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O95218

- ZRAB2_HUMAN

UniProt

O95218 - ZRAB2_HUMAN

Protein

Zinc finger Ran-binding domain-containing protein 2

Gene

ZRANB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri9 – 4032RanBP2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri65 – 9430RanBP2-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. RNA binding Source: ProtInc
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: GOC
    3. RNA splicing Source: ProtInc

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger Ran-binding domain-containing protein 2
    Alternative name(s):
    Zinc finger protein 265
    Zinc finger, splicing
    Gene namesi
    Name:ZRANB2
    Synonyms:ZIS, ZNF265
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13058. ZRANB2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37636.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Zinc finger Ran-binding domain-containing protein 2PRO_0000066585Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91Phosphoserine1 Publication
    Modified residuei18 – 181N6-acetyllysineBy similarity
    Modified residuei54 – 541N6-acetyllysine1 Publication
    Modified residuei92 – 921N6-acetyllysineBy similarity
    Modified residuei120 – 1201Phosphoserine7 Publications
    Modified residuei153 – 1531Phosphoserine5 Publications
    Modified residuei181 – 1811Phosphoserine4 Publications
    Modified residuei188 – 1881Phosphoserine5 Publications
    Modified residuei193 – 1931Phosphoserine3 Publications

    Post-translational modificationi

    Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.7 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO95218.
    PaxDbiO95218.
    PRIDEiO95218.

    PTM databases

    PhosphoSiteiO95218.

    Expressioni

    Gene expression databases

    BgeeiO95218.
    CleanExiHS_ZRANB2.
    GenevestigatoriO95218.

    Organism-specific databases

    HPAiHPA053960.
    HPA063298.

    Interactioni

    Subunit structurei

    Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AKAP17AQ020404EBI-1051583,EBI-1042725
    ARRB1P494074EBI-1051583,EBI-743313
    ARRB2P321214EBI-1051583,EBI-714559

    Protein-protein interaction databases

    BioGridi114802. 52 interactions.
    IntActiO95218. 12 interactions.
    STRINGi9606.ENSP00000359958.

    Structurei

    Secondary structure

    1
    330
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi10 – 123
    Turni18 – 203
    Beta strandi32 – 343
    Beta strandi65 – 684
    Turni72 – 743
    Turni86 – 883

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1N0ZNMR-A1-40[»]
    2K1PNMR-A65-95[»]
    3G9YX-ray1.40A65-95[»]
    ProteinModelPortaliO95218.
    SMRiO95218. Positions 1-40, 67-95.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95218.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni151 – 324174Required for nuclear targetingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi198 – 26265Arg/Ser-richAdd
    BLAST

    Domaini

    The RanBP2-type zinc fingers mediate binding to RNA.

    Sequence similaritiesi

    Belongs to the ZRANB2 family.Curated
    Contains 2 RanBP2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri9 – 4032RanBP2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri65 – 9430RanBP2-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG275779.
    HOVERGENiHBG066285.
    OMAiRSPERHH.
    OrthoDBiEOG7ZD1XK.
    PhylomeDBiO95218.
    TreeFamiTF105996.

    Family and domain databases

    Gene3Di4.10.1060.10. 2 hits.
    InterProiIPR017337. UCP037956_Znf_RanB2.
    IPR001876. Znf_RanBP2.
    [Graphical view]
    PfamiPF00641. zf-RanBP. 2 hits.
    [Graphical view]
    PIRSFiPIRSF037956. UCP037956_ZnF_Ran. 1 hit.
    SMARTiSM00547. ZnF_RBZ. 2 hits.
    [Graphical view]
    PROSITEiPS01358. ZF_RANBP2_1. 2 hits.
    PS50199. ZF_RANBP2_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95218-1) [UniParc]FASTAAdd to Basket

    Also known as: ZIS-1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTKNFRVSD GDWICPDKKC GNVNFARRTS CNRCGREKTT EAKMMKAGGT    50
    EIGKTLAEKS RGLFSANDWQ CKTCSNVNWA RRSECNMCNT PKYAKLEERT 100
    GYGGGFNERE NVEYIEREES DGEYDEFGRK KKKYRGKAVG PASILKEVED 150
    KESEGEEEDE DEDLSKYKLD EDEDEDDADL SKYNLDASEE EDSNKKKSNR 200
    RSRSKSRSSH SRSSSRSSSP SSSRSRSRSR SRSSSSSQSR SRSSSRERSR 250
    SRGSKSRSSS RSHRGSSSPR KRSYSSSSSS PERNRKRSRS RSSSSGDRKK 300
    RRTRSRSPER RHRSSSGSSH SGSRSSSKKK 330
    Length:330
    Mass (Da):37,404
    Last modified:May 1, 2007 - v2
    Checksum:i99BE2D12EBE0FF8E
    GO
    Isoform 2 (identifier: O95218-2) [UniParc]FASTAAdd to Basket

    Also known as: ZIS-2

    The sequence of this isoform differs from the canonical sequence as follows:
         310-330: RRHRSSSGSSHSGSRSSSKKK → SQVIGENTKQP

    Note: Contains a phosphoserine at position 305. Contains a phosphoserine at position 307. Contains a phosphoserine at position 310. Contains a phosphothreonine at position 303.

    Show »
    Length:320
    Mass (Da):36,318
    Checksum:i15F1DFB7CD6CF611
    GO

    Sequence cautioni

    The sequence BAD92805.1 differs from that shown. Reason: Intron retention.
    The sequence AAD09746.1 differs from that shown. Reason: Frameshift at position 236.
    The sequence AAD09747.1 differs from that shown. Reason: Frameshift at position 236.
    The sequence CAB66879.1 differs from that shown. Reason: Frameshift at position 236.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411E → G in BAD96578. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti207 – 2071R → G.2 Publications
    Corresponds to variant rs11583800 [ dbSNP | Ensembl ].
    VAR_030783

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei310 – 33021RRHRS…SSKKK → SQVIGENTKQP in isoform 2. 5 PublicationsVSP_024945Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF065391 mRNA. Translation: AAD09746.1. Frameshift.
    AF065392 mRNA. Translation: AAD09747.1. Frameshift.
    AL136945 mRNA. Translation: CAB66879.1. Frameshift.
    AB209568 mRNA. Translation: BAD92805.1. Sequence problems.
    AK222858 mRNA. Translation: BAD96578.1.
    AL512443 Genomic DNA. Translation: CAH70058.1.
    AL512443 Genomic DNA. Translation: CAH70059.1.
    CH471059 Genomic DNA. Translation: EAX06433.1.
    CH471059 Genomic DNA. Translation: EAX06435.1.
    BC039814 mRNA. Translation: AAH39814.1.
    CCDSiCCDS659.1. [O95218-1]
    CCDS660.1. [O95218-2]
    RefSeqiNP_005446.2. NM_005455.4. [O95218-2]
    NP_976225.1. NM_203350.2. [O95218-1]
    UniGeneiHs.194718.

    Genome annotation databases

    EnsembliENST00000254821; ENSP00000254821; ENSG00000132485. [O95218-2]
    ENST00000370920; ENSP00000359958; ENSG00000132485. [O95218-1]
    GeneIDi9406.
    KEGGihsa:9406.
    UCSCiuc001dfs.3. human. [O95218-2]
    uc001dft.3. human. [O95218-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF065391 mRNA. Translation: AAD09746.1 . Frameshift.
    AF065392 mRNA. Translation: AAD09747.1 . Frameshift.
    AL136945 mRNA. Translation: CAB66879.1 . Frameshift.
    AB209568 mRNA. Translation: BAD92805.1 . Sequence problems.
    AK222858 mRNA. Translation: BAD96578.1 .
    AL512443 Genomic DNA. Translation: CAH70058.1 .
    AL512443 Genomic DNA. Translation: CAH70059.1 .
    CH471059 Genomic DNA. Translation: EAX06433.1 .
    CH471059 Genomic DNA. Translation: EAX06435.1 .
    BC039814 mRNA. Translation: AAH39814.1 .
    CCDSi CCDS659.1. [O95218-1 ]
    CCDS660.1. [O95218-2 ]
    RefSeqi NP_005446.2. NM_005455.4. [O95218-2 ]
    NP_976225.1. NM_203350.2. [O95218-1 ]
    UniGenei Hs.194718.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1N0Z NMR - A 1-40 [» ]
    2K1P NMR - A 65-95 [» ]
    3G9Y X-ray 1.40 A 65-95 [» ]
    ProteinModelPortali O95218.
    SMRi O95218. Positions 1-40, 67-95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114802. 52 interactions.
    IntActi O95218. 12 interactions.
    STRINGi 9606.ENSP00000359958.

    PTM databases

    PhosphoSitei O95218.

    Proteomic databases

    MaxQBi O95218.
    PaxDbi O95218.
    PRIDEi O95218.

    Protocols and materials databases

    DNASUi 9406.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254821 ; ENSP00000254821 ; ENSG00000132485 . [O95218-2 ]
    ENST00000370920 ; ENSP00000359958 ; ENSG00000132485 . [O95218-1 ]
    GeneIDi 9406.
    KEGGi hsa:9406.
    UCSCi uc001dfs.3. human. [O95218-2 ]
    uc001dft.3. human. [O95218-1 ]

    Organism-specific databases

    CTDi 9406.
    GeneCardsi GC01M071528.
    HGNCi HGNC:13058. ZRANB2.
    HPAi HPA053960.
    HPA063298.
    MIMi 604347. gene.
    neXtProti NX_O95218.
    PharmGKBi PA37636.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275779.
    HOVERGENi HBG066285.
    OMAi RSPERHH.
    OrthoDBi EOG7ZD1XK.
    PhylomeDBi O95218.
    TreeFami TF105996.

    Miscellaneous databases

    EvolutionaryTracei O95218.
    GeneWikii ZRANB2.
    GenomeRNAii 9406.
    NextBioi 35236.
    PROi O95218.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95218.
    CleanExi HS_ZRANB2.
    Genevestigatori O95218.

    Family and domain databases

    Gene3Di 4.10.1060.10. 2 hits.
    InterProi IPR017337. UCP037956_Znf_RanB2.
    IPR001876. Znf_RanBP2.
    [Graphical view ]
    Pfami PF00641. zf-RanBP. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF037956. UCP037956_ZnF_Ran. 1 hit.
    SMARTi SM00547. ZnF_RBZ. 2 hits.
    [Graphical view ]
    PROSITEi PS01358. ZF_RANBP2_1. 2 hits.
    PS50199. ZF_RANBP2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene."
      Nakano M., Yoshiura K., Oikawa M., Miyoshi O., Yamada K., Kondo S., Miwa N., Soeda E., Jinno Y., Fujii T., Niikawa N.
      Gene 225:59-65(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Fetal brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Liver.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-207.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-207.
      Tissue: Skin.
    8. "ZNF265 -- a novel spliceosomal protein able to induce alternative splicing."
      Adams D.J., van der Weyden L., Mayeda A., Stamm S., Morris B.J., Rasko J.E.J.
      J. Cell Biol. 154:25-32(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SNRNP70; U2AF1 AND CLK1.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-153; SER-181; SER-188 AND SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265."
      Mangs A.H., Speirs H.J.L., Goy C., Adams D.J., Markus M.A., Morris B.J.
      Nucleic Acids Res. 34:4976-4986(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AKAP17A.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305; SER-307 AND SER-310 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-153; SER-181 AND SER-188, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-303; SER-305; SER-307 AND SER-310 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-188, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305 AND SER-307 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-54, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-120; SER-153; SER-181; SER-188 AND SER-193, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305; SER-307 AND SER-310 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-153; SER-181; SER-188 AND SER-193, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-303; SER-305 AND SER-307 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. Cited for: STRUCTURE BY NMR OF 1-40, RNA-BINDING.

    Entry informationi

    Entry nameiZRAB2_HUMAN
    AccessioniPrimary (citable) accession number: O95218
    Secondary accession number(s): D3DQ75
    , Q53GS3, Q59F92, Q5VV33, Q5VV34, Q8IXN6, Q9UP63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3