O95206 (PCDH8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protocadherin-8

Alternative name(s):
Arcadlin

Gene names

Name:

PCDH8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1070 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Calcium-dependent cell-adhesion protein By similarity. May play a role in activity-induced synaptic reorganization underlying long term memory By similarity. Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis By similarity.
Subunit structure	The N-terminal extracellular domain forms homophilic interactions; these interactions activate p38 MAPK via TAOK2 and trigger endocytosis By similarity. Interacts with CDH2; this interaction may lead to CDH2 cointernalization By similarity. Interacts with CDH11 By similarity. Interacts with TAOK2 By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Cell projection › dendrite By similarity. Cell junction › synapse › presynaptic cell membrane. Cell junction › synapse › postsynaptic cell membrane. Note: Also expressed in neuronal cell bodies By similarity. Localized to excitatory, but not with inhibitory, synapses By similarity.
Sequence similarities	Contains 6 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Cell projection Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Traceable author statement Ref.1. Source: ProtInc homophilic cell adhesion Inferred from electronic annotation. Source: InterPro morphogenesis of embryonic epithelium Inferred from electronic annotation. Source: Compara somitogenesis Inferred from electronic annotation. Source: Compara synaptic transmission Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW dendrite Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell presynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95206-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95206-2)

The sequence of this isoform differs from the canonical sequence as follows:
     780-876: Missing.

Isoform 3 (identifier: O95206-3)

The sequence of this isoform differs from the canonical sequence as follows:
     134-607: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 1070	1041	Protocadherin-8		PRO_0000003993
Regions
	Topological domain	30 – 749	720	Extracellular Potential
	Transmembrane	750 – 770	21	Helical; Potential
	Topological domain	771 – 1070	300	Cytoplasmic Potential
	Domain	30 – 135	106	Cadherin 1
	Domain	136 – 245	110	Cadherin 2
	Domain	247 – 354	108	Cadherin 3
	Domain	393 – 497	105	Cadherin 4
	Domain	498 – 609	112	Cadherin 5
	Domain	615 – 723	109	Cadherin 6
Amino acid modifications
	Glycosylation	70	1	N-linked (GlcNAc...) Potential
	Glycosylation	464	1	N-linked (GlcNAc...) Potential
	Glycosylation	616	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	134 – 607	474	Missing in isoform 3.		VSP_040566
	Alternative sequence	780 – 876	97	Missing in isoform 2.		VSP_008706
	Natural variant	7	1	W → R. Ref.7 Corresponds to variant rs3742301 [ dbSNP | Ensembl ].		VAR_017171
	Natural variant	39	1	E → A. Ref.7 Corresponds to variant rs5030683 [ dbSNP | Ensembl ].		VAR_017172
	Natural variant	367	1	T → A. Corresponds to variant rs9596693 [ dbSNP | Ensembl ].		VAR_059191
	Natural variant	743	1	V → A. Ref.7 Corresponds to variant rs5030685 [ dbSNP | Ensembl ].		VAR_017173
	Natural variant	956	1	K → N in a breast cancer sample; somatic mutation. Ref.8		VAR_036108
Experimental info
	Sequence conflict	39	1	E → K in AAK21986. Ref.2
	Sequence conflict	834	1	S → C in AAH36025. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 2. Checksum: CBCCE3C43C0E02D8	FASTA	1,070	113,019
	10 20 30 40 50 60 MSPVRRWGSP CLFPLQLFSL CWVLSVAQSK TVRYSTFEED APGTVIGTLA EDLHMKVSGD 70 80 90 100 110 120 TSFRLMKQFN SSLLRVREGD GQLTVGDAGL DRERLCGQAP QCVLAFDVVS FSQEQFRLVH 130 140 150 160 170 180 VEVEVRDVND HAPRFPRAQI PVEVSEGAAV GTRIPLEVPV DEDVGANGLQ TVRLAEPHSP 190 200 210 220 230 240 FRVELQTRAD GAQCADLVLL QELDRESQAA YSLELVAQDG GRPPRSATAA LSVRVLDAND 250 260 270 280 290 300 HSPAFPQGAV AEVELAEDAP VGSLLLDLDA ADPDEGPNGD VVFAFGARTP PEARRLFRLD 310 320 330 340 350 360 PRSGRLTLAG PVDYERQDTY ELDVRAQDRG PGPRAATCKV IVRIRDVNDN APDIAITPLA 370 380 390 400 410 420 APGAPATSPF AAAAAAAALG GADASSPAGA GTPEAGATSL VPEGAARESL VALVSTSDRD 430 440 450 460 470 480 SGANGQVRCA LYGHEHFRLQ PAYAGSYLVV TAASLDRERI AEYNLTLVAE DRGAPPLRTV 490 500 510 520 530 540 RPYTVRVGDE NDNAPLFTRP VYEVSVRENN PPGAYLATVA ARDRDLGRNG QVTYRLLEAE 550 560 570 580 590 600 VGRAGGAVST YVSVDPATGA IYALRSFDYE TLRQLDVRIQ ASDGGSPQLS SSALVQVRVL 610 620 630 640 650 660 DQNDHAPVLV HPAPANGSLE VAVPGRTAKD TVVARVQARD ADEGANGELA FELQQQEPRE 670 680 690 700 710 720 AFAIGRRTGE ILLTGDLSQE PPGRVFRALL VISDGGRPPL TTTATVSFVV TAGGGRGPAA 730 740 750 760 770 780 PASAGSPERS RPPGSRLGVS GSVLQWDTPL IVIIVLAGSC TLLLAAIIAI ATTCNRRKKE 790 800 810 820 830 840 VRKGGALREE RPGAAGGGAS APGSPEEAAR GAGPRPNMFD VLTFPGTGKA PFGSPAADAP 850 860 870 880 890 900 PPAVAAAEVP GSEGGSATGE SACHFEGQQR LRGAHAEPYG ASPGFGKEPA PPVAVWKGHS 910 920 930 940 950 960 FNTISGREAE KFSGKDSGKG DSDFNDSDSD ISGDALKKDL INHMQSGLWA CTAECKILGH 970 980 990 1000 1010 1020 SDRCWSPSCS GPNAHPSPHP PAQMSTFCKS TSLPRDPLRR DNYYQAQLPK TVGLQSVYEK 1030 1040 1050 1060 1070 VLHRDYDRTV TLLSPPRPGR LPDLQEIGVP LYQSPPGRYL SPKKGANENV
	Isoform 2 [UniParc]. Checksum: 83F24DB14FE08126	FASTA	973	103,633
	10 20 30 40 50 60 MSPVRRWGSP CLFPLQLFSL CWVLSVAQSK TVRYSTFEED APGTVIGTLA EDLHMKVSGD 70 80 90 100 110 120 TSFRLMKQFN SSLLRVREGD GQLTVGDAGL DRERLCGQAP QCVLAFDVVS FSQEQFRLVH 130 140 150 160 170 180 VEVEVRDVND HAPRFPRAQI PVEVSEGAAV GTRIPLEVPV DEDVGANGLQ TVRLAEPHSP 190 200 210 220 230 240 FRVELQTRAD GAQCADLVLL QELDRESQAA YSLELVAQDG GRPPRSATAA LSVRVLDAND 250 260 270 280 290 300 HSPAFPQGAV AEVELAEDAP VGSLLLDLDA ADPDEGPNGD VVFAFGARTP PEARRLFRLD 310 320 330 340 350 360 PRSGRLTLAG PVDYERQDTY ELDVRAQDRG PGPRAATCKV IVRIRDVNDN APDIAITPLA 370 380 390 400 410 420 APGAPATSPF AAAAAAAALG GADASSPAGA GTPEAGATSL VPEGAARESL VALVSTSDRD 430 440 450 460 470 480 SGANGQVRCA LYGHEHFRLQ PAYAGSYLVV TAASLDRERI AEYNLTLVAE DRGAPPLRTV 490 500 510 520 530 540 RPYTVRVGDE NDNAPLFTRP VYEVSVRENN PPGAYLATVA ARDRDLGRNG QVTYRLLEAE 550 560 570 580 590 600 VGRAGGAVST YVSVDPATGA IYALRSFDYE TLRQLDVRIQ ASDGGSPQLS SSALVQVRVL 610 620 630 640 650 660 DQNDHAPVLV HPAPANGSLE VAVPGRTAKD TVVARVQARD ADEGANGELA FELQQQEPRE 670 680 690 700 710 720 AFAIGRRTGE ILLTGDLSQE PPGRVFRALL VISDGGRPPL TTTATVSFVV TAGGGRGPAA 730 740 750 760 770 780 PASAGSPERS RPPGSRLGVS GSVLQWDTPL IVIIVLAGSC TLLLAAIIAI ATTCNRRKKE 790 800 810 820 830 840 PYGASPGFGK EPAPPVAVWK GHSFNTISGR EAEKFSGKDS GKGDSDFNDS DSDISGDALK 850 860 870 880 890 900 KDLINHMQSG LWACTAECKI LGHSDRCWSP SCSGPNAHPS PHPPAQMSTF CKSTSLPRDP 910 920 930 940 950 960 LRRDNYYQAQ LPKTVGLQSV YEKVLHRDYD RTVTLLSPPR PGRLPDLQEI GVPLYQSPPG 970 RYLSPKKGAN ENV
	Isoform 3 [UniParc]. Checksum: B9526F8F1586E3EC	FASTA	596	63,106
	10 20 30 40 50 60 MSPVRRWGSP CLFPLQLFSL CWVLSVAQSK TVRYSTFEED APGTVIGTLA EDLHMKVSGD 70 80 90 100 110 120 TSFRLMKQFN SSLLRVREGD GQLTVGDAGL DRERLCGQAP QCVLAFDVVS FSQEQFRLVH 130 140 150 160 170 180 VEVEVRDVND HAPVLVHPAP ANGSLEVAVP GRTAKDTVVA RVQARDADEG ANGELAFELQ 190 200 210 220 230 240 QQEPREAFAI GRRTGEILLT GDLSQEPPGR VFRALLVISD GGRPPLTTTA TVSFVVTAGG 250 260 270 280 290 300 GRGPAAPASA GSPERSRPPG SRLGVSGSVL QWDTPLIVII VLAGSCTLLL AAIIAIATTC 310 320 330 340 350 360 NRRKKEVRKG GALREERPGA AGGGASAPGS PEEAARGAGP RPNMFDVLTF PGTGKAPFGS 370 380 390 400 410 420 PAADAPPPAV AAAEVPGSEG GSATGESACH FEGQQRLRGA HAEPYGASPG FGKEPAPPVA 430 440 450 460 470 480 VWKGHSFNTI SGREAEKFSG KDSGKGDSDF NDSDSDISGD ALKKDLINHM QSGLWACTAE 490 500 510 520 530 540 CKILGHSDRC WSPSCSGPNA HPSPHPPAQM STFCKSTSLP RDPLRRDNYY QAQLPKTVGL 550 560 570 580 590 QSVYEKVLHR DYDRTVTLLS PPRPGRLPDL QEIGVPLYQS PPGRYLSPKK GANENV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14." Strehl S., Glatt K., Liu Q.M., Glatt H., Lalande M. Genomics 53:81-89(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Comparative DNA sequence analysis of mouse and human protocadherin gene clusters." Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T. Genome Res. 11:389-404(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Fetal brain.
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[7]	"Screening the human protocadherin 8 (PCDH8) gene in schizophrenia." Bray N.J., Kirov G., Owen R.J., Jacobsen N.J., Georgieva L., Williams H.J., Norton N., Spurlock G., Jones S., Zammit S., O'Donovan M.C., Owen M.J. Genes Brain Behav. 1:187-191(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ARG-7; ALA-39 AND ALA-743.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-956.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF061573 mRNA. Translation: AAC70009.2. AY013873 mRNA. Translation: AAK21986.1. AK297652 mRNA. Translation: BAG60019.1. AL139085 Genomic DNA. Translation: CAI14110.1. AL139085 Genomic DNA. Translation: CAI14111.1. CH471124 Genomic DNA. Translation: EAW52049.1. CH471124 Genomic DNA. Translation: EAW52050.1. BC036025 mRNA. Translation: AAH36025.1.
IPI	IPI00001895. IPI00374110. IPI00910395.
RefSeq	NP_002581.2. NM_002590.3. NP_116567.1. NM_032949.2.
UniGene	Hs.19492.
3D structure databases
ProteinModelPortal	O95206.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95206. 1 interaction.
MINT	MINT-2861561.
STRING	9606.ENSP00000367177.
PTM databases
PhosphoSite	O95206.
Proteomic databases
PaxDb	O95206.
PRIDE	O95206.
Protocols and materials databases
DNASU	5100.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338862; ENSP00000341350; ENSG00000136099. ENST00000377942; ENSP00000367177; ENSG00000136099.
GeneID	5100.
KEGG	hsa:5100.
UCSC	uc001vhi.3. human. uc001vhj.3. human.
Organism-specific databases
CTD	5100.
GeneCards	GC13M053418.
HGNC	HGNC:8660. PCDH8.
HPA	HPA010509.
MIM	603580. gene.
neXtProt	NX_O95206.
PharmGKB	PA33007.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG245309.
HOGENOM	HOG000220892.
HOVERGEN	HBG054878.
InParanoid	O95206.
KO	K16499.
OMA	PAQMSTF.
OrthoDB	EOG4FJ8B5.
PhylomeDB	O95206.
Gene expression databases
Bgee	O95206.
CleanEx	HS_PCDH8.
Genevestigator	O95206.
GermOnline	ENSG00000136099. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5100.
NextBio	19686.
SOURCE	Search...

Entry information

Entry name

PCDH8_HUMAN

Accession

Primary (citable) accession number: O95206
Secondary accession number(s): B4DMV7 , Q5TAN1, Q5TAN2, Q8IYE9, Q96SF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.