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Protein

Vesicle-associated membrane protein 5

Gene

VAMP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 5
Short name:
VAMP-5
Alternative name(s):
Myobrevin
Gene namesi
Name:VAMP5
ORF Names:HSPC191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12646. VAMP5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72CytoplasmicSequence analysisAdd BLAST72
Transmembranei73 – 93Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini94 – 116VesicularSequence analysisAdd BLAST23

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • cytoplasmic vesicle membrane Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of organelle membrane Source: BHF-UCL
  • integral component of plasma membrane Source: Ensembl
  • intercalated disc Source: BHF-UCL
  • late endosome Source: BHF-UCL
  • perinuclear region of cytoplasm Source: BHF-UCL
  • plasma membrane Source: ProtInc
  • SNARE complex Source: GO_Central

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168899.
PharmGKBiPA37270.

Polymorphism and mutation databases

BioMutaiVAMP5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067331 – 116Vesicle-associated membrane protein 5Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95183.
PaxDbiO95183.
PeptideAtlasiO95183.
PRIDEiO95183.

PTM databases

iPTMnetiO95183.
PhosphoSitePlusiO95183.
SwissPalmiO95183.

Expressioni

Inductioni

During myogenesis.

Gene expression databases

BgeeiENSG00000168899.
CleanExiHS_VAMP5.
ExpressionAtlasiO95183. baseline and differential.
GenevisibleiO95183. HS.

Organism-specific databases

HPAiHPA035082.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116007. 35 interactors.
IntActiO95183. 20 interactors.
MINTiMINT-4658060.
STRINGi9606.ENSP00000305647.

Structurei

3D structure databases

ProteinModelPortaliO95183.
SMRiO95183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 65v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00730000111371.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiO95183.
KOiK08514.
OMAiKRWENIR.
OrthoDBiEOG091G0ZXR.
PhylomeDBiO95183.
TreeFamiTF313666.

Family and domain databases

InterProiView protein in InterPro
IPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
PfamiView protein in Pfam
PF00957. Synaptobrevin. 1 hit.
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiView protein in PROSITE
PS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.

Sequencei

Sequence statusi: Complete.

O95183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST
60 70 80 90 100
FNKTTQNLAQ KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS
110
SAPRTQDAGI ASGPGN
Length:116
Mass (Da):12,805
Last modified:May 1, 1999 - v1
Checksum:i32A1F3B808A6016C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17T → M in AAF36111 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054825 mRNA. Translation: AAC97473.1.
AF077197 mRNA. Translation: AAD26992.1.
AF151025 mRNA. Translation: AAF36111.1.
BC017891 mRNA. Translation: AAH17891.1.
CCDSiCCDS1980.1.
RefSeqiNP_006625.1. NM_006634.2.
UniGeneiHs.534373.

Genome annotation databases

EnsembliENST00000306384; ENSP00000305647; ENSG00000168899.
GeneIDi10791.
KEGGihsa:10791.

Similar proteinsi

Entry informationi

Entry nameiVAMP5_HUMAN
AccessioniPrimary (citable) accession number: O95183
Secondary accession number(s): Q9P0T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: August 30, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families