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Protein

Chondroitin sulfate proteoglycan 5

Gene

CSPG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.1 Publication

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Growth regulation, Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114646-MONOMER.
ReactomeiR-HSA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-HSA-2022870. Chondroitin sulfate biosynthesis.
R-HSA-2022923. Dermatan sulfate biosynthesis.
R-HSA-2024101. CS/DS degradation.
R-HSA-3560783. Defective B4GALT7 causes EDS, progeroid type.
R-HSA-3560801. Defective B3GAT3 causes JDSSDHD.
R-HSA-3595172. Defective CHST3 causes SEDCJD.
R-HSA-3595174. Defective CHST14 causes EDS, musculocontractural type.
R-HSA-3595177. Defective CHSY1 causes TPBS.
R-HSA-4420332. Defective B3GALT6 causes EDSP2 and SEMDJL1.

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin sulfate proteoglycan 5
Alternative name(s):
Acidic leucine-rich EGF-like domain-containing brain protein
Neuroglycan C
Gene namesi
Name:CSPG5
Synonyms:CALEB, NGC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:2467. CSPG5.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
  • Golgi apparatus membrane By similarity; Single-pass type I membrane protein By similarity
  • Cell surface By similarity

  • Note: In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 423ExtracellularSequence analysisAdd BLAST393
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 566CytoplasmicSequence analysisAdd BLAST122

GO - Cellular componenti

  • cell surface Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • extracellular region Source: Reactome
  • Golgi apparatus Source: UniProtKB
  • Golgi-associated vesicle membrane Source: UniProtKB
  • Golgi lumen Source: Reactome
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • lysosomal lumen Source: Reactome
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10675.
OpenTargetsiENSG00000114646.
PharmGKBiPA26965.

Polymorphism and mutation databases

BioMutaiCSPG5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004215131 – 566Chondroitin sulfate proteoglycan 5Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117O-linked (Xyl...) (chondroitin sulfate)By similarity1
Glycosylationi165O-linked (GalNAc...)1 Publication1
Disulfide bondi374 ↔ 387By similarity
Disulfide bondi381 ↔ 397By similarity
Disulfide bondi399 ↔ 412By similarity
Modified residuei467PhosphoserineBy similarity1
Modified residuei475PhosphoserineBy similarity1
Modified residuei483PhosphoserineBy similarity1
Modified residuei543PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity
O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation (By similarity).By similarity
Phosphorylated; in intracellular and extracellular parts.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiO95196.
PeptideAtlasiO95196.
PRIDEiO95196.

PTM databases

iPTMnetiO95196.
PhosphoSitePlusiO95196.
UniCarbKBiO95196.

Expressioni

Tissue specificityi

Restricted to brain (at protein level).1 Publication

Developmental stagei

Expressed in brain of 3 months, 5 and 10-year-old individuals.1 Publication

Gene expression databases

BgeeiENSG00000114646.
CleanExiHS_CSPG5.
ExpressionAtlasiO95196. baseline and differential.
GenevisibleiO95196. HS.

Organism-specific databases

HPAiHPA071779.

Interactioni

Subunit structurei

Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GopcQ8BH603EBI-296349,EBI-296357From a different organism.

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi115917. 5 interactors.
IntActiO95196. 1 interactor.
STRINGi9606.ENSP00000373244.

Structurei

3D structure databases

ProteinModelPortaliO95196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini371 – 413EGF-likeAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni264 – 301Interaction with TNC and TNRBy similarityAdd BLAST38
Regioni442 – 460Interaction with GOPC1 PublicationAdd BLAST19

Sequence similaritiesi

Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJTR. Eukaryota.
ENOG410YF9F. LUCA.
GeneTreeiENSGT00440000034270.
HOGENOMiHOG000112020.
HOVERGENiHBG081361.
InParanoidiO95196.
KOiK08116.
OMAiEPTYPFQ.
OrthoDBiEOG091G05S8.
PhylomeDBiO95196.
TreeFamiTF338636.

Family and domain databases

InterProiIPR010555. Chon_Sulph_att.
IPR009505. Neural_ProG_Cyt.
[Graphical view]
PfamiPF06566. Chon_Sulph_att. 1 hit.
PF06567. Neural_ProG_Cyt. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95196-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRAGGGGPG RGPPPLLLFL GAALVLASGA VPAREAGSAV EAEELVKGSP
60 70 80 90 100
AWEPPANDTR EEAGPPAAGE DEASWTAPGG ELAGPEEVLQ ESAAVTGTAW
110 120 130 140 150
LEADSPGLGG VTAEAGSGDA QALPATLQAP HEVLGQSIMP PAIPEATEAS
160 170 180 190 200
GPPSPTPGDK LSPASELPKE SPLEVWLNLG GSTPDPQGPE LTYPFQGTLE
210 220 230 240 250
PQPASDIIDI DYFEGLDGEG RGADLGSFPG SPGTSENHPD TEGETPSWSL
260 270 280 290 300
LDLYDDFTPF DESDFYPTTS FYDDLDEEEE EEEDDKDAVG GGDLEDENEL
310 320 330 340 350
LVPTGKPGLG PGTGQPTSRW HAVPPQHTLG SVPGSSIALR PRPGEPGRDL
360 370 380 390 400
ASSENGTECR SGFVRHNGSC RSVCDLFPSY CHNGGQCYLV ENIGAFCRCN
410 420 430 440 450
TQDYIWHKGM RCESIITDFQ VMCVAVGSAA LVLLLLFMMT VFFAKKLYLL
460 470 480 490 500
KTENTKLRRT NKFRTPSELH NDNFSLSTIA EGSHPNVRKL CNTPRTSSPH
510 520 530 540 550
ARALAHYDNV ICQDDPSAPH KIQEVLKSCL KEEESFNIQN SMSPKLEGGK
560
GDQADLDVNC LQNNLT
Length:566
Mass (Da):60,016
Last modified:May 5, 2009 - v3
Checksum:iDD8DA045C1BE31E5
GO
Isoform 2 (identifier: O95196-2) [UniParc]FASTAAdd to basket
Also known as: CSPG5-I

The sequence of this isoform differs from the canonical sequence as follows:
     487-513: Missing.

Show »
Length:539
Mass (Da):56,983
Checksum:iBBD8B64B93091DDF
GO
Isoform 3 (identifier: O95196-3) [UniParc]FASTAAdd to basket
Also known as: CSPG5-II

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     487-513: Missing.

Show »
Length:401
Mass (Da):43,621
Checksum:i9F0D31F21854FCEB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055089188G → V.2 PublicationsCorresponds to variant rs3732530dbSNPEnsembl.1
Natural variantiVAR_055090417T → P.Corresponds to variant rs34016925dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0157601 – 138Missing in isoform 3. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_015761487 – 513Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059274 mRNA. Translation: AAC69612.1.
AF461087 mRNA. Translation: AAQ04774.1.
AF461088 mRNA. Translation: AAQ04775.1.
AF461089 mRNA. Translation: AAQ04776.1.
AC099778 Genomic DNA. No translation available.
AC112512 Genomic DNA. No translation available.
CCDSiCCDS2757.1. [O95196-2]
CCDS56252.1. [O95196-3]
CCDS56253.1. [O95196-1]
RefSeqiNP_001193872.1. NM_001206943.1. [O95196-1]
NP_001193873.1. NM_001206944.1.
NP_006565.2. NM_006574.3. [O95196-2]
UniGeneiHs.45127.

Genome annotation databases

EnsembliENST00000264723; ENSP00000264723; ENSG00000114646. [O95196-2]
ENST00000383738; ENSP00000373244; ENSG00000114646. [O95196-1]
ENST00000456150; ENSP00000392096; ENSG00000114646. [O95196-3]
GeneIDi10675.
KEGGihsa:10675.
UCSCiuc003crn.4. human. [O95196-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059274 mRNA. Translation: AAC69612.1.
AF461087 mRNA. Translation: AAQ04774.1.
AF461088 mRNA. Translation: AAQ04775.1.
AF461089 mRNA. Translation: AAQ04776.1.
AC099778 Genomic DNA. No translation available.
AC112512 Genomic DNA. No translation available.
CCDSiCCDS2757.1. [O95196-2]
CCDS56252.1. [O95196-3]
CCDS56253.1. [O95196-1]
RefSeqiNP_001193872.1. NM_001206943.1. [O95196-1]
NP_001193873.1. NM_001206944.1.
NP_006565.2. NM_006574.3. [O95196-2]
UniGeneiHs.45127.

3D structure databases

ProteinModelPortaliO95196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115917. 5 interactors.
IntActiO95196. 1 interactor.
STRINGi9606.ENSP00000373244.

PTM databases

iPTMnetiO95196.
PhosphoSitePlusiO95196.
UniCarbKBiO95196.

Polymorphism and mutation databases

BioMutaiCSPG5.

Proteomic databases

PaxDbiO95196.
PeptideAtlasiO95196.
PRIDEiO95196.

Protocols and materials databases

DNASUi10675.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264723; ENSP00000264723; ENSG00000114646. [O95196-2]
ENST00000383738; ENSP00000373244; ENSG00000114646. [O95196-1]
ENST00000456150; ENSP00000392096; ENSG00000114646. [O95196-3]
GeneIDi10675.
KEGGihsa:10675.
UCSCiuc003crn.4. human. [O95196-1]

Organism-specific databases

CTDi10675.
DisGeNETi10675.
GeneCardsiCSPG5.
H-InvDBHIX0003276.
HGNCiHGNC:2467. CSPG5.
HPAiHPA071779.
MIMi606775. gene.
neXtProtiNX_O95196.
OpenTargetsiENSG00000114646.
PharmGKBiPA26965.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJTR. Eukaryota.
ENOG410YF9F. LUCA.
GeneTreeiENSGT00440000034270.
HOGENOMiHOG000112020.
HOVERGENiHBG081361.
InParanoidiO95196.
KOiK08116.
OMAiEPTYPFQ.
OrthoDBiEOG091G05S8.
PhylomeDBiO95196.
TreeFamiTF338636.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114646-MONOMER.
ReactomeiR-HSA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-HSA-2022870. Chondroitin sulfate biosynthesis.
R-HSA-2022923. Dermatan sulfate biosynthesis.
R-HSA-2024101. CS/DS degradation.
R-HSA-3560783. Defective B4GALT7 causes EDS, progeroid type.
R-HSA-3560801. Defective B3GAT3 causes JDSSDHD.
R-HSA-3595172. Defective CHST3 causes SEDCJD.
R-HSA-3595174. Defective CHST14 causes EDS, musculocontractural type.
R-HSA-3595177. Defective CHSY1 causes TPBS.
R-HSA-4420332. Defective B3GALT6 causes EDSP2 and SEMDJL1.

Miscellaneous databases

ChiTaRSiCSPG5. human.
GenomeRNAii10675.
PROiO95196.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114646.
CleanExiHS_CSPG5.
ExpressionAtlasiO95196. baseline and differential.
GenevisibleiO95196. HS.

Family and domain databases

InterProiIPR010555. Chon_Sulph_att.
IPR009505. Neural_ProG_Cyt.
[Graphical view]
PfamiPF06566. Chon_Sulph_att. 1 hit.
PF06567. Neural_ProG_Cyt. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSPG5_HUMAN
AccessioniPrimary (citable) accession number: O95196
Secondary accession number(s): Q71M39, Q71M40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.