Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leptin receptor overlapping transcript-like 1

Gene

LEPROTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin receptor overlapping transcript-like 1
Alternative name(s):
Endospanin-2
Gene namesi
ORF Names:My047, UNQ577/PRO1139
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:6555. LEPROTL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Leptin receptor overlapping transcript-like 1PRO_0000215197Add
BLAST

Proteomic databases

MaxQBiO95214.
PRIDEiO95214.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.

Gene expression databases

BgeeiO95214.
CleanExiHS_LEPROTL1.
ExpressionAtlasiO95214. baseline and differential.
GenevestigatoriO95214.

Organism-specific databases

HPAiHPA047911.

Interactioni

Subunit structurei

Interacts with RAB13.By similarity

Protein-protein interaction databases

BioGridi117042. 4 interactions.
IntActiO95214. 1 interaction.
MINTiMINT-1465794.
STRINGi9606.ENSP00000412803.

Structurei

3D structure databases

ProteinModelPortaliO95214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OB-RGRP/VPS55 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG116508.
GeneTreeiENSGT00390000006503.
HOGENOMiHOG000038515.
HOVERGENiHBG001034.
InParanoidiO95214.
OrthoDBiEOG76QFK9.
PhylomeDBiO95214.
TreeFamiTF313689.

Family and domain databases

InterProiIPR007262. VPS55.
[Graphical view]
PANTHERiPTHR12050. PTHR12050. 1 hit.
PfamiPF04133. Vps55. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95214-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC
60 70 80 90 100
IARRLVDDTD AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA
110 120 130
LVLTGNTVIF ATILGFFLVF GSNDDFSWQQ W
Length:131
Mass (Da):14,428
Last modified:April 12, 2004 - v2
Checksum:iE5E75B7C77A99DD7
GO
Isoform 2 (identifier: O95214-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-131: IEWGACALVL...SNDDFSWQQW → MGRLPFFSKM...FLLCPPSQAQ

Note: No experimental confirmation available.

Show »
Length:169
Mass (Da):18,366
Checksum:i4B9D1D720138E4D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231N → K in AAC98697 (PubMed:11342119).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei94 – 13138IEWGA…SWQQW → MGRLPFFSKMGTAESEGRET LTQQLPLPAAAMRRLLPASR VSTQPVLRLADSAESLLGRP ALWALGFLLCPPSQAQ in isoform 2. 1 PublicationVSP_046307Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063605 mRNA. Translation: AAC98697.1.
AY358674 mRNA. Translation: AAQ89037.1.
AC026979 Genomic DNA. No translation available.
AC044849 Genomic DNA. No translation available.
AL546441 mRNA. No translation available.
BC000642 mRNA. Translation: AAH00642.1.
CCDSiCCDS47834.1. [O95214-2]
CCDS6075.1. [O95214-1]
RefSeqiNP_001121680.1. NM_001128208.1. [O95214-2]
NP_056159.2. NM_015344.2. [O95214-1]
UniGeneiHs.146585.

Genome annotation databases

EnsembliENST00000321250; ENSP00000314625; ENSG00000104660. [O95214-1]
ENST00000523116; ENSP00000428281; ENSG00000104660. [O95214-2]
GeneIDi23484.
KEGGihsa:23484.
UCSCiuc003xhw.4. human. [O95214-1]
uc003xhx.2. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063605 mRNA. Translation: AAC98697.1.
AY358674 mRNA. Translation: AAQ89037.1.
AC026979 Genomic DNA. No translation available.
AC044849 Genomic DNA. No translation available.
AL546441 mRNA. No translation available.
BC000642 mRNA. Translation: AAH00642.1.
CCDSiCCDS47834.1. [O95214-2]
CCDS6075.1. [O95214-1]
RefSeqiNP_001121680.1. NM_001128208.1. [O95214-2]
NP_056159.2. NM_015344.2. [O95214-1]
UniGeneiHs.146585.

3D structure databases

ProteinModelPortaliO95214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117042. 4 interactions.
IntActiO95214. 1 interaction.
MINTiMINT-1465794.
STRINGi9606.ENSP00000412803.

Proteomic databases

MaxQBiO95214.
PRIDEiO95214.

Protocols and materials databases

DNASUi23484.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321250; ENSP00000314625; ENSG00000104660. [O95214-1]
ENST00000523116; ENSP00000428281; ENSG00000104660. [O95214-2]
GeneIDi23484.
KEGGihsa:23484.
UCSCiuc003xhw.4. human. [O95214-1]
uc003xhx.2. human.

Organism-specific databases

CTDi23484.
GeneCardsiGC08P030010.
HGNCiHGNC:6555. LEPROTL1.
HPAiHPA047911.
MIMi607338. gene.
neXtProtiNX_O95214.
PharmGKBiPA30334.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG116508.
GeneTreeiENSGT00390000006503.
HOGENOMiHOG000038515.
HOVERGENiHBG001034.
InParanoidiO95214.
OrthoDBiEOG76QFK9.
PhylomeDBiO95214.
TreeFamiTF313689.

Miscellaneous databases

GenomeRNAii23484.
NextBioi45847.
PROiO95214.
SOURCEiSearch...

Gene expression databases

BgeeiO95214.
CleanExiHS_LEPROTL1.
ExpressionAtlasiO95214. baseline and differential.
GenevestigatoriO95214.

Family and domain databases

InterProiIPR007262. VPS55.
[Graphical view]
PANTHERiPTHR12050. PTHR12050. 1 hit.
PfamiPF04133. Vps55. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1)."
    Huang Y., Ying K., Xie Y., Zhou Z., Wang W., Tang R., Zhao W., Zhao S., Wu H., Gu S., Mao Y.M.
    Biochim. Biophys. Acta 1517:327-331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  6. Cited for: FUNCTION.

Entry informationi

Entry nameiLERL1_HUMAN
AccessioniPrimary (citable) accession number: O95214
Secondary accession number(s): E9PHP8, Q9BW48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: April 12, 2004
Last modified: February 3, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.