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Protein

Epsin-2

Gene

EPN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the formation of clathrin-coated invaginations and endocytosis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Phosphatidylinositol lipid headgroupBy similarity
Binding sitei11 – 111Phosphatidylinositol lipid headgroupBy similarity
Binding sitei25 – 251Phosphatidylinositol lipid headgroupBy similarity
Binding sitei30 – 301Phosphatidylinositol lipid headgroupBy similarity
Binding sitei63 – 631Phosphatidylinositol lipid headgroupBy similarity
Binding sitei73 – 731Phosphatidylinositol lipid headgroupBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Epsin-2
Alternative name(s):
EPS-15-interacting protein 2
Gene namesi
Name:EPN2
Synonyms:KIAA1065
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18639. EPN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38615.

Polymorphism and mutation databases

BioMutaiEPN2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 641641Epsin-2PRO_0000074516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei570 – 5701Phosphoserine1 Publication

Post-translational modificationi

Ubiquitinated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO95208.
PaxDbiO95208.
PRIDEiO95208.

PTM databases

PhosphoSiteiO95208.

Miscellaneous databases

PMAP-CutDBO95208.

Expressioni

Tissue specificityi

Highest expression is found in brain. Detected at lower levels in lung and liver.1 Publication

Gene expression databases

BgeeiO95208.
CleanExiHS_EPN2.
ExpressionAtlasiO95208. baseline and differential.
GenevestigatoriO95208.

Organism-specific databases

HPAiHPA049809.
HPA053360.

Interactioni

Subunit structurei

Binds EPS15 (By similarity). Binds AP-2 and clathrin.By similarity

Protein-protein interaction databases

BioGridi116569. 10 interactions.
STRINGi9606.ENSP00000320543.

Structurei

3D structure databases

ProteinModelPortaliO95208.
SMRiO95208. Positions 1-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 144133ENTHPROSITE-ProRule annotationAdd
BLAST
Domaini275 – 29420UIM 1PROSITE-ProRule annotationAdd
BLAST
Domaini300 – 31920UIM 2PROSITE-ProRule annotationAdd
BLAST
Repeati352 – 35431
Repeati364 – 36632
Repeati377 – 37933
Repeati391 – 39334
Repeati409 – 41135
Repeati427 – 42936
Repeati537 – 53931
Repeati552 – 55432
Repeati637 – 63933

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni352 – 6392886 X 3 AA repeats of [DE]-P-WAdd
BLAST
Regioni537 – 6391033 X 3 AA repeats of N-P-FAdd
BLAST

Domaini

The NPF repeat domain is involved in EPS15 binding.
The DPW repeat domain is involved in AP-2 and clathrin binding.

Sequence similaritiesi

Belongs to the epsin family.Curated
Contains 1 ENTH (epsin N-terminal homology) domain.PROSITE-ProRule annotation
Contains 2 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG263730.
GeneTreeiENSGT00550000074611.
HOGENOMiHOG000008298.
HOVERGENiHBG006690.
InParanoidiO95208.
KOiK12471.
OMAiQEYGKSG.
OrthoDBiEOG7F511Z.
PhylomeDBiO95208.
TreeFamiTF313361.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR013809. ENTH.
IPR008942. ENTH_VHS.
IPR027319. Epsin-2_metazoa.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PANTHERiPTHR12276:SF50. PTHR12276:SF50. 1 hit.
PfamiPF01417. ENTH. 1 hit.
[Graphical view]
SMARTiSM00273. ENTH. 1 hit.
SM00726. UIM. 2 hits.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
PS50330. UIM. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95208-1) [UniParc]FASTAAdd to basket

Also known as: 2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTSSIRRQM KNIVNNYSEA EIKVREATSN DPWGPSSSLM TEIADLTYNV
60 70 80 90 100
VAFSEIMSMV WKRLNDHGKN WRHVYKALTL LDYLIKTGSE RVAQQCRENI
110 120 130 140 150
FAIQTLKDFQ YIDRDGKDQG INVREKSKQL VALLKDEERL KAERAQALKT
160 170 180 190 200
KERMAQVATG MGSNQITFGR GSSQPNLSTS HSEQEYGKAG GSPASYHGSP
210 220 230 240 250
EASLCPQHRT GAPLGQSEEL QPLSQRHPFL PHLGLASRPN GDWSQPCLTC
260 270 280 290 300
DRAARATSPR VSSELEQARP QTSGEEELQL QLALAMSREV AEQEERLRRG
310 320 330 340 350
DDLRLQMALE ESRRDTVKIP KKKEHGSLPQ QTTLLDLMDA LPSSGPAAQK
360 370 380 390 400
AEPWGPSAST NQTNPWGGPA APASTSDPWP SFGTKPAASI DPWGVPTGAT
410 420 430 440 450
VQSVPKNSDP WAASQQPASS AGKRASDAWG AVSTTKPVSV SGSFELFSNL
460 470 480 490 500
NGTIKDDFSE FDNLRTSKKT AESVTSLPSQ NNGTTSPDPF ESQPLTVASS
510 520 530 540 550
KPSSARKTPE SFLGPNAALV NLDSLVTRPA PPAQSLNPFL APGAPATSAP
560 570 580 590 600
VNPFQVNQPQ PLTLNQLRGS PVLGTSTSFG PGPGVESMAV ASMTSAAPQP
610 620 630 640
ALGATGSSLT PLGPAMMNMV GSVGIPPSAA QATGTTNPFL L
Length:641
Mass (Da):68,482
Last modified:December 16, 2008 - v3
Checksum:i0BE24CBD824F357A
GO
Isoform 2 (identifier: O95208-2) [UniParc]FASTAAdd to basket

Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     200-256: Missing.

Note: Contains a phosphoserine at position 192. Contains a phosphoserine at position 195.3 Publications

Show »
Length:584
Mass (Da):62,300
Checksum:iD668242ECACD26EF
GO
Isoform 3 (identifier: O95208-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     200-256: Missing.

Note: No experimental confirmation available. Contains a phosphoserine at position 153. Contains a phosphoserine at position 156.3 Publications

Show »
Length:545
Mass (Da):57,919
Checksum:iC8D6661429926997
GO
Isoform 4 (identifier: O95208-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.

Note: No experimental confirmation available.

Show »
Length:356
Mass (Da):36,729
Checksum:iEF6741C03E5744A3
GO

Sequence cautioni

The sequence BAA83017.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG52540.1 differs from that shown. Reason: Erroneous termination at position 324. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti256 – 2561A → AS in AAC78609 (PubMed:10567358).Curated
Sequence conflicti547 – 5471T → N in AAC78608 (PubMed:10567358).Curated
Sequence conflicti547 – 5471T → N in AAC78609 (PubMed:10567358).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti401 – 4011V → A.5 Publications
Corresponds to variant rs6587220 [ dbSNP | Ensembl ].
VAR_053080
Natural varianti531 – 5311P → T.
Corresponds to variant rs1062727 [ dbSNP | Ensembl ].
VAR_047923
Natural varianti532 – 5321P → T.
Corresponds to variant rs1062727 [ dbSNP | Ensembl ].
VAR_053081

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 285285Missing in isoform 4. 1 PublicationVSP_047003Add
BLAST
Alternative sequencei1 – 3939Missing in isoform 3. 1 PublicationVSP_009154Add
BLAST
Alternative sequencei200 – 25657Missing in isoform 2 and isoform 3. 2 PublicationsVSP_009155Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062084 mRNA. Translation: AAC78608.1.
AF062085 mRNA. Translation: AAC78609.1.
AB028988 mRNA. Translation: BAA83017.2. Different initiation.
AK001996 mRNA. Translation: BAG51000.1.
AK024115 mRNA. Translation: BAB14831.1.
AK092366 mRNA. Translation: BAG52540.1. Sequence problems.
AC106017 Genomic DNA. No translation available.
AC124066 Genomic DNA. No translation available.
CH471212 Genomic DNA. Translation: EAW50876.1.
BC093972 mRNA. Translation: AAH93972.1.
BC093974 mRNA. Translation: AAH93974.1.
CCDSiCCDS11203.1. [O95208-1]
CCDS11204.1. [O95208-2]
CCDS42277.1. [O95208-5]
RefSeqiNP_001096134.1. NM_001102664.1. [O95208-5]
NP_055779.2. NM_014964.4. [O95208-1]
NP_683723.2. NM_148921.3. [O95208-2]
UniGeneiHs.743983.

Genome annotation databases

EnsembliENST00000314728; ENSP00000320543; ENSG00000072134. [O95208-1]
ENST00000347697; ENSP00000261495; ENSG00000072134. [O95208-2]
ENST00000395618; ENSP00000378980; ENSG00000072134. [O95208-5]
ENST00000395620; ENSP00000378982; ENSG00000072134. [O95208-2]
GeneIDi22905.
KEGGihsa:22905.
UCSCiuc002gvd.4. human. [O95208-1]
uc002gve.4. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062084 mRNA. Translation: AAC78608.1.
AF062085 mRNA. Translation: AAC78609.1.
AB028988 mRNA. Translation: BAA83017.2. Different initiation.
AK001996 mRNA. Translation: BAG51000.1.
AK024115 mRNA. Translation: BAB14831.1.
AK092366 mRNA. Translation: BAG52540.1. Sequence problems.
AC106017 Genomic DNA. No translation available.
AC124066 Genomic DNA. No translation available.
CH471212 Genomic DNA. Translation: EAW50876.1.
BC093972 mRNA. Translation: AAH93972.1.
BC093974 mRNA. Translation: AAH93974.1.
CCDSiCCDS11203.1. [O95208-1]
CCDS11204.1. [O95208-2]
CCDS42277.1. [O95208-5]
RefSeqiNP_001096134.1. NM_001102664.1. [O95208-5]
NP_055779.2. NM_014964.4. [O95208-1]
NP_683723.2. NM_148921.3. [O95208-2]
UniGeneiHs.743983.

3D structure databases

ProteinModelPortaliO95208.
SMRiO95208. Positions 1-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116569. 10 interactions.
STRINGi9606.ENSP00000320543.

PTM databases

PhosphoSiteiO95208.

Polymorphism and mutation databases

BioMutaiEPN2.

Proteomic databases

MaxQBiO95208.
PaxDbiO95208.
PRIDEiO95208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314728; ENSP00000320543; ENSG00000072134. [O95208-1]
ENST00000347697; ENSP00000261495; ENSG00000072134. [O95208-2]
ENST00000395618; ENSP00000378980; ENSG00000072134. [O95208-5]
ENST00000395620; ENSP00000378982; ENSG00000072134. [O95208-2]
GeneIDi22905.
KEGGihsa:22905.
UCSCiuc002gvd.4. human. [O95208-1]
uc002gve.4. human.

Organism-specific databases

CTDi22905.
GeneCardsiGC17P019118.
H-InvDBHIX0013614.
HGNCiHGNC:18639. EPN2.
HPAiHPA049809.
HPA053360.
MIMi607263. gene.
neXtProtiNX_O95208.
PharmGKBiPA38615.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG263730.
GeneTreeiENSGT00550000074611.
HOGENOMiHOG000008298.
HOVERGENiHBG006690.
InParanoidiO95208.
KOiK12471.
OMAiQEYGKSG.
OrthoDBiEOG7F511Z.
PhylomeDBiO95208.
TreeFamiTF313361.

Miscellaneous databases

ChiTaRSiEPN2. human.
GeneWikiiEPN2.
GenomeRNAii22905.
NextBioi43557.
PMAP-CutDBO95208.
PROiO95208.
SOURCEiSearch...

Gene expression databases

BgeeiO95208.
CleanExiHS_EPN2.
ExpressionAtlasiO95208. baseline and differential.
GenevestigatoriO95208.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR013809. ENTH.
IPR008942. ENTH_VHS.
IPR027319. Epsin-2_metazoa.
IPR003903. Ubiquitin-int_motif.
[Graphical view]
PANTHERiPTHR12276:SF50. PTHR12276:SF50. 1 hit.
PfamiPF01417. ENTH. 1 hit.
[Graphical view]
SMARTiSM00273. ENTH. 1 hit.
SM00726. UIM. 2 hits.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
PS50330. UIM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module."
    Rosenthal J.A., Chen H., Slepnev V.I., Pellegrini L., Salcini A.E., Di Fiore P.P., De Camilli P.
    J. Biol. Chem. 274:33959-33965(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, INTERACTION WITH AP-2 AND CLATHRIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ALA-401.
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-401.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-467 (ISOFORM 3), VARIANT ALA-401.
    Tissue: Embryo, Fetal brain and Placenta.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-401.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-401.
    Tissue: Brain.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192 AND SER-195 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153 AND SER-156 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiEPN2_HUMAN
AccessioniPrimary (citable) accession number: O95208
Secondary accession number(s): A8MTV8
, B3KRX8, E9PBC2, O95207, Q52LD0, Q9H7Z2, Q9UPT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 16, 2008
Last modified: April 29, 2015
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.