O95190 (OAZ2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine decarboxylase antizyme 2
Short name=AZ2
Short name=ODC-Az 2

Gene names

Name:

OAZ2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the ODC antizyme family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism Ribosomal frameshifting
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	polyamine metabolic process Traceable author statement. Source: ProtInc regulation of cellular amino acid metabolic process Traceable author statement. Source: Reactome
Cellular component	cytosol Traceable author statement. Source: Reactome nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ornithine decarboxylase inhibitor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by ribosomal frameshifting. [Select]

Note: A ribosomal frameshift occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.

Isoform 1 (identifier: O95190-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Ornithine decarboxylase antizyme 2		PRO_0000220857
Amino acid modifications
	Modified residue	186	1	Phosphoserine By similarity
Natural variations
	Natural variant	70	1	P → L. Corresponds to variant rs3751534 [ dbSNP | Ensembl ].		VAR_050420

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 66390D87EB30CB8F	FASTA	189	21,011
	10 20 30 40 50 60 MINTQDSSIL PLSNCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD PSLSALIYKD 70 80 90 100 110 120 EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ SLFVEIPDGL LADGSKEGLL 130 140 150 160 170 180 ALLEFAEEKM KVNYVFICFR KGREDRAPLL KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP LDQNLSDED

References

[1]	"A second mammalian antizyme: conservation of programmed ribosomal frameshifting." Ivanov I.P., Gesteland R.F., Atkins J.F. Genomics 52:119-129(1998) [PubMed: 9782076] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure of human ornithine decarboxylase antizyme 2 gene." Zhou J., Atkins J.F., Gesteland R.F. Gene 232:165-171(1999) [PubMed: 10352227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF057297 mRNA. Translation: AAD03265.1.
IPI	IPI00028937.
RefSeq	NP_002528.1. NM_002537.2.
UniGene	Hs.74563.
3D structure databases
ProteinModelPortal	O95190.
SMR	O95190. Positions 56-182.
ModBase	Search...
Protein-protein interaction databases
STRING	O95190.
PTM databases
PhosphoSite	O95190.
Proteomic databases
PRIDE	O95190.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326005; ENSP00000316264; ENSG00000180304. ENST00000403937; ENSP00000385120; ENSG00000180304.
GeneID	4947.
KEGG	hsa:4947.
Organism-specific databases
CTD	4947.
GeneCards	GC15M064979.
H-InvDB	HIX0026777.
HGNC	HGNC:8096. OAZ2.
MIM	604152. gene.
neXtProt	NX_O95190.
PharmGKB	PA31885.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06132.
HOGENOM	HBG445846.
HOVERGEN	HBG007857.
InParanoid	O95190.
OrthoDB	EOG4F7NM4.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	O95190.
Bgee	O95190.
CleanEx	HS_OAZ2.
Genevestigator	O95190.
GermOnline	ENSG00000180304. Homo sapiens.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR002993. ODC_AZ. [Graphical view]
PANTHER	PTHR10279. ODC_AZ. 1 hit.
Pfam	PF02100. ODC_AZ. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS01337. ODC_AZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00129. L-Ornithine.
NextBio	19057.
SOURCE	Search...

Entry information

Entry name

OAZ2_HUMAN

Accession

Primary (citable) accession number: O95190

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.