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Protein

Zinc finger protein 205

Gene

ZNF205

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri308 – 330C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of hydrogen peroxide biosynthetic process Source: BHF-UCL
  • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 205
Alternative name(s):
Zinc finger protein 210
Gene namesi
Name:ZNF205
Synonyms:ZNF210
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000122386.10
HGNCiHGNC:12996 ZNF205
MIMi603436 gene
neXtProtiNX_O95201

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7755
OpenTargetsiENSG00000122386
PharmGKBiPA37576

Polymorphism and mutation databases

BioMutaiZNF205

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474511 – 554Zinc finger protein 205Add BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki219Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei292PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95201
MaxQBiO95201
PaxDbiO95201
PeptideAtlasiO95201
PRIDEiO95201
ProteomicsDBi50709

PTM databases

iPTMnetiO95201
PhosphoSitePlusiO95201

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, pancreas and brain. Weakly expressed in placenta, lung, liver, kidney and thymus.

Gene expression databases

BgeeiENSG00000122386
CleanExiHS_ZNF205
ExpressionAtlasiO95201 baseline and differential
GenevisibleiO95201 HS

Organism-specific databases

HPAiHPA001791

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN4Q9NRR52EBI-747343,EBI-711226

Protein-protein interaction databases

BioGridi113539, 12 interactors
IntActiO95201, 18 interactors
MINTiO95201
STRINGi9606.ENSP00000219091

Structurei

3D structure databases

ProteinModelPortaliO95201
SMRiO95201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 193KRABPROSITE-ProRule annotationAdd BLAST70

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri308 – 330C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129916
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO95201
KOiK09228
OMAiPLSHGSK
OrthoDBiEOG091G02KC
PhylomeDBiO95201
TreeFamiTF338003

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequencei

Sequence statusi: Complete.

O95201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADGGGIQD TQDKETPPEV PDRGHPHQEM PSKLGEAVPS GDTQESLHIK
60 70 80 90 100
MEPEEPHSEG ASQEDGAQGA WGWAPLSHGS KEKALFLPGG ALPSPRIPVL
110 120 130 140 150
SREGRTRDRQ MAAALLTAWS QMPVTFEDVA LYLSREEWGR LDHTQQNFYR
160 170 180 190 200
DVLQKKNGLS LGFPFSRPFW APQAHGKGEA SGSSRQAGDE KEWRGACTGA
210 220 230 240 250
VEVGQRVQTS SVAALGNVKP FRTRAGRVQW GVPQCAQEAA CGRSSGPAKD
260 270 280 290 300
SGQPAEPDRT PDAAPPDPSP TEPQEYRVPE KPNEEEKGAP ESGEEGLAPD
310 320 330 340 350
SEVGRKSYRC EQCGKGFSWH SHLVTHRRTH TGEKPYACTD CGKRFGRSSH
360 370 380 390 400
LIQHQIIHTG EKPYTCPACR KSFSHHSTLI QHQRIHTGEK PYVCDRCAKR
410 420 430 440 450
FTRRSDLVTH QGTHTGAKPH KCPICAKCFT QSSALVTHQR THTGVKPYPC
460 470 480 490 500
PECGKCFSQR SNLIAHNRTH TGEKPYHCLD CGKSFSHSSH LTAHQRTHRG
510 520 530 540 550
VRPYACPLCG KSFSRRSNLH RHEKIHTTGP KALAMLMLGA AAAGALATPP

PAPT
Length:554
Mass (Da):60,630
Last modified:October 31, 2006 - v2
Checksum:iB70DC15F0DFDC7FC
GO

Sequence cautioni

The sequence AAC70007 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02879843T → A1 PublicationCorresponds to variant dbSNP:rs909410Ensembl.1
Natural variantiVAR_028799255A → D. Corresponds to variant dbSNP:rs12445220Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060865 mRNA Translation: AAC70007.1 Different initiation.
AC108134 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85396.1
CH471112 Genomic DNA Translation: EAW85398.1
CH471112 Genomic DNA Translation: EAW85399.1
CH471112 Genomic DNA Translation: EAW85400.1
BC002810 mRNA Translation: AAH02810.1
CCDSiCCDS10494.2
RefSeqiNP_001035893.1, NM_001042428.1
NP_001265087.1, NM_001278158.1
NP_003447.2, NM_003456.2
XP_005255615.1, XM_005255558.2
UniGeneiHs.592088

Genome annotation databases

EnsembliENST00000219091; ENSP00000219091; ENSG00000122386
ENST00000382192; ENSP00000371627; ENSG00000122386
ENST00000620094; ENSP00000480401; ENSG00000122386
GeneIDi7755
KEGGihsa:7755
UCSCiuc002cua.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN205_HUMAN
AccessioniPrimary (citable) accession number: O95201
Secondary accession number(s): A8MZK0, D3DUB4, Q9BU95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 31, 2006
Last modified: June 20, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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