SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O95210

- STBD1_HUMAN

UniProt

O95210 - STBD1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Starch-binding domain-containing protein 1
Gene
STBD1, GENX-3414
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May have the capability to bind to carbohydrates Reviewed prediction.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. starch binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. muscle contraction Source: ProtInc
Complete GO annotation...

Protein family/group databases

CAZyiCBM20. Carbohydrate-Binding Module Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Starch-binding domain-containing protein 1
Alternative name(s):
Genethonin-1
Gene namesi
Name:STBD1
ORF Names:GENX-3414
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:24854. STBD1.

Subcellular locationi

Membrane; Single-pass type III membrane protein Inferred
Note: Distributed in the transverse tubules and/or near the junctional sarcoplasmic reticulum.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Extracellular Reviewed prediction
Transmembranei7 – 2317Helical; Reviewed prediction
Add
BLAST
Topological domaini24 – 358335Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Starch-binding domain-containing protein 1
PRO_0000087476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei148 – 1481Phosphoserine1 Publication
Modified residuei175 – 1751Phosphoserine By similarity
Modified residuei211 – 2111Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95210.
PaxDbiO95210.
PeptideAtlasiO95210.
PRIDEiO95210.

PTM databases

PhosphoSiteiO95210.

Expressioni

Tissue specificityi

Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).1 Publication

Gene expression databases

BgeeiO95210.
CleanExiHS_STBD1.
GenevestigatoriO95210.

Organism-specific databases

HPAiHPA011952.
HPA012849.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951665EBI-2947137,EBI-712001
GABARAPL1Q9H0R87EBI-2947137,EBI-746969
GABARAPL2P605205EBI-2947137,EBI-720116
MAP1LC3BQ9GZQ82EBI-2947137,EBI-373144

Protein-protein interaction databases

BioGridi114469. 3 interactions.
IntActiO95210. 5 interactions.
MINTiMINT-5003946.

Structurei

3D structure databases

ProteinModelPortaliO95210.
SMRiO95210. Positions 260-354.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini258 – 357100CBM20
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74064.
HOGENOMiHOG000065763.
HOVERGENiHBG048985.
InParanoidiO95210.
OMAiRHSSWGD.
OrthoDBiEOG7W9RVP.
PhylomeDBiO95210.
TreeFamiTF338505.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00686. CBM_20. 1 hit.
[Graphical view]
SMARTiSM01065. CBM_2. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.
PROSITEiPS51166. CBM20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95210-1 [UniParc]FASTAAdd to Basket

« Hide

MGAVWSALLV GGGLAGALFV WLLRGGPGDT GKDGDAEQEK DAPLGGAAIP    50
GGHQSGSSGL SPGPSGQELV TKPEHLQESN GHLISKTKDL GKLQAASWRL 100
QNPSREVCDN SREHVPSGQF PDTEAPATSE TSNSRSYSEV SRNESLESPM 150
GEWGFQKGQE ISAKAATCFA EKLPSSNLLK NRAKEEMSLS DLNSQDRVDH 200
EEWEMVPRHS SWGDVGVGGS LKAPVLNLNQ GMDNGRSTLV EARGQQVHGK 250
MERVAVMPAG SQQVSVRFQV HYVTSTDVQF IAVTGDHECL GRWNTYIPLH 300
YNKDGFWSHS IFLPADTVVE WKFVLVENGG VTRWEECSNR FLETGHEDKV 350
VHAWWGIH 358
Length:358
Mass (Da):39,007
Last modified:May 1, 1999 - v1
Checksum:i9C98018B82B1578C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF062534 mRNA. Translation: AAC78827.1.
AK123795 mRNA. Translation: BAG53961.1.
CH471057 Genomic DNA. Translation: EAX05783.1.
BC022301 mRNA. Translation: AAH22301.1.
CCDSiCCDS3578.1.
RefSeqiNP_003934.1. NM_003943.4.
UniGeneiHs.109590.

Genome annotation databases

GeneIDi8987.
KEGGihsa:8987.
UCSCiuc003hka.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF062534 mRNA. Translation: AAC78827.1 .
AK123795 mRNA. Translation: BAG53961.1 .
CH471057 Genomic DNA. Translation: EAX05783.1 .
BC022301 mRNA. Translation: AAH22301.1 .
CCDSi CCDS3578.1.
RefSeqi NP_003934.1. NM_003943.4.
UniGenei Hs.109590.

3D structure databases

ProteinModelPortali O95210.
SMRi O95210. Positions 260-354.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114469. 3 interactions.
IntActi O95210. 5 interactions.
MINTi MINT-5003946.

Protein family/group databases

CAZyi CBM20. Carbohydrate-Binding Module Family 20.

PTM databases

PhosphoSitei O95210.

Proteomic databases

MaxQBi O95210.
PaxDbi O95210.
PeptideAtlasi O95210.
PRIDEi O95210.

Protocols and materials databases

DNASUi 8987.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8987.
KEGGi hsa:8987.
UCSCi uc003hka.3. human.

Organism-specific databases

CTDi 8987.
GeneCardsi GC04P077174.
GC04P077175.
HGNCi HGNC:24854. STBD1.
HPAi HPA011952.
HPA012849.
MIMi 607406. gene.
neXtProti NX_O95210.
PharmGKBi PA162405002.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74064.
HOGENOMi HOG000065763.
HOVERGENi HBG048985.
InParanoidi O95210.
OMAi RHSSWGD.
OrthoDBi EOG7W9RVP.
PhylomeDBi O95210.
TreeFami TF338505.

Miscellaneous databases

GenomeRNAii 8987.
NextBioi 33703.
PROi O95210.
SOURCEi Search...

Gene expression databases

Bgeei O95210.
CleanExi HS_STBD1.
Genevestigatori O95210.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00686. CBM_20. 1 hit.
[Graphical view ]
SMARTi SM01065. CBM_2. 1 hit.
[Graphical view ]
SUPFAMi SSF49452. SSF49452. 1 hit.
PROSITEi PS51166. CBM20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of a novel human gene encoding two 41-43 kDa skeletal muscle internal membrane proteins."
    Bouju S., Lignon M.-F., Pietu G., Le Cunff M., Leger J.-J., Auffray C., Dechesne C.A.
    Biochem. J. 335:549-556(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Muscle.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "A motif of a microbial starch-binding domain found in human genethonin."
    Janecek S.
    Bioinformatics 18:1534-1537(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 260-358, PUTATIVE FUNCTION OF STARCH-BINDING DOMAIN.

Entry informationi

Entry nameiSTBD1_HUMAN
AccessioniPrimary (citable) accession number: O95210
Secondary accession number(s): B3KVZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi