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O95214

- LERL1_HUMAN

UniProt

O95214 - LERL1_HUMAN

Protein

Leptin receptor overlapping transcript-like 1

Gene

LEPROTL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leptin receptor overlapping transcript-like 1
    Alternative name(s):
    Endospanin-2
    Gene namesi
    ORF Names:My047, UNQ577/PRO1139
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:6555. LEPROTL1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30334.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 131131Leptin receptor overlapping transcript-like 1PRO_0000215197Add
    BLAST

    Proteomic databases

    MaxQBiO95214.
    PRIDEiO95214.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.

    Gene expression databases

    ArrayExpressiO95214.
    BgeeiO95214.
    CleanExiHS_LEPROTL1.
    GenevestigatoriO95214.

    Organism-specific databases

    HPAiHPA047911.

    Interactioni

    Subunit structurei

    Interacts with RAB13.By similarity

    Protein-protein interaction databases

    BioGridi117042. 2 interactions.
    IntActiO95214. 1 interaction.
    MINTiMINT-1465794.
    STRINGi9606.ENSP00000412803.

    Structurei

    3D structure databases

    ProteinModelPortaliO95214.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OB-RGRP/VPS55 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG116508.
    HOGENOMiHOG000038515.
    HOVERGENiHBG001034.
    InParanoidiO95214.
    OrthoDBiEOG76QFK9.
    PhylomeDBiO95214.
    TreeFamiTF313689.

    Family and domain databases

    InterProiIPR007262. VPS55.
    [Graphical view]
    PANTHERiPTHR12050. PTHR12050. 1 hit.
    PfamiPF04133. Vps55. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95214-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC    50
    IARRLVDDTD AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA 100
    LVLTGNTVIF ATILGFFLVF GSNDDFSWQQ W 131
    Length:131
    Mass (Da):14,428
    Last modified:April 13, 2004 - v2
    Checksum:iE5E75B7C77A99DD7
    GO
    Isoform 2 (identifier: O95214-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         94-131: IEWGACALVL...SNDDFSWQQW → MGRLPFFSKM...FLLCPPSQAQ

    Note: No experimental confirmation available.

    Show »
    Length:169
    Mass (Da):18,366
    Checksum:i4B9D1D720138E4D6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1231N → K in AAC98697. (PubMed:11342119)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei94 – 13138IEWGA…SWQQW → MGRLPFFSKMGTAESEGRET LTQQLPLPAAAMRRLLPASR VSTQPVLRLADSAESLLGRP ALWALGFLLCPPSQAQ in isoform 2. 1 PublicationVSP_046307Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF063605 mRNA. Translation: AAC98697.1.
    AY358674 mRNA. Translation: AAQ89037.1.
    AC026979 Genomic DNA. No translation available.
    AC044849 Genomic DNA. No translation available.
    AL546441 mRNA. No translation available.
    BC000642 mRNA. Translation: AAH00642.1.
    CCDSiCCDS47834.1. [O95214-2]
    CCDS6075.1. [O95214-1]
    RefSeqiNP_001121680.1. NM_001128208.1. [O95214-2]
    NP_056159.2. NM_015344.2. [O95214-1]
    UniGeneiHs.146585.

    Genome annotation databases

    EnsembliENST00000321250; ENSP00000314625; ENSG00000104660. [O95214-1]
    ENST00000523116; ENSP00000428281; ENSG00000104660. [O95214-2]
    GeneIDi23484.
    KEGGihsa:23484.
    UCSCiuc003xhw.4. human. [O95214-1]
    uc003xhx.2. human.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF063605 mRNA. Translation: AAC98697.1 .
    AY358674 mRNA. Translation: AAQ89037.1 .
    AC026979 Genomic DNA. No translation available.
    AC044849 Genomic DNA. No translation available.
    AL546441 mRNA. No translation available.
    BC000642 mRNA. Translation: AAH00642.1 .
    CCDSi CCDS47834.1. [O95214-2 ]
    CCDS6075.1. [O95214-1 ]
    RefSeqi NP_001121680.1. NM_001128208.1. [O95214-2 ]
    NP_056159.2. NM_015344.2. [O95214-1 ]
    UniGenei Hs.146585.

    3D structure databases

    ProteinModelPortali O95214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117042. 2 interactions.
    IntActi O95214. 1 interaction.
    MINTi MINT-1465794.
    STRINGi 9606.ENSP00000412803.

    Proteomic databases

    MaxQBi O95214.
    PRIDEi O95214.

    Protocols and materials databases

    DNASUi 23484.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321250 ; ENSP00000314625 ; ENSG00000104660 . [O95214-1 ]
    ENST00000523116 ; ENSP00000428281 ; ENSG00000104660 . [O95214-2 ]
    GeneIDi 23484.
    KEGGi hsa:23484.
    UCSCi uc003xhw.4. human. [O95214-1 ]
    uc003xhx.2. human.

    Organism-specific databases

    CTDi 23484.
    GeneCardsi GC08P030010.
    HGNCi HGNC:6555. LEPROTL1.
    HPAi HPA047911.
    MIMi 607338. gene.
    neXtProti NX_O95214.
    PharmGKBi PA30334.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG116508.
    HOGENOMi HOG000038515.
    HOVERGENi HBG001034.
    InParanoidi O95214.
    OrthoDBi EOG76QFK9.
    PhylomeDBi O95214.
    TreeFami TF313689.

    Miscellaneous databases

    GenomeRNAii 23484.
    NextBioi 45847.
    PROi O95214.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95214.
    Bgeei O95214.
    CleanExi HS_LEPROTL1.
    Genevestigatori O95214.

    Family and domain databases

    InterProi IPR007262. VPS55.
    [Graphical view ]
    PANTHERi PTHR12050. PTHR12050. 1 hit.
    Pfami PF04133. Vps55. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1)."
      Huang Y., Ying K., Xie Y., Zhou Z., Wang W., Tang R., Zhao W., Zhao S., Wu H., Gu S., Mao Y.M.
      Biochim. Biophys. Acta 1517:327-331(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    4. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    6. Cited for: FUNCTION.

    Entry informationi

    Entry nameiLERL1_HUMAN
    AccessioniPrimary (citable) accession number: O95214
    Secondary accession number(s): E9PHP8, Q9BW48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3