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O95210

- STBD1_HUMAN

UniProt

O95210 - STBD1_HUMAN

Protein

Starch-binding domain-containing protein 1

Gene

STBD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    May have the capability to bind to carbohydrates.Curated

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. starch binding Source: InterPro

    GO - Biological processi

    1. muscle contraction Source: ProtInc

    Protein family/group databases

    CAZyiCBM20. Carbohydrate-Binding Module Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Starch-binding domain-containing protein 1
    Alternative name(s):
    Genethonin-1
    Gene namesi
    Name:STBD1
    ORF Names:GENX-3414
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:24854. STBD1.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type III membrane protein 1 Publication
    Note: Distributed in the transverse tubules and/or near the junctional sarcoplasmic reticulum.

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162405002.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Starch-binding domain-containing protein 1PRO_0000087476Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei148 – 1481Phosphoserine1 Publication
    Modified residuei175 – 1751PhosphoserineBy similarity
    Modified residuei211 – 2111PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95210.
    PaxDbiO95210.
    PeptideAtlasiO95210.
    PRIDEiO95210.

    PTM databases

    PhosphoSiteiO95210.

    Expressioni

    Tissue specificityi

    Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).1 Publication

    Gene expression databases

    BgeeiO95210.
    CleanExiHS_STBD1.
    GenevestigatoriO95210.

    Organism-specific databases

    HPAiHPA011952.
    HPA012849.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GABARAPO951665EBI-2947137,EBI-712001
    GABARAPL1Q9H0R87EBI-2947137,EBI-746969
    GABARAPL2P605205EBI-2947137,EBI-720116
    MAP1LC3BQ9GZQ82EBI-2947137,EBI-373144

    Protein-protein interaction databases

    BioGridi114469. 3 interactions.
    IntActiO95210. 5 interactions.
    MINTiMINT-5003946.

    Structurei

    3D structure databases

    ProteinModelPortaliO95210.
    SMRiO95210. Positions 260-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66ExtracellularSequence Analysis
    Topological domaini24 – 358335CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2317HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini258 – 357100CBM20PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CBM20 (carbohydrate binding type-20) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74064.
    HOGENOMiHOG000065763.
    HOVERGENiHBG048985.
    InParanoidiO95210.
    OMAiRHSSWGD.
    OrthoDBiEOG7W9RVP.
    PhylomeDBiO95210.
    TreeFamiTF338505.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR013784. Carb-bd-like_fold.
    IPR002044. CBM_fam20.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF00686. CBM_20. 1 hit.
    [Graphical view]
    SMARTiSM01065. CBM_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49452. SSF49452. 1 hit.
    PROSITEiPS51166. CBM20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95210-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAVWSALLV GGGLAGALFV WLLRGGPGDT GKDGDAEQEK DAPLGGAAIP    50
    GGHQSGSSGL SPGPSGQELV TKPEHLQESN GHLISKTKDL GKLQAASWRL 100
    QNPSREVCDN SREHVPSGQF PDTEAPATSE TSNSRSYSEV SRNESLESPM 150
    GEWGFQKGQE ISAKAATCFA EKLPSSNLLK NRAKEEMSLS DLNSQDRVDH 200
    EEWEMVPRHS SWGDVGVGGS LKAPVLNLNQ GMDNGRSTLV EARGQQVHGK 250
    MERVAVMPAG SQQVSVRFQV HYVTSTDVQF IAVTGDHECL GRWNTYIPLH 300
    YNKDGFWSHS IFLPADTVVE WKFVLVENGG VTRWEECSNR FLETGHEDKV 350
    VHAWWGIH 358
    Length:358
    Mass (Da):39,007
    Last modified:May 1, 1999 - v1
    Checksum:i9C98018B82B1578C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF062534 mRNA. Translation: AAC78827.1.
    AK123795 mRNA. Translation: BAG53961.1.
    CH471057 Genomic DNA. Translation: EAX05783.1.
    BC022301 mRNA. Translation: AAH22301.1.
    CCDSiCCDS3578.1.
    RefSeqiNP_003934.1. NM_003943.4.
    UniGeneiHs.109590.

    Genome annotation databases

    GeneIDi8987.
    KEGGihsa:8987.
    UCSCiuc003hka.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF062534 mRNA. Translation: AAC78827.1 .
    AK123795 mRNA. Translation: BAG53961.1 .
    CH471057 Genomic DNA. Translation: EAX05783.1 .
    BC022301 mRNA. Translation: AAH22301.1 .
    CCDSi CCDS3578.1.
    RefSeqi NP_003934.1. NM_003943.4.
    UniGenei Hs.109590.

    3D structure databases

    ProteinModelPortali O95210.
    SMRi O95210. Positions 260-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114469. 3 interactions.
    IntActi O95210. 5 interactions.
    MINTi MINT-5003946.

    Protein family/group databases

    CAZyi CBM20. Carbohydrate-Binding Module Family 20.

    PTM databases

    PhosphoSitei O95210.

    Proteomic databases

    MaxQBi O95210.
    PaxDbi O95210.
    PeptideAtlasi O95210.
    PRIDEi O95210.

    Protocols and materials databases

    DNASUi 8987.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8987.
    KEGGi hsa:8987.
    UCSCi uc003hka.3. human.

    Organism-specific databases

    CTDi 8987.
    GeneCardsi GC04P077174.
    GC04P077175.
    HGNCi HGNC:24854. STBD1.
    HPAi HPA011952.
    HPA012849.
    MIMi 607406. gene.
    neXtProti NX_O95210.
    PharmGKBi PA162405002.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74064.
    HOGENOMi HOG000065763.
    HOVERGENi HBG048985.
    InParanoidi O95210.
    OMAi RHSSWGD.
    OrthoDBi EOG7W9RVP.
    PhylomeDBi O95210.
    TreeFami TF338505.

    Miscellaneous databases

    GenomeRNAii 8987.
    NextBioi 33703.
    PROi O95210.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95210.
    CleanExi HS_STBD1.
    Genevestigatori O95210.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR013784. Carb-bd-like_fold.
    IPR002044. CBM_fam20.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF00686. CBM_20. 1 hit.
    [Graphical view ]
    SMARTi SM01065. CBM_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49452. SSF49452. 1 hit.
    PROSITEi PS51166. CBM20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of a novel human gene encoding two 41-43 kDa skeletal muscle internal membrane proteins."
      Bouju S., Lignon M.-F., Pietu G., Le Cunff M., Leger J.-J., Auffray C., Dechesne C.A.
      Biochem. J. 335:549-556(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Muscle.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "A motif of a microbial starch-binding domain found in human genethonin."
      Janecek S.
      Bioinformatics 18:1534-1537(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 260-358, PUTATIVE FUNCTION OF STARCH-BINDING DOMAIN.

    Entry informationi

    Entry nameiSTBD1_HUMAN
    AccessioniPrimary (citable) accession number: O95210
    Secondary accession number(s): B3KVZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3