O95214 (LERL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leptin receptor overlapping transcript-like 1

Gene names

Name:	LEPROTL1
ORF Names:	My047, UNQ577/PRO1139

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Ref.6
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.
Sequence similarities	Belongs to the OB-RGRP/VPS55 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95214-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95214-2)

The sequence of this isoform differs from the canonical sequence as follows:
     94-131: IEWGACALVL...SNDDFSWQQW → MGRLPFFSKM...FLLCPPSQAQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Leptin receptor overlapping transcript-like 1		PRO_0000215197
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	32 – 52	21	Helical; Potential
	Transmembrane	69 – 89	21	Helical; Potential
	Transmembrane	100 – 120	21	Helical; Potential
Natural variations
	Alternative sequence	94 – 131	38	IEWGA…SWQQW → MGRLPFFSKMGTAESEGRET LTQQLPLPAAAMRRLLPASR VSTQPVLRLADSAESLLGRP ALWALGFLLCPPSQAQ in isoform 2.		VSP_046307
Experimental info
	Sequence conflict	123	1	N → K in AAC98697. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: E5E75B7C77A99DD7	FASTA	131	14,428
	10 20 30 40 50 60 MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC IARRLVDDTD 70 80 90 100 110 120 AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA LVLTGNTVIF ATILGFFLVF 130 GSNDDFSWQQ W
	Isoform 2 [UniParc]. Checksum: 4B9D1D720138E4D6	FASTA	169	18,366
	10 20 30 40 50 60 MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC IARRLVDDTD 70 80 90 100 110 120 AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLMGRLPFF SKMGTAESEG RETLTQQLPL 130 140 150 160 PAAAMRRLLP ASRVSTQPVL RLADSAESLL GRPALWALGF LLCPPSQAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1)." Huang Y., Ying K., Xie Y., Zhou Z., Wang W., Tang R., Zhao W., Zhao S., Wu H., Gu S., Mao Y.M. Biochim. Biophys. Acta 1517:327-331(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[4]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye.
[6]	"LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice." Touvier T., Conte-Auriol F., Briand O., Cudejko C., Paumelle R., Caron S., Bauge E., Rouille Y., Salles J.P., Staels B., Bailleul B. J. Clin. Invest. 119:3830-3838(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF063605 mRNA. Translation: AAC98697.1. AY358674 mRNA. Translation: AAQ89037.1. AC026979 Genomic DNA. No translation available. AC044849 Genomic DNA. No translation available. AL546441 mRNA. No translation available. BC000642 mRNA. Translation: AAH00642.1.
IPI	IPI00790750. IPI00981526.
RefSeq	NP_001121680.1. NM_001128208.1. NP_056159.2. NM_015344.2.
UniGene	Hs.146585.
3D structure databases
ProteinModelPortal	O95214.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95214. 1 interaction.
MINT	MINT-1465794.
STRING	9606.ENSP00000412803.
Proteomic databases
PRIDE	O95214.
Protocols and materials databases
DNASU	23484.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321250; ENSP00000314625; ENSG00000104660. ENST00000523116; ENSP00000428281; ENSG00000104660.
GeneID	23484.
KEGG	hsa:23484.
UCSC	uc003xhw.4. human.
Organism-specific databases
CTD	23484.
GeneCards	GC08P030010.
HGNC	HGNC:6555. LEPROTL1.
MIM	607338. gene.
neXtProt	NX_O95214.
PharmGKB	PA30334.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG116508.
HOGENOM	HOG000038515.
HOVERGEN	HBG001034.
InParanoid	O95214.
OrthoDB	EOG4WQ142.
PhylomeDB	O95214.
Gene expression databases
ArrayExpress	O95214.
Bgee	O95214.
CleanEx	HS_LEPROTL1.
Genevestigator	O95214.
GermOnline	ENSG00000104660. Homo sapiens.
Family and domain databases
InterPro	IPR007262. VPS55. [Graphical view]
PANTHER	PTHR12050. PTHR12050. 1 hit.
Pfam	PF04133. Vps55. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23484.
NextBio	45847.
SOURCE	Search...

Entry information

Entry name

LERL1_HUMAN

Accession

Primary (citable) accession number: O95214
Secondary accession number(s): E9PHP8, Q9BW48

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	April 13, 2004
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.