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Protein

Vesicle-associated membrane protein 5

Gene

VAMP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 5
Short name:
VAMP-5
Alternative name(s):
Myobrevin
Gene namesi
Name:VAMP5
ORF Names:HSPC191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12646. VAMP5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272CytoplasmicSequence analysisAdd
BLAST
Transmembranei73 – 9321Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini94 – 11623VesicularSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • cytoplasmic vesicle membrane Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of organelle membrane Source: BHF-UCL
  • integral component of plasma membrane Source: Ensembl
  • intercalated disc Source: BHF-UCL
  • late endosome Source: BHF-UCL
  • perinuclear region of cytoplasm Source: BHF-UCL
  • plasma membrane Source: ProtInc
  • SNARE complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37270.

Polymorphism and mutation databases

BioMutaiVAMP5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116Vesicle-associated membrane protein 5PRO_0000206733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphoserineBy similarity
Modified residuei48 – 481PhosphoserineCombined sources
Modified residuei49 – 491PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95183.
PaxDbiO95183.
PeptideAtlasiO95183.
PRIDEiO95183.

PTM databases

iPTMnetiO95183.
PhosphoSiteiO95183.
SwissPalmiO95183.

Expressioni

Inductioni

During myogenesis.

Gene expression databases

BgeeiENSG00000168899.
CleanExiHS_VAMP5.
ExpressionAtlasiO95183. baseline and differential.
GenevisibleiO95183. HS.

Organism-specific databases

HPAiHPA035082.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SNAP23A8K2873EBI-10191195,EBI-10188497
SNAP29O957213EBI-10191195,EBI-490676
STX16O146623EBI-10191195,EBI-2853548
STX4Q128463EBI-10191195,EBI-744942

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116007. 7 interactions.
IntActiO95183. 5 interactions.
MINTiMINT-4658060.
STRINGi9606.ENSP00000305647.

Structurei

3D structure databases

ProteinModelPortaliO95183.
SMRiO95183. Positions 6-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 6561v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00730000111371.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiO95183.
KOiK08514.
OMAiKRWENIR.
OrthoDBiEOG091G0ZXR.
PhylomeDBiO95183.
TreeFamiTF313666.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST
60 70 80 90 100
FNKTTQNLAQ KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS
110
SAPRTQDAGI ASGPGN
Length:116
Mass (Da):12,805
Last modified:May 1, 1999 - v1
Checksum:i32A1F3B808A6016C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171T → M in AAF36111 (PubMed:11042152).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054825 mRNA. Translation: AAC97473.1.
AF077197 mRNA. Translation: AAD26992.1.
AF151025 mRNA. Translation: AAF36111.1.
BC017891 mRNA. Translation: AAH17891.1.
CCDSiCCDS1980.1.
RefSeqiNP_006625.1. NM_006634.2.
UniGeneiHs.534373.

Genome annotation databases

EnsembliENST00000306384; ENSP00000305647; ENSG00000168899.
GeneIDi10791.
KEGGihsa:10791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054825 mRNA. Translation: AAC97473.1.
AF077197 mRNA. Translation: AAD26992.1.
AF151025 mRNA. Translation: AAF36111.1.
BC017891 mRNA. Translation: AAH17891.1.
CCDSiCCDS1980.1.
RefSeqiNP_006625.1. NM_006634.2.
UniGeneiHs.534373.

3D structure databases

ProteinModelPortaliO95183.
SMRiO95183. Positions 6-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116007. 7 interactions.
IntActiO95183. 5 interactions.
MINTiMINT-4658060.
STRINGi9606.ENSP00000305647.

PTM databases

iPTMnetiO95183.
PhosphoSiteiO95183.
SwissPalmiO95183.

Polymorphism and mutation databases

BioMutaiVAMP5.

Proteomic databases

EPDiO95183.
PaxDbiO95183.
PeptideAtlasiO95183.
PRIDEiO95183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306384; ENSP00000305647; ENSG00000168899.
GeneIDi10791.
KEGGihsa:10791.

Organism-specific databases

CTDi10791.
GeneCardsiVAMP5.
HGNCiHGNC:12646. VAMP5.
HPAiHPA035082.
MIMi607029. gene.
neXtProtiNX_O95183.
PharmGKBiPA37270.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00730000111371.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiO95183.
KOiK08514.
OMAiKRWENIR.
OrthoDBiEOG091G0ZXR.
PhylomeDBiO95183.
TreeFamiTF313666.

Miscellaneous databases

ChiTaRSiVAMP5. human.
GenomeRNAii10791.
PROiO95183.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168899.
CleanExiHS_VAMP5.
ExpressionAtlasiO95183. baseline and differential.
GenevisibleiO95183. HS.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAMP5_HUMAN
AccessioniPrimary (citable) accession number: O95183
Secondary accession number(s): Q9P0T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.