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O95214 (LERL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leptin receptor overlapping transcript-like 1
Alternative name(s):
Endospanin-2
Gene names
Name:LEPROTL1
ORF Names:My047, UNQ577/PRO1139
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Ref.6

Subunit structure

Interacts with RAB13 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.

Sequence similarities

Belongs to the OB-RGRP/VPS55 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95214-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95214-2)

The sequence of this isoform differs from the canonical sequence as follows:
     94-131: IEWGACALVL...SNDDFSWQQW → MGRLPFFSKM...FLLCPPSQAQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 131131Leptin receptor overlapping transcript-like 1
PRO_0000215197

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane32 – 5221Helical; Potential
Transmembrane69 – 8921Helical; Potential
Transmembrane100 – 12021Helical; Potential

Natural variations

Alternative sequence94 – 13138IEWGA…SWQQW → MGRLPFFSKMGTAESEGRET LTQQLPLPAAAMRRLLPASR VSTQPVLRLADSAESLLGRP ALWALGFLLCPPSQAQ in isoform 2.
VSP_046307

Experimental info

Sequence conflict1231N → K in AAC98697. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: E5E75B7C77A99DD7

FASTA13114,428
        10         20         30         40         50         60 
MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC IARRLVDDTD 

        70         80         90        100        110        120 
AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA LVLTGNTVIF ATILGFFLVF 

       130 
GSNDDFSWQQ W 

« Hide

Isoform 2 [UniParc].

Checksum: 4B9D1D720138E4D6
Show »

FASTA16918,366

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1)."
Huang Y., Ying K., Xie Y., Zhou Z., Wang W., Tang R., Zhao W., Zhao S., Wu H., Gu S., Mao Y.M.
Biochim. Biophys. Acta 1517:327-331(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal brain.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[4]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[6]"LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice."
Touvier T., Conte-Auriol F., Briand O., Cudejko C., Paumelle R., Caron S., Bauge E., Rouille Y., Salles J.P., Staels B., Bailleul B.
J. Clin. Invest. 119:3830-3838(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF063605 mRNA. Translation: AAC98697.1.
AY358674 mRNA. Translation: AAQ89037.1.
AC026979 Genomic DNA. No translation available.
AC044849 Genomic DNA. No translation available.
AL546441 mRNA. No translation available.
BC000642 mRNA. Translation: AAH00642.1.
RefSeqNP_001121680.1. NM_001128208.1.
NP_056159.2. NM_015344.2.
UniGeneHs.146585.

3D structure databases

ProteinModelPortalO95214.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117042. 2 interactions.
IntActO95214. 1 interaction.
MINTMINT-1465794.
STRING9606.ENSP00000412803.

Proteomic databases

PRIDEO95214.

Protocols and materials databases

DNASU23484.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321250; ENSP00000314625; ENSG00000104660. [O95214-1]
ENST00000523116; ENSP00000428281; ENSG00000104660. [O95214-2]
GeneID23484.
KEGGhsa:23484.
UCSCuc003xhw.4. human. [O95214-1]
uc003xhx.2. human.

Organism-specific databases

CTD23484.
GeneCardsGC08P030010.
HGNCHGNC:6555. LEPROTL1.
HPAHPA047911.
MIM607338. gene.
neXtProtNX_O95214.
PharmGKBPA30334.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG116508.
HOGENOMHOG000038515.
HOVERGENHBG001034.
InParanoidO95214.
OrthoDBEOG76QFK9.
PhylomeDBO95214.
TreeFamTF313689.

Gene expression databases

ArrayExpressO95214.
BgeeO95214.
CleanExHS_LEPROTL1.
GenevestigatorO95214.

Family and domain databases

InterProIPR007262. VPS55.
[Graphical view]
PANTHERPTHR12050. PTHR12050. 1 hit.
PfamPF04133. Vps55. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi23484.
NextBio45847.
PROO95214.
SOURCESearch...

Entry information

Entry nameLERL1_HUMAN
AccessionPrimary (citable) accession number: O95214
Secondary accession number(s): E9PHP8, Q9BW48
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: March 19, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM