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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

Gene

NDUFA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  • mitochondrial respiratory chain complex I assembly Source: Reactome
  • mitochondrial translation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Alternative name(s):
Complex I-B14.5a
Short name:
CI-B14.5a
NADH-ubiquinone oxidoreductase subunit B14.5a
Gene namesi
Name:NDUFA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7691. NDUFA7.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial respiratory chain complex I Source: UniProtKB
  • mitochondrial ribosome Source: UniProtKB
  • mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31497.

Chemistry

ChEMBLiCHEMBL2363065.

Polymorphism and mutation databases

BioMutaiNDUFA7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 113112NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7PRO_0000118834Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei40 – 401N6-acetyllysineBy similarity
Modified residuei96 – 961PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95182.
MaxQBiO95182.
PaxDbiO95182.
PeptideAtlasiO95182.
PRIDEiO95182.
TopDownProteomicsiO95182.

PTM databases

iPTMnetiO95182.
PhosphoSiteiO95182.

Expressioni

Gene expression databases

BgeeiENSG00000267855.
CleanExiHS_NDUFA7.
ExpressionAtlasiO95182. baseline and differential.
GenevisibleiO95182. HS.

Organism-specific databases

HPAiHPA059251.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

BioGridi110781. 77 interactions.
IntActiO95182. 22 interactions.
MINTiMINT-1400829.
STRINGi9606.ENSP00000470609.

Structurei

3D structure databases

ProteinModelPortaliO95182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA7 subunit family.Curated

Phylogenomic databases

eggNOGiKOG4630. Eukaryota.
ENOG410XW5P. LUCA.
GeneTreeiENSGT00390000006553.
HOVERGENiHBG002178.
InParanoidiO95182.
KOiK03951.
OMAiGHDLQAK.
OrthoDBiEOG091G16YW.
PhylomeDBiO95182.
TreeFamiTF319126.

Family and domain databases

InterProiIPR009947. NADH-UbQ_OxRdtase_B14.5a_su.
[Graphical view]
PANTHERiPTHR12485. PTHR12485. 1 hit.
PfamiPF07347. CI-B14_5a. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASATRLIQR LRNWASGHDL QGKLQLRYQE ISKRTQPPPK LPVGPSHKLS
60 70 80 90 100
NNYYCTRDGR RESVPPSIIM SSQKALVSGK PAESSAVAAT EKKAVTPAPP
110
IKRWELSSDQ PYL
Length:113
Mass (Da):12,551
Last modified:January 23, 2007 - v3
Checksum:i0B6BF051809B5E9E
GO

Sequence cautioni

The sequence AAC99399 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661P → A.
Corresponds to variant rs2288415 [ dbSNP | Ensembl ].
VAR_050589

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050637 mRNA. Translation: AAD05427.1.
AF054178 mRNA. Translation: AAC99399.1. Different initiation.
BC003102 mRNA. Translation: AAH03102.1.
CCDSiCCDS42492.1.
PIRiJE0380.
RefSeqiNP_004992.2. NM_005001.4.
UniGeneiHs.333427.

Genome annotation databases

EnsembliENST00000301457; ENSP00000301457; ENSG00000267855.
ENST00000593729; ENSP00000470962; ENSG00000267855.
GeneIDi4701.
KEGGihsa:4701.
UCSCiuc002mjm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050637 mRNA. Translation: AAD05427.1.
AF054178 mRNA. Translation: AAC99399.1. Different initiation.
BC003102 mRNA. Translation: AAH03102.1.
CCDSiCCDS42492.1.
PIRiJE0380.
RefSeqiNP_004992.2. NM_005001.4.
UniGeneiHs.333427.

3D structure databases

ProteinModelPortaliO95182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110781. 77 interactions.
IntActiO95182. 22 interactions.
MINTiMINT-1400829.
STRINGi9606.ENSP00000470609.

Chemistry

ChEMBLiCHEMBL2363065.

PTM databases

iPTMnetiO95182.
PhosphoSiteiO95182.

Polymorphism and mutation databases

BioMutaiNDUFA7.

Proteomic databases

EPDiO95182.
MaxQBiO95182.
PaxDbiO95182.
PeptideAtlasiO95182.
PRIDEiO95182.
TopDownProteomicsiO95182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301457; ENSP00000301457; ENSG00000267855.
ENST00000593729; ENSP00000470962; ENSG00000267855.
GeneIDi4701.
KEGGihsa:4701.
UCSCiuc002mjm.3. human.

Organism-specific databases

CTDi4701.
GeneCardsiNDUFA7.
HGNCiHGNC:7691. NDUFA7.
HPAiHPA059251.
MIMi602139. gene.
neXtProtiNX_O95182.
PharmGKBiPA31497.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4630. Eukaryota.
ENOG410XW5P. LUCA.
GeneTreeiENSGT00390000006553.
HOVERGENiHBG002178.
InParanoidiO95182.
KOiK03951.
OMAiGHDLQAK.
OrthoDBiEOG091G16YW.
PhylomeDBiO95182.
TreeFamiTF319126.

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNDUFA7. human.
GenomeRNAii4701.
PROiO95182.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000267855.
CleanExiHS_NDUFA7.
ExpressionAtlasiO95182. baseline and differential.
GenevisibleiO95182. HS.

Family and domain databases

InterProiIPR009947. NADH-UbQ_OxRdtase_B14.5a_su.
[Graphical view]
PANTHERiPTHR12485. PTHR12485. 1 hit.
PfamiPF07347. CI-B14_5a. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUA7_HUMAN
AccessioniPrimary (citable) accession number: O95182
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.