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O95210 (STBD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Starch-binding domain-containing protein 1
Alternative name(s):
Genethonin-1
Gene names
Name:STBD1
ORF Names:GENX-3414
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have the capability to bind to carbohydrates Potential. Ref.6

Subcellular location

Membrane; Single-pass type III membrane protein Probable. Note: Distributed in the transverse tubules and/or near the junctional sarcoplasmic reticulum. Ref.1

Tissue specificity

Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level). Ref.1

Sequence similarities

Contains 1 CBM20 (carbohydrate binding type-20) domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmuscle contraction

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

membrane

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionstarch binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Starch-binding domain-containing protein 1
PRO_0000087476

Regions

Topological domain1 – 66Extracellular Potential
Transmembrane7 – 2317Helical; Potential
Topological domain24 – 358335Cytoplasmic Potential
Domain258 – 357100CBM20

Amino acid modifications

Modified residue1481Phosphoserine Ref.5
Modified residue1751Phosphoserine By similarity
Modified residue2111Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O95210 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 9C98018B82B1578C

FASTA35839,007
        10         20         30         40         50         60 
MGAVWSALLV GGGLAGALFV WLLRGGPGDT GKDGDAEQEK DAPLGGAAIP GGHQSGSSGL 

        70         80         90        100        110        120 
SPGPSGQELV TKPEHLQESN GHLISKTKDL GKLQAASWRL QNPSREVCDN SREHVPSGQF 

       130        140        150        160        170        180 
PDTEAPATSE TSNSRSYSEV SRNESLESPM GEWGFQKGQE ISAKAATCFA EKLPSSNLLK 

       190        200        210        220        230        240 
NRAKEEMSLS DLNSQDRVDH EEWEMVPRHS SWGDVGVGGS LKAPVLNLNQ GMDNGRSTLV 

       250        260        270        280        290        300 
EARGQQVHGK MERVAVMPAG SQQVSVRFQV HYVTSTDVQF IAVTGDHECL GRWNTYIPLH 

       310        320        330        340        350 
YNKDGFWSHS IFLPADTVVE WKFVLVENGG VTRWEECSNR FLETGHEDKV VHAWWGIH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of a novel human gene encoding two 41-43 kDa skeletal muscle internal membrane proteins."
Bouju S., Lignon M.-F., Pietu G., Le Cunff M., Leger J.-J., Auffray C., Dechesne C.A.
Biochem. J. 335:549-556(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Muscle.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A motif of a microbial starch-binding domain found in human genethonin."
Janecek S.
Bioinformatics 18:1534-1537(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF 260-358, PUTATIVE FUNCTION OF STARCH-BINDING DOMAIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF062534 mRNA. Translation: AAC78827.1.
AK123795 mRNA. Translation: BAG53961.1.
CH471057 Genomic DNA. Translation: EAX05783.1.
BC022301 mRNA. Translation: AAH22301.1.
RefSeqNP_003934.1. NM_003943.4.
UniGeneHs.109590.

3D structure databases

ProteinModelPortalO95210.
SMRO95210. Positions 261-348.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114469. 3 interactions.
IntActO95210. 5 interactions.
MINTMINT-5003946.

Protein family/group databases

CAZyCBM20. Carbohydrate-Binding Module Family 20.

PTM databases

PhosphoSiteO95210.

Proteomic databases

PaxDbO95210.
PeptideAtlasO95210.
PRIDEO95210.

Protocols and materials databases

DNASU8987.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8987.
KEGGhsa:8987.
UCSCuc003hka.3. human.

Organism-specific databases

CTD8987.
GeneCardsGC04P077174.
GC04P077175.
HGNCHGNC:24854. STBD1.
HPAHPA011952.
HPA012849.
MIM607406. gene.
neXtProtNX_O95210.
PharmGKBPA162405002.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG74064.
HOGENOMHOG000065763.
HOVERGENHBG048985.
InParanoidO95210.
OMARHSSWGD.
OrthoDBEOG7W9RVP.
PhylomeDBO95210.
TreeFamTF338505.

Gene expression databases

BgeeO95210.
CleanExHS_STBD1.
GenevestigatorO95210.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF00686. CBM_20. 1 hit.
[Graphical view]
SMARTSM01065. CBM_2. 1 hit.
[Graphical view]
SUPFAMSSF49452. SSF49452. 1 hit.
PROSITEPS51166. CBM20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8987.
NextBio33703.
PROO95210.
SOURCESearch...

Entry information

Entry nameSTBD1_HUMAN
AccessionPrimary (citable) accession number: O95210
Secondary accession number(s): B3KVZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM