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Protein

Leptin receptor overlapping transcript-like 1

Gene

LEPROTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104660-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin receptor overlapping transcript-like 1
Alternative name(s):
Endospanin-2
Gene namesi
ORF Names:My047, UNQ577/PRO1139
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:6555. LEPROTL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23484.
OpenTargetsiENSG00000104660.
PharmGKBiPA30334.

Polymorphism and mutation databases

BioMutaiLEPROTL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151971 – 131Leptin receptor overlapping transcript-like 1Add BLAST131

Proteomic databases

EPDiO95214.
PaxDbiO95214.
PeptideAtlasiO95214.
PRIDEiO95214.

PTM databases

SwissPalmiO95214.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.

Gene expression databases

BgeeiENSG00000104660.
CleanExiHS_LEPROTL1.
ExpressionAtlasiO95214. baseline and differential.
GenevisibleiO95214. HS.

Organism-specific databases

HPAiHPA047911.

Interactioni

Subunit structurei

Interacts with RAB13.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KLRG1Q96E933EBI-750776,EBI-750770

Protein-protein interaction databases

BioGridi117042. 5 interactors.
IntActiO95214. 2 interactors.
MINTiMINT-1465794.
STRINGi9606.ENSP00000428281.

Structurei

3D structure databases

ProteinModelPortaliO95214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OB-RGRP/VPS55 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2174. Eukaryota.
ENOG4111UCZ. LUCA.
GeneTreeiENSGT00390000006503.
HOGENOMiHOG000038515.
HOVERGENiHBG001034.
InParanoidiO95214.
OrthoDBiEOG091G0V32.
PhylomeDBiO95214.
TreeFamiTF313689.

Family and domain databases

InterProiIPR007262. VPS55.
[Graphical view]
PANTHERiPTHR12050. PTHR12050. 1 hit.
PfamiPF04133. Vps55. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95214-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC
60 70 80 90 100
IARRLVDDTD AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA
110 120 130
LVLTGNTVIF ATILGFFLVF GSNDDFSWQQ W
Length:131
Mass (Da):14,428
Last modified:April 13, 2004 - v2
Checksum:iE5E75B7C77A99DD7
GO
Isoform 2 (identifier: O95214-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-131: IEWGACALVL...SNDDFSWQQW → MGRLPFFSKM...FLLCPPSQAQ

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):18,366
Checksum:i4B9D1D720138E4D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123N → K in AAC98697 (PubMed:11342119).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04630794 – 131IEWGA…SWQQW → MGRLPFFSKMGTAESEGRET LTQQLPLPAAAMRRLLPASR VSTQPVLRLADSAESLLGRP ALWALGFLLCPPSQAQ in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063605 mRNA. Translation: AAC98697.1.
AY358674 mRNA. Translation: AAQ89037.1.
AC026979 Genomic DNA. No translation available.
AC044849 Genomic DNA. No translation available.
AL546441 mRNA. No translation available.
BC000642 mRNA. Translation: AAH00642.1.
CCDSiCCDS47834.1. [O95214-2]
CCDS6075.1. [O95214-1]
RefSeqiNP_001121680.1. NM_001128208.1. [O95214-2]
NP_056159.2. NM_015344.2. [O95214-1]
UniGeneiHs.146585.

Genome annotation databases

EnsembliENST00000321250; ENSP00000314625; ENSG00000104660. [O95214-1]
ENST00000523116; ENSP00000428281; ENSG00000104660. [O95214-2]
GeneIDi23484.
KEGGihsa:23484.
UCSCiuc003xhx.3. human. [O95214-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063605 mRNA. Translation: AAC98697.1.
AY358674 mRNA. Translation: AAQ89037.1.
AC026979 Genomic DNA. No translation available.
AC044849 Genomic DNA. No translation available.
AL546441 mRNA. No translation available.
BC000642 mRNA. Translation: AAH00642.1.
CCDSiCCDS47834.1. [O95214-2]
CCDS6075.1. [O95214-1]
RefSeqiNP_001121680.1. NM_001128208.1. [O95214-2]
NP_056159.2. NM_015344.2. [O95214-1]
UniGeneiHs.146585.

3D structure databases

ProteinModelPortaliO95214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117042. 5 interactors.
IntActiO95214. 2 interactors.
MINTiMINT-1465794.
STRINGi9606.ENSP00000428281.

PTM databases

SwissPalmiO95214.

Polymorphism and mutation databases

BioMutaiLEPROTL1.

Proteomic databases

EPDiO95214.
PaxDbiO95214.
PeptideAtlasiO95214.
PRIDEiO95214.

Protocols and materials databases

DNASUi23484.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321250; ENSP00000314625; ENSG00000104660. [O95214-1]
ENST00000523116; ENSP00000428281; ENSG00000104660. [O95214-2]
GeneIDi23484.
KEGGihsa:23484.
UCSCiuc003xhx.3. human. [O95214-1]

Organism-specific databases

CTDi23484.
DisGeNETi23484.
GeneCardsiLEPROTL1.
HGNCiHGNC:6555. LEPROTL1.
HPAiHPA047911.
MIMi607338. gene.
neXtProtiNX_O95214.
OpenTargetsiENSG00000104660.
PharmGKBiPA30334.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2174. Eukaryota.
ENOG4111UCZ. LUCA.
GeneTreeiENSGT00390000006503.
HOGENOMiHOG000038515.
HOVERGENiHBG001034.
InParanoidiO95214.
OrthoDBiEOG091G0V32.
PhylomeDBiO95214.
TreeFamiTF313689.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104660-MONOMER.

Miscellaneous databases

GenomeRNAii23484.
PROiO95214.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104660.
CleanExiHS_LEPROTL1.
ExpressionAtlasiO95214. baseline and differential.
GenevisibleiO95214. HS.

Family and domain databases

InterProiIPR007262. VPS55.
[Graphical view]
PANTHERiPTHR12050. PTHR12050. 1 hit.
PfamiPF04133. Vps55. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLERL1_HUMAN
AccessioniPrimary (citable) accession number: O95214
Secondary accession number(s): E9PHP8, Q9BW48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.