O95183 (VAMP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vesicle-associated membrane protein 5
Short name=VAMP-5

Alternative name(s):
Myobrevin

Gene names

Name:	VAMP5
ORF Names:	HSPC191

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
Subcellular location	Cell membrane; Single-pass type IV membrane protein Probable. Endomembrane system; Single-pass type IV membrane protein Probable. Golgi apparatus › trans-Golgi network membrane; Single-pass type IV membrane protein Probable. Note: Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus By similarity.
Induction	During myogenesis.
Sequence similarities	Belongs to the synaptobrevin family. Contains 1 v-SNARE coiled-coil homology domain.

Ontologies

Keywords
Biological process	Differentiation Myogenesis
Cellular component	Cell membrane Golgi apparatus Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular component	endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 116	116	Vesicle-associated membrane protein 5		PRO_0000206733
Regions
	Topological domain	1 – 72	72	Cytoplasmic Potential
	Transmembrane	73 – 93	21	Helical; Anchor for type IV membrane protein; Potential
	Topological domain	94 – 116	23	Vesicular Potential
	Domain	5 – 65	61	v-SNARE coiled-coil homology
Amino acid modifications
	Modified residue	41	1	Phosphoserine Ref.4
	Modified residue	48	1	Phosphoserine Ref.4
	Modified residue	49	1	Phosphoserine Ref.4
Experimental info
	Sequence conflict	17	1	T → M in AAF36111. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O95183 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 32A1F3B808A6016C	FASTA	116	12,805
	10 20 30 40 50 60 MAGIELERCQ QQANEVTEIM RNNFGKVLER GVKLAELQQR SDQLLDMSST FNKTTQNLAQ 70 80 90 100 110 KKCWENIRYR ICVGLVVVGV LLIILIVLLV VFLPQSSDSS SAPRTQDAGI ASGPGN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane." Zeng Q., Subramaniam V.N., Wong S.H., Tang B.L., Parton R.G., Rea S., James D.E., Hong W. Mol. Biol. Cell 9:2423-2437(1998) [PubMed: 9725904] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-48 AND SER-49, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF054825 mRNA. Translation: AAC97473.1. AF077197 mRNA. Translation: AAD26992.1. AF151025 mRNA. Translation: AAF36111.1. BC017891 mRNA. Translation: AAH17891.1.
IPI	IPI00293756.
RefSeq	NP_006625.1. NM_006634.2.
UniGene	Hs.534373.
3D structure databases
ProteinModelPortal	O95183.
SMR	O95183. Positions 3-89.
ModBase	Search...
Protein-protein interaction databases
STRING	O95183.
PTM databases
PhosphoSite	O95183.
Proteomic databases
PeptideAtlas	O95183.
PRIDE	O95183.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306384; ENSP00000305647; ENSG00000168899.
GeneID	10791.
KEGG	hsa:10791.
UCSC	uc002spu.1. human.
Organism-specific databases
CTD	10791.
GeneCards	GC02P085811.
H-InvDB	HIX0200251.
HGNC	HGNC:12646. VAMP5.
HPA	HPA035082.
MIM	607029. gene.
neXtProt	NX_O95183.
PharmGKB	PA37270.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21031.
HOGENOM	HBG386095.
HOVERGEN	HBG006675.
InParanoid	O95183.
OMA	LDMSSAF.
OrthoDB	EOG4HMJBV.
PhylomeDB	O95183.
Gene expression databases
ArrayExpress	O95183.
Bgee	O95183.
CleanEx	HS_VAMP5.
Genevestigator	O95183.
GermOnline	ENSG00000168899. Homo sapiens.
Family and domain databases
InterPro	IPR001388. Synaptobrevin. IPR016444. Synaptobrevin_met/fun. [Graphical view]
KO	K08514.
Pfam	PF00957. Synaptobrevin. 1 hit. [Graphical view]
PIRSF	PIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTS	PR00219. SYNAPTOBREVN.
PROSITE	PS00417. SYNAPTOBREVIN. 1 hit. PS50892. V_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	40986.
SOURCE	Search...

Entry information

Entry name

VAMP5_HUMAN

Accession

Primary (citable) accession number: O95183
Secondary accession number(s): Q9P0T2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.