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Protein

Starch-binding domain-containing protein 1

Gene

STBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.3 Publications

GO - Molecular functioni

  • enzyme binding Source: ParkinsonsUK-UCL
  • glycogen binding Source: GO_Central
  • polysaccharide binding Source: ParkinsonsUK-UCL
  • starch binding Source: InterPro

GO - Biological processi

  • glycogen catabolic process Source: GO_Central
  • glycophagy Source: GO_Central
  • intracellular transport Source: ParkinsonsUK-UCL
  • neutrophil degranulation Source: Reactome

Keywordsi

Biological processAutophagy, Carbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Protein family/group databases

CAZyiCBM20 Carbohydrate-Binding Module Family 20
TCDBi9.B.207.1.1 the starch-binding domain-containing protein, stbd1 (stbd1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Starch-binding domain-containing protein 11 Publication
Alternative name(s):
Genethonin-11 Publication
Glycophagy cargo receptor STBD1Curated
Gene namesi
Name:STBD11 Publication
ORF Names:GENX-3414
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000118804.8
HGNCiHGNC:24854 STBD1
MIMi607406 gene
neXtProtiNX_O95210

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6ExtracellularSequence analysis6
Transmembranei7 – 23HelicalSequence analysisAdd BLAST17
Topological domaini24 – 358CytoplasmicSequence analysisAdd BLAST335

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi203W → A: Abolishes interaction with GABARAPL1. 1 Publication1
Mutagenesisi206V → A: Abolishes interaction with GABARAPL1. 1 Publication1
Mutagenesisi293W → G or L: Abolishes GYS2- and glycogen-binding, and leads to rapid degradation. 2 Publications1

Organism-specific databases

DisGeNETi8987
OpenTargetsiENSG00000118804
PharmGKBiPA162405002

Polymorphism and mutation databases

BioMutaiSTBD1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874761 – 358Starch-binding domain-containing protein 1Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineBy similarity1
Modified residuei117PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei175PhosphoserineBy similarity1
Modified residuei188PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated, which leads to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95210
MaxQBiO95210
PaxDbiO95210
PeptideAtlasiO95210
PRIDEiO95210

PTM databases

iPTMnetiO95210
PhosphoSitePlusiO95210

Expressioni

Tissue specificityi

Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000118804
CleanExiHS_STBD1
GenevisibleiO95210 HS

Organism-specific databases

HPAiHPA011952
HPA012849

Interactioni

Subunit structurei

Interacts with the ATG8 family proteins GABARAP and GABARAPL1 (PubMed:20810658, PubMed:21893048). Interacts with several glycogen-associated proteins, such as GYS2 (liver glycogen synthase), GDE (glycogen debranching enzyme), GBE1 (glycogen branching enzyme 1) and EPM2A (Laforin) (PubMed:24837458).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi114469, 21 interactors
IntActiO95210, 10 interactors
MINTiO95210
STRINGi9606.ENSP00000237642

Structurei

3D structure databases

ProteinModelPortaliO95210
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini258 – 357CBM20PROSITE-ProRule annotationAdd BLAST100

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi200 – 206LIR1 Publication7

Domaini

The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.1 Publication
The C-terminal CBM20 domain is required for the interaction with glycogen and glycogen-associated proteins.2 Publications

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ19 Eukaryota
ENOG410Y3IB LUCA
GeneTreeiENSGT00390000007731
HOGENOMiHOG000065763
HOVERGENiHBG048985
InParanoidiO95210
KOiK22267
OMAiMGAVWSA
OrthoDBiEOG091G0LFT
PhylomeDBiO95210
TreeFamiTF338505

Family and domain databases

CDDicd05813 CBM20_genethonin_1, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013784 Carb-bd-like_fold
IPR034838 CBM20_genethonin_1
IPR002044 CBM_fam20
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00686 CBM_20, 1 hit
SMARTiView protein in SMART
SM01065 CBM_2, 1 hit
SUPFAMiSSF49452 SSF49452, 1 hit
PROSITEiView protein in PROSITE
PS51166 CBM20, 1 hit

Sequencei

Sequence statusi: Complete.

O95210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVWSALLV GGGLAGALFV WLLRGGPGDT GKDGDAEQEK DAPLGGAAIP
60 70 80 90 100
GGHQSGSSGL SPGPSGQELV TKPEHLQESN GHLISKTKDL GKLQAASWRL
110 120 130 140 150
QNPSREVCDN SREHVPSGQF PDTEAPATSE TSNSRSYSEV SRNESLESPM
160 170 180 190 200
GEWGFQKGQE ISAKAATCFA EKLPSSNLLK NRAKEEMSLS DLNSQDRVDH
210 220 230 240 250
EEWEMVPRHS SWGDVGVGGS LKAPVLNLNQ GMDNGRSTLV EARGQQVHGK
260 270 280 290 300
MERVAVMPAG SQQVSVRFQV HYVTSTDVQF IAVTGDHECL GRWNTYIPLH
310 320 330 340 350
YNKDGFWSHS IFLPADTVVE WKFVLVENGG VTRWEECSNR FLETGHEDKV

VHAWWGIH
Length:358
Mass (Da):39,007
Last modified:May 1, 1999 - v1
Checksum:i9C98018B82B1578C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062534 mRNA Translation: AAC78827.1
AK123795 mRNA Translation: BAG53961.1
CH471057 Genomic DNA Translation: EAX05783.1
BC022301 mRNA Translation: AAH22301.1
CCDSiCCDS3578.1
RefSeqiNP_003934.1, NM_003943.4
UniGeneiHs.109590

Genome annotation databases

EnsembliENST00000237642; ENSP00000237642; ENSG00000118804
GeneIDi8987
KEGGihsa:8987
UCSCiuc003hka.4 human

Similar proteinsi

Entry informationi

Entry nameiSTBD1_HUMAN
AccessioniPrimary (citable) accession number: O95210
Secondary accession number(s): B3KVZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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