Reviewed, UniProtKB/Swiss-Prot O95190 (OAZ2_HUMAN)

Names and origin

Protein names

Recommended name:
    Ornithine decarboxylase antizyme 2
      Short name=ODC-Az 2
      Short name=AZ2

Gene names

Name:

OAZ2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration By similarity.
Sequence similarities	Belongs to the ODC antizyme family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism Ribosomal frameshifting
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	polyamine metabolic process Traceable author statement. Source: ProtInc
Molecular function	ornithine decarboxylase inhibitor activity Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AZIN1	O14977	1	EBI-1051861,EBI-1054824
ODC1	P11926	1	EBI-1051861,EBI-1044287

Alternative products

This entry describes 1 isoform produced by ribosomal frameshifting. [Select]

Note: A ribosomal frameshift occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.

Isoform 1 (identifier: O95190-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Ornithine decarboxylase antizyme 2		PRO_0000220857
Natural variations
	Natural variant	70	1	P → L: dbSNP rs3751534.		VAR_050420

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 66390D87EB30CB8F	FASTA	189	21,011
	10 20 30 40 50 60 MINTQDSSIL PLSNCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD PSLSALIYKD 70 80 90 100 110 120 EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ SLFVEIPDGL LADGSKEGLL 130 140 150 160 170 180 ALLEFAEEKM KVNYVFICFR KGREDRAPLL KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP LDQNLSDED

References

[1]	"A second mammalian antizyme: conservation of programmed ribosomal frameshifting." Ivanov I.P., Gesteland R.F., Atkins J.F. Genomics 52:119-129(1998) [PubMed: 9782076] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure of human ornithine decarboxylase antizyme 2 gene." Zhou J., Atkins J.F., Gesteland R.F. Gene 232:165-171(1999) [PubMed: 10352227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF057297 mRNA. Translation: AAD03265.1.
IPI	IPI00028937.
RefSeq	NP_002528.1.
UniGene	Hs.713816 Hs.74563
3D structure databases
SMR	O95190. Positions 56-182.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95190. 2 interactions.
STRING	O95190.
PTM databases
PhosphoSite	O95190.
Proteomic databases
PRIDE	O95190.
Genome annotation databases
Ensembl	ENST00000326005; ENSP00000316264; ENSG00000180304; Homo sapiens. [Genome view] ENST00000403937; ENSP00000385120; ENSG00000180304; Homo sapiens. [Genome view]
GeneID	4947.
KEGG	hsa:4947.
Organism-specific databases
CTD	4947.
GeneCards	GC15M062766.
H-InvDB	HIX0026777.
HGNC	HGNC:8096. OAZ2.
MIM	604152. gene.
PharmGKB	PA31885.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06132.
HOGENOM	HBG445846.
HOVERGEN	O95190.
InParanoid	O95190.
Enzyme and pathway databases
Reactome	REACT_13. Metabolism of amino acids.
Gene expression databases
ArrayExpress	O95190.
Bgee	O95190.
CleanEx	HS_OAZ2.
Genevestigator	O95190.
GermOnline	ENSG00000180304. Homo sapiens.
Family and domain databases
InterPro	IPR002993. ODC_AZ. [Graphical view]
PANTHER	PTHR10279. ODC_AZ. 1 hit.
Pfam	PF02100. ODC_AZ. 1 hit. [Graphical view]
PROSITE	PS01337. ODC_AZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00129. L-Ornithine.
NextBio	19057.
SOURCE	Search...

Entry information

Entry name

OAZ2_HUMAN

Accession

Primary (citable) accession number: O95190

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1999
Last modified:	January 19, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.