20
Modified residue1531Phosphoserine Ref.9 Ref.13 Ref.14 Ref.18 Ref.20
Modified residue1811Phosphoserine Ref.9 Ref.13 Ref.18 Ref.20
Modified residue1881Phosphoserine Ref.9 Ref.13 Ref.16 Ref.18 Ref.20
Modified residue1931Phosphoserine Ref.9 Ref.18 Ref.20

Natural variations

Alternative sequence310 – 33021RRHRS…SSKKK → SQVIGENTKQP in isoform 2.
VSP_024945
Natural variant2071R → G. Ref.6 Ref.7
Corresponds to variant rs11583800 [ dbSNP | Ensembl ].
VAR_030783

Experimental info

Sequence conflict411E → G in BAD96578. Ref.4

Secondary structure

............. 330
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (ZIS-1) [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 99BE2D12EBE0FF8E

FASTA33037,404
        10         20         30         40         50         60 
MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT EIGKTLAEKS 

        70         80         90        100        110        120 
RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT GYGGGFNERE NVEYIEREES 

       130        140        150        160        170        180 
DGEYDEFGRK KKKYRGKAVG PASILKEVED KESEGEEEDE DEDLSKYKLD EDEDEDDADL 

       190        200        210        220        230        240 
SKYNLDASEE EDSNKKKSNR RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR 

       250        260        270        280        290        300 
SRSSSRERSR SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERNRKRSRS RSSSSGDRKK 

       310        320        330 
RRTRSRSPER RHRSSSGSSH SGSRSSSKKK 

« Hide

Isoform 2 (ZIS-2) [UniParc].

Checksum: 15F1DFB7CD6CF611
Show »

FASTA32036,318

References

« Hide 'large scale' references
[1]"Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene."
Nakano M., Yoshiura K., Oikawa M., Miyoshi O., Yamada K., Kondo S., Miwa N., Soeda E., Jinno Y., Fujii T., Niikawa N.
Gene 225:59-65(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Fetal brain.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
[3]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[4]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Liver.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-207.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-207.
Tissue: Skin.
[8]"ZNF265 -- a novel spliceosomal protein able to induce alternative splicing."
Adams D.J., van der Weyden L., Mayeda A., Stamm S., Morris B.J., Rasko J.E.J.
J. Cell Biol. 154:25-32(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SNRNP70; U2AF1 AND CLK1.
[9]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-153; SER-181; SER-188 AND SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265."
Mangs A.H., Speirs H.J.L., Goy C., Adams D.J., Markus M.A., Morris B.J.
Nucleic Acids Res. 34:4976-4986(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AKAP17A.
[11]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305; SER-307 AND SER-310 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[12]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-153; SER-181 AND SER-188, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-303; SER-305; SER-307 AND SER-310 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[15]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-188, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305 AND SER-307 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[17]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-54, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-120; SER-153; SER-181; SER-188 AND SER-193, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305; SER-307 AND SER-310 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[19]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[20]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-153; SER-181; SER-188 AND SER-193, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-303; SER-305 AND SER-307 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[21]"The structure of the zinc finger domain from human splicing factor ZNF265 fold."
Plambeck C.A., Kwan A.H.Y., Adams D.J., Westman B.J., van der Weyden L., Medcalf R.L., Morris B.J., Mackay J.P.
J. Biol. Chem. 278:22805-22811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 1-40, RNA-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF065391 mRNA. Translation: AAD09746.1. Frameshift.
AF065392 mRNA. Translation: AAD09747.1. Frameshift.
AL136945 mRNA. Translation: CAB66879.1. Frameshift.
AB209568 mRNA. Translation: BAD92805.1. Sequence problems.
AK222858 mRNA. Translation: BAD96578.1.
AL512443 Genomic DNA. Translation: CAH70058.1.
AL512443 Genomic DNA. Translation: CAH70059.1.
CH471059 Genomic DNA. Translation: EAX06433.1.
CH471059 Genomic DNA. Translation: EAX06435.1.
BC039814 mRNA. Translation: AAH39814.1.
RefSeqNP_005446.2. NM_005455.4.
NP_976225.1. NM_203350.2.
UniGeneHs.194718.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1N0ZNMR-A1-40[»]
2K1PNMR-A65-95[»]
3G9YX-ray1.40A65-95[»]
ProteinModelPortalO95218.
SMRO95218. Positions 1-40, 67-95.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114802. 52 interactions.
IntActO95218. 12 interactions.
STRING9606.ENSP00000359958.

PTM databases

PhosphoSiteO95218.

Proteomic databases

PaxDbO95218.
PRIDEO95218.

Protocols and materials databases

DNASU9406.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254821; ENSP00000254821; ENSG00000132485. [O95218-2]
ENST00000370920; ENSP00000359958; ENSG00000132485. [O95218-1]
GeneID9406.
KEGGhsa:9406.
UCSCuc001dfs.3. human. [O95218-2]
uc001dft.3. human. [O95218-1]

Organism-specific databases

CTD9406.
GeneCardsGC01M071528.
HGNCHGNC:13058. ZRANB2.
HPAHPA053960.
HPA063298.
MIM604347. gene.
neXtProtNX_O95218.
PharmGKBPA37636.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG275779.
HOVERGENHBG066285.
OMARSPERHH.
OrthoDBEOG7ZD1XK.
PhylomeDBO95218.
TreeFamTF105996.

Gene expression databases

BgeeO95218.
CleanExHS_ZRANB2.
GenevestigatorO95218.

Family and domain databases

Gene3D4.10.1060.10. 2 hits.
InterProIPR017337. UCP037956_Znf_RanB2.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamPF00641. zf-RanBP. 2 hits.
[Graphical view]
PIRSFPIRSF037956. UCP037956_ZnF_Ran. 1 hit.
SMARTSM00547. ZnF_RBZ. 2 hits.
[Graphical view]
PROSITEPS01358. ZF_RANBP2_1. 2 hits.
PS50199. ZF_RANBP2_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO95218.
GeneWikiZRANB2.
GenomeRNAi9406.
NextBio35236.
PROO95218.
SOURCESearch...

Entry information

Entry nameZRAB2_HUMAN
AccessionPrimary (citable) accession number: O95218
Secondary accession number(s): D3DQ75 expand/collapse secondary AC list , Q53GS3, Q59F92, Q5VV33, Q5VV34, Q8IXN6, Q9UP63
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM