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Protein

Zinc finger protein 205

Gene

ZNF205

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri308 – 33023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: GO_Central
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  2. positive regulation of hydrogen peroxide biosynthetic process Source: BHF-UCL
  3. positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: BHF-UCL
  4. regulation of transcription, DNA-templated Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 205
Alternative name(s):
Zinc finger protein 210
Gene namesi
Name:ZNF205
Synonyms:ZNF210
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:12996. ZNF205.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37576.

Polymorphism and mutation databases

BioMutaiZNF205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Zinc finger protein 205PRO_0000047451Add
BLAST

Proteomic databases

MaxQBiO95201.
PaxDbiO95201.
PRIDEiO95201.

PTM databases

PhosphoSiteiO95201.

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, pancreas and brain. Weakly expressed in placenta, lung, liver, kidney and thymus.

Gene expression databases

BgeeiO95201.
CleanExiHS_ZNF205.
ExpressionAtlasiO95201. baseline and differential.
GenevestigatoriO95201.

Organism-specific databases

HPAiHPA001791.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN4Q9NRR52EBI-747343,EBI-711226

Protein-protein interaction databases

BioGridi113539. 12 interactions.
IntActiO95201. 12 interactions.
MINTiMINT-1458097.
STRINGi9606.ENSP00000219091.

Structurei

3D structure databases

ProteinModelPortaliO95201.
SMRiO95201. Positions 306-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 19370KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri308 – 33023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00730000111027.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO95201.
KOiK09228.
OMAiPLSHGSK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiO95201.
TreeFamiTF338003.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADGGGIQD TQDKETPPEV PDRGHPHQEM PSKLGEAVPS GDTQESLHIK
60 70 80 90 100
MEPEEPHSEG ASQEDGAQGA WGWAPLSHGS KEKALFLPGG ALPSPRIPVL
110 120 130 140 150
SREGRTRDRQ MAAALLTAWS QMPVTFEDVA LYLSREEWGR LDHTQQNFYR
160 170 180 190 200
DVLQKKNGLS LGFPFSRPFW APQAHGKGEA SGSSRQAGDE KEWRGACTGA
210 220 230 240 250
VEVGQRVQTS SVAALGNVKP FRTRAGRVQW GVPQCAQEAA CGRSSGPAKD
260 270 280 290 300
SGQPAEPDRT PDAAPPDPSP TEPQEYRVPE KPNEEEKGAP ESGEEGLAPD
310 320 330 340 350
SEVGRKSYRC EQCGKGFSWH SHLVTHRRTH TGEKPYACTD CGKRFGRSSH
360 370 380 390 400
LIQHQIIHTG EKPYTCPACR KSFSHHSTLI QHQRIHTGEK PYVCDRCAKR
410 420 430 440 450
FTRRSDLVTH QGTHTGAKPH KCPICAKCFT QSSALVTHQR THTGVKPYPC
460 470 480 490 500
PECGKCFSQR SNLIAHNRTH TGEKPYHCLD CGKSFSHSSH LTAHQRTHRG
510 520 530 540 550
VRPYACPLCG KSFSRRSNLH RHEKIHTTGP KALAMLMLGA AAAGALATPP

PAPT
Length:554
Mass (Da):60,630
Last modified:October 31, 2006 - v2
Checksum:iB70DC15F0DFDC7FC
GO

Sequence cautioni

The sequence AAC70007.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431T → A.1 Publication
Corresponds to variant rs909410 [ dbSNP | Ensembl ].
VAR_028798
Natural varianti255 – 2551A → D.
Corresponds to variant rs12445220 [ dbSNP | Ensembl ].
VAR_028799

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060865 mRNA. Translation: AAC70007.1. Different initiation.
AC108134 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85396.1.
CH471112 Genomic DNA. Translation: EAW85398.1.
CH471112 Genomic DNA. Translation: EAW85399.1.
CH471112 Genomic DNA. Translation: EAW85400.1.
BC002810 mRNA. Translation: AAH02810.1.
CCDSiCCDS10494.2.
RefSeqiNP_001035893.1. NM_001042428.1.
NP_001265087.1. NM_001278158.1.
NP_003447.2. NM_003456.2.
XP_005255615.1. XM_005255558.1.
UniGeneiHs.592088.

Genome annotation databases

EnsembliENST00000219091; ENSP00000219091; ENSG00000122386.
ENST00000382192; ENSP00000371627; ENSG00000122386.
ENST00000620094; ENSP00000480401; ENSG00000122386.
GeneIDi7755.
KEGGihsa:7755.
UCSCiuc002cua.3. human.

Polymorphism and mutation databases

BioMutaiZNF205.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060865 mRNA. Translation: AAC70007.1. Different initiation.
AC108134 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85396.1.
CH471112 Genomic DNA. Translation: EAW85398.1.
CH471112 Genomic DNA. Translation: EAW85399.1.
CH471112 Genomic DNA. Translation: EAW85400.1.
BC002810 mRNA. Translation: AAH02810.1.
CCDSiCCDS10494.2.
RefSeqiNP_001035893.1. NM_001042428.1.
NP_001265087.1. NM_001278158.1.
NP_003447.2. NM_003456.2.
XP_005255615.1. XM_005255558.1.
UniGeneiHs.592088.

3D structure databases

ProteinModelPortaliO95201.
SMRiO95201. Positions 306-527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113539. 12 interactions.
IntActiO95201. 12 interactions.
MINTiMINT-1458097.
STRINGi9606.ENSP00000219091.

PTM databases

PhosphoSiteiO95201.

Polymorphism and mutation databases

BioMutaiZNF205.

Proteomic databases

MaxQBiO95201.
PaxDbiO95201.
PRIDEiO95201.

Protocols and materials databases

DNASUi7755.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219091; ENSP00000219091; ENSG00000122386.
ENST00000382192; ENSP00000371627; ENSG00000122386.
ENST00000620094; ENSP00000480401; ENSG00000122386.
GeneIDi7755.
KEGGihsa:7755.
UCSCiuc002cua.3. human.

Organism-specific databases

CTDi7755.
GeneCardsiGC16P003162.
HGNCiHGNC:12996. ZNF205.
HPAiHPA001791.
MIMi603436. gene.
neXtProtiNX_O95201.
PharmGKBiPA37576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00730000111027.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO95201.
KOiK09228.
OMAiPLSHGSK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiO95201.
TreeFamiTF338003.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7755.
NextBioi30015.
PROiO95201.
SOURCEiSearch...

Gene expression databases

BgeeiO95201.
CleanExiHS_ZNF205.
ExpressionAtlasiO95201. baseline and differential.
GenevestigatoriO95201.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3."
    Deng Z., Centola M., Chen X., Sood R., Vedula A., Fischel-Ghodsian N., Kastner D.L.
    Genomics 53:97-103(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-43.
    Tissue: Placenta.

Entry informationi

Entry nameiZN205_HUMAN
AccessioniPrimary (citable) accession number: O95201
Secondary accession number(s): A8MZK0, D3DUB4, Q9BU95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 31, 2006
Last modified: April 29, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.