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O95201 (ZN205_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 205
Alternative name(s):
Zinc finger protein 210
Gene names
Name:ZNF205
Synonyms:ZNF210
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in heart, skeletal muscle, pancreas and brain. Weakly expressed in placenta, lung, liver, kidney and thymus.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 8 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAC70007.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

UBQLN4Q9NRR52EBI-747343,EBI-711226

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Zinc finger protein 205
PRO_0000047451

Regions

Domain124 – 19370KRAB
Zinc finger308 – 33023C2H2-type 1
Zinc finger336 – 35823C2H2-type 2
Zinc finger364 – 38623C2H2-type 3
Zinc finger392 – 41423C2H2-type 4
Zinc finger420 – 44223C2H2-type 5
Zinc finger448 – 47023C2H2-type 6
Zinc finger476 – 49823C2H2-type 7
Zinc finger504 – 52623C2H2-type 8

Natural variations

Natural variant431T → A. Ref.4
Corresponds to variant rs909410 [ dbSNP | Ensembl ].
VAR_028798
Natural variant2551A → D.
Corresponds to variant rs12445220 [ dbSNP | Ensembl ].
VAR_028799

Sequences

Sequence LengthMass (Da)Tools
O95201 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: B70DC15F0DFDC7FC

FASTA55460,630
        10         20         30         40         50         60 
MSADGGGIQD TQDKETPPEV PDRGHPHQEM PSKLGEAVPS GDTQESLHIK MEPEEPHSEG 

        70         80         90        100        110        120 
ASQEDGAQGA WGWAPLSHGS KEKALFLPGG ALPSPRIPVL SREGRTRDRQ MAAALLTAWS 

       130        140        150        160        170        180 
QMPVTFEDVA LYLSREEWGR LDHTQQNFYR DVLQKKNGLS LGFPFSRPFW APQAHGKGEA 

       190        200        210        220        230        240 
SGSSRQAGDE KEWRGACTGA VEVGQRVQTS SVAALGNVKP FRTRAGRVQW GVPQCAQEAA 

       250        260        270        280        290        300 
CGRSSGPAKD SGQPAEPDRT PDAAPPDPSP TEPQEYRVPE KPNEEEKGAP ESGEEGLAPD 

       310        320        330        340        350        360 
SEVGRKSYRC EQCGKGFSWH SHLVTHRRTH TGEKPYACTD CGKRFGRSSH LIQHQIIHTG 

       370        380        390        400        410        420 
EKPYTCPACR KSFSHHSTLI QHQRIHTGEK PYVCDRCAKR FTRRSDLVTH QGTHTGAKPH 

       430        440        450        460        470        480 
KCPICAKCFT QSSALVTHQR THTGVKPYPC PECGKCFSQR SNLIAHNRTH TGEKPYHCLD 

       490        500        510        520        530        540 
CGKSFSHSSH LTAHQRTHRG VRPYACPLCG KSFSRRSNLH RHEKIHTTGP KALAMLMLGA 

       550 
AAAGALATPP PAPT 

« Hide

References

« Hide 'large scale' references
[1]"Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3."
Deng Z., Centola M., Chen X., Sood R., Vedula A., Fischel-Ghodsian N., Kastner D.L.
Genomics 53:97-103(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-43.
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF060865 mRNA. Translation: AAC70007.1. Different initiation.
AC108134 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85396.1.
CH471112 Genomic DNA. Translation: EAW85398.1.
CH471112 Genomic DNA. Translation: EAW85399.1.
CH471112 Genomic DNA. Translation: EAW85400.1.
BC002810 mRNA. Translation: AAH02810.1.
CCDSCCDS10494.2.
RefSeqNP_001035893.1. NM_001042428.1.
NP_001265087.1. NM_001278158.1.
NP_003447.2. NM_003456.2.
XP_005255615.1. XM_005255558.1.
UniGeneHs.592088.

3D structure databases

ProteinModelPortalO95201.
SMRO95201. Positions 306-527.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113539. 12 interactions.
IntActO95201. 12 interactions.
MINTMINT-1458097.
STRING9606.ENSP00000219091.

PTM databases

PhosphoSiteO95201.

Proteomic databases

MaxQBO95201.
PaxDbO95201.
PRIDEO95201.

Protocols and materials databases

DNASU7755.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000219091; ENSP00000219091; ENSG00000122386.
ENST00000382192; ENSP00000371627; ENSG00000122386.
GeneID7755.
KEGGhsa:7755.
UCSCuc002cua.3. human.

Organism-specific databases

CTD7755.
GeneCardsGC16P003162.
HGNCHGNC:12996. ZNF205.
HPAHPA001791.
MIM603436. gene.
neXtProtNX_O95201.
PharmGKBPA37576.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidO95201.
KOK09228.
OMAPLSHGSK.
OrthoDBEOG7KSX7Q.
PhylomeDBO95201.
TreeFamTF338003.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressO95201.
BgeeO95201.
CleanExHS_ZNF205.
GenevestigatorO95201.

Family and domain databases

Gene3D3.30.160.60. 8 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7755.
NextBio30015.
PROO95201.
SOURCESearch...

Entry information

Entry nameZN205_HUMAN
AccessionPrimary (citable) accession number: O95201
Secondary accession number(s): A8MZK0, D3DUB4, Q9BU95
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM