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O95214

- LERL1_HUMAN

UniProt

O95214 - LERL1_HUMAN

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Protein
Leptin receptor overlapping transcript-like 1
Gene
LEPROTL1, My047, UNQ577/PRO1139
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin receptor overlapping transcript-like 1
Alternative name(s):
Endospanin-2
Gene namesi
ORF Names:My047, UNQ577/PRO1139
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:6555. LEPROTL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei32 – 5221Helical; Reviewed prediction
Add
BLAST
Transmembranei69 – 8921Helical; Reviewed prediction
Add
BLAST
Transmembranei100 – 12021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Leptin receptor overlapping transcript-like 1
PRO_0000215197Add
BLAST

Proteomic databases

MaxQBiO95214.
PRIDEiO95214.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.

Gene expression databases

ArrayExpressiO95214.
BgeeiO95214.
CleanExiHS_LEPROTL1.
GenevestigatoriO95214.

Organism-specific databases

HPAiHPA047911.

Interactioni

Subunit structurei

Interacts with RAB13 By similarity.

Protein-protein interaction databases

BioGridi117042. 2 interactions.
IntActiO95214. 1 interaction.
MINTiMINT-1465794.
STRINGi9606.ENSP00000412803.

Structurei

3D structure databases

ProteinModelPortaliO95214.

Family & Domainsi

Sequence similaritiesi

Belongs to the OB-RGRP/VPS55 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG116508.
HOGENOMiHOG000038515.
HOVERGENiHBG001034.
InParanoidiO95214.
OrthoDBiEOG76QFK9.
PhylomeDBiO95214.
TreeFamiTF313689.

Family and domain databases

InterProiIPR007262. VPS55.
[Graphical view]
PANTHERiPTHR12050. PTHR12050. 1 hit.
PfamiPF04133. Vps55. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95214-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC    50
IARRLVDDTD AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA 100
LVLTGNTVIF ATILGFFLVF GSNDDFSWQQ W 131
Length:131
Mass (Da):14,428
Last modified:April 13, 2004 - v2
Checksum:iE5E75B7C77A99DD7
GO
Isoform 2 (identifier: O95214-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-131: IEWGACALVL...SNDDFSWQQW → MGRLPFFSKM...FLLCPPSQAQ

Note: No experimental confirmation available.

Show »
Length:169
Mass (Da):18,366
Checksum:i4B9D1D720138E4D6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei94 – 13138IEWGA…SWQQW → MGRLPFFSKMGTAESEGRET LTQQLPLPAAAMRRLLPASR VSTQPVLRLADSAESLLGRP ALWALGFLLCPPSQAQ in isoform 2.
VSP_046307Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231N → K in AAC98697. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063605 mRNA. Translation: AAC98697.1.
AY358674 mRNA. Translation: AAQ89037.1.
AC026979 Genomic DNA. No translation available.
AC044849 Genomic DNA. No translation available.
AL546441 mRNA. No translation available.
BC000642 mRNA. Translation: AAH00642.1.
CCDSiCCDS47834.1. [O95214-2]
CCDS6075.1. [O95214-1]
RefSeqiNP_001121680.1. NM_001128208.1. [O95214-2]
NP_056159.2. NM_015344.2. [O95214-1]
UniGeneiHs.146585.

Genome annotation databases

EnsembliENST00000321250; ENSP00000314625; ENSG00000104660. [O95214-1]
ENST00000523116; ENSP00000428281; ENSG00000104660. [O95214-2]
GeneIDi23484.
KEGGihsa:23484.
UCSCiuc003xhw.4. human. [O95214-1]
uc003xhx.2. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063605 mRNA. Translation: AAC98697.1 .
AY358674 mRNA. Translation: AAQ89037.1 .
AC026979 Genomic DNA. No translation available.
AC044849 Genomic DNA. No translation available.
AL546441 mRNA. No translation available.
BC000642 mRNA. Translation: AAH00642.1 .
CCDSi CCDS47834.1. [O95214-2 ]
CCDS6075.1. [O95214-1 ]
RefSeqi NP_001121680.1. NM_001128208.1. [O95214-2 ]
NP_056159.2. NM_015344.2. [O95214-1 ]
UniGenei Hs.146585.

3D structure databases

ProteinModelPortali O95214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117042. 2 interactions.
IntActi O95214. 1 interaction.
MINTi MINT-1465794.
STRINGi 9606.ENSP00000412803.

Proteomic databases

MaxQBi O95214.
PRIDEi O95214.

Protocols and materials databases

DNASUi 23484.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321250 ; ENSP00000314625 ; ENSG00000104660 . [O95214-1 ]
ENST00000523116 ; ENSP00000428281 ; ENSG00000104660 . [O95214-2 ]
GeneIDi 23484.
KEGGi hsa:23484.
UCSCi uc003xhw.4. human. [O95214-1 ]
uc003xhx.2. human.

Organism-specific databases

CTDi 23484.
GeneCardsi GC08P030010.
HGNCi HGNC:6555. LEPROTL1.
HPAi HPA047911.
MIMi 607338. gene.
neXtProti NX_O95214.
PharmGKBi PA30334.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG116508.
HOGENOMi HOG000038515.
HOVERGENi HBG001034.
InParanoidi O95214.
OrthoDBi EOG76QFK9.
PhylomeDBi O95214.
TreeFami TF313689.

Miscellaneous databases

GenomeRNAii 23484.
NextBioi 45847.
PROi O95214.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95214.
Bgeei O95214.
CleanExi HS_LEPROTL1.
Genevestigatori O95214.

Family and domain databases

InterProi IPR007262. VPS55.
[Graphical view ]
PANTHERi PTHR12050. PTHR12050. 1 hit.
Pfami PF04133. Vps55. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1)."
    Huang Y., Ying K., Xie Y., Zhou Z., Wang W., Tang R., Zhao W., Zhao S., Wu H., Gu S., Mao Y.M.
    Biochim. Biophys. Acta 1517:327-331(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  6. Cited for: FUNCTION.

Entry informationi

Entry nameiLERL1_HUMAN
AccessioniPrimary (citable) accession number: O95214
Secondary accession number(s): E9PHP8, Q9BW48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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