ID   OAZ2_HUMAN              Reviewed;         189 AA.
AC   O95190;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   13-OCT-2009, entry version 62.
DE   RecName: Full=Ornithine decarboxylase antizyme 2;
DE            Short=ODC-Az 2;
DE            Short=AZ2;
GN   Name=OAZ2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=99000830; PubMed=9782076; DOI=10.1006/geno.1998.5434;
RA   Ivanov I.P., Gesteland R.F., Atkins J.F.;
RT   "A second mammalian antizyme: conservation of programmed ribosomal
RT   frameshifting.";
RL   Genomics 52:119-129(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=99282521; PubMed=10352227; DOI=10.1016/S0378-1119(99)00128-6;
RA   Zhou J., Atkins J.F., Gesteland R.F.;
RT   "Structure of human ornithine decarboxylase antizyme 2 gene.";
RL   Gene 232:165-171(1999).
CC   -!- FUNCTION: Binds to, and destabilizes, ornithine decarboxylase.
CC       Does not accelerate ornithine decarboxylase degeneration (By
CC       similarity).
CC   -!- INTERACTION:
CC       O14977:AZIN1; NbExp=1; IntAct=EBI-1051861, EBI-1054824;
CC       P11926:ODC1; NbExp=1; IntAct=EBI-1051861, EBI-1044287;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=1;
CC         Comment=A ribosomal frameshift occurs between the codons for
CC         Ser-32 and Asp-33. An autoregulatory mechanism enables
CC         modulation of frameshifting according to the cellular
CC         concentration of polyamines;
CC       Name=1;
CC         IsoId=O95190-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the ODC antizyme family.
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DR   EMBL; AF057297; AAD03265.1; -; mRNA.
DR   IPI; IPI00028937; -.
DR   RefSeq; NP_002528.1; -.
DR   UniGene; Hs.713816; -.
DR   UniGene; Hs.74563; -.
DR   IntAct; O95190; 2.
DR   STRING; O95190; -.
DR   PhosphoSite; O95190; -.
DR   PRIDE; O95190; -.
DR   Ensembl; ENST00000326005; ENSP00000316264; ENSG00000180304; Homo sapiens.
DR   Ensembl; ENST00000403937; ENSP00000385120; ENSG00000180304; Homo sapiens.
DR   GeneID; 4947; -.
DR   KEGG; hsa:4947; -.
DR   CTD; 4947; -.
DR   GeneCards; GC15M062766; -.
DR   H-InvDB; HIX0026777; -.
DR   HGNC; HGNC:8096; OAZ2.
DR   MIM; 604152; gene.
DR   PharmGKB; PA31885; -.
DR   HOGENOM; O95190; -.
DR   HOVERGEN; O95190; -.
DR   Reactome; REACT_13; Metabolism of amino acids.
DR   DrugBank; DB00129; L-Ornithine.
DR   NextBio; 19057; -.
DR   ArrayExpress; O95190; -.
DR   Bgee; O95190; -.
DR   CleanEx; HS_OAZ2; -.
DR   Genevestigator; O95190; -.
DR   GermOnline; ENSG00000180304; Homo sapiens.
DR   GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; TAS:ProtInc.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0006595; P:polyamine metabolic process; TAS:ProtInc.
DR   InterPro; IPR002993; ODC_AZ.
DR   PANTHER; PTHR10279; ODC_AZ; 1.
DR   Pfam; PF02100; ODC_AZ; 1.
DR   ProDom; PD007483; ODC_AZ; 1.
DR   PROSITE; PS01337; ODC_AZ; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Polymorphism; Ribosomal frameshifting.
FT   CHAIN         1    189       Ornithine decarboxylase antizyme 2.
FT                                /FTId=PRO_0000220857.
FT   VARIANT      70     70       P -> L (in dbSNP:rs3751534).
FT                                /FTId=VAR_050420.
SQ   SEQUENCE   189 AA;  21011 MW;  66390D87EB30CB8F CRC64;
     MINTQDSSIL PLSNCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD PSLSALIYKD
     EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ SLFVEIPDGL LADGSKEGLL
     ALLEFAEEKM KVNYVFICFR KGREDRAPLL KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP
     LDQNLSDED
//