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Protein

Starch-binding domain-containing protein 1

Gene

STBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have the capability to bind to carbohydrates.Curated

GO - Molecular functioni

GO - Biological processi

  • muscle contraction Source: ProtInc
Complete GO annotation...

Protein family/group databases

CAZyiCBM20. Carbohydrate-Binding Module Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Starch-binding domain-containing protein 1
Alternative name(s):
Genethonin-1
Gene namesi
Name:STBD1
ORF Names:GENX-3414
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:24854. STBD1.

Subcellular locationi

  • Membrane 1 Publication; Single-pass type III membrane protein 1 Publication

  • Note: Distributed in the transverse tubules and/or near the junctional sarcoplasmic reticulum.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66ExtracellularSequence Analysis
Transmembranei7 – 2317HelicalSequence AnalysisAdd
BLAST
Topological domaini24 – 358335CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405002.

Polymorphism and mutation databases

BioMutaiSTBD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Starch-binding domain-containing protein 1PRO_0000087476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171Phosphoserine1 Publication
Modified residuei148 – 1481Phosphoserine1 Publication
Modified residuei175 – 1751PhosphoserineBy similarity
Modified residuei188 – 1881Phosphoserine1 Publication
Modified residuei194 – 1941Phosphoserine1 Publication
Modified residuei210 – 2101Phosphoserine1 Publication
Modified residuei211 – 2111Phosphoserine1 Publication
Modified residuei220 – 2201Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95210.
PaxDbiO95210.
PeptideAtlasiO95210.
PRIDEiO95210.

PTM databases

PhosphoSiteiO95210.

Expressioni

Tissue specificityi

Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).1 Publication

Gene expression databases

BgeeiO95210.
CleanExiHS_STBD1.
GenevisibleiO95210. HS.

Organism-specific databases

HPAiHPA011952.
HPA012849.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-2947137,EBI-749265
GABARAPO951665EBI-2947137,EBI-712001
GABARAPL1Q9H0R87EBI-2947137,EBI-746969
GABARAPL2P605205EBI-2947137,EBI-720116
MAP1LC3BQ9GZQ82EBI-2947137,EBI-373144

Protein-protein interaction databases

BioGridi114469. 17 interactions.
IntActiO95210. 6 interactions.
MINTiMINT-5003946.

Structurei

3D structure databases

ProteinModelPortaliO95210.
SMRiO95210. Positions 262-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini258 – 357100CBM20PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CBM20 (carbohydrate binding type-20) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74064.
GeneTreeiENSGT00390000007731.
HOGENOMiHOG000065763.
HOVERGENiHBG048985.
InParanoidiO95210.
OMAiMGAVWSA.
OrthoDBiEOG7W9RVP.
PhylomeDBiO95210.
TreeFamiTF338505.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00686. CBM_20. 1 hit.
[Graphical view]
SMARTiSM01065. CBM_2. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.
PROSITEiPS51166. CBM20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVWSALLV GGGLAGALFV WLLRGGPGDT GKDGDAEQEK DAPLGGAAIP
60 70 80 90 100
GGHQSGSSGL SPGPSGQELV TKPEHLQESN GHLISKTKDL GKLQAASWRL
110 120 130 140 150
QNPSREVCDN SREHVPSGQF PDTEAPATSE TSNSRSYSEV SRNESLESPM
160 170 180 190 200
GEWGFQKGQE ISAKAATCFA EKLPSSNLLK NRAKEEMSLS DLNSQDRVDH
210 220 230 240 250
EEWEMVPRHS SWGDVGVGGS LKAPVLNLNQ GMDNGRSTLV EARGQQVHGK
260 270 280 290 300
MERVAVMPAG SQQVSVRFQV HYVTSTDVQF IAVTGDHECL GRWNTYIPLH
310 320 330 340 350
YNKDGFWSHS IFLPADTVVE WKFVLVENGG VTRWEECSNR FLETGHEDKV

VHAWWGIH
Length:358
Mass (Da):39,007
Last modified:May 1, 1999 - v1
Checksum:i9C98018B82B1578C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062534 mRNA. Translation: AAC78827.1.
AK123795 mRNA. Translation: BAG53961.1.
CH471057 Genomic DNA. Translation: EAX05783.1.
BC022301 mRNA. Translation: AAH22301.1.
CCDSiCCDS3578.1.
RefSeqiNP_003934.1. NM_003943.4.
UniGeneiHs.109590.

Genome annotation databases

GeneIDi8987.
KEGGihsa:8987.
UCSCiuc003hka.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062534 mRNA. Translation: AAC78827.1.
AK123795 mRNA. Translation: BAG53961.1.
CH471057 Genomic DNA. Translation: EAX05783.1.
BC022301 mRNA. Translation: AAH22301.1.
CCDSiCCDS3578.1.
RefSeqiNP_003934.1. NM_003943.4.
UniGeneiHs.109590.

3D structure databases

ProteinModelPortaliO95210.
SMRiO95210. Positions 262-348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114469. 17 interactions.
IntActiO95210. 6 interactions.
MINTiMINT-5003946.

Protein family/group databases

CAZyiCBM20. Carbohydrate-Binding Module Family 20.

PTM databases

PhosphoSiteiO95210.

Polymorphism and mutation databases

BioMutaiSTBD1.

Proteomic databases

MaxQBiO95210.
PaxDbiO95210.
PeptideAtlasiO95210.
PRIDEiO95210.

Protocols and materials databases

DNASUi8987.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8987.
KEGGihsa:8987.
UCSCiuc003hka.3. human.

Organism-specific databases

CTDi8987.
GeneCardsiGC04P077174.
GC04P077175.
HGNCiHGNC:24854. STBD1.
HPAiHPA011952.
HPA012849.
MIMi607406. gene.
neXtProtiNX_O95210.
PharmGKBiPA162405002.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG74064.
GeneTreeiENSGT00390000007731.
HOGENOMiHOG000065763.
HOVERGENiHBG048985.
InParanoidiO95210.
OMAiMGAVWSA.
OrthoDBiEOG7W9RVP.
PhylomeDBiO95210.
TreeFamiTF338505.

Miscellaneous databases

GenomeRNAii8987.
NextBioi33703.
PROiO95210.
SOURCEiSearch...

Gene expression databases

BgeeiO95210.
CleanExiHS_STBD1.
GenevisibleiO95210. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00686. CBM_20. 1 hit.
[Graphical view]
SMARTiSM01065. CBM_2. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.
PROSITEiPS51166. CBM20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of a novel human gene encoding two 41-43 kDa skeletal muscle internal membrane proteins."
    Bouju S., Lignon M.-F., Pietu G., Le Cunff M., Leger J.-J., Auffray C., Dechesne C.A.
    Biochem. J. 335:549-556(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Muscle.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117; SER-188; SER-194; SER-210; SER-211 AND SER-220, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "A motif of a microbial starch-binding domain found in human genethonin."
    Janecek S.
    Bioinformatics 18:1534-1537(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 260-358, PUTATIVE FUNCTION OF STARCH-BINDING DOMAIN.

Entry informationi

Entry nameiSTBD1_HUMAN
AccessioniPrimary (citable) accession number: O95210
Secondary accession number(s): B3KVZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.