O95210 (STBD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Starch-binding domain-containing protein 1

Alternative name(s):
Genethonin-1

Gene names

Name:	STBD1
ORF Names:	GENX-3414

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have the capability to bind to carbohydrates Potential. Ref.6
Subcellular location	Membrane; Single-pass type III membrane protein Probable. Note: Distributed in the transverse tubules and/or near the junctional sarcoplasmic reticulum. Ref.1
Tissue specificity	Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level). Ref.1
Sequence similarities	Contains 1 CBM20 (carbohydrate binding type-20) domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	muscle contraction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	starch binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GABARAP	O95166	5	EBI-2947137,EBI-712001
GABARAPL1	Q9H0R8	7	EBI-2947137,EBI-746969
GABARAPL2	P60520	5	EBI-2947137,EBI-720116
MAP1LC3B	Q9GZQ8	2	EBI-2947137,EBI-373144

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Starch-binding domain-containing protein 1		PRO_0000087476
Regions
	Topological domain	1 – 6	6	Extracellular Potential
	Transmembrane	7 – 23	17	Helical; Potential
	Topological domain	24 – 358	335	Cytoplasmic Potential
	Domain	258 – 357	100	CBM20
Amino acid modifications
	Modified residue	57	1	Phosphoserine By similarity
	Modified residue	65	1	Phosphoserine By similarity
	Modified residue	148	1	Phosphoserine Ref.5
	Modified residue	175	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O95210 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 9C98018B82B1578C	FASTA	358	39,007
	10 20 30 40 50 60 MGAVWSALLV GGGLAGALFV WLLRGGPGDT GKDGDAEQEK DAPLGGAAIP GGHQSGSSGL 70 80 90 100 110 120 SPGPSGQELV TKPEHLQESN GHLISKTKDL GKLQAASWRL QNPSREVCDN SREHVPSGQF 130 140 150 160 170 180 PDTEAPATSE TSNSRSYSEV SRNESLESPM GEWGFQKGQE ISAKAATCFA EKLPSSNLLK 190 200 210 220 230 240 NRAKEEMSLS DLNSQDRVDH EEWEMVPRHS SWGDVGVGGS LKAPVLNLNQ GMDNGRSTLV 250 260 270 280 290 300 EARGQQVHGK MERVAVMPAG SQQVSVRFQV HYVTSTDVQF IAVTGDHECL GRWNTYIPLH 310 320 330 340 350 YNKDGFWSHS IFLPADTVVE WKFVLVENGG VTRWEECSNR FLETGHEDKV VHAWWGIH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional expression of a novel human gene encoding two 41-43 kDa skeletal muscle internal membrane proteins." Bouju S., Lignon M.-F., Pietu G., Le Cunff M., Leger J.-J., Auffray C., Dechesne C.A. Biochem. J. 335:549-556(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Muscle.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"A motif of a microbial starch-binding domain found in human genethonin." Janecek S. Bioinformatics 18:1534-1537(2002) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 260-358, PUTATIVE FUNCTION OF STARCH-BINDING DOMAIN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF062534 mRNA. Translation: AAC78827.1. AK123795 mRNA. Translation: BAG53961.1. CH471057 Genomic DNA. Translation: EAX05783.1. BC022301 mRNA. Translation: AAH22301.1.
IPI	IPI00022538.
RefSeq	NP_003934.1. NM_003943.4.
UniGene	Hs.109590. Hs.720509.
3D structure databases
ProteinModelPortal	O95210.
SMR	O95210. Positions 261-354.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95210. 4 interactions.
MINT	MINT-5003946.
Protein family/group databases
CAZy	CBM20. Carbohydrate-Binding Module Family 20.
PTM databases
PhosphoSite	O95210.
Proteomic databases
PaxDb	O95210.
PeptideAtlas	O95210.
PRIDE	O95210.
Protocols and materials databases
DNASU	8987.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000237642; ENSP00000237642; ENSG00000118804.
GeneID	8987.
KEGG	hsa:8987.
UCSC	uc003hka.3. human.
Organism-specific databases
CTD	8987.
GeneCards	GC04P077173.
HGNC	HGNC:24854. STBD1.
HPA	HPA011952. HPA012849.
MIM	607406. gene.
neXtProt	NX_O95210.
PharmGKB	PA162405002.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG74064.
HOGENOM	HOG000065763.
HOVERGEN	HBG048985.
InParanoid	O95210.
OMA	GDHESLG.
OrthoDB	EOG4CC41Q.
PhylomeDB	O95210.
Gene expression databases
ArrayExpress	O95210.
Bgee	O95210.
CleanEx	HS_STBD1.
Genevestigator	O95210.
GermOnline	ENSG00000118804. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR013784. Carb-bd-like_fold. IPR002044. CBM_fam20. IPR013783. Ig-like_fold. [Graphical view]
Pfam	PF00686. CBM_20. 1 hit. [Graphical view]
SMART	SM01065. CBM_2. 1 hit. [Graphical view]
SUPFAM	SSF49452. CBD_4. 1 hit.
PROSITE	PS51166. CBM20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8987.
NextBio	33703.
SOURCE	Search...

Entry information

Entry name

STBD1_HUMAN

Accession

Primary (citable) accession number: O95210
Secondary accession number(s): B3KVZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.