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O95201

- ZN205_HUMAN

UniProt

O95201 - ZN205_HUMAN

Protein

Zinc finger protein 205

Gene

ZNF205

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri308 – 33023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri476 – 49823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri504 – 52623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome
    4. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    2. positive regulation of hydrogen peroxide biosynthetic process Source: BHF-UCL
    3. positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: BHF-UCL
    4. regulation of transcription, DNA-templated Source: UniProtKB
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 205
    Alternative name(s):
    Zinc finger protein 210
    Gene namesi
    Name:ZNF205
    Synonyms:ZNF210
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:12996. ZNF205.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37576.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Zinc finger protein 205PRO_0000047451Add
    BLAST

    Proteomic databases

    MaxQBiO95201.
    PaxDbiO95201.
    PRIDEiO95201.

    PTM databases

    PhosphoSiteiO95201.

    Expressioni

    Tissue specificityi

    Expressed in heart, skeletal muscle, pancreas and brain. Weakly expressed in placenta, lung, liver, kidney and thymus.

    Gene expression databases

    ArrayExpressiO95201.
    BgeeiO95201.
    CleanExiHS_ZNF205.
    GenevestigatoriO95201.

    Organism-specific databases

    HPAiHPA001791.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UBQLN4Q9NRR52EBI-747343,EBI-711226

    Protein-protein interaction databases

    BioGridi113539. 12 interactions.
    IntActiO95201. 12 interactions.
    MINTiMINT-1458097.
    STRINGi9606.ENSP00000219091.

    Structurei

    3D structure databases

    ProteinModelPortaliO95201.
    SMRiO95201. Positions 306-527.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini124 – 19370KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri308 – 33023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri476 – 49823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri504 – 52623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiO95201.
    KOiK09228.
    OMAiPLSHGSK.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiO95201.
    TreeFamiTF338003.

    Family and domain databases

    Gene3Di3.30.160.60. 8 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95201-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSADGGGIQD TQDKETPPEV PDRGHPHQEM PSKLGEAVPS GDTQESLHIK    50
    MEPEEPHSEG ASQEDGAQGA WGWAPLSHGS KEKALFLPGG ALPSPRIPVL 100
    SREGRTRDRQ MAAALLTAWS QMPVTFEDVA LYLSREEWGR LDHTQQNFYR 150
    DVLQKKNGLS LGFPFSRPFW APQAHGKGEA SGSSRQAGDE KEWRGACTGA 200
    VEVGQRVQTS SVAALGNVKP FRTRAGRVQW GVPQCAQEAA CGRSSGPAKD 250
    SGQPAEPDRT PDAAPPDPSP TEPQEYRVPE KPNEEEKGAP ESGEEGLAPD 300
    SEVGRKSYRC EQCGKGFSWH SHLVTHRRTH TGEKPYACTD CGKRFGRSSH 350
    LIQHQIIHTG EKPYTCPACR KSFSHHSTLI QHQRIHTGEK PYVCDRCAKR 400
    FTRRSDLVTH QGTHTGAKPH KCPICAKCFT QSSALVTHQR THTGVKPYPC 450
    PECGKCFSQR SNLIAHNRTH TGEKPYHCLD CGKSFSHSSH LTAHQRTHRG 500
    VRPYACPLCG KSFSRRSNLH RHEKIHTTGP KALAMLMLGA AAAGALATPP 550
    PAPT 554
    Length:554
    Mass (Da):60,630
    Last modified:October 31, 2006 - v2
    Checksum:iB70DC15F0DFDC7FC
    GO

    Sequence cautioni

    The sequence AAC70007.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431T → A.1 Publication
    Corresponds to variant rs909410 [ dbSNP | Ensembl ].
    VAR_028798
    Natural varianti255 – 2551A → D.
    Corresponds to variant rs12445220 [ dbSNP | Ensembl ].
    VAR_028799

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF060865 mRNA. Translation: AAC70007.1. Different initiation.
    AC108134 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85396.1.
    CH471112 Genomic DNA. Translation: EAW85398.1.
    CH471112 Genomic DNA. Translation: EAW85399.1.
    CH471112 Genomic DNA. Translation: EAW85400.1.
    BC002810 mRNA. Translation: AAH02810.1.
    CCDSiCCDS10494.2.
    RefSeqiNP_001035893.1. NM_001042428.1.
    NP_001265087.1. NM_001278158.1.
    NP_003447.2. NM_003456.2.
    XP_005255615.1. XM_005255558.1.
    UniGeneiHs.592088.

    Genome annotation databases

    EnsembliENST00000219091; ENSP00000219091; ENSG00000122386.
    ENST00000382192; ENSP00000371627; ENSG00000122386.
    GeneIDi7755.
    KEGGihsa:7755.
    UCSCiuc002cua.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF060865 mRNA. Translation: AAC70007.1 . Different initiation.
    AC108134 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85396.1 .
    CH471112 Genomic DNA. Translation: EAW85398.1 .
    CH471112 Genomic DNA. Translation: EAW85399.1 .
    CH471112 Genomic DNA. Translation: EAW85400.1 .
    BC002810 mRNA. Translation: AAH02810.1 .
    CCDSi CCDS10494.2.
    RefSeqi NP_001035893.1. NM_001042428.1.
    NP_001265087.1. NM_001278158.1.
    NP_003447.2. NM_003456.2.
    XP_005255615.1. XM_005255558.1.
    UniGenei Hs.592088.

    3D structure databases

    ProteinModelPortali O95201.
    SMRi O95201. Positions 306-527.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113539. 12 interactions.
    IntActi O95201. 12 interactions.
    MINTi MINT-1458097.
    STRINGi 9606.ENSP00000219091.

    PTM databases

    PhosphoSitei O95201.

    Proteomic databases

    MaxQBi O95201.
    PaxDbi O95201.
    PRIDEi O95201.

    Protocols and materials databases

    DNASUi 7755.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219091 ; ENSP00000219091 ; ENSG00000122386 .
    ENST00000382192 ; ENSP00000371627 ; ENSG00000122386 .
    GeneIDi 7755.
    KEGGi hsa:7755.
    UCSCi uc002cua.3. human.

    Organism-specific databases

    CTDi 7755.
    GeneCardsi GC16P003162.
    HGNCi HGNC:12996. ZNF205.
    HPAi HPA001791.
    MIMi 603436. gene.
    neXtProti NX_O95201.
    PharmGKBi PA37576.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi O95201.
    KOi K09228.
    OMAi PLSHGSK.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi O95201.
    TreeFami TF338003.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 7755.
    NextBioi 30015.
    PROi O95201.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95201.
    Bgeei O95201.
    CleanExi HS_ZNF205.
    Genevestigatori O95201.

    Family and domain databases

    Gene3Di 3.30.160.60. 8 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3."
      Deng Z., Centola M., Chen X., Sood R., Vedula A., Fischel-Ghodsian N., Kastner D.L.
      Genomics 53:97-103(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-43.
      Tissue: Placenta.

    Entry informationi

    Entry nameiZN205_HUMAN
    AccessioniPrimary (citable) accession number: O95201
    Secondary accession number(s): A8MZK0, D3DUB4, Q9BU95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3