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Protein

Ornithine decarboxylase antizyme 2

Gene

OAZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.1 Publication

GO - Molecular functioni

  • ornithine decarboxylase inhibitor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Polyamine biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-350562. Regulation of ornithine decarboxylase (ODC).

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase antizyme 2
Short name:
AZ2
Short name:
ODC-Az 2
Gene namesi
Name:OAZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:8096. OAZ2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4947.
OpenTargetsiENSG00000180304.
PharmGKBiPA31885.

Chemistry databases

DrugBankiDB00129. L-Ornithine.

Polymorphism and mutation databases

BioMutaiOAZ2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208571 – 189Ornithine decarboxylase antizyme 2Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO95190.
PRIDEiO95190.

PTM databases

iPTMnetiO95190.
PhosphoSitePlusiO95190.

Expressioni

Gene expression databases

BgeeiENSG00000180304.
CleanExiHS_OAZ2.
ExpressionAtlasiO95190. baseline and differential.
GenevisibleiO95190. HS.

Organism-specific databases

HPAiHPA047694.
HPA054139.

Interactioni

Subunit structurei

Interacts with AZIN2; the interaction leads to increased ornithine decarboxylase (ODC) activity and decreased rate of ODC degradation.1 Publication

Protein-protein interaction databases

BioGridi111001. 6 interactors.
STRINGi9606.ENSP00000463013.

Structurei

3D structure databases

ProteinModelPortaliO95190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ODC antizyme family.Curated

Phylogenomic databases

eggNOGiKOG4387. Eukaryota.
ENOG4112791. LUCA.
GeneTreeiENSGT00390000009476.
HOGENOMiHOG000115253.
HOVERGENiHBG007857.
InParanoidiO95190.
KOiK16613.
OMAiFICFRKS.
OrthoDBiEOG091G0SR0.
PhylomeDBiO95190.
TreeFamiTF314741.

Family and domain databases

InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR029916. ODC-AZ_2.
IPR002993. ODC_AZ.
[Graphical view]
PANTHERiPTHR10279. PTHR10279. 1 hit.
PTHR10279:SF6. PTHR10279:SF6. 1 hit.
PfamiPF02100. ODC_AZ. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS01337. ODC_AZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by ribosomal frameshifting. AlignAdd to basket

Note: A ribosomal frameshift occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.
Isoform 1 (identifier: O95190-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MINTQDSSIL PLSNCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD
60 70 80 90 100
PSLSALIYKD EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ
110 120 130 140 150
SLFVEIPDGL LADGSKEGLL ALLEFAEEKM KVNYVFICFR KGREDRAPLL
160 170 180
KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP LDQNLSDED
Length:189
Mass (Da):21,011
Last modified:May 1, 1999 - v1
Checksum:i66390D87EB30CB8F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05042070P → L.Corresponds to variant rs3751534dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057297 mRNA. Translation: AAD03265.1.
CCDSiCCDS58372.1. [O95190-1]
RefSeqiNP_002528.1. NM_002537.3. [O95190-1]
UniGeneiHs.744924.

Genome annotation databases

EnsembliENST00000326005; ENSP00000463013; ENSG00000180304. [O95190-1]
GeneIDi4947.
KEGGihsa:4947.
UCSCiuc002ano.3. human. [O95190-1]

Keywords - Coding sequence diversityi

Polymorphism, Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057297 mRNA. Translation: AAD03265.1.
CCDSiCCDS58372.1. [O95190-1]
RefSeqiNP_002528.1. NM_002537.3. [O95190-1]
UniGeneiHs.744924.

3D structure databases

ProteinModelPortaliO95190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111001. 6 interactors.
STRINGi9606.ENSP00000463013.

Chemistry databases

DrugBankiDB00129. L-Ornithine.

PTM databases

iPTMnetiO95190.
PhosphoSitePlusiO95190.

Polymorphism and mutation databases

BioMutaiOAZ2.

Proteomic databases

PaxDbiO95190.
PRIDEiO95190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326005; ENSP00000463013; ENSG00000180304. [O95190-1]
GeneIDi4947.
KEGGihsa:4947.
UCSCiuc002ano.3. human. [O95190-1]

Organism-specific databases

CTDi4947.
DisGeNETi4947.
GeneCardsiOAZ2.
H-InvDBHIX0026777.
HGNCiHGNC:8096. OAZ2.
HPAiHPA047694.
HPA054139.
MIMi604152. gene.
neXtProtiNX_O95190.
OpenTargetsiENSG00000180304.
PharmGKBiPA31885.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4387. Eukaryota.
ENOG4112791. LUCA.
GeneTreeiENSGT00390000009476.
HOGENOMiHOG000115253.
HOVERGENiHBG007857.
InParanoidiO95190.
KOiK16613.
OMAiFICFRKS.
OrthoDBiEOG091G0SR0.
PhylomeDBiO95190.
TreeFamiTF314741.

Enzyme and pathway databases

ReactomeiR-HSA-350562. Regulation of ornithine decarboxylase (ODC).

Miscellaneous databases

ChiTaRSiOAZ2. human.
GeneWikiiOAZ2.
GenomeRNAii4947.
PROiO95190.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180304.
CleanExiHS_OAZ2.
ExpressionAtlasiO95190. baseline and differential.
GenevisibleiO95190. HS.

Family and domain databases

InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR029916. ODC-AZ_2.
IPR002993. ODC_AZ.
[Graphical view]
PANTHERiPTHR10279. PTHR10279. 1 hit.
PTHR10279:SF6. PTHR10279:SF6. 1 hit.
PfamiPF02100. ODC_AZ. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS01337. ODC_AZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAZ2_HUMAN
AccessioniPrimary (citable) accession number: O95190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.